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The map label for this gene is tdh [H]

Identifier: 119855020

GI number: 119855020

Start: 140423

End: 141448

Strand: Direct

Name: tdh [H]

Synonym: Mkms_5628

Alternate gene names: 119855020

Gene position: 140423-141448 (Clockwise)

Preceding gene: 119855019

Following gene: 119855021

Centisome position: 46.48

GC content: 67.74

Gene sequence:

>1026_bases
ATGGAAGCGATCGTTCTCAACGGCACCAACGACGTCGGTCTGACGTCGGTGCCAGACCCGGCGCCGCAGGACGGTGAGGT
CATCATCGAAGTGGCGGCGACAGGGCTGTGTGGAACTGACCTCCACGAGTATGTCGCGGGGCCCACCTTCTCGCAGCCGC
CGGTGGTGCTCGGTCACGAGGTCTCGGGCCGGATCGTGGAGGTCGGAGCGGGCGTCGACCAATCCCGCATCGGGCAGGGC
GCCGCGGTGATCCCGATGGATTTCTGCGGGAGCTGCCACTACTGCCACCGGTCGCTCTACCACCTGTGCCAGCGCCCAGG
ATGGATCGGCTTCACCCGAAACGGAGGCCTCGCGAACTACGTCGCAGTGCCCTCTCGGCTCGCAGTCCGAGTGCCGGACG
TGGTGGACCTCGAGGAGGCGGCGCTGACCGAGCCGACGGCGGTGGCGTTCCACGCGGTGCGGCGAGCGGAACTGCTCCTC
GGCGAAACGGTGATGGTCCTCGGGGCCGGGGCACTCGGGCTCACCGTGATCCAGTGCGCACGCGCGGCCGGAGCTGCGCG
AATCTTCGTCACGGAACCAAGCGGCGTGCGGGCCAGCCTGGCGCGCGACCTCGGCGCCACGTTGGTGCTCGATCCGCATG
ACCCCGGGACCACCGCGTGCATCCTGGAGGAGACCCGCGGTGTAGGGGTGGACGTGGTCTTCCATGTGGCGGGCAGCGCG
GAGGCGTTCACACAGGGCCTGGACTGCCTCCGCAAACAGGGCCGTTTCATGGAGATGTCGTCGTGGGCCGGCGCGGCCTC
GCTCGATGTCAACCGCCATCTGCTCAAGGAGATTCAGCTCCGGATGGTTTTCGGTTACGACATGTTCGACGATTTCCCGG
CCGTTCTCGCCCTGATCGCCGACGGAAAACTCGCGCTCGCGCCGCAAATCACCGCTCGAGTCCCGCTGGACCGCGCCGTC
AAGGAGGGATTGGGCGGGCTATTGGAGGGCCGGGAGGGTCTGGTCAAGGTGCTGGTGAAGCCGTGA

Upstream 100 bases:

>100_bases
CATGACCGCCGGCGTCACTTTCCGGGCGTTCGAGGCGGTATGAGCATGATCCCCAACCGCTGGAATCTACACCGGACCCA
CGAAAGCACCGCGAGCTGAG

Downstream 100 bases:

>100_bases
GTGAGGGAGACTTGATGGTCGTCGCCGCGACAAGCCGCGGTGTGTTCACCGTGTCCGGCGACGGCAAGGCCCGGGCCTGG
CCCGAGTTGCCGGGGCAGGT

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MEAIVLNGTNDVGLTSVPDPAPQDGEVIIEVAATGLCGTDLHEYVAGPTFSQPPVVLGHEVSGRIVEVGAGVDQSRIGQG
AAVIPMDFCGSCHYCHRSLYHLCQRPGWIGFTRNGGLANYVAVPSRLAVRVPDVVDLEEAALTEPTAVAFHAVRRAELLL
GETVMVLGAGALGLTVIQCARAAGAARIFVTEPSGVRASLARDLGATLVLDPHDPGTTACILEETRGVGVDVVFHVAGSA
EAFTQGLDCLRKQGRFMEMSSWAGAASLDVNRHLLKEIQLRMVFGYDMFDDFPAVLALIADGKLALAPQITARVPLDRAV
KEGLGGLLEGREGLVKVLVKP

Sequences:

