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The map label for this gene is purK [H]

Identifier: 119774200

GI number: 119774200

Start: 1288065

End: 1289150

Strand: Reverse

Name: purK [H]

Synonym: Sama_1063

Alternate gene names: 119774200

Gene position: 1289150-1288065 (Counterclockwise)

Preceding gene: 119774201

Following gene: 119774199

Centisome position: 29.94

GC content: 57.37

Gene sequence:

>1086_bases
ATGGCAAACACCAAACGCGTTTGGGTACTGGGCAATGGTCAGCTCGGTGCTATGCTGTCACACGCCGGTCAGCCACTGGC
CATCGAGGTGCTGCCGGTGGATATCATGGCGCCCAGCGATGAAAAACTGCCGCTGGCGGACGATGACATCATCACCGCAG
AGCGTGAACAATGGCCTGAATCCAGTCTGAGCCTGCAGCTCTCTACCCATAAGAATTTCATCAACGGCCCGGTGTTTGGT
CGTCTGGCCGACCGGTACACCCAAAAATCCTTGCTGGATGAGCTTAAGGTAGCCACCGCCCCCTGGGAGTTGGTGGATGA
CAACACAGACGTCAACGCCCTCTATGGCAAATATGGCGAGCGGGTGCTGATGAAGCGCCGCACCGGCGGCTACGACGGCA
AGGGCCAGCATTGGCTCAAGCAGGCCGAAAACGGTCAGATCCCTGCCGACTGGCGCGGTGAAGCCATTGCCGAGCAAGCC
ATTAATTTTGACGAGGAAGTCTCCGTTGTGGGCGTGCGTACTCACACGGGCGAATGCTTCTTCTACCCGCTGACACTGAA
CCTGCATCAGGATGGCATTCTGATGGCATCCGTTTCGCCGCTGCCCCGCCTTGTGCCACTGCAGGCCGAAGCCGAAACCA
TGCTGGGCACCATCATGAACGGCCTTAACTATGTCGGAGTGATGGCGATGGAGTGTTTCCGCGTTGGCGACCACCTGCTG
GTGAATGAGCTGGCGCCACGGGTGCATAACTCGGGTCACTGGACCCAAGCAGGCACCCATATGGACCAGTTCCAGTTACA
CCTGCGTGCCCTGTGTCACCTGCCAATCCAACAGCCACAGGTAAACTTTCCCTGTGTGATGGTGAACCTTATCGGCATCG
ACAAGGATGACCGCTGGCTGAGCCTGCCCAACGCCGAGCTCTTCTGGTATGCCAAAGAGGTGCGTCCGGGCCGCAAAGTG
GGTCACCTGAACCTGTCAGTGCACAGCAAAACTATGCTTGAGCACAGCATCAGTCAGCTTAAAAGCTGGATGCCGACACA
ATATCAGGCACCACTTCAGTGGATCCTCGATAACGCCGACTTCTAA

Upstream 100 bases:

>100_bases
TCGCCAACAACGACGCCGCCCTCGCCGAGCGCCTGGAGGCATTCCGCGCCGAACAGACCCAGAGCGTTCTGGAAAATCCG
GATCCGAGGGACGCGTAATC

Downstream 100 bases:

>100_bases
GCAAAGTCATCATCAAAGCCCCGAGAATTCGGGGCTTTTTTATGGCCTCTGTCGCGCTTTTAGCCAGTGCAAGAGCTGGA
TTTCATCCGTATAATGGTCG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MANTKRVWVLGNGQLGAMLSHAGQPLAIEVLPVDIMAPSDEKLPLADDDIITAEREQWPESSLSLQLSTHKNFINGPVFG
RLADRYTQKSLLDELKVATAPWELVDDNTDVNALYGKYGERVLMKRRTGGYDGKGQHWLKQAENGQIPADWRGEAIAEQA
INFDEEVSVVGVRTHTGECFFYPLTLNLHQDGILMASVSPLPRLVPLQAEAETMLGTIMNGLNYVGVMAMECFRVGDHLL
VNELAPRVHNSGHWTQAGTHMDQFQLHLRALCHLPIQQPQVNFPCVMVNLIGIDKDDRWLSLPNAELFWYAKEVRPGRKV
GHLNLSVHSKTMLEHSISQLKSWMPTQYQAPLQWILDNADF

Sequences:

>Translated_361_residues
MANTKRVWVLGNGQLGAMLSHAGQPLAIEVLPVDIMAPSDEKLPLADDDIITAEREQWPESSLSLQLSTHKNFINGPVFG
RLADRYTQKSLLDELKVATAPWELVDDNTDVNALYGKYGERVLMKRRTGGYDGKGQHWLKQAENGQIPADWRGEAIAEQA
INFDEEVSVVGVRTHTGECFFYPLTLNLHQDGILMASVSPLPRLVPLQAEAETMLGTIMNGLNYVGVMAMECFRVGDHLL
VNELAPRVHNSGHWTQAGTHMDQFQLHLRALCHLPIQQPQVNFPCVMVNLIGIDKDDRWLSLPNAELFWYAKEVRPGRKV
GHLNLSVHSKTMLEHSISQLKSWMPTQYQAPLQWILDNADF
>Mature_360_residues
ANTKRVWVLGNGQLGAMLSHAGQPLAIEVLPVDIMAPSDEKLPLADDDIITAEREQWPESSLSLQLSTHKNFINGPVFGR
LADRYTQKSLLDELKVATAPWELVDDNTDVNALYGKYGERVLMKRRTGGYDGKGQHWLKQAENGQIPADWRGEAIAEQAI
NFDEEVSVVGVRTHTGECFFYPLTLNLHQDGILMASVSPLPRLVPLQAEAETMLGTIMNGLNYVGVMAMECFRVGDHLLV
NELAPRVHNSGHWTQAGTHMDQFQLHLRALCHLPIQQPQVNFPCVMVNLIGIDKDDRWLSLPNAELFWYAKEVRPGRKVG
HLNLSVHSKTMLEHSISQLKSWMPTQYQAPLQWILDNADF

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=350, Percent_Identity=52.5714285714286, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI1788155, Length=304, Percent_Identity=25, Blast_Score=72, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324702, Length=382, Percent_Identity=27.7486910994764, Blast_Score=126, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 40559; Mature: 40428

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANTKRVWVLGNGQLGAMLSHAGQPLAIEVLPVDIMAPSDEKLPLADDDIITAEREQWPE
CCCCCEEEEEECCCHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCCEEECHHHHCCC
SSLSLQLSTHKNFINGPVFGRLADRYTQKSLLDELKVATAPWELVDDNTDVNALYGKYGE
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHH
RVLMKRRTGGYDGKGQHWLKQAENGQIPADWRGEAIAEQAINFDEEVSVVGVRTHTGECF
HEEEHHCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEEEEECCCEE
FYPLTLNLHQDGILMASVSPLPRLVPLQAEAETMLGTIMNGLNYVGVMAMECFRVGDHLL
EEEEEEEECCCCEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VNELAPRVHNSGHWTQAGTHMDQFQLHLRALCHLPIQQPQVNFPCVMVNLIGIDKDDRWL
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCEE
SLPNAELFWYAKEVRPGRKVGHLNLSVHSKTMLEHSISQLKSWMPTQYQAPLQWILDNAD
ECCCCEEEEEEECCCCCCEEEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCC
F
C
>Mature Secondary Structure 
ANTKRVWVLGNGQLGAMLSHAGQPLAIEVLPVDIMAPSDEKLPLADDDIITAEREQWPE
CCCCEEEEEECCCHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCCEEECHHHHCCC
SSLSLQLSTHKNFINGPVFGRLADRYTQKSLLDELKVATAPWELVDDNTDVNALYGKYGE
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHH
RVLMKRRTGGYDGKGQHWLKQAENGQIPADWRGEAIAEQAINFDEEVSVVGVRTHTGECF
HEEEHHCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEEEEECCCEE
FYPLTLNLHQDGILMASVSPLPRLVPLQAEAETMLGTIMNGLNYVGVMAMECFRVGDHLL
EEEEEEEECCCCEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VNELAPRVHNSGHWTQAGTHMDQFQLHLRALCHLPIQQPQVNFPCVMVNLIGIDKDDRWL
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCEE
SLPNAELFWYAKEVRPGRKVGHLNLSVHSKTMLEHSISQLKSWMPTQYQAPLQWILDNAD
ECCCCEEEEEEECCCCCCEEEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCC
F
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]