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The map label for this gene is mutY [H]

Identifier: 119900101

GI number: 119900101

Start: 4172470

End: 4173570

Strand: Direct

Name: mutY [H]

Synonym: azo3812

Alternate gene names: 119900101

Gene position: 4172470-4173570 (Clockwise)

Preceding gene: 119900099

Following gene: 119900104

Centisome position: 95.35

GC content: 74.21

Gene sequence:

>1101_bases
ATGACACCCCCACGCCCCGCTCCGTCCGCCCCCCCGCCCGCTGCCGCCGGCCCGCGGGACTTCGCCGCGCGCCTGCTCGA
CTGGCAGCGTACCGACGGCCGTCACGACCTGCCCTGGCAACGCAGCGCCGACCCGTACCGGATCTGGCTGTCGGAGATCA
TGCTGCAGCAGACCCAGGTGGAAACGGTGATCCCGTACTACGCGCGCTTTCTCGACCGTTTCCCGACGCTGGCGGACCTT
GCGGCGGCGCCGGTGGAGGACGTGATGGCGCTGTGGAGCGGGCTGGGCTACTACGCCCGCGCGCGCAACCTGCACCGCGC
GGCGGTGGCGGTGGCGACGCAGCACGGCGGCCGCTTCCCGCCCAGCGCGGCGGCCATCGCCGAGCTGCCCGGCATCGGCC
GTTCGACCGCGGCGGCGATTGCCGCCTTTGCCTACGGCGAGCGCGCCGCGATCCTCGACGGCAACGTCAAGCGCGTGTTG
TGCCGCGCCTTCGGCATCGACGGTTTTCCGGGCGAAAAGGCGGTGGAAAACCGGCTGTGGGCGCTGGCCGACGCGCTGCT
GCCGCAGGCCGAGGTCGGGCGCTACATCCAGGCGCAGATGGACCTGGGCGCCACCGTATGCACCCGCGGCAAGCCGGCTT
GCACGCGCTGTCCGTTCGCCGCGGACTGCGTGGCGCTCACGACCGGGCGCGTCGGCGAACTGCCCGTGCCGCGGCCGCGG
AAGGCGGCGCCGCGCCGCCACAGCCGCATGGCCGTGCTGCGGTGCGGGGATCGGGTCCTGCTGGAGCGCCGCCCGCCGGC
CGGCATCTGGGGCGGGCTGCTGGCGCTGCCGGAAATCCCGCCAGACGGCGCCAATGTCGGCCAATGGACGCAGGCGCGCT
TCGGCCTGCGCGCCACGACGATGACGCCGCTGCCGCCGCTGACCCATGTGTTCACCCACTTCGTGCTGGAGATCGCGCCG
CTGCAGATCGAGGTCGAAGCCGGCGGGAGCCGGGCGGATGACGATGGCGCGCTGTGCTGGCTGGCGCTGTCCGACACCAC
GGGCGCGGCGCTGCCGACGCCGGTGCGGCGCATCCTCGACGGGCTGGCGACGCCGGACTGA

Upstream 100 bases:

>100_bases
GCCGGAAGGCCCCGGGCGCGTCTGCCCGACGCACCGAAGGGCGAAAACGCCCGATTATCGCCGTGAAGCCCTGCCCCGTC
GAGCACTGCACTCCCCACTG

Downstream 100 bases:

>100_bases
ATGAAAGCGCGCTCCCCTTCAAGGGAGCGTAGGCGGGGTTTTACAGCGCATCGCGCTGCGCCGCCGAAGGGGCGGAGCGA
AGCGAGGATTCCCGGGTTGG

Product: putative A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MTPPRPAPSAPPPAAAGPRDFAARLLDWQRTDGRHDLPWQRSADPYRIWLSEIMLQQTQVETVIPYYARFLDRFPTLADL
AAAPVEDVMALWSGLGYYARARNLHRAAVAVATQHGGRFPPSAAAIAELPGIGRSTAAAIAAFAYGERAAILDGNVKRVL
CRAFGIDGFPGEKAVENRLWALADALLPQAEVGRYIQAQMDLGATVCTRGKPACTRCPFAADCVALTTGRVGELPVPRPR
KAAPRRHSRMAVLRCGDRVLLERRPPAGIWGGLLALPEIPPDGANVGQWTQARFGLRATTMTPLPPLTHVFTHFVLEIAP
LQIEVEAGGSRADDDGALCWLALSDTTGAALPTPVRRILDGLATPD

