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The map label for this gene is ubiB [C]

Identifier: 119854937

GI number: 119854937

Start: 50416

End: 51846

Strand: Direct

Name: ubiB [C]

Synonym: Mkms_5542

Alternate gene names: 119854937

Gene position: 50416-51846 (Clockwise)

Preceding gene: 119854936

Following gene: 119854938

Centisome position: 16.69

GC content: 62.61

Gene sequence:

>1431_bases
ATGACCACCCCTGAACAGAACGGCTCTCAGAAGGGCGATTTCATCCCGCGGGGGCGGATCCGTCGGACCATGCCCCTGGC
CGGTTTCACCGCACGCGCGGCGACCGCGCGCCTGGTCGCCGGGGCTCGCGAAAAGGCCGGTGACGCGGGTGCCCTCGAAC
GGTTTCACGAACGCACGGCCGAGCACTACGTGGACCTGCTCGGCCACTCGAAGGGCGCGCTCATGAAAGCCGGCCAGTTC
TTCTCCATGATCGACGTGGATGCACTCGGCAACGGTGGATTCGCCCGCTATCAAAAAGTGTTGAGCCGACTACAAACTGA
CGCACCCCCCATGACTCCCACGCTTCTGCACGCCGTTCTGCTCACCGAACTCCAGAGGCCGGCCGATGAGCTGTTCGCCA
CCTTCGATGACGCGCCGATGGCTGCAGCGTCGATCGGCCAGGTCCACCGCGCCCTAATGCACGACGGCCGCGACGTTGTA
GTCAAGGTCCAGTATCCGGGCGTGGACGAAGCGATTCGCGGCGACCTCGCCAACGCCGAACTACTGGCCACGTTCCTGCG
ATTCTTAACCGCAGCTTCGGGCATGAAGGCCGACGTGCGGACAATGGCCCGGGAGGCGACCGCTCGTTTGACCGAGGAAC
TCGACTACCGGCACGAGGCCGACATGATCACTCGCTTCAGTGAGCTGTACCGCGATCACCCGTTCATTCGGATCCCCGAG
GTCGTGCCGGAGTTGTCTGGCGACCGCGTGCTCACGATGACCCACCTCGACGGAATCGACTGGTCTGCGGCACAACTGGC
CGATCAGGATCTAAAGAACACCTGGGCTGAGGTGATACACCGATTCAGCTACGCCAACTATCGCCATTCCAACTTGATGC
ACGCCGATCCTCATCCCGGCAACTACCGCTTTCGCGCCGACGGGACGGTGGGGTTCGTTGACTTCGGCTGTGTGCGCATC
CTTCCCGAACATATCCGTCGAGGCTGGATTGCAATGGGCCGCGCCGCCATTGAAGGGCGAAAGAATGATTTGCGCGCTGT
GATGACAGAACTCGGCTTCCTGGACGCAGACCCGACCTTGACCGCCGACGACCTCTACCACTGGTTTTCACAAATGCTCT
ACGAGGTCCTTGCACCCGAGCAACCCGTCACCTACAACCAGGCCACCACCGACCGGGCGCTGCGCAACTTGTTCGACACC
CGCAACCACACCGGTGTCCTGGCCCGGCTCAGCGTTCCCGAGGAATTGACAATGACCTCCCGAGTCATTTTTGCCGTCAA
CGCAATCTCGGGTTCGCTCAACGCCACTTTGCACGCGCGGGCAGCGGCCAACGATATTGACAGCGTTGCCGAGCCGGTCA
CCGAATTCGGTAAGGCTCACCACGCCTGGGTCCGTGCCCGGGGATTGCCCACCGCGCTGGAGCCCCAATGA

Upstream 100 bases:

>100_bases
GTCGAGGACTTCGATGGAGCGGCCGATCCCGTCACCGAGCTCGGCAAGAAGCACCATGCCTGGGCCCGCGAGCGCGGCCT
ACCCTCCGCGTTGGACCATC

Downstream 100 bases:

>100_bases
CATCTGCCGGAAGCGCCCAGGTGACCCTGCCGTGGGATGCTGCCAATCCCTACCCGTTCTACGCCCGCAAGCGATGTGAA
GGCACCGTGGTGTGGGATGA

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MTTPEQNGSQKGDFIPRGRIRRTMPLAGFTARAATARLVAGAREKAGDAGALERFHERTAEHYVDLLGHSKGALMKAGQF
FSMIDVDALGNGGFARYQKVLSRLQTDAPPMTPTLLHAVLLTELQRPADELFATFDDAPMAAASIGQVHRALMHDGRDVV
VKVQYPGVDEAIRGDLANAELLATFLRFLTAASGMKADVRTMAREATARLTEELDYRHEADMITRFSELYRDHPFIRIPE
VVPELSGDRVLTMTHLDGIDWSAAQLADQDLKNTWAEVIHRFSYANYRHSNLMHADPHPGNYRFRADGTVGFVDFGCVRI
LPEHIRRGWIAMGRAAIEGRKNDLRAVMTELGFLDADPTLTADDLYHWFSQMLYEVLAPEQPVTYNQATTDRALRNLFDT
RNHTGVLARLSVPEELTMTSRVIFAVNAISGSLNATLHARAAANDIDSVAEPVTEFGKAHHAWVRARGLPTALEPQ

Sequences:

