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The map label for this gene is lolE [H]

Identifier: 119774471

GI number: 119774471

Start: 1625401

End: 1626663

Strand: Direct

Name: lolE [H]

Synonym: Sama_1334

Alternate gene names: 119774471

Gene position: 1625401-1626663 (Clockwise)

Preceding gene: 119774470

Following gene: 119774473

Centisome position: 37.75

GC content: 56.14

Gene sequence:

>1263_bases
ATGAGTTCCAGGGCAGGTGCTGCATTGTCGCTGTGGCTGGGTTTCAGGTTTTACCGTGCCCGCCAGTCCAACAGTTTTAT
CAGCTTCATCTCCTTTGCCTCGACCGCAGGCATCGCTCTCGGGGTGGCAGTCTTGATTATTGTTCTGTCTGCCATGAACG
GCTTTGAGCGTGAGCTCAGAGAGCGTTTTTTGGACGTGGTGCCCCACGCCGAGCTGGTTGGCGTGAATGAACCTGTACAC
AGTTGGCAGGCGATGGTTGCTGATGCATCAAAAATCCCGGGCATTCGTGGCGCAGCGCCTTTTATCAGATTGCAGGGATT
GGCGCAGCGTCAGGGCGGTTTTCAGGGGCTGAGTCTGGTGGGCATAGACACATCCCTTGAAGGGCAGGTTTCGGGTATCG
AGAGCTATATGCCCACCGATGCCTGGCAGGCCCTTGGTCAGGATGAAAATGCCATCGTATTGGGGCGATCTCTGATGGAA
AAGCTTGGCCTGAACGAAGGCGATGCACTGGTGCTTTTTGTGCCGGATTTGAGTGGTCGCCAAAATGGTAAGCTTGGTGC
CACCCGCAGCCACAAATTTGTGGTGCGTGGCAGTTATCATTTGGGCGGCGAGCTTGAACTGGTCACTGCCTATGCCTCCA
TGGCCCATTTGGCGCGGGTGCTGGAAATGGGTGAGGATGTCAGCGGCGTGCGCATCGCCGTGGACGATGTGTTCAAGGCT
CCCAAGCTTATCCGTGAGCTGGGCTTTACCCAGAGTCAATACCTGTACATGAGTGACTGGACCCGCACCCAGGGGCACCT
GTATCAGGATATTCAATTGGTGCGTACCCTGATGTATCTGGTGCTGGCATTGGTGATTGCCGTGGCCTGCTTCAATATCG
TCTCTACTCTGGTGATGGCGGTGAGAGACAAAACCTCGGAAATTGCCATCCTGATGACCATGGGGCTCAGGCGCAGCGCC
ATAGTACTGGTCTTTATGGTGCATGGCGCCATCAGTGGACTCCTTGGCACCCTGCTTGGCGTCAGTGCCGGTGTACTGGT
GGCGCTCAATTTGTCCGGGCTCGCCAAGGCGGCCGAAAGTGCCCTTGGTGTACAGCTGCTGTCATCCGACGTTTACTTTA
TCGATTTTCTGCCCTCTGAGCTTCATGGACAGGATGTTGCTGTGGTTGCTGCCATGGCACTGCTGATGAGTCTGTTGGCG
ACCCTGTATCCTGCCTACAAGGCGAGCCTCACTGAACCTGCGCCGGCTCTGGCAGGTCGCTGA

Upstream 100 bases:

>100_bases
GCACCGCCTTCGTGGTGGTGACCCACGACAATGCGCTGGCCGCGCGCATGGACAGGCAGTTATCGATGAAAAGCGGCAAA
TTAACCACCGGAGCCCGCCA

Downstream 100 bases:

>100_bases
TGCAATCAGAATCGAACATAAAAAAACGCGCCTTCAGAGCGCGTTTTTTATGTTCGGAAACTGGGGTGGCTGGATGTTGA
AACTGCAATTTTCGCCTGAG

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSSRAGAALSLWLGFRFYRARQSNSFISFISFASTAGIALGVAVLIIVLSAMNGFERELRERFLDVVPHAELVGVNEPVH
SWQAMVADASKIPGIRGAAPFIRLQGLAQRQGGFQGLSLVGIDTSLEGQVSGIESYMPTDAWQALGQDENAIVLGRSLME
KLGLNEGDALVLFVPDLSGRQNGKLGATRSHKFVVRGSYHLGGELELVTAYASMAHLARVLEMGEDVSGVRIAVDDVFKA
PKLIRELGFTQSQYLYMSDWTRTQGHLYQDIQLVRTLMYLVLALVIAVACFNIVSTLVMAVRDKTSEIAILMTMGLRRSA
IVLVFMVHGAISGLLGTLLGVSAGVLVALNLSGLAKAAESALGVQLLSSDVYFIDFLPSELHGQDVAVVAAMALLMSLLA
TLYPAYKASLTEPAPALAGR

