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The map label for this gene is mmsB [H]

Identifier: 119774517

GI number: 119774517

Start: 1671828

End: 1672733

Strand: Direct

Name: mmsB [H]

Synonym: Sama_1380

Alternate gene names: 119774517

Gene position: 1671828-1672733 (Clockwise)

Preceding gene: 119774516

Following gene: 119774518

Centisome position: 38.82

GC content: 58.72

Gene sequence:

>906_bases
ATGGCGAAGATAGCGTTTATTGGCCTTGGCAACATGGGTGGCCCAATGGCGGCCAACCTGCTCAAGGCGGGACACAGTGT
ATCGGTATTCGATCTCAACCCTGCTGCGGTTGAGTCACTCAAGGCCCAGGGAGCAGGCCGTGGCGACACGGCCCAGGCCA
TCGCCGCCGATGCGGACTTTGTGGTGAGCATGCTGCCAGCCGGCAAGCATGTACGCGGTCTCTATTTAGGCACTGATACC
GCCAAGGGGCTGATTGAGGTGGTGAAAGCAGGTTGTCTCTTGATAGACTGCTCCACCATAGATGCCGGCAGCGCCCGCAC
AGTGGCCGACGCCGCGGCGGCAAAGGGCCTGGAATTTATTGATGCGCCTGTGTCCGGCGGCACGGCCGGCGCCGCAGCCG
GAACCCTGACCTTTATCTGTGGCGGCACAGACGCGGCCTTTGAGAAGGCACGTACCGTGCTGGCCAACATGGGCGTGAAC
ATTTTCCATGCCGGTGGTCCGGGTGCCGGTCAGGTGGCCAAAATTTGCAATAACATGCTTTTGTCAGTACTCATGGTTGG
CACCAGCGAGGCATTGTCGTTGGGGATTGACCATGGGCTCGACCCCAAGGTGCTTTCTGACATCATGAAGGTGTCCAGCG
GCGGTAACTGGACGCTGGAAAAGTACAATCCCTGCCCGGGTGTGATGGAAAATGTCCCATCCTCCAAAGGCTACCAGGGC
GGCTTTATGGTCGACCTGATGGTGAAAGATCTGGGATTGTCGCAGGAAGCAGCCCTCGGCAGTCAGTCCAGCACCCCCAT
GGGCGCACTGGCTCGCAGCCTGTATGTGTCCCATGCCCGCGCCGGCAATGGCACAAGGGACTTCTCAAGTATTTTTGAAC
ATTTTGCCAAAGGCGATAAGGCCTAA

Upstream 100 bases:

>100_bases
CGCTGCAGGACCTCTGATAGATACCCTATTCACAGCCCGGCACATACCGGGCTTATCCGATTTTTGGCCCGGCCAGCCGG
GCTTGGCAAGGAGCGACATC

Downstream 100 bases:

>100_bases
GGAATCACAATGGAATTGAAGGATAAGGTAATTGTCATTACCGGCGGCGCCGGTGGTCTGGGACTGGCCATGGCCAAAGA
TCTCGCCGCCCATGGCGCCA

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MAKIAFIGLGNMGGPMAANLLKAGHSVSVFDLNPAAVESLKAQGAGRGDTAQAIAADADFVVSMLPAGKHVRGLYLGTDT
AKGLIEVVKAGCLLIDCSTIDAGSARTVADAAAAKGLEFIDAPVSGGTAGAAAGTLTFICGGTDAAFEKARTVLANMGVN
IFHAGGPGAGQVAKICNNMLLSVLMVGTSEALSLGIDHGLDPKVLSDIMKVSSGGNWTLEKYNPCPGVMENVPSSKGYQG
GFMVDLMVKDLGLSQEAALGSQSSTPMGALARSLYVSHARAGNGTRDFSSIFEHFAKGDKA

Sequences:

>Translated_301_residues
MAKIAFIGLGNMGGPMAANLLKAGHSVSVFDLNPAAVESLKAQGAGRGDTAQAIAADADFVVSMLPAGKHVRGLYLGTDT
AKGLIEVVKAGCLLIDCSTIDAGSARTVADAAAAKGLEFIDAPVSGGTAGAAAGTLTFICGGTDAAFEKARTVLANMGVN
IFHAGGPGAGQVAKICNNMLLSVLMVGTSEALSLGIDHGLDPKVLSDIMKVSSGGNWTLEKYNPCPGVMENVPSSKGYQG
GFMVDLMVKDLGLSQEAALGSQSSTPMGALARSLYVSHARAGNGTRDFSSIFEHFAKGDKA
>Mature_300_residues
AKIAFIGLGNMGGPMAANLLKAGHSVSVFDLNPAAVESLKAQGAGRGDTAQAIAADADFVVSMLPAGKHVRGLYLGTDTA
KGLIEVVKAGCLLIDCSTIDAGSARTVADAAAAKGLEFIDAPVSGGTAGAAAGTLTFICGGTDAAFEKARTVLANMGVNI
FHAGGPGAGQVAKICNNMLLSVLMVGTSEALSLGIDHGLDPKVLSDIMKVSSGGNWTLEKYNPCPGVMENVPSSKGYQGG
FMVDLMVKDLGLSQEAALGSQSSTPMGALARSLYVSHARAGNGTRDFSSIFEHFAKGDKA

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=296, Percent_Identity=43.9189189189189, Blast_Score=254, Evalue=5e-68,
Organism=Homo sapiens, GI40556376, Length=295, Percent_Identity=26.1016949152542, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI145693186, Length=298, Percent_Identity=36.241610738255, Blast_Score=177, Evalue=7e-46,
Organism=Escherichia coli, GI1790315, Length=294, Percent_Identity=36.3945578231293, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1786719, Length=291, Percent_Identity=30.5841924398625, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789092, Length=295, Percent_Identity=31.1864406779661, Blast_Score=113, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17557316, Length=301, Percent_Identity=45.1827242524917, Blast_Score=250, Evalue=7e-67,
Organism=Drosophila melanogaster, GI24655230, Length=294, Percent_Identity=43.5374149659864, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI19922568, Length=294, Percent_Identity=43.5374149659864, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI28574115, Length=288, Percent_Identity=22.5694444444444, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24655240, Length=63, Percent_Identity=49.2063492063492, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30423; Mature: 30292

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIAFIGLGNMGGPMAANLLKAGHSVSVFDLNPAAVESLKAQGAGRGDTAQAIAADADF
CCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHCCHHH
VVSMLPAGKHVRGLYLGTDTAKGLIEVVKAGCLLIDCSTIDAGSARTVADAAAAKGLEFI
HHHHCCCCCCEEEEEECCHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHCCCCEE
DAPVSGGTAGAAAGTLTFICGGTDAAFEKARTVLANMGVNIFHAGGPGAGQVAKICNNML
ECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHH
LSVLMVGTSEALSLGIDHGLDPKVLSDIMKVSSGGNWTLEKYNPCPGVMENVPSSKGYQG
HHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCHHHCCCCCCCCCC
GFMVDLMVKDLGLSQEAALGSQSSTPMGALARSLYVSHARAGNGTRDFSSIFEHFAKGDK
CEEEEEHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
A
C
>Mature Secondary Structure 
AKIAFIGLGNMGGPMAANLLKAGHSVSVFDLNPAAVESLKAQGAGRGDTAQAIAADADF
CEEEEEECCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHCCHHH
VVSMLPAGKHVRGLYLGTDTAKGLIEVVKAGCLLIDCSTIDAGSARTVADAAAAKGLEFI
HHHHCCCCCCEEEEEECCHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHCCCCEE
DAPVSGGTAGAAAGTLTFICGGTDAAFEKARTVLANMGVNIFHAGGPGAGQVAKICNNML
ECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHH
LSVLMVGTSEALSLGIDHGLDPKVLSDIMKVSSGGNWTLEKYNPCPGVMENVPSSKGYQG
HHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCHHHCCCCCCCCCC
GFMVDLMVKDLGLSQEAALGSQSSTPMGALARSLYVSHARAGNGTRDFSSIFEHFAKGDK
CEEEEEHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]