Sequences:

>Translated_366_residues
MTPPRPAPSAPPPAAAGPRDFAARLLDWQRTDGRHDLPWQRSADPYRIWLSEIMLQQTQVETVIPYYARFLDRFPTLADL
AAAPVEDVMALWSGLGYYARARNLHRAAVAVATQHGGRFPPSAAAIAELPGIGRSTAAAIAAFAYGERAAILDGNVKRVL
CRAFGIDGFPGEKAVENRLWALADALLPQAEVGRYIQAQMDLGATVCTRGKPACTRCPFAADCVALTTGRVGELPVPRPR
KAAPRRHSRMAVLRCGDRVLLERRPPAGIWGGLLALPEIPPDGANVGQWTQARFGLRATTMTPLPPLTHVFTHFVLEIAP
LQIEVEAGGSRADDDGALCWLALSDTTGAALPTPVRRILDGLATPD
>Mature_365_residues
TPPRPAPSAPPPAAAGPRDFAARLLDWQRTDGRHDLPWQRSADPYRIWLSEIMLQQTQVETVIPYYARFLDRFPTLADLA
AAPVEDVMALWSGLGYYARARNLHRAAVAVATQHGGRFPPSAAAIAELPGIGRSTAAAIAAFAYGERAAILDGNVKRVLC
RAFGIDGFPGEKAVENRLWALADALLPQAEVGRYIQAQMDLGATVCTRGKPACTRCPFAADCVALTTGRVGELPVPRPRK
AAPRRHSRMAVLRCGDRVLLERRPPAGIWGGLLALPEIPPDGANVGQWTQARFGLRATTMTPLPPLTHVFTHFVLEIAPL
QIEVEAGGSRADDDGALCWLALSDTTGAALPTPVRRILDGLATPD

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298650, Length=400, Percent_Identity=33.5, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI115298654, Length=400, Percent_Identity=33.5, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI115298652, Length=400, Percent_Identity=33.5, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI190358497, Length=400, Percent_Identity=34, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI115298648, Length=400, Percent_Identity=34, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI6912520, Length=400, Percent_Identity=34, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1789331, Length=345, Percent_Identity=47.2463768115942, Blast_Score=335, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39402; Mature: 39270

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPPRPAPSAPPPAAAGPRDFAARLLDWQRTDGRHDLPWQRSADPYRIWLSEIMLQQTQV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ETVIPYYARFLDRFPTLADLAAAPVEDVMALWSGLGYYARARNLHRAAVAVATQHGGRFP
HHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCC
PSAAAIAELPGIGRSTAAAIAAFAYGERAAILDGNVKRVLCRAFGIDGFPGEKAVENRLW
CHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHH
ALADALLPQAEVGRYIQAQMDLGATVCTRGKPACTRCPFAADCVALTTGRVGELPVPRPR
HHHHHHCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCC
KAAPRRHSRMAVLRCGDRVLLERRPPAGIWGGLLALPEIPPDGANVGQWTQARFGLRATT
CCCCHHHHCCCEECCCCHHEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHCCEEEC
MTPLPPLTHVFTHFVLEIAPLQIEVEAGGSRADDDGALCWLALSDTTGAALPTPVRRILD
CCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHH
GLATPD
HCCCCC
>Mature Secondary Structure 
TPPRPAPSAPPPAAAGPRDFAARLLDWQRTDGRHDLPWQRSADPYRIWLSEIMLQQTQV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ETVIPYYARFLDRFPTLADLAAAPVEDVMALWSGLGYYARARNLHRAAVAVATQHGGRFP
HHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCC
PSAAAIAELPGIGRSTAAAIAAFAYGERAAILDGNVKRVLCRAFGIDGFPGEKAVENRLW
CHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHH
ALADALLPQAEVGRYIQAQMDLGATVCTRGKPACTRCPFAADCVALTTGRVGELPVPRPR
HHHHHHCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCC
KAAPRRHSRMAVLRCGDRVLLERRPPAGIWGGLLALPEIPPDGANVGQWTQARFGLRATT
CCCCHHHHCCCEECCCCHHEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHCCEEEC
MTPLPPLTHVFTHFVLEIAPLQIEVEAGGSRADDDGALCWLALSDTTGAALPTPVRRILD
CCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHH
GLATPD
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]