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The map label for this gene is hoxC [C]

Identifier: 119900097

GI number: 119900097

Start: 4167356

End: 4168807

Strand: Direct

Name: hoxC [C]

Synonym: azo3808

Alternate gene names: 119900097

Gene position: 4167356-4168807 (Clockwise)

Preceding gene: 119900096

Following gene: 119900098

Centisome position: 95.23

GC content: 72.73

Gene sequence:

>1452_bases
ATGAACCGCATCGTCGTCGGGCCCTTCAACCGCGTCGAGGGCGACCTGGAGGTGACGCTGGACGTGGCCGACGGCCGGGT
GGCGGCGGCGCGGGTCAATTCGCCGCTCTTCCGCGGTTTCGAGCAGATCCTGGTGGGCAAGGACCCGCGCGACGCGCTGG
TGTTCGTGCCGCGCATCTGCGGCATCTGCTCGGTGTCGCAGTCGGCCGCGGCGGCGGCGGCGCTGCGCGCGGCGATGGGA
CTGGCCGTGCCCGACAACGGCCGCCACGCCGCCAACCTGGTCCTCGCCACCGAGAACCTTGCCGACCACTTCACCCATTT
CTACCTCTTCTTCATGCCCGACTTCGCCCGCGACGCCTATGCGGGGCGGCCGTGGTTCGAGGCGGCGCGGGCGCGCTTCA
AGGCGGTGGAAGGCAGTGCCACGGCGGACGCGCTGCCGGCGCGCGCCGCCTTCATGCACACCCTGGGGCTGCTCGCCGGC
AAGTGGCCGCACACCTTGTCGCTGCAGCCAGGCGGTTCGGCGCGTGCGGTGTCGGCTGCGGAAAAGATCCGCCTCTATGC
GCTGCTGCGCGAGTTCCGCGGCTGGCTGGAGCGGCGCTTGTTCGGCGACAGTCTGGAAGCGATCGCGGCGCTCGATTCGA
TGGCGGCGCTCGAAGCCTGGGCCACGGCGCGAGCGCCGGGCGCGTCGGACTTCCGCCTGTTCCTGGAGATCGCCGCGGAC
CTTGAGCTGCGCCGCGCGGGCCGCGCCACCGACGTCTATCTGAGCTACGGCGCCTATGGCGACGCGGACGACGCGCTGTT
CGCGCGCGGCGTGTGGCGGCCGGGCAGCGCCACCACGGCGCTCGATGCGGGCGCGATCGTCGAGGATGTCAGCCACGCCT
GGCTGCGCGACGAGGCGCCGCGCCATCCGCTGCAGGGCCACACCTGGCCCGATGCCGACAAGGCCGGCGCCTACAGCTGG
TGCAAGGCGCCGCGGCTGGGCGGCGAGGTGGTGGAATGCGGCGCGCTTGCGCGCCAGCTGGTGGATGGCCAGCCGCTGCT
GCGCGAGCTGGTGACGGGCGAGGGCGGCAGCGTGTTCGCGCGCGTGCTCGGCCGCCTGCTCGAATTCGCCCGCGTGCTGC
CGGCGATGGAAACCTGGGTGCGGGCGATCGAGCCCGGCGCCCCGTTCTGCGCCCAAGGGGAACTGCCGGACGACGCGCAG
GGCGTGGGCCTGGTGGAAGCGGCGCGCGGCGCGCTCGGCCACTGGCTGACGGTGCGCCACGGCCGCATCGTCGGGTATCA
GATCATCGCGCCGACCACCTGGAACTTCTCGCCGCGCGACGCAGCCGGAACACCCGGGGCGCTGGAGCAGGCCCTGGTCG
GGCTGCCGATGGCCGAAGACGGCAGCGTGCCCGCGCTGGTCCAGCACGTGGTGCGCTCTTTCGACCCCTGCATGGTATGT
ACGGTGCATTGA

Upstream 100 bases:

>100_bases
ACCGGCACGGCGCAGTGCGCCGCGAAACCCCGGTCTCGCCCCCCCGAGGGGGCTTCGCCACGCTTGGGGCGGCCCGGCGC
ATGGCGACCACGAGGTGGTC

Downstream 100 bases:

>100_bases
CCTCGATCGCGGCCGGCTCGGTGCCGTGCCGCATGCCCTTGGCCGCAGGAGCGGCAAGTGGATACCCTGTACCCGGACAG
GTCGTGAAGGAGAGTGCGTG

Product: ferredoxin hydrogenase large subunit

Products: NA

Alternate protein names: NiFeSe hydrogenlyase large chain [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNRIVVGPFNRVEGDLEVTLDVADGRVAAARVNSPLFRGFEQILVGKDPRDALVFVPRICGICSVSQSAAAAAALRAAMG
LAVPDNGRHAANLVLATENLADHFTHFYLFFMPDFARDAYAGRPWFEAARARFKAVEGSATADALPARAAFMHTLGLLAG
KWPHTLSLQPGGSARAVSAAEKIRLYALLREFRGWLERRLFGDSLEAIAALDSMAALEAWATARAPGASDFRLFLEIAAD
LELRRAGRATDVYLSYGAYGDADDALFARGVWRPGSATTALDAGAIVEDVSHAWLRDEAPRHPLQGHTWPDADKAGAYSW
CKAPRLGGEVVECGALARQLVDGQPLLRELVTGEGGSVFARVLGRLLEFARVLPAMETWVRAIEPGAPFCAQGELPDDAQ
GVGLVEAARGALGHWLTVRHGRIVGYQIIAPTTWNFSPRDAAGTPGALEQALVGLPMAEDGSVPALVQHVVRSFDPCMVC
TVH

Sequences:

>Translated_483_residues
MNRIVVGPFNRVEGDLEVTLDVADGRVAAARVNSPLFRGFEQILVGKDPRDALVFVPRICGICSVSQSAAAAAALRAAMG
LAVPDNGRHAANLVLATENLADHFTHFYLFFMPDFARDAYAGRPWFEAARARFKAVEGSATADALPARAAFMHTLGLLAG
KWPHTLSLQPGGSARAVSAAEKIRLYALLREFRGWLERRLFGDSLEAIAALDSMAALEAWATARAPGASDFRLFLEIAAD
LELRRAGRATDVYLSYGAYGDADDALFARGVWRPGSATTALDAGAIVEDVSHAWLRDEAPRHPLQGHTWPDADKAGAYSW
CKAPRLGGEVVECGALARQLVDGQPLLRELVTGEGGSVFARVLGRLLEFARVLPAMETWVRAIEPGAPFCAQGELPDDAQ
GVGLVEAARGALGHWLTVRHGRIVGYQIIAPTTWNFSPRDAAGTPGALEQALVGLPMAEDGSVPALVQHVVRSFDPCMVC
TVH
>Mature_483_residues
MNRIVVGPFNRVEGDLEVTLDVADGRVAAARVNSPLFRGFEQILVGKDPRDALVFVPRICGICSVSQSAAAAAALRAAMG
LAVPDNGRHAANLVLATENLADHFTHFYLFFMPDFARDAYAGRPWFEAARARFKAVEGSATADALPARAAFMHTLGLLAG
KWPHTLSLQPGGSARAVSAAEKIRLYALLREFRGWLERRLFGDSLEAIAALDSMAALEAWATARAPGASDFRLFLEIAAD
LELRRAGRATDVYLSYGAYGDADDALFARGVWRPGSATTALDAGAIVEDVSHAWLRDEAPRHPLQGHTWPDADKAGAYSW
CKAPRLGGEVVECGALARQLVDGQPLLRELVTGEGGSVFARVLGRLLEFARVLPAMETWVRAIEPGAPFCAQGELPDDAQ
GVGLVEAARGALGHWLTVRHGRIVGYQIIAPTTWNFSPRDAAGTPGALEQALVGLPMAEDGSVPALVQHVVRSFDPCMVC
TVH

Specific function: This Is One Of Three E.Coli Hydrogenases Synthesized In Response To Different Physiological Conditions. Hyd2 Is Involved In Hydrogen Uptake. [C]

COG id: COG0374

COG function: function code C; Ni,Fe-hydrogenase I large subunit

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789368, Length=569, Percent_Identity=28.6467486818981, Blast_Score=205, Evalue=6e-54,
Organism=Escherichia coli, GI1787207, Length=290, Percent_Identity=32.4137931034483, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001501
- InterPro:   IPR018194 [H]

Pfam domain/function: PF00374 NiFeSe_Hases [H]

EC number: =1.12.99.6 [H]

Molecular weight: Translated: 51746; Mature: 51746

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00507 NI_HGENASE_L_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRIVVGPFNRVEGDLEVTLDVADGRVAAARVNSPLFRGFEQILVGKDPRDALVFVPRIC
CCCEEECCHHHCCCCEEEEEEECCCEEEEHHCCCHHHHHHHHHHCCCCCCHHHEEHHHHH
GICSVSQSAAAAAALRAAMGLAVPDNGRHAANLVLATENLADHFTHFYLFFMPDFARDAY
HHHHCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHEECCHHHHHHC
AGRPWFEAARARFKAVEGSATADALPARAAFMHTLGLLAGKWPHTLSLQPGGSARAVSAA
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHH
EKIRLYALLREFRGWLERRLFGDSLEAIAALDSMAALEAWATARAPGASDFRLFLEIAAD
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LELRRAGRATDVYLSYGAYGDADDALFARGVWRPGSATTALDAGAIVEDVSHAWLRDEAP
HHHHHCCCCEEEEEEECCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
RHPLQGHTWPDADKAGAYSWCKAPRLGGEVVECGALARQLVDGQPLLRELVTGEGGSVFA
CCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHH
RVLGRLLEFARVLPAMETWVRAIEPGAPFCAQGELPDDAQGVGLVEAARGALGHWLTVRH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCEEEEEC
GRIVGYQIIAPTTWNFSPRDAAGTPGALEQALVGLPMAEDGSVPALVQHVVRSFDPCMVC
CEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEE
TVH
EEC
>Mature Secondary Structure
MNRIVVGPFNRVEGDLEVTLDVADGRVAAARVNSPLFRGFEQILVGKDPRDALVFVPRIC
CCCEEECCHHHCCCCEEEEEEECCCEEEEHHCCCHHHHHHHHHHCCCCCCHHHEEHHHHH
GICSVSQSAAAAAALRAAMGLAVPDNGRHAANLVLATENLADHFTHFYLFFMPDFARDAY
HHHHCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHEECCHHHHHHC
AGRPWFEAARARFKAVEGSATADALPARAAFMHTLGLLAGKWPHTLSLQPGGSARAVSAA
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHH
EKIRLYALLREFRGWLERRLFGDSLEAIAALDSMAALEAWATARAPGASDFRLFLEIAAD
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LELRRAGRATDVYLSYGAYGDADDALFARGVWRPGSATTALDAGAIVEDVSHAWLRDEAP
HHHHHCCCCEEEEEEECCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
RHPLQGHTWPDADKAGAYSWCKAPRLGGEVVECGALARQLVDGQPLLRELVTGEGGSVFA
CCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHH
RVLGRLLEFARVLPAMETWVRAIEPGAPFCAQGELPDDAQGVGLVEAARGALGHWLTVRH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCEEEEEC
GRIVGYQIIAPTTWNFSPRDAAGTPGALEQALVGLPMAEDGSVPALVQHVVRSFDPCMVC
CEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEE
TVH
EEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3316183; 10378275 [H]