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The map label for this gene is gcvT

Identifier: 119775853

GI number: 119775853

Start: 3255570

End: 3256664

Strand: Reverse

Name: gcvT

Synonym: Sama_2721

Alternate gene names: 119775853

Gene position: 3256664-3255570 (Counterclockwise)

Preceding gene: 119775854

Following gene: 119775852

Centisome position: 75.63

GC content: 56.62

Gene sequence:

>1095_bases
ATGGCTAATAAAACTGTACTCTTTAGCAAGCACCTGGAATCGAACGCCAAGATGGTGGACTTCCACGGCTGGAATATGCC
CCTCAACTATGGCTCCCAAATCGAAGAGCACCATGCCGTGCGCCGTGACGCCGGTATGTTCGACGTATCTCACATGACTG
TAGTGGACGTTGAAGGTGCCGATGCCCGCGCTTTCCTGCGCAAACTGCTGGCTAACGACATTGCCAAACTGACCGTTCCC
GGCAAAGCCCTCTACGGCGGCATGCTGAACCACGACGGCGGCGTCATTGACGACCTCATCACCTACTATCTCAGCGACAC
TCAATACCGCGTGGTAGTGAACTCTGCTACCCGCGAAAAAGATCTGGCGTGGATTGGTGAGCAGGCCAAAGGCTTCGATG
TCACCATCACCGAGCGTCCTGAACTGGCCATGATTGCCGTGCAGGGTCCCAATGCCAAAGCCAAAGCCGCCACCGTATTT
ACTGCCGAGCAAAACGCTGCTGTAGAAGGTATGAAGCCTTTCTTCGGCAAGCAAGCTGGCAGCCTCTTTATTGCCACCAC
AGGTTACACAGGTGAAGCCGGCTACGAGATCATCGTGCCAGAAGCCGAAGCCGAGGCCCTGTGGCAAGCCCTGCTGGATG
CCGGTGTGCAGCCATGTGGTCTGGGTGCCCGTGACACCCTGCGCCTGGAAGCCGGTATGAACCTCTACGGTCAGGACATG
GACGAGAGCGTCAACCCACTGGCCGCCAACATGGGCTGGACCATTGCATGGGAACCTGCGGATCGCGACTTTATCGGCCG
TGAAGCGCTGGAAGCCATCAAGGCCAAGGGCAGCGACAAATTAGTCGGTCTGGTGATGGAAGAGAAGGGCGTTCTGCGCC
ATGATATGCCAGTGTTTTTTACCGACGCCAATGGCGTTGAGCACCAGGGCGTGATCACCAGCGGTACATTCTCACCCACT
TTGGGCTATTCTATCGCGATGGCTCGCGTACCCGGCGCCATCGGTGAGACTGCCGAAGTGGAAATGCGCAAGAAGCGTGT
GACGGTGCGTGTCATCGCACCCAGCTTCGTACGCAATGGAAAACAAGCATTTTAA

Upstream 100 bases:

>100_bases
TCTTGTATACAAATTTGTGACGCAAGGTATAATTTCGCCGCATTTTAACCAGGTGCCGTTTCTATTTTTGGCACCAAAGC
CCCGGATAGAAGGGATAATA

Downstream 100 bases:

>100_bases
AAGACCCGATTAAGGAACAAGAACAATGAGCAATATCCCGTCCGAACTCAAGTATGCTTCTTCCCACGAATGGATCCGCA
AGGAAGACGACGGCACCTAC

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MANKTVLFSKHLESNAKMVDFHGWNMPLNYGSQIEEHHAVRRDAGMFDVSHMTVVDVEGADARAFLRKLLANDIAKLTVP
GKALYGGMLNHDGGVIDDLITYYLSDTQYRVVVNSATREKDLAWIGEQAKGFDVTITERPELAMIAVQGPNAKAKAATVF
TAEQNAAVEGMKPFFGKQAGSLFIATTGYTGEAGYEIIVPEAEAEALWQALLDAGVQPCGLGARDTLRLEAGMNLYGQDM
DESVNPLAANMGWTIAWEPADRDFIGREALEAIKAKGSDKLVGLVMEEKGVLRHDMPVFFTDANGVEHQGVITSGTFSPT
LGYSIAMARVPGAIGETAEVEMRKKRVTVRVIAPSFVRNGKQAF

Sequences:

