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The map label for this gene is ubiB [C]

Identifier: 119854936

GI number: 119854936

Start: 49008

End: 50429

Strand: Direct

Name: ubiB [C]

Synonym: Mkms_5541

Alternate gene names: 119854936

Gene position: 49008-50429 (Clockwise)

Preceding gene: 119854933

Following gene: 119854937

Centisome position: 16.22

GC content: 63.57

Gene sequence:

>1422_bases
ATGCACCATCAGGACGTTCCCGTTCCTTTTGGACGGATCCGGCGGACGATGCCGCTGGCGGGTTTCACCGCCCGGGCTGC
TGGCGGCCGAGTCATCGCAGGGTTGCGCGAGAAGGCGGGCCAGGACGGTGCTGTCGAACAGTTTCACGAGCGCACCGCCG
AGCGGTACGCCGAGCTTCTCGGCCACTCTCGCGGCGTCCTGATGAAGGTCGGCCAGATCATGTCACTGCTCGATACTCGC
GCGGTGGGCACCGGCGGATTTTGGCCGTACCAGAAAGCCATGAGCAGATTGCAGGCAGACGCACCGCCCATGCATCCCGT
ACTGGTCCATGAGGTTCTCGAAGGCGAACTCGGTTCTGCGGTCGAGCATTTCGCGGAGTTCACTGAGGAGCCGATGGCTG
CTGCGTCGATCGGCCAGGTGCACCGCGCCGTCCTGCGCGACGGTCGTCGGGTCGCCGTCAAAATCCAGTACCCCGGTGTC
GCTCAAGCCATCCGCGACGATCTGGCCAACGCTGAGCTGCTGGCGACGTTCCTGCGCTTCCTCGCCGCCTCGACGTCGGG
AGTGAAGCGGGATGTTAAGAGCGTCGCGCGCGAAGTCGCAGCGCGAATCTCCGAGGAGGTGGACTATCGGCATGAGGCAG
CCACAATCGCAGCATTCAGCGAACTCTACCGAGACCACCCGTTCATCCGAGTCCCCGAAGTCATTGCCGAAATGTCTACC
AATCGGGTGTTGACCATGACCTATCTCGACGGGATGGACTGGGCGGCAGCGCAACAGGCCGATCAAGATCTCAGAAACGT
CTGGGCCGAGACCATCCTGCGATTCGCGTACGGAAGCTTCCGCCACGCCAATCTGATGCACGCCGACCCCCACCCGGGCA
ACTACCGCTTCAACACTGACGGCACCGTCGGGTTCGTCGACTTCGGCTGCGTCAAGGTCCTACCCGAACTCCAGCGCTGG
CGACAGGTCGCGATGAACCGAGCCCTCCAAGAGGGTCGCAAACAGGATCTTCGAGACATCATGGTGCTGGCCGGCTACCT
GACCGCTGACTCCGACCTGACCGCAGACGAACTCTACCAGTGGCAGTCCGAACTCCTCGGCGAGTGTATGGCGACCACAC
CACAACCCGTGACCTACACAGCTGATTCGATAAATCGTGTCGTCCGCTGCTTGTTCGACGTCCGTGACACCAACCATCCA
GTGGCCCGCATGACCGCCCCCGACGACTACGTGTTCGCCGCCCGCCTTCAACTCGCCGTCAGCAGTGTCTGCGCCGGCCT
CAACGCCACGCTGCCAGTCCGGGCGATCGTCGAGGACTTCGATGGAGCGGCCGATCCCGTCACCGAGCTCGGCAAGAAGC
ACCATGCCTGGGCCCGCGAGCGCGGCCTACCCTCCGCGTTGGACCATCATGACCACCCCTGA

Upstream 100 bases:

>100_bases
TCGCGTGTGGGCGCCGCTGCCGACATTGACCTCTCCCAAGTGATCACTTACCTTGAACCAGGCATCACTTTACTACGCCG
CCGAACGGGAGGAGCCCTCG

Downstream 100 bases:

>100_bases
ACAGAACGGCTCTCAGAAGGGCGATTTCATCCCGCGGGGGCGGATCCGTCGGACCATGCCCCTGGCCGGTTTCACCGCAC
GCGCGGCGACCGCGCGCCTG

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MHHQDVPVPFGRIRRTMPLAGFTARAAGGRVIAGLREKAGQDGAVEQFHERTAERYAELLGHSRGVLMKVGQIMSLLDTR
AVGTGGFWPYQKAMSRLQADAPPMHPVLVHEVLEGELGSAVEHFAEFTEEPMAAASIGQVHRAVLRDGRRVAVKIQYPGV
AQAIRDDLANAELLATFLRFLAASTSGVKRDVKSVAREVAARISEEVDYRHEAATIAAFSELYRDHPFIRVPEVIAEMST
NRVLTMTYLDGMDWAAAQQADQDLRNVWAETILRFAYGSFRHANLMHADPHPGNYRFNTDGTVGFVDFGCVKVLPELQRW
RQVAMNRALQEGRKQDLRDIMVLAGYLTADSDLTADELYQWQSELLGECMATTPQPVTYTADSINRVVRCLFDVRDTNHP
VARMTAPDDYVFAARLQLAVSSVCAGLNATLPVRAIVEDFDGAADPVTELGKKHHAWARERGLPSALDHHDHP

Sequences:

