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The map label for this gene is mucD4 [H]

Identifier: 119899963

GI number: 119899963

Start: 4033530

End: 4034963

Strand: Direct

Name: mucD4 [H]

Synonym: azo3674

Alternate gene names: 119899963

Gene position: 4033530-4034963 (Clockwise)

Preceding gene: 119899962

Following gene: 119899964

Centisome position: 92.17

GC content: 69.25

Gene sequence:

>1434_bases
ATGCAACACCCCCTGCGCGCCACCACCACCGCCTCTGCCCTGATCCTCGCCCTCGCCGGCGCCTTCGGCACCGACGCGCT
GGCGCAGGCGCCTGCTCCACGCGGATTGCCCGCCGGCAGCATCGTGCTGCCGAGCTTCGACACCATCATCCAGCGCGTCG
GCCCCGCGGTCGTCAACATCAGCACCGAAGGCCCGGTGCGCACCGGCGGGCCGTCCGGCGGCCTCAGCCCGGATGATCCG
TTCTCCGAATTCTTCCGTCGCTTCGGCCCGCCGCTCGGCCCCCAGTTCGGCAACCCGCCGGGGCAGGGCCCGGTACGCGG
CCAGGGGTCCGGCTTCATCGTCAGCGCCGACGGTATCGTACTGACCAACGCACACGTGGTCGACGGCGCTAGCGAAGTCA
CCGTGAAGCTGACCGACAAGCGCGAGTTCAAGGCCAAGGTGCTCGGCGTCGACAAACCGACCGACGTCGCGGTGCTGCGC
ATCGACGCCAAGAACCTGCCCACGGTGCCGCTGGGCGATCCGCAGAAAGCGCACGTGGGCGACTGGGTGCTCGCGATCGG
CGCGCCCTTCGGCTTCGAAAACTCCGTTACGGCCGGCATCATCTCGGCCAAGTCGCGCTCGCTGCCCAATGAAGGCTACG
TGCCCTTCATCCAGACCGACGTCGCGATCAACCCAGGCAACTCGGGTGGCCCGCTGCTCAATCTTGCCGGCGAAGTGGTG
GGCATCAACTCACAGATCTACTCGCGCTCGGGTGGCTACCAGGGCCTTTCGTTCGCGATTCCGATCGACGTCGCGGCCGG
CGTGCGCGACCAGATCGTGGCCCACGGCAAGGTCACGCGCGGCCGCATCGGCGTTGCCGTACAGGACGTCAATCAGGCGT
TGGCGGAATCCTTCGGCCTCAAGAGCGCCGGCGGCGCGCTGATCAGCTCGGTCGAACCCGGCGCGCCGGGCGACAAGGCC
GGGTTGAAGGTCGGCGACGTCATCATCGAACTGAACGGCGAGAAGATCGTCAACTCGGCTGACCTGCCGCCGCGCGTGGC
AGCGGTACGCCCCGGCAACACGGTGCGCATGAAGGTCTGGCGCAAGGGCGAAAGCCGCGACCTGGAGGTGAAGGTCGGCG
AGTTCCCGGACGACAGCCAGGTGGCAAGCAGCACCGGCAAGGCCGACCAGGGTCGCCTCGGGCTGGCGGTGCGCGCGTTG
TCGGGCGAGGAGCGGCGCCAGGCGGGCTTGCCGGGCGGGCTGGTCGTGACCGAGGTGGCAGGGCCCGCGGCCCGCGCCGG
CATCCAGCGCGGCGACCTCATCCTGTCGATCAACGGCCAGCCGGTGGAAACGGTGGACCAGCTGCGCGCGCTGGTGGCCA
AGGCTGGCAAGCATGTCGCGCTGCTCGTCCAGCGCGATGAAGCACGCATATTCGTACCGGTCGAGCTGGGTTGA

Upstream 100 bases:

>100_bases
ACACGGCAGGGGTAGAACCTTAAGTCTGCTTTAAGTCGGCCTCCCTTAAGGTGCCGGGCAAGCGGAACAACCGCATACCG
AGCCTTCCAGGAGACCGAGC

Downstream 100 bases:

>100_bases
TAAACCCGCGACCGCCCCCAACTAGCGACCCGGAACGAGAGAACAAAGACATGAAGATGAAGATCCGCAAGACCGCAAAC
CCCACTCCCGCCGCCGAACG

Product: serine protease MucD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MQHPLRATTTASALILALAGAFGTDALAQAPAPRGLPAGSIVLPSFDTIIQRVGPAVVNISTEGPVRTGGPSGGLSPDDP
FSEFFRRFGPPLGPQFGNPPGQGPVRGQGSGFIVSADGIVLTNAHVVDGASEVTVKLTDKREFKAKVLGVDKPTDVAVLR
IDAKNLPTVPLGDPQKAHVGDWVLAIGAPFGFENSVTAGIISAKSRSLPNEGYVPFIQTDVAINPGNSGGPLLNLAGEVV
GINSQIYSRSGGYQGLSFAIPIDVAAGVRDQIVAHGKVTRGRIGVAVQDVNQALAESFGLKSAGGALISSVEPGAPGDKA
GLKVGDVIIELNGEKIVNSADLPPRVAAVRPGNTVRMKVWRKGESRDLEVKVGEFPDDSQVASSTGKADQGRLGLAVRAL
SGEERRQAGLPGGLVVTEVAGPAARAGIQRGDLILSINGQPVETVDQLRALVAKAGKHVALLVQRDEARIFVPVELG

Sequences:

>Translated_477_residues
MQHPLRATTTASALILALAGAFGTDALAQAPAPRGLPAGSIVLPSFDTIIQRVGPAVVNISTEGPVRTGGPSGGLSPDDP
FSEFFRRFGPPLGPQFGNPPGQGPVRGQGSGFIVSADGIVLTNAHVVDGASEVTVKLTDKREFKAKVLGVDKPTDVAVLR
IDAKNLPTVPLGDPQKAHVGDWVLAIGAPFGFENSVTAGIISAKSRSLPNEGYVPFIQTDVAINPGNSGGPLLNLAGEVV
GINSQIYSRSGGYQGLSFAIPIDVAAGVRDQIVAHGKVTRGRIGVAVQDVNQALAESFGLKSAGGALISSVEPGAPGDKA
GLKVGDVIIELNGEKIVNSADLPPRVAAVRPGNTVRMKVWRKGESRDLEVKVGEFPDDSQVASSTGKADQGRLGLAVRAL
SGEERRQAGLPGGLVVTEVAGPAARAGIQRGDLILSINGQPVETVDQLRALVAKAGKHVALLVQRDEARIFVPVELG
>Mature_477_residues
MQHPLRATTTASALILALAGAFGTDALAQAPAPRGLPAGSIVLPSFDTIIQRVGPAVVNISTEGPVRTGGPSGGLSPDDP
FSEFFRRFGPPLGPQFGNPPGQGPVRGQGSGFIVSADGIVLTNAHVVDGASEVTVKLTDKREFKAKVLGVDKPTDVAVLR
IDAKNLPTVPLGDPQKAHVGDWVLAIGAPFGFENSVTAGIISAKSRSLPNEGYVPFIQTDVAINPGNSGGPLLNLAGEVV
GINSQIYSRSGGYQGLSFAIPIDVAAGVRDQIVAHGKVTRGRIGVAVQDVNQALAESFGLKSAGGALISSVEPGAPGDKA
GLKVGDVIIELNGEKIVNSADLPPRVAAVRPGNTVRMKVWRKGESRDLEVKVGEFPDDSQVASSTGKADQGRLGLAVRAL
SGEERRQAGLPGGLVVTEVAGPAARAGIQRGDLILSINGQPVETVDQLRALVAKAGKHVALLVQRDEARIFVPVELG

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=334, Percent_Identity=33.2335329341317, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI7019477, Length=283, Percent_Identity=36.3957597173145, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI22129776, Length=334, Percent_Identity=31.7365269461078, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI24308541, Length=250, Percent_Identity=34, Blast_Score=138, Evalue=9e-33,
Organism=Escherichia coli, GI1789629, Length=472, Percent_Identity=35.3813559322034, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1786356, Length=454, Percent_Identity=35.2422907488987, Blast_Score=244, Evalue=8e-66,
Organism=Escherichia coli, GI1789630, Length=284, Percent_Identity=36.9718309859155, Blast_Score=188, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24646839, Length=272, Percent_Identity=36.7647058823529, Blast_Score=152, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 49067; Mature: 49067

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHPLRATTTASALILALAGAFGTDALAQAPAPRGLPAGSIVLPSFDTIIQRVGPAVVNI
CCCCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCEECCCHHHHHHHCCCEEEEE
STEGPVRTGGPSGGLSPDDPFSEFFRRFGPPLGPQFGNPPGQGPVRGQGSGFIVSADGIV
ECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEE
LTNAHVVDGASEVTVKLTDKREFKAKVLGVDKPTDVAVLRIDAKNLPTVPLGDPQKAHVG
EECCEEECCCCEEEEEEECCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
DWVLAIGAPFGFENSVTAGIISAKSRSLPNEGYVPFIQTDVAINPGNSGGPLLNLAGEVV
CEEEEEECCCCCCCCCEEEEEEHHCCCCCCCCCCCEEEEEEEECCCCCCCCEEEECCEEE
GINSQIYSRSGGYQGLSFAIPIDVAAGVRDQIVAHGKVTRGRIGVAVQDVNQALAESFGL
ECCHHHCCCCCCCCCEEEEEEEHHHCCCHHHHEECCCEECCEEEEEHHHHHHHHHHHCCC
KSAGGALISSVEPGAPGDKAGLKVGDVIIELNGEKIVNSADLPPRVAAVRPGNTVRMKVW
CCCCCCEEECCCCCCCCCCCCCEEEEEEEEECCCEEECCCCCCCCEEEECCCCEEEEEEE
RKGESRDLEVKVGEFPDDSQVASSTGKADQGRLGLAVRALSGEERRQAGLPGGLVVTEVA
ECCCCCEEEEEECCCCCCHHHHHCCCCCCCCCEEEEEEECCCCHHHHCCCCCCEEEEECC
GPAARAGIQRGDLILSINGQPVETVDQLRALVAKAGKHVALLVQRDEARIFVPVELG
CCHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEECC
>Mature Secondary Structure
MQHPLRATTTASALILALAGAFGTDALAQAPAPRGLPAGSIVLPSFDTIIQRVGPAVVNI
CCCCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCEECCCHHHHHHHCCCEEEEE
STEGPVRTGGPSGGLSPDDPFSEFFRRFGPPLGPQFGNPPGQGPVRGQGSGFIVSADGIV
ECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEE
LTNAHVVDGASEVTVKLTDKREFKAKVLGVDKPTDVAVLRIDAKNLPTVPLGDPQKAHVG
EECCEEECCCCEEEEEEECCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
DWVLAIGAPFGFENSVTAGIISAKSRSLPNEGYVPFIQTDVAINPGNSGGPLLNLAGEVV
CEEEEEECCCCCCCCCEEEEEEHHCCCCCCCCCCCEEEEEEEECCCCCCCCEEEECCEEE
GINSQIYSRSGGYQGLSFAIPIDVAAGVRDQIVAHGKVTRGRIGVAVQDVNQALAESFGL
ECCHHHCCCCCCCCCEEEEEEEHHHCCCHHHHEECCCEECCEEEEEHHHHHHHHHHHCCC
KSAGGALISSVEPGAPGDKAGLKVGDVIIELNGEKIVNSADLPPRVAAVRPGNTVRMKVW
CCCCCCEEECCCCCCCCCCCCCEEEEEEEEECCCEEECCCCCCCCEEEECCCCEEEEEEE
RKGESRDLEVKVGEFPDDSQVASSTGKADQGRLGLAVRALSGEERRQAGLPGGLVVTEVA
ECCCCCEEEEEECCCCCCHHHHHCCCCCCCCCEEEEEEECCCCHHHHCCCCCCEEEEECC
GPAARAGIQRGDLILSINGQPVETVDQLRALVAKAGKHVALLVQRDEARIFVPVELG
CCHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550509; 11481430 [H]