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The map label for this gene is ampC [C]

Identifier: 119776053

GI number: 119776053

Start: 3473330

End: 3474685

Strand: Reverse

Name: ampC [C]

Synonym: Sama_2921

Alternate gene names: 119776053

Gene position: 3474685-3473330 (Counterclockwise)

Preceding gene: 119776054

Following gene: 119776051

Centisome position: 80.69

GC content: 45.58

Gene sequence:

>1356_bases
ATGACTAGAGTTTTACTTGCCGTACTATGCAGTGCAGCGGTGTTGATGTCTTGTGGCAAAAAAGACACAGATACCACGCA
GATTGACGATATTCAGTCAAGGCAGGAGAGGCTGCACAGGGCATTTGATGACATCCGCTCGCAATCTGACTTTATGGGCA
GTGTTGTGTTGATGCATTCAGGTAAAGTGATTTTTTCAGATAGCTCGGGCTTCGATGATATAAGCAAGAATGAAAAATCG
ACCACACATTCAGCTTACTTGATTGGCTCAGTGTCAAAAACCTACACAGCCGCCCTTGTGCTAAAGGCGGTTGACGAACA
AAAGCTGACGCTGGAACAAACACTCGAGGCATTTTTTCCGACCCTTGAAAATGGACACCTAATCAGCATCAAAAATCTGC
TTCAGCACACCAGTGGCATTGGCAATTACACCAAAAAAGGAAAAGGATTTTTTGACTATCGGACAGAGAATCAAAGCAGT
GAGAGTATGCTCAACCGAATTTTGGCGCTGGGCAGCGATTTTGAACCAGGCACCAAAGCGGAGTACAGCAACTCCAACTA
TTATCTGCTGGCTCTCATCCTGGAAAAGGTATACCAAAAGAGCTTTGGTGAGATACTCAGTGAAAAGATAACAACGCCAT
TAAACCTGACTCAAACGGTACATGTGCGCGATACCCATCAAACTCAACATTCGTACTCCTTTGATAATGGGCAATGGTCA
ATGTTTCCTGCATCCAATATGTCTGTTGGGCTGGGGGCGGGTTCCATTAAGGCAACACCCACAGAGGTTGCGATTTTTTA
TAATGCCTTGTTTAACGGTGAGATTATCCCTTTGCCATTGGTTGATACCATGAAGCAGACCAAAAATGGTTTTGGTTTGG
GTATTAAACCCATTGATTTTTTTGACAAGCAAGGATTTGGGCACGGTGGGACTTTTGATGCATATAACGCGATGGCGGCC
TATTTCCCTCAGGAAAAGATGACGCTGGTTTTAGCATCCAATGGATCAAATGATAACTTTCATGACACCTATCAACAGAT
GCTGAAAAGCTACTTTAATCAAACCCTGACTGATCTGCCAGTCGCGGCAGAAGAGCTGGCGCGCTATGTGGGTCAGTATC
AGGCCATCCCTGACGATCCCTATGGGGTGACCCTGATTAACCTCGATGGCAAGCTCGCCAATCAATTTCCTGATGGTTAT
ACCCAGGCGCTGCGATATGAAGGCGATGGCCGCTTTGTTTATGACCAGGTCGGCGCCGAACCTGTTTATTTTATTATTTC
AGACAATGGCGACAGGCTGTCGACCAGGTTAGGGGAAAAGGGCGAGGAAGAAGTGAAAATGAAGGTCGTTCATTAA

Upstream 100 bases:

>100_bases
ACATAACAAGCGGCTCCAGCGGATTCACTTCGCTCACCGCTGAGCCGGGCGTTATCTCCGTGAAAGCCTTAGCTTGTGCA
TTAAAACAAGGACGTGACTG

Downstream 100 bases:

>100_bases
CTCTTGCTTTGAGAAGCGAGCATTCACATTATTGTTTAGCGTCGTTTTACCCGCGTTCTCAGCGTCGTCTTCAGTTATTG
GGGCGACGCTTTTATGTAAC

Product: beta-lactamase class C-like protein

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTRVLLAVLCSAAVLMSCGKKDTDTTQIDDIQSRQERLHRAFDDIRSQSDFMGSVVLMHSGKVIFSDSSGFDDISKNEKS
TTHSAYLIGSVSKTYTAALVLKAVDEQKLTLEQTLEAFFPTLENGHLISIKNLLQHTSGIGNYTKKGKGFFDYRTENQSS
ESMLNRILALGSDFEPGTKAEYSNSNYYLLALILEKVYQKSFGEILSEKITTPLNLTQTVHVRDTHQTQHSYSFDNGQWS
MFPASNMSVGLGAGSIKATPTEVAIFYNALFNGEIIPLPLVDTMKQTKNGFGLGIKPIDFFDKQGFGHGGTFDAYNAMAA
YFPQEKMTLVLASNGSNDNFHDTYQQMLKSYFNQTLTDLPVAAEELARYVGQYQAIPDDPYGVTLINLDGKLANQFPDGY
TQALRYEGDGRFVYDQVGAEPVYFIISDNGDRLSTRLGEKGEEEVKMKVVH

Sequences:

>Translated_451_residues
MTRVLLAVLCSAAVLMSCGKKDTDTTQIDDIQSRQERLHRAFDDIRSQSDFMGSVVLMHSGKVIFSDSSGFDDISKNEKS
TTHSAYLIGSVSKTYTAALVLKAVDEQKLTLEQTLEAFFPTLENGHLISIKNLLQHTSGIGNYTKKGKGFFDYRTENQSS
ESMLNRILALGSDFEPGTKAEYSNSNYYLLALILEKVYQKSFGEILSEKITTPLNLTQTVHVRDTHQTQHSYSFDNGQWS
MFPASNMSVGLGAGSIKATPTEVAIFYNALFNGEIIPLPLVDTMKQTKNGFGLGIKPIDFFDKQGFGHGGTFDAYNAMAA
YFPQEKMTLVLASNGSNDNFHDTYQQMLKSYFNQTLTDLPVAAEELARYVGQYQAIPDDPYGVTLINLDGKLANQFPDGY
TQALRYEGDGRFVYDQVGAEPVYFIISDNGDRLSTRLGEKGEEEVKMKVVH
>Mature_450_residues
TRVLLAVLCSAAVLMSCGKKDTDTTQIDDIQSRQERLHRAFDDIRSQSDFMGSVVLMHSGKVIFSDSSGFDDISKNEKST
THSAYLIGSVSKTYTAALVLKAVDEQKLTLEQTLEAFFPTLENGHLISIKNLLQHTSGIGNYTKKGKGFFDYRTENQSSE
SMLNRILALGSDFEPGTKAEYSNSNYYLLALILEKVYQKSFGEILSEKITTPLNLTQTVHVRDTHQTQHSYSFDNGQWSM
FPASNMSVGLGAGSIKATPTEVAIFYNALFNGEIIPLPLVDTMKQTKNGFGLGIKPIDFFDKQGFGHGGTFDAYNAMAAY
FPQEKMTLVLASNGSNDNFHDTYQQMLKSYFNQTLTDLPVAAEELARYVGQYQAIPDDPYGVTLINLDGKLANQFPDGYT
QALRYEGDGRFVYDQVGAEPVYFIISDNGDRLSTRLGEKGEEEVKMKVVH

Specific function: Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i.e., a D-alanyl-D-alanine- terminated peptide), it becomes im

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S12 family [H]

Homologues:

Organism=Escherichia coli, GI1786574, Length=274, Percent_Identity=25.1824817518248, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 50121; Mature: 49990

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVLLAVLCSAAVLMSCGKKDTDTTQIDDIQSRQERLHRAFDDIRSQSDFMGSVVLMHS
CHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHCEEEEEEC
GKVIFSDSSGFDDISKNEKSTTHSAYLIGSVSKTYTAALVLKAVDEQKLTLEQTLEAFFP
CEEEEECCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
TLENGHLISIKNLLQHTSGIGNYTKKGKGFFDYRTENQSSESMLNRILALGSDFEPGTKA
CCCCCCEEEHHHHHHHHCCCCCCHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
EYSNSNYYLLALILEKVYQKSFGEILSEKITTPLNLTQTVHVRDTHQTQHSYSFDNGQWS
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCEEE
MFPASNMSVGLGAGSIKATPTEVAIFYNALFNGEIIPLPLVDTMKQTKNGFGLGIKPIDF
EECCCCCEEECCCCCCCCCCHHEEEEEHHHHCCCEEEECHHHHHHHHCCCCCCCCCCCHH
FDKQGFGHGGTFDAYNAMAAYFPQEKMTLVLASNGSNDNFHDTYQQMLKSYFNQTLTDLP
HCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
VAAEELARYVGQYQAIPDDPYGVTLINLDGKLANQFPDGYTQALRYEGDGRFVYDQVGAE
HHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHCCCCHHHHEEECCCCCEEEECCCCC
PVYFIISDNGDRLSTRLGEKGEEEVKMKVVH
EEEEEEECCCCCHHHHHCCCCCCCEEEEECC
>Mature Secondary Structure 
TRVLLAVLCSAAVLMSCGKKDTDTTQIDDIQSRQERLHRAFDDIRSQSDFMGSVVLMHS
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHCEEEEEEC
GKVIFSDSSGFDDISKNEKSTTHSAYLIGSVSKTYTAALVLKAVDEQKLTLEQTLEAFFP
CEEEEECCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
TLENGHLISIKNLLQHTSGIGNYTKKGKGFFDYRTENQSSESMLNRILALGSDFEPGTKA
CCCCCCEEEHHHHHHHHCCCCCCHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
EYSNSNYYLLALILEKVYQKSFGEILSEKITTPLNLTQTVHVRDTHQTQHSYSFDNGQWS
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCEEE
MFPASNMSVGLGAGSIKATPTEVAIFYNALFNGEIIPLPLVDTMKQTKNGFGLGIKPIDF
EECCCCCEEECCCCCCCCCCHHEEEEEHHHHCCCEEEECHHHHHHHHCCCCCCCCCCCHH
FDKQGFGHGGTFDAYNAMAAYFPQEKMTLVLASNGSNDNFHDTYQQMLKSYFNQTLTDLP
HCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
VAAEELARYVGQYQAIPDDPYGVTLINLDGKLANQFPDGYTQALRYEGDGRFVYDQVGAE
HHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHCCCCHHHHEEECCCCCEEEECCCCC
PVYFIISDNGDRLSTRLGEKGEEEVKMKVVH
EEEEEEECCCCCHHHHHCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3830154; 7925404; 3030739; 2175384; 2386365; 3997832; 7490745 [H]