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The map label for this gene is atoC [H]

Identifier: 119774686

GI number: 119774686

Start: 1885854

End: 1887188

Strand: Direct

Name: atoC [H]

Synonym: Sama_1549

Alternate gene names: 119774686

Gene position: 1885854-1887188 (Clockwise)

Preceding gene: 119774685

Following gene: 119774689

Centisome position: 43.79

GC content: 57.45

Gene sequence:

>1335_bases
ATGGCGCTCAGTATTTTGGTGGTAGAGGATGAGCCCGGCCAGCGTGAGCTCATCGTGGGTATGCTCAAGACCGAAGGCTA
TCGACTGCGTGAGGCTGATTGTGTCGAGGCGGCCATCGTATCCATCAAGGCGGATACCCCGGATCTGGTGTTTTCAGACT
GGAAGCTGGGGCAGCTCAGCGGTATGGATTTACTCAACTACGTTAAACGCGAGTTTCCCGACGTCGGCTTTATCATGGCC
ACCGCTTACGGCACCATCACCCATGCCGTGGATGCCATTCAGGCCGGGGCGGATGATTATCTCACCAAGCCCTATCAGCG
CCAGGCGCTGCTGCTTGCCATCTCCAAGGTGGCGCGCTCACAAGCGCTCAGGAAAGAAAACAAGGCGCTGAGTCTGGCAT
TGTCAGAGCAGCAATCCCTGGTGGGGCTGGTGGGGAAGGCGCCCTGTATGCAAGGGGTGTTTGACCGTATAAGTCGCATC
AGCGGCACGGATGCCACTGTGCTTATTGGCGGCGAGAGTGGTACCGGCAAGGAGCTGGCTGCCCGGGCGTTGCATCAACT
GTCCCGCCGCGCGCACATGCCGTTTATTGCTATTAACTGTGGTGCCATCCCCGAAAACATCGCTGAAGCCGAGCTGTTTG
GTGCCGAGAAGGGCGCCTTTACCGGCGCCACCGCGCTGAAGCTTGGCAAGCTGGAGGCGGCCCATGGCGGCACAGTATTT
TTAGATGAAATCGGTGAGCTGCCTTTGCTTCAGCAAACCAAGCTGCTGCGATTTTTGCAGGAAGGTACCATCACCCGCGT
GGGCGCCCAAAAAGAGTTGCAGCTGGATGTGAGGGTCATTGCCGCCACCCACAGGGACTTGCGTCTCGAAGTCGCCGAGG
CCCGTTTTCGGGAAGATTTATTTTATCGTTTGAACGTGGTGCCTGTGCTGATGCCGCCGCTTCGGGAGCGCCGTGAGGAC
ATAGGCCGTCTGGTGGAGCATTTCCTGAAACTCCATGCCAGTCAGTACGGATTTGACCAACCTAAAATCAGCCCCACTGC
CTTGCGGTTTTTACTGGACTACCGCTGGCCGGGGAATGTGCGTGAACTGTCCAATCGTATCGAGCGCTTTGTGCTGCTTG
GCGATGAAGCGGAATTAATGCAGGTAAGCGAGCATGCGTCCAAAGAACCGGGGCTGCAGCTGCCCGATGAAGGTATCGAG
TGGGAGGCCTTTGAGGCCCGCTGTTTGTCTCAGGCTATGGCCCGCTTCGATGGTAACCGCACCAAGGCCGCTAAATGGCT
GGGCATGAGCTATAAAGCCTTTTTGTACCGCCTGGAAAAGCACCGCCTGGTGTAG

Upstream 100 bases:

>100_bases
GTAGGCTCTTGGCGAGCCATTATGGCGGCAGCCTGCACTTTGTGCGCCTCGATGAAGGCGGCAGCCGGGTTGTGGTGCAT
TTTAAACAGCAGGAGGCTTG

Downstream 100 bases:

>100_bases
TGTCTGATGAGAATGCGCGAGACGGGTTAGCTTACACCCGGCTCGCTTCTCAAAGATACGTTTCGGTTCGGGAACTATGA
ATCCTGGCATCGGAAAACGA

Product: response regulator receiver protein

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MALSILVVEDEPGQRELIVGMLKTEGYRLREADCVEAAIVSIKADTPDLVFSDWKLGQLSGMDLLNYVKREFPDVGFIMA
TAYGTITHAVDAIQAGADDYLTKPYQRQALLLAISKVARSQALRKENKALSLALSEQQSLVGLVGKAPCMQGVFDRISRI
SGTDATVLIGGESGTGKELAARALHQLSRRAHMPFIAINCGAIPENIAEAELFGAEKGAFTGATALKLGKLEAAHGGTVF
LDEIGELPLLQQTKLLRFLQEGTITRVGAQKELQLDVRVIAATHRDLRLEVAEARFREDLFYRLNVVPVLMPPLRERRED
IGRLVEHFLKLHASQYGFDQPKISPTALRFLLDYRWPGNVRELSNRIERFVLLGDEAELMQVSEHASKEPGLQLPDEGIE
WEAFEARCLSQAMARFDGNRTKAAKWLGMSYKAFLYRLEKHRLV

Sequences:

>Translated_444_residues
MALSILVVEDEPGQRELIVGMLKTEGYRLREADCVEAAIVSIKADTPDLVFSDWKLGQLSGMDLLNYVKREFPDVGFIMA
TAYGTITHAVDAIQAGADDYLTKPYQRQALLLAISKVARSQALRKENKALSLALSEQQSLVGLVGKAPCMQGVFDRISRI
SGTDATVLIGGESGTGKELAARALHQLSRRAHMPFIAINCGAIPENIAEAELFGAEKGAFTGATALKLGKLEAAHGGTVF
LDEIGELPLLQQTKLLRFLQEGTITRVGAQKELQLDVRVIAATHRDLRLEVAEARFREDLFYRLNVVPVLMPPLRERRED
IGRLVEHFLKLHASQYGFDQPKISPTALRFLLDYRWPGNVRELSNRIERFVLLGDEAELMQVSEHASKEPGLQLPDEGIE
WEAFEARCLSQAMARFDGNRTKAAKWLGMSYKAFLYRLEKHRLV
>Mature_443_residues
ALSILVVEDEPGQRELIVGMLKTEGYRLREADCVEAAIVSIKADTPDLVFSDWKLGQLSGMDLLNYVKREFPDVGFIMAT
AYGTITHAVDAIQAGADDYLTKPYQRQALLLAISKVARSQALRKENKALSLALSEQQSLVGLVGKAPCMQGVFDRISRIS
GTDATVLIGGESGTGKELAARALHQLSRRAHMPFIAINCGAIPENIAEAELFGAEKGAFTGATALKLGKLEAAHGGTVFL
DEIGELPLLQQTKLLRFLQEGTITRVGAQKELQLDVRVIAATHRDLRLEVAEARFREDLFYRLNVVPVLMPPLRERREDI
GRLVEHFLKLHASQYGFDQPKISPTALRFLLDYRWPGNVRELSNRIERFVLLGDEAELMQVSEHASKEPGLQLPDEGIEW
EAFEARCLSQAMARFDGNRTKAAKWLGMSYKAFLYRLEKHRLV

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=458, Percent_Identity=39.0829694323144, Blast_Score=327, Evalue=1e-90,
Organism=Escherichia coli, GI1790437, Length=442, Percent_Identity=38.4615384615385, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI1790299, Length=376, Percent_Identity=41.2234042553192, Blast_Score=288, Evalue=3e-79,
Organism=Escherichia coli, GI1788905, Length=440, Percent_Identity=38.1818181818182, Blast_Score=278, Evalue=4e-76,
Organism=Escherichia coli, GI1789233, Length=320, Percent_Identity=43.4375, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI87082117, Length=253, Percent_Identity=49.802371541502, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI1789087, Length=343, Percent_Identity=41.399416909621, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87082152, Length=314, Percent_Identity=43.9490445859873, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI1786524, Length=332, Percent_Identity=43.6746987951807, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87081872, Length=325, Percent_Identity=39.0769230769231, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1787583, Length=330, Percent_Identity=38.4848484848485, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1789828, Length=255, Percent_Identity=36.078431372549, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI87081858, Length=213, Percent_Identity=37.5586854460094, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786599, Length=121, Percent_Identity=37.1900826446281, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49412; Mature: 49281

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSILVVEDEPGQRELIVGMLKTEGYRLREADCVEAAIVSIKADTPDLVFSDWKLGQLS
CEEEEEEEECCCCCHHHEEEEHHCCCCEECHHHHHHHHHEEEECCCCCEEECCCCCCCCC
GMDLLNYVKREFPDVGFIMATAYGTITHAVDAIQAGADDYLTKPYQRQALLLAISKVARS
CHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHH
QALRKENKALSLALSEQQSLVGLVGKAPCMQGVFDRISRISGTDATVLIGGESGTGKELA
HHHHHHCHHEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
ARALHQLSRRAHMPFIAINCGAIPENIAEAELFGAEKGAFTGATALKLGKLEAAHGGTVF
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHEECCEECCCCCEEE
LDEIGELPLLQQTKLLRFLQEGTITRVGAQKELQLDVRVIAATHRDLRLEVAEARFREDL
EHHCCCCCCHHHHHHHHHHHCCCEEECCCCCHHEEEEEEEEECCCCHHHHHHHHHHHHHH
FYRLNVVPVLMPPLRERREDIGRLVEHFLKLHASQYGFDQPKISPTALRFLLDYRWPGNV
HHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCH
RELSNRIERFVLLGDEAELMQVSEHASKEPGLQLPDEGIEWEAFEARCLSQAMARFDGNR
HHHHHHHHHEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCH
TKAAKWLGMSYKAFLYRLEKHRLV
HHHHHHHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALSILVVEDEPGQRELIVGMLKTEGYRLREADCVEAAIVSIKADTPDLVFSDWKLGQLS
EEEEEEEECCCCCHHHEEEEHHCCCCEECHHHHHHHHHEEEECCCCCEEECCCCCCCCC
GMDLLNYVKREFPDVGFIMATAYGTITHAVDAIQAGADDYLTKPYQRQALLLAISKVARS
CHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHH
QALRKENKALSLALSEQQSLVGLVGKAPCMQGVFDRISRISGTDATVLIGGESGTGKELA
HHHHHHCHHEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
ARALHQLSRRAHMPFIAINCGAIPENIAEAELFGAEKGAFTGATALKLGKLEAAHGGTVF
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHEECCEECCCCCEEE
LDEIGELPLLQQTKLLRFLQEGTITRVGAQKELQLDVRVIAATHRDLRLEVAEARFREDL
EHHCCCCCCHHHHHHHHHHHCCCEEECCCCCHHEEEEEEEEECCCCHHHHHHHHHHHHHH
FYRLNVVPVLMPPLRERREDIGRLVEHFLKLHASQYGFDQPKISPTALRFLLDYRWPGNV
HHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCH
RELSNRIERFVLLGDEAELMQVSEHASKEPGLQLPDEGIEWEAFEARCLSQAMARFDGNR
HHHHHHHHHEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCH
TKAAKWLGMSYKAFLYRLEKHRLV
HHHHHHHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]