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The map label for this gene is fba [H]

Identifier: 119775888

GI number: 119775888

Start: 3295251

End: 3296318

Strand: Reverse

Name: fba [H]

Synonym: Sama_2756

Alternate gene names: 119775888

Gene position: 3296318-3295251 (Counterclockwise)

Preceding gene: 119775889

Following gene: 119775887

Centisome position: 76.55

GC content: 57.87

Gene sequence:

>1068_bases
ATGGCCCTTATTTCCCTACGTCAACTGCTGGACCACGCTGCAGAGCATGGTTACGGTGTGCCTGCGTTCAACGTGAACAA
CCTTGAGCAGATGCGCGCCATCATGCAGGCGGCCGAAGCCACCGACAGCCCTGTGATTGTTCAGGCCTCTGCCGGTGCCC
GCAAGTACGCCCGTCCTCAGTTCCTCAAGTATCTGATGAACGCCGCCCTCGAGCAGTATCCTGATATCCCTGTGTGTATT
CACCAGGACCACGGCACCCACCCCGACGTGTGCCAGCGTTCTATCCAGCTGGGTATGAGCTCAGTGATGATGGACGGCTC
TTTGATGTCCGACGGTAAAACCCCGGCTTCTTACGATTACAACGTCGACGTGACCCGCAAGACTGTGGCATTCGCCCACG
CCTGTGGTGTGTCTGTTGAAGGTGAAATCGGCTGTCTGGGTAGCCTGGAAACCGGTACTGCCGGTGAAGAAGATGGTATC
GGCGCCGTTGGCGTGCTGAGCCACGACCAGCTGCTGACCACCGCCGAAGAAGCCGCGCGCTTTGTGGCCGACACCCACGT
GGATGCCCTGGCCATCGCTATCGGTACCAGCCACGGCGCCTACAAGTTCAGCCGCAAGCCTACCGGTGACGTGCTGCGTA
TTGACCGCATCAAAGAAATCCATGCCCGTATCCCCAACACCCACCTGGTAATGCACGGCTCTTCTTCTGTGCCCCAGTAC
TGGCTGGAAATCATCAACCAATACGGTGGTGAAATCCCTGAGACCTACGGCGTGCCGCTGGAAGAAATCGTTGAAGGCAT
CAAGCACGGCGTGCGTAAGGTGAACATCGACACCGACCTGCGTCTGGCCTCCACTGGCGCGGTACGTAAGTTCCTGGCCG
AGAACCCAAGTGAGTTCGACCCACGTAAGTTCCTCAAGGCCTCCATGGAAGCCATGGCCGATATCTGTACCGAGCGCTAC
GAAGCCTTTGGCTGTGCCGGTATGGCATCGAAAATCAAGCCGCTGTCACTGCAGGCTATGTACAAGCGTTATCAGACCGG
CGAGCTGGATCCCAAGATCAACCTCTAA

Upstream 100 bases:

>100_bases
CGCCTCCCGGGAGACCGGGAGGCATAAAAATCAGTCCAAACGATAGCGACCTCGGTGACCCACATTCAGCATGGATGTCA
CCCTATTAATGGAGTAAAAA

Downstream 100 bases:

>100_bases
TCTCTCTGAACTGAAAAAGCCCGCCATTGCGGGCTTTTTATTTACCTGGCGTCTGCAAGCGGGTAAATGTGCGCTTTTGC
TTATGCTTGCCGGACAAACG

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MALISLRQLLDHAAEHGYGVPAFNVNNLEQMRAIMQAAEATDSPVIVQASAGARKYARPQFLKYLMNAALEQYPDIPVCI
HQDHGTHPDVCQRSIQLGMSSVMMDGSLMSDGKTPASYDYNVDVTRKTVAFAHACGVSVEGEIGCLGSLETGTAGEEDGI
GAVGVLSHDQLLTTAEEAARFVADTHVDALAIAIGTSHGAYKFSRKPTGDVLRIDRIKEIHARIPNTHLVMHGSSSVPQY
WLEIINQYGGEIPETYGVPLEEIVEGIKHGVRKVNIDTDLRLASTGAVRKFLAENPSEFDPRKFLKASMEAMADICTERY
EAFGCAGMASKIKPLSLQAMYKRYQTGELDPKINL

Sequences:

>Translated_355_residues
MALISLRQLLDHAAEHGYGVPAFNVNNLEQMRAIMQAAEATDSPVIVQASAGARKYARPQFLKYLMNAALEQYPDIPVCI
HQDHGTHPDVCQRSIQLGMSSVMMDGSLMSDGKTPASYDYNVDVTRKTVAFAHACGVSVEGEIGCLGSLETGTAGEEDGI
GAVGVLSHDQLLTTAEEAARFVADTHVDALAIAIGTSHGAYKFSRKPTGDVLRIDRIKEIHARIPNTHLVMHGSSSVPQY
WLEIINQYGGEIPETYGVPLEEIVEGIKHGVRKVNIDTDLRLASTGAVRKFLAENPSEFDPRKFLKASMEAMADICTERY
EAFGCAGMASKIKPLSLQAMYKRYQTGELDPKINL
>Mature_354_residues
ALISLRQLLDHAAEHGYGVPAFNVNNLEQMRAIMQAAEATDSPVIVQASAGARKYARPQFLKYLMNAALEQYPDIPVCIH
QDHGTHPDVCQRSIQLGMSSVMMDGSLMSDGKTPASYDYNVDVTRKTVAFAHACGVSVEGEIGCLGSLETGTAGEEDGIG
AVGVLSHDQLLTTAEEAARFVADTHVDALAIAIGTSHGAYKFSRKPTGDVLRIDRIKEIHARIPNTHLVMHGSSSVPQYW
LEIINQYGGEIPETYGVPLEEIVEGIKHGVRKVNIDTDLRLASTGAVRKFLAENPSEFDPRKFLKASMEAMADICTERYE
AFGCAGMASKIKPLSLQAMYKRYQTGELDPKINL

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=330, Percent_Identity=33.6363636363636, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=32.8267477203647, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1788072, Length=330, Percent_Identity=27.5757575757576, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38666; Mature: 38534

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALISLRQLLDHAAEHGYGVPAFNVNNLEQMRAIMQAAEATDSPVIVQASAGARKYARPQ
CHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHCCHH
FLKYLMNAALEQYPDIPVCIHQDHGTHPDVCQRSIQLGMSSVMMDGSLMSDGKTPASYDY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NVDVTRKTVAFAHACGVSVEGEIGCLGSLETGTAGEEDGIGAVGVLSHDQLLTTAEEAAR
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHH
FVADTHVDALAIAIGTSHGAYKFSRKPTGDVLRIDRIKEIHARIPNTHLVMHGSSSVPQY
HHHHHCHHEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
WLEIINQYGGEIPETYGVPLEEIVEGIKHGVRKVNIDTDLRLASTGAVRKFLAENPSEFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCEEHHHHHHHHHHHCCCCCCC
PRKFLKASMEAMADICTERYEAFGCAGMASKIKPLSLQAMYKRYQTGELDPKINL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ALISLRQLLDHAAEHGYGVPAFNVNNLEQMRAIMQAAEATDSPVIVQASAGARKYARPQ
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHCCHH
FLKYLMNAALEQYPDIPVCIHQDHGTHPDVCQRSIQLGMSSVMMDGSLMSDGKTPASYDY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NVDVTRKTVAFAHACGVSVEGEIGCLGSLETGTAGEEDGIGAVGVLSHDQLLTTAEEAAR
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHH
FVADTHVDALAIAIGTSHGAYKFSRKPTGDVLRIDRIKEIHARIPNTHLVMHGSSSVPQY
HHHHHCHHEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
WLEIINQYGGEIPETYGVPLEEIVEGIKHGVRKVNIDTDLRLASTGAVRKFLAENPSEFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCEEHHHHHHHHHHHCCCCCCC
PRKFLKASMEAMADICTERYEAFGCAGMASKIKPLSLQAMYKRYQTGELDPKINL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]