>Translated_364_residues
MANKTVLFSKHLESNAKMVDFHGWNMPLNYGSQIEEHHAVRRDAGMFDVSHMTVVDVEGADARAFLRKLLANDIAKLTVP
GKALYGGMLNHDGGVIDDLITYYLSDTQYRVVVNSATREKDLAWIGEQAKGFDVTITERPELAMIAVQGPNAKAKAATVF
TAEQNAAVEGMKPFFGKQAGSLFIATTGYTGEAGYEIIVPEAEAEALWQALLDAGVQPCGLGARDTLRLEAGMNLYGQDM
DESVNPLAANMGWTIAWEPADRDFIGREALEAIKAKGSDKLVGLVMEEKGVLRHDMPVFFTDANGVEHQGVITSGTFSPT
LGYSIAMARVPGAIGETAEVEMRKKRVTVRVIAPSFVRNGKQAF
>Mature_363_residues
ANKTVLFSKHLESNAKMVDFHGWNMPLNYGSQIEEHHAVRRDAGMFDVSHMTVVDVEGADARAFLRKLLANDIAKLTVPG
KALYGGMLNHDGGVIDDLITYYLSDTQYRVVVNSATREKDLAWIGEQAKGFDVTITERPELAMIAVQGPNAKAKAATVFT
AEQNAAVEGMKPFFGKQAGSLFIATTGYTGEAGYEIIVPEAEAEALWQALLDAGVQPCGLGARDTLRLEAGMNLYGQDMD
ESVNPLAANMGWTIAWEPADRDFIGREALEAIKAKGSDKLVGLVMEEKGVLRHDMPVFFTDANGVEHQGVITSGTFSPTL
GYSIAMARVPGAIGETAEVEMRKKRVTVRVIAPSFVRNGKQAF

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=373, Percent_Identity=34.5844504021448, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI257796258, Length=344, Percent_Identity=35.1744186046512, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI257796254, Length=368, Percent_Identity=31.25, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI257796256, Length=318, Percent_Identity=33.9622641509434, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI24797151, Length=341, Percent_Identity=29.0322580645161, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI197927446, Length=295, Percent_Identity=27.4576271186441, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI21361378, Length=295, Percent_Identity=27.4576271186441, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1789272, Length=361, Percent_Identity=70.3601108033241, Blast_Score=536, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17560118, Length=374, Percent_Identity=34.4919786096257, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71994045, Length=338, Percent_Identity=27.2189349112426, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71994052, Length=338, Percent_Identity=27.2189349112426, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320222, Length=343, Percent_Identity=34.6938775510204, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI20129441, Length=377, Percent_Identity=33.42175066313, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI28571104, Length=262, Percent_Identity=24.4274809160305, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI20130091, Length=373, Percent_Identity=24.3967828418231, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_SHEAM (A1S967)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_928593.1
- ProteinModelPortal:   A1S967
- SMR:   A1S967
- STRING:   A1S967
- GeneID:   4604968
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_2721
- NMPDR:   fig|326297.7.peg.2551
- eggNOG:   COG0404
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- PhylomeDB:   A1S967
- ProtClustDB:   PRK00389
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 39501; Mature: 39370

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANKTVLFSKHLESNAKMVDFHGWNMPLNYGSQIEEHHAVRRDAGMFDVSHMTVVDVEGA
CCCCEEEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEECCEEEEEECCC
DARAFLRKLLANDIAKLTVPGKALYGGMLNHDGGVIDDLITYYLSDTQYRVVVNSATREK
CHHHHHHHHHHCCHHEEEECCHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCC
DLAWIGEQAKGFDVTITERPELAMIAVQGPNAKAKAATVFTAEQNAAVEGMKPFFGKQAG
HHHEECCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCC
SLFIATTGYTGEAGYEIIVPEAEAEALWQALLDAGVQPCGLGARDTLRLEAGMNLYGQDM
CEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCC
DESVNPLAANMGWTIAWEPADRDFIGREALEAIKAKGSDKLVGLVMEEKGVLRHDMPVFF
CCCCCCHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEE
TDANGVEHQGVITSGTFSPTLGYSIAMARVPGAIGETAEVEMRKKRVTVRVIAPSFVRNG
ECCCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCCCHHHEEEEEEEEEEEECCHHHCCC
KQAF
CCCC
>Mature Secondary Structure 
ANKTVLFSKHLESNAKMVDFHGWNMPLNYGSQIEEHHAVRRDAGMFDVSHMTVVDVEGA
CCCEEEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEECCEEEEEECCC
DARAFLRKLLANDIAKLTVPGKALYGGMLNHDGGVIDDLITYYLSDTQYRVVVNSATREK
CHHHHHHHHHHCCHHEEEECCHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCC
DLAWIGEQAKGFDVTITERPELAMIAVQGPNAKAKAATVFTAEQNAAVEGMKPFFGKQAG
HHHEECCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCC
SLFIATTGYTGEAGYEIIVPEAEAEALWQALLDAGVQPCGLGARDTLRLEAGMNLYGQDM
CEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCC
DESVNPLAANMGWTIAWEPADRDFIGREALEAIKAKGSDKLVGLVMEEKGVLRHDMPVFF
CCCCCCHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEE
TDANGVEHQGVITSGTFSPTLGYSIAMARVPGAIGETAEVEMRKKRVTVRVIAPSFVRNG
ECCCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCCCHHHEEEEEEEEEEEECCHHHCCC
KQAF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA