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The map label for this gene is cyp18 [H]

Identifier: 119775686

GI number: 119775686

Start: 3062156

End: 3062743

Strand: Direct

Name: cyp18 [H]

Synonym: Sama_2554

Alternate gene names: 119775686

Gene position: 3062156-3062743 (Clockwise)

Preceding gene: 119775685

Following gene: 119775687

Centisome position: 71.11

GC content: 53.23

Gene sequence:

>588_bases
ATGAAATGGATCATTGCAGCCCTGATGCTGGGCTTGTCTAACGTGGCGCTGGCGGCCAAAGTGGATATTCAACCCGATAA
CCTCTACCCCCAGGTTGAAATGCAAACCACCATGGGCAAAATTGTGGTGGAGCTCGACCGCACCCGCGCCCCCATTACTG
TCGATAACTTCCTGACCTATGTGGTGAAAGGTGACTACGACAACACTATCTTCCACCGCATTATTCCGGAATTTGTGGTT
CAGGGCGGCGGTCTTAATCCCAAACTGGAGGAACTGCCAGAATCAGCCCCCATCGTTAATGAGTCAGGCAACGGCCTGTC
CAATGCCTTCGGCACCATCGCCATGGCAAGGGAGAACAACCCCCACTCGGCCACCCGCCAGTTTTATTTCAACGTGGCAG
ATAATACCAAGCTCGACCCCTCCAAGCGCCGCTGGGGCTATGCCGTTTTCGGTGAAGTGGTGGAAGGCCGCGAAATTCTG
GAAGCTATGGCGGTCGTGCCCACAGAACACAACAGCAAACTGAACTGGCCCGATGTTCCTGTTACTCAGATTGTGCTCAA
GTCAGCCAAATTGTTGCCAAGAAAATAA

Upstream 100 bases:

>100_bases
GGAAATGAATAAGCTCATCACCCAGCTTGCTGGCGACATAGTCAATGACCCCGAACTGACCCAGTTTCTGATGCAATAAC
AACGAAAAAGGAAATCATAA

Downstream 100 bases:

>100_bases
ACTGTGTTTTGAGTCAGCACTCTAAAGCTGACTATACTCAGTGAGCTAAACAAGGAGGCGATACGATGACACCAACGGAT
TTCATCGATAGCAAAGCGCC

Product: peptidyl-prolyl cis-trans isomerase A

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MKWIIAALMLGLSNVALAAKVDIQPDNLYPQVEMQTTMGKIVVELDRTRAPITVDNFLTYVVKGDYDNTIFHRIIPEFVV
QGGGLNPKLEELPESAPIVNESGNGLSNAFGTIAMARENNPHSATRQFYFNVADNTKLDPSKRRWGYAVFGEVVEGREIL
EAMAVVPTEHNSKLNWPDVPVTQIVLKSAKLLPRK

Sequences:

>Translated_195_residues
MKWIIAALMLGLSNVALAAKVDIQPDNLYPQVEMQTTMGKIVVELDRTRAPITVDNFLTYVVKGDYDNTIFHRIIPEFVV
QGGGLNPKLEELPESAPIVNESGNGLSNAFGTIAMARENNPHSATRQFYFNVADNTKLDPSKRRWGYAVFGEVVEGREIL
EAMAVVPTEHNSKLNWPDVPVTQIVLKSAKLLPRK
>Mature_195_residues
MKWIIAALMLGLSNVALAAKVDIQPDNLYPQVEMQTTMGKIVVELDRTRAPITVDNFLTYVVKGDYDNTIFHRIIPEFVV
QGGGLNPKLEELPESAPIVNESGNGLSNAFGTIAMARENNPHSATRQFYFNVADNTKLDPSKRRWGYAVFGEVVEGREIL
EAMAVVPTEHNSKLNWPDVPVTQIVLKSAKLLPRK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Escherichia coli, GI1789763, Length=182, Percent_Identity=46.1538461538462, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1786736, Length=160, Percent_Identity=43.75, Blast_Score=134, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17539496, Length=149, Percent_Identity=29.5302013422819, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17986117, Length=188, Percent_Identity=31.3829787234043, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21675; Mature: 21675

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWIIAALMLGLSNVALAAKVDIQPDNLYPQVEMQTTMGKIVVELDRTRAPITVDNFLTY
CHHHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEHHHHCEEEEEECCCCCCEEHHHEEEE
VVKGDYDNTIFHRIIPEFVVQGGGLNPKLEELPESAPIVNESGNGLSNAFGTIAMARENN
EEECCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEECCCCCCCHHHHHEEEEECCCC
PHSATRQFYFNVADNTKLDPSKRRWGYAVFGEVVEGREILEAMAVVPTEHNSKLNWPDVP
CCCCEEEEEEEECCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
VTQIVLKSAKLLPRK
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MKWIIAALMLGLSNVALAAKVDIQPDNLYPQVEMQTTMGKIVVELDRTRAPITVDNFLTY
CHHHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEHHHHCEEEEEECCCCCCEEHHHEEEE
VVKGDYDNTIFHRIIPEFVVQGGGLNPKLEELPESAPIVNESGNGLSNAFGTIAMARENN
EEECCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEECCCCCCCHHHHHEEEEECCCC
PHSATRQFYFNVADNTKLDPSKRRWGYAVFGEVVEGREILEAMAVVPTEHNSKLNWPDVP
CCCCEEEEEEEECCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
VTQIVLKSAKLLPRK
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]