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The map label for this gene is serA [H]

Identifier: 119944373

GI number: 119944373

Start: 782254

End: 783483

Strand: Reverse

Name: serA [H]

Synonym: Ping_0600

Alternate gene names: 119944373

Gene position: 783483-782254 (Counterclockwise)

Preceding gene: 119944374

Following gene: 119944361

Centisome position: 17.18

GC content: 39.92

Gene sequence:

>1230_bases
ATGACTAAGCTTTCGCTTGATAAAGATAAAATAAAAATTCTGCTACTTGAAGGATTACATCAAAGTGCGGTTGATACTTT
CACCCAGGCTGGTTACAACAACATCCAAAACATCAAAACAGCGTTAAGCGAAGAAGAATTAATTGAAAAAATTAAAGATG
CACATTTTGTTGGTATCCGTTCCCGTTCTAACCTTAATGCAACCGTATTAGCTGCCGCAGATAAACTGGTTGGCATCGGT
TGTTTTTGTATCGGTACCAATCAGGTTGATTTGAATGCGGCTCAAGCAAAAGGAATCGCAGTATTTAACGCGCCTTTTTC
AAATACCCGCAGTGTTGCTGAATTAGTGTTAGGTCAGTCATTATTATTATTGCGTGGTATTCCAGAGCGTAACGCAAAAG
CGCATCGCGGCGAGTGGGATAAATCAGCCACTAAGTCCTATGAAGCGCGTGGTAAAAATTTAGGTATTATTGGCTATGGC
CATATTGGAACTCAGTTTGGTATTCTTGCTGAAAACTTAGGTTTTAAGGTGTCATATTACGACGTCGAAAATAAATTAAG
CTTAGGTAATGCGGTACAGATAGCGACAATGGAAGCCTTGCTTGCTCAGTCTGATATTATTAGTCTGCATGTTCCTGAAC
TTGACTCGACTAAAAACATGATGGGTGCTAAAGAATTTGCACAAATGAAAGATGGTGCGATCTTTATGAACGCAGCACGT
GGCACCGTTGTTGATATCCCGGCGTTATGCGCAGCACTTGAGAGTAAAAAACTTTCTGGAGCCGCTATTGATGTGTTCCC
AACTGAGCCCGGATCAAATAAAGAAGAGTTTATTTCTCCGTTGCGTAAGTTTGATAACGTACTCTTAACTCCCCACGTTG
GTGGCAGCACCCAGGAAGCACAAGAAAATATTGGCTATGAAGTTGCGGGCAAGTTAGTTAAATACTCTGATAATGGTTCA
ACATTGTCTTCTAATAACTTTCCTGAAGTATCTCTACCGGTGCATGTTGATGCCAGCCGTTTACTGCATATTCATAAAAA
TATGCCGGGTATTCTAACCAAAATCAACTTGACCTTTGAAGAGTATGGCATCAATATTGCGGCACAATACCTGCAAACAA
ATGCAAATATTGGTTATGTGGTCATTGATGTAAATAGTGATGATGCGCAACTTGCATTAGCTAAATTAAATGAGATCGAA
GGGACAATTAAAGCGCGTTTATTAAGATAA

Upstream 100 bases:

>100_bases
TTTATCAACTAAGTCTGCTTATTGAATACTTAGTTGGCATATTGGAACTCTTAAAATTTGTTTGTCCATTTACCTTATTG
ACAGACCACAAGGAAATATA

Downstream 100 bases:

>100_bases
ACCCACCAACATCTAGCATCTCTCGACCCTTAAAAAACCTGAATGTGATATTCAGGTTTTTTAAGGTCGTAATCAAAGTG
CCAGATTCTCCGGCTTGATC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MTKLSLDKDKIKILLLEGLHQSAVDTFTQAGYNNIQNIKTALSEEELIEKIKDAHFVGIRSRSNLNATVLAAADKLVGIG
CFCIGTNQVDLNAAQAKGIAVFNAPFSNTRSVAELVLGQSLLLLRGIPERNAKAHRGEWDKSATKSYEARGKNLGIIGYG
HIGTQFGILAENLGFKVSYYDVENKLSLGNAVQIATMEALLAQSDIISLHVPELDSTKNMMGAKEFAQMKDGAIFMNAAR
GTVVDIPALCAALESKKLSGAAIDVFPTEPGSNKEEFISPLRKFDNVLLTPHVGGSTQEAQENIGYEVAGKLVKYSDNGS
TLSSNNFPEVSLPVHVDASRLLHIHKNMPGILTKINLTFEEYGINIAAQYLQTNANIGYVVIDVNSDDAQLALAKLNEIE
GTIKARLLR

Sequences:

>Translated_409_residues
MTKLSLDKDKIKILLLEGLHQSAVDTFTQAGYNNIQNIKTALSEEELIEKIKDAHFVGIRSRSNLNATVLAAADKLVGIG
CFCIGTNQVDLNAAQAKGIAVFNAPFSNTRSVAELVLGQSLLLLRGIPERNAKAHRGEWDKSATKSYEARGKNLGIIGYG
HIGTQFGILAENLGFKVSYYDVENKLSLGNAVQIATMEALLAQSDIISLHVPELDSTKNMMGAKEFAQMKDGAIFMNAAR
GTVVDIPALCAALESKKLSGAAIDVFPTEPGSNKEEFISPLRKFDNVLLTPHVGGSTQEAQENIGYEVAGKLVKYSDNGS
TLSSNNFPEVSLPVHVDASRLLHIHKNMPGILTKINLTFEEYGINIAAQYLQTNANIGYVVIDVNSDDAQLALAKLNEIE
GTIKARLLR
>Mature_408_residues
TKLSLDKDKIKILLLEGLHQSAVDTFTQAGYNNIQNIKTALSEEELIEKIKDAHFVGIRSRSNLNATVLAAADKLVGIGC
FCIGTNQVDLNAAQAKGIAVFNAPFSNTRSVAELVLGQSLLLLRGIPERNAKAHRGEWDKSATKSYEARGKNLGIIGYGH
IGTQFGILAENLGFKVSYYDVENKLSLGNAVQIATMEALLAQSDIISLHVPELDSTKNMMGAKEFAQMKDGAIFMNAARG
TVVDIPALCAALESKKLSGAAIDVFPTEPGSNKEEFISPLRKFDNVLLTPHVGGSTQEAQENIGYEVAGKLVKYSDNGST
LSSNNFPEVSLPVHVDASRLLHIHKNMPGILTKINLTFEEYGINIAAQYLQTNANIGYVVIDVNSDDAQLALAKLNEIEG
TIKARLLR

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=304, Percent_Identity=36.1842105263158, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI145580578, Length=230, Percent_Identity=32.1739130434783, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4557499, Length=230, Percent_Identity=32.1739130434783, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI61743967, Length=247, Percent_Identity=30.3643724696356, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI4557497, Length=247, Percent_Identity=30.3643724696356, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI145580575, Length=230, Percent_Identity=32.1739130434783, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI6912396, Length=249, Percent_Identity=26.9076305220884, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1789279, Length=410, Percent_Identity=67.5609756097561, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI87082289, Length=252, Percent_Identity=32.1428571428571, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1787645, Length=232, Percent_Identity=28.448275862069, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788660, Length=259, Percent_Identity=27.7992277992278, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=32.2981366459627, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=244, Percent_Identity=28.2786885245902, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320925, Length=413, Percent_Identity=47.4576271186441, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6322116, Length=413, Percent_Identity=46.9733656174334, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6324964, Length=258, Percent_Identity=29.8449612403101, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=242, Percent_Identity=28.9256198347107, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6324980, Length=193, Percent_Identity=27.4611398963731, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325144, Length=155, Percent_Identity=32.258064516129, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921140, Length=319, Percent_Identity=31.0344827586207, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI28574286, Length=265, Percent_Identity=30.188679245283, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24646446, Length=246, Percent_Identity=30.4878048780488, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646448, Length=246, Percent_Identity=30.4878048780488, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646452, Length=246, Percent_Identity=30.4878048780488, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646450, Length=246, Percent_Identity=30.4878048780488, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI62472511, Length=246, Percent_Identity=30.4878048780488, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28571528, Length=275, Percent_Identity=29.4545454545455, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24585514, Length=285, Percent_Identity=25.9649122807018, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574282, Length=285, Percent_Identity=25.9649122807018, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574284, Length=285, Percent_Identity=25.9649122807018, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45551003, Length=285, Percent_Identity=25.9649122807018, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45552429, Length=285, Percent_Identity=25.9649122807018, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24585516, Length=282, Percent_Identity=26.5957446808511, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44225; Mature: 44094

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLSLDKDKIKILLLEGLHQSAVDTFTQAGYNNIQNIKTALSEEELIEKIKDAHFVGIR
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHCCCEEEEEE
SRSNLNATVLAAADKLVGIGCFCIGTNQVDLNAAQAKGIAVFNAPFSNTRSVAELVLGQS
CCCCCCEEEEEECCCEEEEEEEEEECCEEECCHHCCCCEEEEECCCCCHHHHHHHHHCCC
LLLLRGIPERNAKAHRGEWDKSATKSYEARGKNLGIIGYGHIGTQFGILAENLGFKVSYY
EEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCCEEEEE
DVENKLSLGNAVQIATMEALLAQSDIISLHVPELDSTKNMMGAKEFAQMKDGAIFMNAAR
ECCCCCCCCCEEEHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECC
GTVVDIPALCAALESKKLSGAAIDVFPTEPGSNKEEFISPLRKFDNVLLTPHVGGSTQEA
CCEEEHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEECCCCCCCHHH
QENIGYEVAGKLVKYSDNGSTLSSNNFPEVSLPVHVDASRLLHIHKNMPGILTKINLTFE
HHHCCHHEECEEEEECCCCCCCCCCCCCEEEEEEEECHHHHHEECCCCCCEEEEEEEEHH
EYGINIAAQYLQTNANIGYVVIDVNSDDAQLALAKLNEIEGTIKARLLR
HHCCCEEEEEHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHHEECC
>Mature Secondary Structure 
TKLSLDKDKIKILLLEGLHQSAVDTFTQAGYNNIQNIKTALSEEELIEKIKDAHFVGIR
CCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHCCCEEEEEE
SRSNLNATVLAAADKLVGIGCFCIGTNQVDLNAAQAKGIAVFNAPFSNTRSVAELVLGQS
CCCCCCEEEEEECCCEEEEEEEEEECCEEECCHHCCCCEEEEECCCCCHHHHHHHHHCCC
LLLLRGIPERNAKAHRGEWDKSATKSYEARGKNLGIIGYGHIGTQFGILAENLGFKVSYY
EEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCCEEEEE
DVENKLSLGNAVQIATMEALLAQSDIISLHVPELDSTKNMMGAKEFAQMKDGAIFMNAAR
ECCCCCCCCCEEEHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECC
GTVVDIPALCAALESKKLSGAAIDVFPTEPGSNKEEFISPLRKFDNVLLTPHVGGSTQEA
CCEEEHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEECCCCCCCHHH
QENIGYEVAGKLVKYSDNGSTLSSNNFPEVSLPVHVDASRLLHIHKNMPGILTKINLTFE
HHHCCHHEECEEEEECCCCCCCCCCCCCEEEEEEEECHHHHHEECCCCCCEEEEEEEEHH
EYGINIAAQYLQTNANIGYVVIDVNSDDAQLALAKLNEIEGTIKARLLR
HHCCCEEEEEHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]