Sequences:

>Translated_420_residues
MSSRAGAALSLWLGFRFYRARQSNSFISFISFASTAGIALGVAVLIIVLSAMNGFERELRERFLDVVPHAELVGVNEPVH
SWQAMVADASKIPGIRGAAPFIRLQGLAQRQGGFQGLSLVGIDTSLEGQVSGIESYMPTDAWQALGQDENAIVLGRSLME
KLGLNEGDALVLFVPDLSGRQNGKLGATRSHKFVVRGSYHLGGELELVTAYASMAHLARVLEMGEDVSGVRIAVDDVFKA
PKLIRELGFTQSQYLYMSDWTRTQGHLYQDIQLVRTLMYLVLALVIAVACFNIVSTLVMAVRDKTSEIAILMTMGLRRSA
IVLVFMVHGAISGLLGTLLGVSAGVLVALNLSGLAKAAESALGVQLLSSDVYFIDFLPSELHGQDVAVVAAMALLMSLLA
TLYPAYKASLTEPAPALAGR
>Mature_419_residues
SSRAGAALSLWLGFRFYRARQSNSFISFISFASTAGIALGVAVLIIVLSAMNGFERELRERFLDVVPHAELVGVNEPVHS
WQAMVADASKIPGIRGAAPFIRLQGLAQRQGGFQGLSLVGIDTSLEGQVSGIESYMPTDAWQALGQDENAIVLGRSLMEK
LGLNEGDALVLFVPDLSGRQNGKLGATRSHKFVVRGSYHLGGELELVTAYASMAHLARVLEMGEDVSGVRIAVDDVFKAP
KLIRELGFTQSQYLYMSDWTRTQGHLYQDIQLVRTLMYLVLALVIAVACFNIVSTLVMAVRDKTSEIAILMTMGLRRSAI
VLVFMVHGAISGLLGTLLGVSAGVLVALNLSGLAKAAESALGVQLLSSDVYFIDFLPSELHGQDVAVVAAMALLMSLLAT
LYPAYKASLTEPAPALAGR

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=412, Percent_Identity=43.6893203883495, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1787360, Length=411, Percent_Identity=31.8734793187348, Blast_Score=167, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925
- InterPro:   IPR011926 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45016; Mature: 44885

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRAGAALSLWLGFRFYRARQSNSFISFISFASTAGIALGVAVLIIVLSAMNGFERELR
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
ERFLDVVPHAELVGVNEPVHSWQAMVADASKIPGIRGAAPFIRLQGLAQRQGGFQGLSLV
HHHHHHCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEE
GIDTSLEGQVSGIESYMPTDAWQALGQDENAIVLGRSLMEKLGLNEGDALVLFVPDLSGR
EECCCCCCCHHHHHHHCCCHHHHHHCCCCCEEEECHHHHHHCCCCCCCEEEEECCCCCCC
QNGKLGATRSHKFVVRGSYHLGGELELVTAYASMAHLARVLEMGEDVSGVRIAVDDVFKA
CCCCCCCCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHH
PKLIRELGFTQSQYLYMSDWTRTQGHLYQDIQLVRTLMYLVLALVIAVACFNIVSTLVMA
HHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRDKTSEIAILMTMGLRRSAIVLVFMVHGAISGLLGTLLGVSAGVLVALNLSGLAKAAES
HHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHH
ALGVQLLSSDVYFIDFLPSELHGQDVAVVAAMALLMSLLATLYPAYKASLTEPAPALAGR
HHHHHHHCCCEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SSRAGAALSLWLGFRFYRARQSNSFISFISFASTAGIALGVAVLIIVLSAMNGFERELR
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
ERFLDVVPHAELVGVNEPVHSWQAMVADASKIPGIRGAAPFIRLQGLAQRQGGFQGLSLV
HHHHHHCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEE
GIDTSLEGQVSGIESYMPTDAWQALGQDENAIVLGRSLMEKLGLNEGDALVLFVPDLSGR
EECCCCCCCHHHHHHHCCCHHHHHHCCCCCEEEECHHHHHHCCCCCCCEEEEECCCCCCC
QNGKLGATRSHKFVVRGSYHLGGELELVTAYASMAHLARVLEMGEDVSGVRIAVDDVFKA
CCCCCCCCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHH
PKLIRELGFTQSQYLYMSDWTRTQGHLYQDIQLVRTLMYLVLALVIAVACFNIVSTLVMA
HHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRDKTSEIAILMTMGLRRSAIVLVFMVHGAISGLLGTLLGVSAGVLVALNLSGLAKAAES
HHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHH
ALGVQLLSSDVYFIDFLPSELHGQDVAVVAAMALLMSLLATLYPAYKASLTEPAPALAGR
HHHHHHHCCCEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10783239 [H]