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The map label for this gene is tesB [H]

Identifier: 119774505

GI number: 119774505

Start: 1660050

End: 1660919

Strand: Direct

Name: tesB [H]

Synonym: Sama_1368

Alternate gene names: 119774505

Gene position: 1660050-1660919 (Clockwise)

Preceding gene: 119774504

Following gene: 119774506

Centisome position: 38.55

GC content: 55.17

Gene sequence:

>870_bases
ATGAGTCAGGTATTGAACGATCTATTGTCACTGCTGACCCTCGAAACCCTGGAGATTGGACTTTATCGTGGTCAGAGCCA
GGACCTGGGCTTTGGTCATGTCTTCGGCGGTCAGGTGATGGGACAGGCTCTGAGCGCCGCCCGGGAAACCGTTGAGCCAA
CCCGTAAAGTTCATTCACTTCACAGCTATTTCTTACGGGCAGGCGATGAGTCTCTTCCCATAGTGTACGACGTGGAAATC
ATGCGCGACGGCGGCTCGTTCAGCGCCCGTCGGGTGAAAGCGGTGCAAAAAGGCCGCCCGATTTTTTACATGACCTGCTC
CTTCCAGGGAGAAGAAGAGGGATTTTCCCATCAGATAAGTATGCCGGATGTGCCGGGGCCCGAAGGTCTATTGAACCAGC
AGGAGTTGGCGGTGACCCTGAGGGACAAAATTCCTGAAAAAATGCTGGAAAAGTTTATGGCCGATGCGCCCATCGAGATG
CGCATTGTCGACCCTGTCAGTCCGGTGGCGCCGCGCTCCCGCGAGCCCGTGCGCCATGTTTGGCTGCGTGCCAACGGTAA
GGTGGAAGGCGACAGCCACGTGCACGATGCGCTTCTTGCCTATGCCTCTGATTTCAACTTTTTGGTGACAGCTGCCCAGC
CGCACGGGGTGTCGTTTTTAACACCGGGCATGCGGATGGCCACCATTGACCATGCCATGTGGTTCCATCGTCCCTTGGAT
ATGAATGATTGGCTGCTATACAGTATCGATAGCCCCAATGCCAGCGGCGGCCGCGGTTTTGTAAAAGGACATTTTTTCAA
TCGCCGTGGTGAGCTGGTGGCGTCGGCTACTCAGGAAGGATTGATGCGTATGAAAAAGGACAGCAACTGA

Upstream 100 bases:

>100_bases
GTGCTGCCCACGAGCAGGGCATTCGACTCGACTGAGACTCGCCAGAGCATGGCGCTTTTTGTTACTCTCTTGGCAATTGA
CTTTAAATCAGAGAGATAAC

Downstream 100 bases:

>100_bases
TGTGGAGCAAAATTGCCAAAGCGGGCCGGGTTATGGCCGCCCTGTGTATACTCGGCGCCCTGAGCGCCTGTGTGACGGTA
GAGGAGCCCAAACCCATAAT

Product: palmitoyl-CoA hydrolase

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSQVLNDLLSLLTLETLEIGLYRGQSQDLGFGHVFGGQVMGQALSAARETVEPTRKVHSLHSYFLRAGDESLPIVYDVEI
MRDGGSFSARRVKAVQKGRPIFYMTCSFQGEEEGFSHQISMPDVPGPEGLLNQQELAVTLRDKIPEKMLEKFMADAPIEM
RIVDPVSPVAPRSREPVRHVWLRANGKVEGDSHVHDALLAYASDFNFLVTAAQPHGVSFLTPGMRMATIDHAMWFHRPLD
MNDWLLYSIDSPNASGGRGFVKGHFFNRRGELVASATQEGLMRMKKDSN

Sequences:

>Translated_289_residues
MSQVLNDLLSLLTLETLEIGLYRGQSQDLGFGHVFGGQVMGQALSAARETVEPTRKVHSLHSYFLRAGDESLPIVYDVEI
MRDGGSFSARRVKAVQKGRPIFYMTCSFQGEEEGFSHQISMPDVPGPEGLLNQQELAVTLRDKIPEKMLEKFMADAPIEM
RIVDPVSPVAPRSREPVRHVWLRANGKVEGDSHVHDALLAYASDFNFLVTAAQPHGVSFLTPGMRMATIDHAMWFHRPLD
MNDWLLYSIDSPNASGGRGFVKGHFFNRRGELVASATQEGLMRMKKDSN
>Mature_288_residues
SQVLNDLLSLLTLETLEIGLYRGQSQDLGFGHVFGGQVMGQALSAARETVEPTRKVHSLHSYFLRAGDESLPIVYDVEIM
RDGGSFSARRVKAVQKGRPIFYMTCSFQGEEEGFSHQISMPDVPGPEGLLNQQELAVTLRDKIPEKMLEKFMADAPIEMR
IVDPVSPVAPRSREPVRHVWLRANGKVEGDSHVHDALLAYASDFNFLVTAAQPHGVSFLTPGMRMATIDHAMWFHRPLDM
NDWLLYSIDSPNASGGRGFVKGHFFNRRGELVASATQEGLMRMKKDSN

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=291, Percent_Identity=41.9243986254296, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI1786657, Length=283, Percent_Identity=57.9505300353357, Blast_Score=333, Evalue=7e-93,
Organism=Caenorhabditis elegans, GI71988741, Length=293, Percent_Identity=35.4948805460751, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17531889, Length=275, Percent_Identity=36, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI115532456, Length=275, Percent_Identity=36, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17531885, Length=275, Percent_Identity=36, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17558508, Length=305, Percent_Identity=36.0655737704918, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI212645202, Length=269, Percent_Identity=33.457249070632, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71982224, Length=279, Percent_Identity=30.1075268817204, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32229; Mature: 32098

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVLNDLLSLLTLETLEIGLYRGQSQDLGFGHVFGGQVMGQALSAARETVEPTRKVHSL
CHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSYFLRAGDESLPIVYDVEIMRDGGSFSARRVKAVQKGRPIFYMTCSFQGEEEGFSHQIS
HHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCEECC
MPDVPGPEGLLNQQELAVTLRDKIPEKMLEKFMADAPIEMRIVDPVSPVAPRSREPVRHV
CCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEE
WLRANGKVEGDSHVHDALLAYASDFNFLVTAAQPHGVSFLTPGMRMATIDHAMWFHRPLD
EEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCCEEHHHHHHHHHCCCCC
MNDWLLYSIDSPNASGGRGFVKGHFFNRRGELVASATQEGLMRMKKDSN
CCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SQVLNDLLSLLTLETLEIGLYRGQSQDLGFGHVFGGQVMGQALSAARETVEPTRKVHSL
HHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSYFLRAGDESLPIVYDVEIMRDGGSFSARRVKAVQKGRPIFYMTCSFQGEEEGFSHQIS
HHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCEECC
MPDVPGPEGLLNQQELAVTLRDKIPEKMLEKFMADAPIEMRIVDPVSPVAPRSREPVRHV
CCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEE
WLRANGKVEGDSHVHDALLAYASDFNFLVTAAQPHGVSFLTPGMRMATIDHAMWFHRPLD
EEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCCEEHHHHHHHHHCCCCC
MNDWLLYSIDSPNASGGRGFVKGHFFNRRGELVASATQEGLMRMKKDSN
CCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]