>Translated_476_residues
MTTPEQNGSQKGDFIPRGRIRRTMPLAGFTARAATARLVAGAREKAGDAGALERFHERTAEHYVDLLGHSKGALMKAGQF
FSMIDVDALGNGGFARYQKVLSRLQTDAPPMTPTLLHAVLLTELQRPADELFATFDDAPMAAASIGQVHRALMHDGRDVV
VKVQYPGVDEAIRGDLANAELLATFLRFLTAASGMKADVRTMAREATARLTEELDYRHEADMITRFSELYRDHPFIRIPE
VVPELSGDRVLTMTHLDGIDWSAAQLADQDLKNTWAEVIHRFSYANYRHSNLMHADPHPGNYRFRADGTVGFVDFGCVRI
LPEHIRRGWIAMGRAAIEGRKNDLRAVMTELGFLDADPTLTADDLYHWFSQMLYEVLAPEQPVTYNQATTDRALRNLFDT
RNHTGVLARLSVPEELTMTSRVIFAVNAISGSLNATLHARAAANDIDSVAEPVTEFGKAHHAWVRARGLPTALEPQ
>Mature_475_residues
TTPEQNGSQKGDFIPRGRIRRTMPLAGFTARAATARLVAGAREKAGDAGALERFHERTAEHYVDLLGHSKGALMKAGQFF
SMIDVDALGNGGFARYQKVLSRLQTDAPPMTPTLLHAVLLTELQRPADELFATFDDAPMAAASIGQVHRALMHDGRDVVV
KVQYPGVDEAIRGDLANAELLATFLRFLTAASGMKADVRTMAREATARLTEELDYRHEADMITRFSELYRDHPFIRIPEV
VPELSGDRVLTMTHLDGIDWSAAQLADQDLKNTWAEVIHRFSYANYRHSNLMHADPHPGNYRFRADGTVGFVDFGCVRIL
PEHIRRGWIAMGRAAIEGRKNDLRAVMTELGFLDADPTLTADDLYHWFSQMLYEVLAPEQPVTYNQATTDRALRNLFDTR
NHTGVLARLSVPEELTMTSRVIFAVNAISGSLNATLHARAAANDIDSVAEPVTEFGKAHHAWVRARGLPTALEPQ

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI27363457, Length=389, Percent_Identity=29.5629820051414, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI34147522, Length=374, Percent_Identity=28.6096256684492, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI217416386, Length=348, Percent_Identity=29.5977011494253, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI40254938, Length=412, Percent_Identity=26.9417475728155, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI217035081, Length=343, Percent_Identity=27.9883381924198, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI41393593, Length=226, Percent_Identity=30.9734513274336, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI2367309, Length=358, Percent_Identity=25.4189944134078, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI32565180, Length=399, Percent_Identity=28.0701754385965, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17559152, Length=340, Percent_Identity=27.3529411764706, Blast_Score=115, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6321319, Length=327, Percent_Identity=31.1926605504587, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI18859849, Length=390, Percent_Identity=26.4102564102564, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24662575, Length=373, Percent_Identity=24.9329758713137, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI22024280, Length=334, Percent_Identity=25.4491017964072, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 52822; Mature: 52690

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS50011 PROTEIN_KINASE_DOM ; PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPEQNGSQKGDFIPRGRIRRTMPLAGFTARAATARLVAGAREKAGDAGALERFHERTA
CCCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EHYVDLLGHSKGALMKAGQFFSMIDVDALGNGGFARYQKVLSRLQTDAPPMTPTLLHAVL
HHHHHHHHCCCCHHHHHCCHHHHEEHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
LTELQRPADELFATFDDAPMAAASIGQVHRALMHDGRDVVVKVQYPGVDEAIRGDLANAE
HHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHCCCCCHH
LLATFLRFLTAASGMKADVRTMAREATARLTEELDYRHEADMITRFSELYRDHPFIRIPE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCH
VVPELSGDRVLTMTHLDGIDWSAAQLADQDLKNTWAEVIHRFSYANYRHSNLMHADPHPG
HHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCC
NYRFRADGTVGFVDFGCVRILPEHIRRGWIAMGRAAIEGRKNDLRAVMTELGFLDADPTL
CEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
TADDLYHWFSQMLYEVLAPEQPVTYNQATTDRALRNLFDTRNHTGVLARLSVPEELTMTS
CHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
RVIFAVNAISGSLNATLHARAAANDIDSVAEPVTEFGKAHHAWVRARGLPTALEPQ
HHHEEEEHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TTPEQNGSQKGDFIPRGRIRRTMPLAGFTARAATARLVAGAREKAGDAGALERFHERTA
CCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EHYVDLLGHSKGALMKAGQFFSMIDVDALGNGGFARYQKVLSRLQTDAPPMTPTLLHAVL
HHHHHHHHCCCCHHHHHCCHHHHEEHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
LTELQRPADELFATFDDAPMAAASIGQVHRALMHDGRDVVVKVQYPGVDEAIRGDLANAE
HHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHCCCCCHH
LLATFLRFLTAASGMKADVRTMAREATARLTEELDYRHEADMITRFSELYRDHPFIRIPE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCH
VVPELSGDRVLTMTHLDGIDWSAAQLADQDLKNTWAEVIHRFSYANYRHSNLMHADPHPG
HHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCC
NYRFRADGTVGFVDFGCVRILPEHIRRGWIAMGRAAIEGRKNDLRAVMTELGFLDADPTL
CEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
TADDLYHWFSQMLYEVLAPEQPVTYNQATTDRALRNLFDTRNHTGVLARLSVPEELTMTS
CHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
RVIFAVNAISGSLNATLHARAAANDIDSVAEPVTEFGKAHHAWVRARGLPTALEPQ
HHHEEEEHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA