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The map label for this gene is hprA [H]

Identifier: 119775943

GI number: 119775943

Start: 3349618

End: 3350571

Strand: Reverse

Name: hprA [H]

Synonym: Sama_2811

Alternate gene names: 119775943

Gene position: 3350571-3349618 (Counterclockwise)

Preceding gene: 119775944

Following gene: 119775938

Centisome position: 77.81

GC content: 58.28

Gene sequence:

>954_bases
ATGACAGCAATTTGTGTATTGGATGGCTTCACCCTTAACCCCGGCGATCTGGATTGGTCGCCCCTGGCTGATATTGGCCC
CTTCGACGTCCATGACAGGACACCGAAAGAGCTTATCCTGAGCAGGGCCGCCGGCGCCCGGTTTTTACTGACCAATAAAA
CCGTGCTCGATGCCGCCACCCTCGAGGCTATGCCTTCGCTGGAATACATAGGGGTGCTGGCAACGGGGACCAATGTGGTG
GATGTGGCGGCCGCAAAACGTCTGGGGATAGCCGTGACCAATGTGCCCGGTTATGGCCCGGATGCGGTGGCGCAAATGGG
CTTTGCCCATGTGCTGCATCATATGTCCCGGGTCAGCGCCCATCATGATGCGGTGACCCAGGGGCAATGGAGCGGGCAGG
CCGACTTTTGCTTTACCCTTGGGCAGTTGGAGTCATTGTCAGGCAAGACCTTGGGCCTGGTGGGCTTTGGCGACATTGCG
CGGCAAATGGCGCGTATCGGTATGGCCTTTGGTATGAAGTTGCTGGTACACAGCCGCAGTAAACCCACGGATTTACCGGA
GGGAGCCAAGTTTGTTGCGCTGGACACCCTGTTTGCCGAATCCGATGTGTTATCGCTCCATTGCCCGCTGACCGACGATA
CCCGGGACATGGTCAATCGCGAAAGCCTGGCGCTCATGAAACAGGGGGCCTTACTTATCAATACCGCCCGTGGCGGTCTG
GTGGATGAAGTGGCTCTGGCGGATGCGCTCAATGCCGGACGCGTCAGGGCTGGAGTCGATGTGCTCTCAACCGAGCCGCC
GGCTCCAAATAACCCGCTGCTCCATGCCGCCAATATCAGCATCACTCCCCATAATGCCTGGGCTACCGTGAAGGCGAGGC
AGAAGCTGCTGGATATTGCGGTTGAAAACCTCAGGGCATTCAGCCGTGGTGAAAGCGTAAACCGGGTCGATTGA

Upstream 100 bases:

>100_bases
ACAGCCTCTTTTGCGATGCCAATAACTGTTTGTGGCAGGTGAACGCCGATTTGATGTGGCAGGGGCAGGCCAACGTCGGC
GTCAGTTTCAGGTTCTAATC

Downstream 100 bases:

>100_bases
CCCGGTTTTTTATGTCTGCTGAAGCTGTTATTGCAATGACGCTTCGAAGGTTAAAAAGATTTCGCTGACCGTCTTGTCGG
CGAGGCGGGTATCTTTCATC

Product: glycerate dehydrogenase

Products: NA

Alternate protein names: GDH; Glyoxylate reductase; Hydroxypyruvate dehydrogenase; NADH-dependent hydroxypyruvate reductase; HPR; HPR-A [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MTAICVLDGFTLNPGDLDWSPLADIGPFDVHDRTPKELILSRAAGARFLLTNKTVLDAATLEAMPSLEYIGVLATGTNVV
DVAAAKRLGIAVTNVPGYGPDAVAQMGFAHVLHHMSRVSAHHDAVTQGQWSGQADFCFTLGQLESLSGKTLGLVGFGDIA
RQMARIGMAFGMKLLVHSRSKPTDLPEGAKFVALDTLFAESDVLSLHCPLTDDTRDMVNRESLALMKQGALLINTARGGL
VDEVALADALNAGRVRAGVDVLSTEPPAPNNPLLHAANISITPHNAWATVKARQKLLDIAVENLRAFSRGESVNRVD

Sequences:

>Translated_317_residues
MTAICVLDGFTLNPGDLDWSPLADIGPFDVHDRTPKELILSRAAGARFLLTNKTVLDAATLEAMPSLEYIGVLATGTNVV
DVAAAKRLGIAVTNVPGYGPDAVAQMGFAHVLHHMSRVSAHHDAVTQGQWSGQADFCFTLGQLESLSGKTLGLVGFGDIA
RQMARIGMAFGMKLLVHSRSKPTDLPEGAKFVALDTLFAESDVLSLHCPLTDDTRDMVNRESLALMKQGALLINTARGGL
VDEVALADALNAGRVRAGVDVLSTEPPAPNNPLLHAANISITPHNAWATVKARQKLLDIAVENLRAFSRGESVNRVD
>Mature_316_residues
TAICVLDGFTLNPGDLDWSPLADIGPFDVHDRTPKELILSRAAGARFLLTNKTVLDAATLEAMPSLEYIGVLATGTNVVD
VAAAKRLGIAVTNVPGYGPDAVAQMGFAHVLHHMSRVSAHHDAVTQGQWSGQADFCFTLGQLESLSGKTLGLVGFGDIAR
QMARIGMAFGMKLLVHSRSKPTDLPEGAKFVALDTLFAESDVLSLHCPLTDDTRDMVNRESLALMKQGALLINTARGGLV
DEVALADALNAGRVRAGVDVLSTEPPAPNNPLLHAANISITPHNAWATVKARQKLLDIAVENLRAFSRGESVNRVD

Specific function: Plays a central role in assimilation of carbon. It converts hydroxypyruvate to glycerate as a key step in the serine cycle, and may also play an important role in C2 reactions, by interconverting glyoxylate and glycolate [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI145580578, Length=275, Percent_Identity=32.3636363636364, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI4557499, Length=275, Percent_Identity=32.3636363636364, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI61743967, Length=275, Percent_Identity=33.4545454545455, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI4557497, Length=275, Percent_Identity=33.4545454545455, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI145580575, Length=279, Percent_Identity=32.6164874551971, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI6912396, Length=301, Percent_Identity=29.9003322259136, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI23308577, Length=281, Percent_Identity=29.1814946619217, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1787645, Length=299, Percent_Identity=32.1070234113712, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI87082289, Length=267, Percent_Identity=35.5805243445693, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789279, Length=279, Percent_Identity=30.8243727598566, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788660, Length=241, Percent_Identity=29.4605809128631, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87081824, Length=217, Percent_Identity=25.3456221198157, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=282, Percent_Identity=29.0780141843972, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25147481, Length=277, Percent_Identity=30.3249097472924, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=282, Percent_Identity=28.3687943262411, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6320925, Length=299, Percent_Identity=28.7625418060201, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=283, Percent_Identity=29.3286219081272, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324964, Length=226, Percent_Identity=27.8761061946903, Blast_Score=82, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=157, Percent_Identity=31.2101910828025, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=181, Percent_Identity=29.8342541436464, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24646446, Length=275, Percent_Identity=34.1818181818182, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646448, Length=275, Percent_Identity=34.1818181818182, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646452, Length=275, Percent_Identity=34.1818181818182, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646450, Length=275, Percent_Identity=34.1818181818182, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI62472511, Length=275, Percent_Identity=34.1818181818182, Blast_Score=134, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24585516, Length=273, Percent_Identity=29.6703296703297, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28574286, Length=273, Percent_Identity=31.5018315018315, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI28571528, Length=266, Percent_Identity=33.0827067669173, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24585514, Length=255, Percent_Identity=32.9411764705882, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI28574282, Length=255, Percent_Identity=32.9411764705882, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI45552429, Length=255, Percent_Identity=32.9411764705882, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI45551003, Length=255, Percent_Identity=32.9411764705882, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI28574284, Length=258, Percent_Identity=32.9457364341085, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI19921140, Length=247, Percent_Identity=29.1497975708502, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.29 [H]

Molecular weight: Translated: 33701; Mature: 33570

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAICVLDGFTLNPGDLDWSPLADIGPFDVHDRTPKELILSRAAGARFLLTNKTVLDAAT
CEEEEEEECEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCHHHHHHH
LEAMPSLEYIGVLATGTNVVDVAAAKRLGIAVTNVPGYGPDAVAQMGFAHVLHHMSRVSA
HHHCCCCCEEEEEECCCCEEHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
HHDAVTQGQWSGQADFCFTLGQLESLSGKTLGLVGFGDIARQMARIGMAFGMKLLVHSRS
HHHHHCCCCCCCCCCEEEEHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHEEECCC
KPTDLPEGAKFVALDTLFAESDVLSLHCPLTDDTRDMVNRESLALMKQGALLINTARGGL
CCCCCCCCCEEEEEEEHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCC
VDEVALADALNAGRVRAGVDVLSTEPPAPNNPLLHAANISITPHNAWATVKARQKLLDIA
HHHHHHHHHHCCCCEECCCEEECCCCCCCCCCEEEEEEEEECCCCCEEHHHHHHHHHHHH
VENLRAFSRGESVNRVD
HHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TAICVLDGFTLNPGDLDWSPLADIGPFDVHDRTPKELILSRAAGARFLLTNKTVLDAAT
EEEEEEECEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCHHHHHHH
LEAMPSLEYIGVLATGTNVVDVAAAKRLGIAVTNVPGYGPDAVAQMGFAHVLHHMSRVSA
HHHCCCCCEEEEEECCCCEEHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
HHDAVTQGQWSGQADFCFTLGQLESLSGKTLGLVGFGDIARQMARIGMAFGMKLLVHSRS
HHHHHCCCCCCCCCCEEEEHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHEEECCC
KPTDLPEGAKFVALDTLFAESDVLSLHCPLTDDTRDMVNRESLALMKQGALLINTARGGL
CCCCCCCCCEEEEEEEHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCC
VDEVALADALNAGRVRAGVDVLSTEPPAPNNPLLHAANISITPHNAWATVKARQKLLDIA
HHHHHHHHHHCCCCEECCCEEECCCCCCCCCCEEEEEEEEECCCCCEEHHHHHHHHHHHH
VENLRAFSRGESVNRVD
HHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8144463; 1729225; 1657886 [H]