>Translated_341_residues
MEAIVLNGTNDVGLTSVPDPAPQDGEVIIEVAATGLCGTDLHEYVAGPTFSQPPVVLGHEVSGRIVEVGAGVDQSRIGQG
AAVIPMDFCGSCHYCHRSLYHLCQRPGWIGFTRNGGLANYVAVPSRLAVRVPDVVDLEEAALTEPTAVAFHAVRRAELLL
GETVMVLGAGALGLTVIQCARAAGAARIFVTEPSGVRASLARDLGATLVLDPHDPGTTACILEETRGVGVDVVFHVAGSA
EAFTQGLDCLRKQGRFMEMSSWAGAASLDVNRHLLKEIQLRMVFGYDMFDDFPAVLALIADGKLALAPQITARVPLDRAV
KEGLGGLLEGREGLVKVLVKP
>Mature_341_residues
MEAIVLNGTNDVGLTSVPDPAPQDGEVIIEVAATGLCGTDLHEYVAGPTFSQPPVVLGHEVSGRIVEVGAGVDQSRIGQG
AAVIPMDFCGSCHYCHRSLYHLCQRPGWIGFTRNGGLANYVAVPSRLAVRVPDVVDLEEAALTEPTAVAFHAVRRAELLL
GETVMVLGAGALGLTVIQCARAAGAARIFVTEPSGVRASLARDLGATLVLDPHDPGTTACILEETRGVGVDVVFHVAGSA
EAFTQGLDCLRKQGRFMEMSSWAGAASLDVNRHLLKEIQLRMVFGYDMFDDFPAVLALIADGKLALAPQITARVPLDRAV
KEGLGGLLEGREGLVKVLVKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=340, Percent_Identity=29.1176470588235, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI4501929, Length=344, Percent_Identity=27.906976744186, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4501933, Length=343, Percent_Identity=27.1137026239067, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI71565152, Length=352, Percent_Identity=26.4204545454545, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI34577061, Length=344, Percent_Identity=27.0348837209302, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI156523966, Length=324, Percent_Identity=25.9259259259259, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI4501939, Length=324, Percent_Identity=25.9259259259259, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI71743840, Length=342, Percent_Identity=26.3157894736842, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI262073058, Length=342, Percent_Identity=26.3157894736842, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI71565154, Length=340, Percent_Identity=24.7058823529412, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788073, Length=335, Percent_Identity=29.2537313432836, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI1790045, Length=334, Percent_Identity=29.3413173652695, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI226510992, Length=298, Percent_Identity=32.2147651006711, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1788407, Length=217, Percent_Identity=33.6405529953917, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1790718, Length=325, Percent_Identity=27.0769230769231, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1787863, Length=212, Percent_Identity=30.6603773584906, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1788075, Length=335, Percent_Identity=27.1641791044776, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1786825, Length=266, Percent_Identity=30.0751879699248, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082125, Length=336, Percent_Identity=27.3809523809524, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI87081918, Length=282, Percent_Identity=29.0780141843972, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1786552, Length=260, Percent_Identity=28.8461538461538, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=322, Percent_Identity=28.8819875776398, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17562878, Length=213, Percent_Identity=34.2723004694836, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71988145, Length=175, Percent_Identity=29.1428571428571, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=244, Percent_Identity=28.2786885245902, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=332, Percent_Identity=25.9036144578313, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=281, Percent_Identity=27.0462633451957, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=267, Percent_Identity=28.0898876404494, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319257, Length=383, Percent_Identity=29.5039164490862, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319258, Length=382, Percent_Identity=29.3193717277487, Blast_Score=142, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6323099, Length=332, Percent_Identity=29.8192771084337, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319955, Length=350, Percent_Identity=27.1428571428571, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322619, Length=350, Percent_Identity=27.1428571428571, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323961, Length=287, Percent_Identity=27.1777003484321, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=270, Percent_Identity=27.7777777777778, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=271, Percent_Identity=27.6752767527675, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=270, Percent_Identity=25.9259259259259, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=281, Percent_Identity=24.9110320284698, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=128, Percent_Identity=31.25, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI17137530, Length=341, Percent_Identity=31.0850439882698, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI17737897, Length=343, Percent_Identity=30.0291545189504, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI221457811, Length=350, Percent_Identity=27.1428571428571, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI45550770, Length=350, Percent_Identity=27.1428571428571, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI45551930, Length=350, Percent_Identity=27.1428571428571, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI17737895, Length=260, Percent_Identity=25.7692307692308, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 35891; Mature: 35891

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAIVLNGTNDVGLTSVPDPAPQDGEVIIEVAATGLCGTDLHEYVAGPTFSQPPVVLGHE
CCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCCCCCCCCEEECCC
VSGRIVEVGAGVDQSRIGQGAAVIPMDFCGSCHYCHRSLYHLCQRPGWIGFTRNGGLANY
CCCEEEEECCCCCHHHCCCCCEEEEHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCEEE
VAVPSRLAVRVPDVVDLEEAALTEPTAVAFHAVRRAELLLGETVMVLGAGALGLTVIQCA
EECCCCEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHH
RAAGAARIFVTEPSGVRASLARDLGATLVLDPHDPGTTACILEETRGVGVDVVFHVAGSA
HHCCCEEEEEECCCCCHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCEEEEEEECCCH
EAFTQGLDCLRKQGRFMEMSSWAGAASLDVNRHLLKEIQLRMVFGYDMFDDFPAVLALIA
HHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHEEECCCHHHHHHHHHHHHC
DGKLALAPQITARVPLDRAVKEGLGGLLEGREGLVKVLVKP
CCCEEECCCEEECCCHHHHHHHHHCHHHCCCCCEEEEEECC
>Mature Secondary Structure
MEAIVLNGTNDVGLTSVPDPAPQDGEVIIEVAATGLCGTDLHEYVAGPTFSQPPVVLGHE
CCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCCCCCCCCEEECCC
VSGRIVEVGAGVDQSRIGQGAAVIPMDFCGSCHYCHRSLYHLCQRPGWIGFTRNGGLANY
CCCEEEEECCCCCHHHCCCCCEEEEHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCEEE
VAVPSRLAVRVPDVVDLEEAALTEPTAVAFHAVRRAELLLGETVMVLGAGALGLTVIQCA
EECCCCEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHH
RAAGAARIFVTEPSGVRASLARDLGATLVLDPHDPGTTACILEETRGVGVDVVFHVAGSA
HHCCCEEEEEECCCCCHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCEEEEEEECCCH
EAFTQGLDCLRKQGRFMEMSSWAGAASLDVNRHLLKEIQLRMVFGYDMFDDFPAVLALIA
HHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHEEECCCHHHHHHHHHHHHC
DGKLALAPQITARVPLDRAVKEGLGGLLEGREGLVKVLVKP
CCCEEECCCEEECCCHHHHHHHHHCHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]