>Translated_473_residues
MHHQDVPVPFGRIRRTMPLAGFTARAAGGRVIAGLREKAGQDGAVEQFHERTAERYAELLGHSRGVLMKVGQIMSLLDTR
AVGTGGFWPYQKAMSRLQADAPPMHPVLVHEVLEGELGSAVEHFAEFTEEPMAAASIGQVHRAVLRDGRRVAVKIQYPGV
AQAIRDDLANAELLATFLRFLAASTSGVKRDVKSVAREVAARISEEVDYRHEAATIAAFSELYRDHPFIRVPEVIAEMST
NRVLTMTYLDGMDWAAAQQADQDLRNVWAETILRFAYGSFRHANLMHADPHPGNYRFNTDGTVGFVDFGCVKVLPELQRW
RQVAMNRALQEGRKQDLRDIMVLAGYLTADSDLTADELYQWQSELLGECMATTPQPVTYTADSINRVVRCLFDVRDTNHP
VARMTAPDDYVFAARLQLAVSSVCAGLNATLPVRAIVEDFDGAADPVTELGKKHHAWARERGLPSALDHHDHP
>Mature_473_residues
MHHQDVPVPFGRIRRTMPLAGFTARAAGGRVIAGLREKAGQDGAVEQFHERTAERYAELLGHSRGVLMKVGQIMSLLDTR
AVGTGGFWPYQKAMSRLQADAPPMHPVLVHEVLEGELGSAVEHFAEFTEEPMAAASIGQVHRAVLRDGRRVAVKIQYPGV
AQAIRDDLANAELLATFLRFLAASTSGVKRDVKSVAREVAARISEEVDYRHEAATIAAFSELYRDHPFIRVPEVIAEMST
NRVLTMTYLDGMDWAAAQQADQDLRNVWAETILRFAYGSFRHANLMHADPHPGNYRFNTDGTVGFVDFGCVKVLPELQRW
RQVAMNRALQEGRKQDLRDIMVLAGYLTADSDLTADELYQWQSELLGECMATTPQPVTYTADSINRVVRCLFDVRDTNHP
VARMTAPDDYVFAARLQLAVSSVCAGLNATLPVRAIVEDFDGAADPVTELGKKHHAWARERGLPSALDHHDHP

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI27363457, Length=402, Percent_Identity=31.8407960199005, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI217416386, Length=379, Percent_Identity=31.6622691292876, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI34147522, Length=452, Percent_Identity=26.9911504424779, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI40254938, Length=288, Percent_Identity=29.1666666666667, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI217035081, Length=181, Percent_Identity=31.4917127071823, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI41393593, Length=219, Percent_Identity=31.5068493150685, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI2367309, Length=207, Percent_Identity=27.536231884058, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32565180, Length=432, Percent_Identity=28.4722222222222, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17559152, Length=277, Percent_Identity=31.0469314079422, Blast_Score=115, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6321319, Length=349, Percent_Identity=29.512893982808, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI18859849, Length=301, Percent_Identity=31.2292358803987, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI22024280, Length=257, Percent_Identity=27.2373540856031, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24662575, Length=285, Percent_Identity=25.9649122807018, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 52468; Mature: 52468

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHQDVPVPFGRIRRTMPLAGFTARAAGGRVIAGLREKAGQDGAVEQFHERTAERYAELL
CCCCCCCCCHHHHHHHCCCCCCHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
GHSRGVLMKVGQIMSLLDTRAVGTGGFWPYQKAMSRLQADAPPMHPVLVHEVLEGELGSA
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCHHHHH
VEHFAEFTEEPMAAASIGQVHRAVLRDGRRVAVKIQYPGVAQAIRDDLANAELLATFLRF
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCHHHHHHHHHH
LAASTSGVKRDVKSVAREVAARISEEVDYRHEAATIAAFSELYRDHPFIRVPEVIAEMST
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCC
NRVLTMTYLDGMDWAAAQQADQDLRNVWAETILRFAYGSFRHANLMHADPHPGNYRFNTD
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCEEECCC
GTVGFVDFGCVKVLPELQRWRQVAMNRALQEGRKQDLRDIMVLAGYLTADSDLTADELYQ
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
WQSELLGECMATTPQPVTYTADSINRVVRCLFDVRDTNHPVARMTAPDDYVFAARLQLAV
HHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHH
SSVCAGLNATLPVRAIVEDFDGAADPVTELGKKHHAWARERGLPSALDHHDHP
HHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHCCCCCC
>Mature Secondary Structure
MHHQDVPVPFGRIRRTMPLAGFTARAAGGRVIAGLREKAGQDGAVEQFHERTAERYAELL
CCCCCCCCCHHHHHHHCCCCCCHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
GHSRGVLMKVGQIMSLLDTRAVGTGGFWPYQKAMSRLQADAPPMHPVLVHEVLEGELGSA
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCHHHHH
VEHFAEFTEEPMAAASIGQVHRAVLRDGRRVAVKIQYPGVAQAIRDDLANAELLATFLRF
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCHHHHHHHHHH
LAASTSGVKRDVKSVAREVAARISEEVDYRHEAATIAAFSELYRDHPFIRVPEVIAEMST
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCC
NRVLTMTYLDGMDWAAAQQADQDLRNVWAETILRFAYGSFRHANLMHADPHPGNYRFNTD
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCEEECCC
GTVGFVDFGCVKVLPELQRWRQVAMNRALQEGRKQDLRDIMVLAGYLTADSDLTADELYQ
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
WQSELLGECMATTPQPVTYTADSINRVVRCLFDVRDTNHPVARMTAPDDYVFAARLQLAV
HHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHH
SSVCAGLNATLPVRAIVEDFDGAADPVTELGKKHHAWARERGLPSALDHHDHP
HHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA