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The map label for this gene is cobC [H]

Identifier: 119899808

GI number: 119899808

Start: 3861138

End: 3862133

Strand: Direct

Name: cobC [H]

Synonym: azo3519

Alternate gene names: 119899808

Gene position: 3861138-3862133 (Clockwise)

Preceding gene: 119899807

Following gene: 119899809

Centisome position: 88.23

GC content: 74.5

Gene sequence:

>996_bases
GTGCTTGAGCACGGCGGCCGCCTGCGCCGCGCCGCCGCGCAGTTCCGCATTCCACTGGCCGACTGGGTGGACCTGTCCAC
CGGCATCAACCCCCGCCCCTACCCGGTCCCGCCGCTGCCCACCGCCGCGTGGCACCGCCTGCCCGAGGACGACGATGGCC
TCGAAGCCGCGGCCGCCGCGTACTACGGCAGCGCCGAGCTGCTGCCCGTGGCGGGTTCGCAGGCCGCCATCCAGGCCTTG
CCGCAGTTGCTGCCCGGCGAACGCGTCGCGCTGCTGCAACCCGGCTATGCCGAACACGCGCACGCCTGGCGCGACCGCCG
GCTACGGCACTGCCGTAACGCCGCGGACCTGGAGGCCGCGGTGGACACCAGCGACATCGTGCTGCTGATCCATCCCAACA
ACCCCACCGGCCTGTGCTTCGAGCGCGACCGCCTGCACGACTGGCACGCGCGCCTGGCGCGCCGCGGCGGCTGGCTGCTG
GTGGACGAGGCCTTTCTCGACTGCGCGCCGGACGCCAGCCTGCTCCCGCGCGCTGGCGCTGCCGGCCTCGTGGTGTTGCG
CTCGCTCGGCAAGTTCTTCGGCCTGGCGGGCGCGCGCGTGGGCTTCGTGTTCGCCCCGCGCGGACTACGGGACGCCCTGG
CCGAACGGCTGGGGCCGTGGGCGCTCAGCGGCCCGGCGCGCTACGCCGCCACGGCCGCGCTTGCCGACACCGCGTGGCAG
GCCGCAACCCGCCACCGGCTCGCGCGGGACGGCGAGCGGCTGCAATCACTGCTGGCGGCCCACGGTCTCGCTGGCAGCCA
GGGCCCGGCGCTGTTCAAGTGGCTGTGTCACCCCCAGGCCGCTGCCCTGCACCAGGCGCTCGCCGCGCAAGCCATCCTGG
TACGCCATTTCGACGCTCCCGCCAGCCTGCGCTTCGGCCTTCCCGCAACCGAAACCGAGTGGCGCCGGCTCGGCACCGCG
CTGGGCGGTCTGCACGACCTGATCCGACAAGGATGA

Upstream 100 bases:

>100_bases
GATGCCGGCACCATCCGCGCCGCCCTCGCGCTCGTCCGTCGTGGCATGCTGCTGTGGCTGGCCGCGGCGGCCTGCGTCGC
CGCAGTGCTGGAGCTGGCGG

Downstream 100 bases:

>100_bases
ACATGCACCGACGACTTGCCGCAACCGCCCTTGCCTGCACCCTTGCAGGACTCCCCGCCGCCGCCGTCGCGGACATCCGC
ATCACCGACGATGCCGGACG

Product: cobalamin biosynthesis protein

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MLEHGGRLRRAAAQFRIPLADWVDLSTGINPRPYPVPPLPTAAWHRLPEDDDGLEAAAAAYYGSAELLPVAGSQAAIQAL
PQLLPGERVALLQPGYAEHAHAWRDRRLRHCRNAADLEAAVDTSDIVLLIHPNNPTGLCFERDRLHDWHARLARRGGWLL
VDEAFLDCAPDASLLPRAGAAGLVVLRSLGKFFGLAGARVGFVFAPRGLRDALAERLGPWALSGPARYAATAALADTAWQ
AATRHRLARDGERLQSLLAAHGLAGSQGPALFKWLCHPQAAALHQALAAQAILVRHFDAPASLRFGLPATETEWRRLGTA
LGGLHDLIRQG

Sequences:

>Translated_331_residues
MLEHGGRLRRAAAQFRIPLADWVDLSTGINPRPYPVPPLPTAAWHRLPEDDDGLEAAAAAYYGSAELLPVAGSQAAIQAL
PQLLPGERVALLQPGYAEHAHAWRDRRLRHCRNAADLEAAVDTSDIVLLIHPNNPTGLCFERDRLHDWHARLARRGGWLL
VDEAFLDCAPDASLLPRAGAAGLVVLRSLGKFFGLAGARVGFVFAPRGLRDALAERLGPWALSGPARYAATAALADTAWQ
AATRHRLARDGERLQSLLAAHGLAGSQGPALFKWLCHPQAAALHQALAAQAILVRHFDAPASLRFGLPATETEWRRLGTA
LGGLHDLIRQG
>Mature_331_residues
MLEHGGRLRRAAAQFRIPLADWVDLSTGINPRPYPVPPLPTAAWHRLPEDDDGLEAAAAAYYGSAELLPVAGSQAAIQAL
PQLLPGERVALLQPGYAEHAHAWRDRRLRHCRNAADLEAAVDTSDIVLLIHPNNPTGLCFERDRLHDWHARLARRGGWLL
VDEAFLDCAPDASLLPRAGAAGLVVLRSLGKFFGLAGARVGFVFAPRGLRDALAERLGPWALSGPARYAATAALADTAWQ
AATRHRLARDGERLQSLLAAHGLAGSQGPALFKWLCHPQAAALHQALAAQAILVRHFDAPASLRFGLPATETEWRRLGTA
LGGLHDLIRQG

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 35716; Mature: 35716

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEHGGRLRRAAAQFRIPLADWVDLSTGINPRPYPVPPLPTAAWHRLPEDDDGLEAAAAA
CCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHH
YYGSAELLPVAGSQAAIQALPQLLPGERVALLQPGYAEHAHAWRDRRLRHCRNAADLEAA
HCCCCCEEEECCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHH
VDTSDIVLLIHPNNPTGLCFERDRLHDWHARLARRGGWLLVDEAFLDCAPDASLLPRAGA
CCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCHHCCCCCH
AGLVVLRSLGKFFGLAGARVGFVFAPRGLRDALAERLGPWALSGPARYAATAALADTAWQ
HHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
AATRHRLARDGERLQSLLAAHGLAGSQGPALFKWLCHPQAAALHQALAAQAILVRHFDAP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCC
ASLRFGLPATETEWRRLGTALGGLHDLIRQG
CCEEECCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLEHGGRLRRAAAQFRIPLADWVDLSTGINPRPYPVPPLPTAAWHRLPEDDDGLEAAAAA
CCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHH
YYGSAELLPVAGSQAAIQALPQLLPGERVALLQPGYAEHAHAWRDRRLRHCRNAADLEAA
HCCCCCEEEECCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHH
VDTSDIVLLIHPNNPTGLCFERDRLHDWHARLARRGGWLLVDEAFLDCAPDASLLPRAGA
CCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCHHCCCCCH
AGLVVLRSLGKFFGLAGARVGFVFAPRGLRDALAERLGPWALSGPARYAATAALADTAWQ
HHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
AATRHRLARDGERLQSLLAAHGLAGSQGPALFKWLCHPQAAALHQALAAQAILVRHFDAP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCC
ASLRFGLPATETEWRRLGTALGGLHDLIRQG
CCEEECCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]