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The map label for this gene is ipdC [H]

Identifier: 119774162

GI number: 119774162

Start: 1238998

End: 1240815

Strand: Reverse

Name: ipdC [H]

Synonym: Sama_1025

Alternate gene names: 119774162

Gene position: 1240815-1238998 (Counterclockwise)

Preceding gene: 119774163

Following gene: 119774150

Centisome position: 28.82

GC content: 54.07

Gene sequence:

>1818_bases
ATGACTTCTATTTCTCAAAATCTGGGCCAGGCATACAGTGAACAACTTCCCAACCTGGGACAAAGCCTTTGCGACATCCT
GTGCTTTTTTGGTTTGAAGCGCGTCTATGGAGTCGGCGGCGATTTTGTGGCAAACCTTATCAATGCCCTGGACGGTCCGC
TGCAGGTACTTCCCTCCAGTAACGAAATGCACGCCGGATTCAGCGCTTGTGCACAGGCTGAGCTGACCGGTCTGGGGGCC
TGTCTGACAACCTACACGGTGGGAAGCCTGCCCTGTGTCAGTGCCGCGGCCCTTGCCCGAACCGAAGGCCTGCCGGTGAT
TTTCATGTCCGGCGCCCCCGGTGAAAATGAAATACAGGGCCATGCCCTGCACCATATGGTGCACCCGGGTTCAGGCTGGC
ATACCGACCTCAATGCGGCGCTCAATGCCTTTAAAGCATTGGGAATTCGAGCCGAGCGGCTGCAGGGACAGCGGCATCAG
GGACAACCCAACGTTGCTGCCGCGCGCTTTTTTGAACTTGTGTGTGAGGCGGTGCAATCCCGCCAGCCCGTGTATATCGA
AGTGCCACGGGATCTGGTCATGCAGCCGACGCAGAGCCTGCGACTTCCCCTGAATATCGATGAGTTAAATGCCATGACCC
GGCTGAATCTTGCTGGCGCAGGACTCATCGCCGACGATATCTGCAGCCGTCTGGTGAAAGCCAAACATCCCCTGGTATAT
CTGGGGGAACGTCTGCGAATGAACAGCGCTTTGCTTGAGCGTATTGTGCATTTTTGCCAGCGCCTGGGACTGCCCTACGC
CACCAGTTGGTTTGCCAAGGGCATGGTCGATGAATCTCATCCCTTGTGTCTTGGGGCATATAATGGGGTATTCAGCCAAT
GCCGTGGTCAGGCGTATATCGAAGAAAACGCGGATTATGTGCTTGAGTTTGGTACTGCCATCTATGACTCAGACACCAAC
AATGCCTTCGCCAGCGGCACTCACGCCATCGACACACATCCAAATAAGACCCTGCTCAAAGGCACCGCCCGTTGGGAGTT
GGATTTACAGGCCGTGGTGGATGCGCTGGAGAGGGCTAACCTGCCGGTACGCAACCTGGCTTTGGTCAATCAGAATAAAG
ACCTGCACGAGGCAATAACACCGGATACCTCGTCGTCCCTGGGATATGCCAACCTTGCACAGACCATCAACCAATTTCAG
CGTGCAGCCGGGAAGGACTTTATTTTGGTACCTGAGGTGGGTAACGCTCTCTTCGCCGCCTTTGCTCTGGACGCCCGAAG
CTCAGATGTAGGCCGCAGTTTTCTTGCCAACCCCTGGTATGCGGCCATGGGTACCAGTCTGCCCTATGCCCGGGCCATTG
CCGATGAACTCAATGCCAAGGGAAGCCCACAGCCGATACTCTTGATCACCGGCGATGGCGGTTTTAATTTTCAATGTAAT
GAGTTGATTAATCTGCAAAAGCAGAATGCAAACCTCATCATTTTGTACATGCGCAACAACCTCTTTCACCTCGGGAAATG
CGGTGATGCTCCCATATACGCCTGCAACGACTTAAGGTTTGATGTCTCAAAACTGATTGCCGCTTACGGTGGCAAATATC
ATCTGTGTCAGTCCGTGGACCGCCTCTATGAGGCGCTGGCAATGGGCGTTCAGGGTGGATTACATCTGATAGAAGTACCC
ACCTCCACTGAACCAGAGCAGCAAAGCCCCATAGCCATCAAATTGAATACCTATATCAGCGCCAAAAACGGCAACCCTGA
GGCCCTTATCTCCTGGAATAAACTCTGCGGTAATCTACCACCGACAGACGCTCAGTAG

Upstream 100 bases:

>100_bases
GCACTGCAAATGATCCACATCAACATCCCTAAGCCGTCTCAGTCATAAGCTGCGAGCATTTGTTGGGCAATCGCCTTTGC
CCCTCTGCGGCGGATAACTT

Downstream 100 bases:

>100_bases
CTTATTGCTGTGTCTTTGACGATGTTAAACCACTGAGATGATTGAGCAGTTCAATCGGCAGGGGGAAGAGTATGGTGGAG
TTATTTTCACCGGCCACTTC

Product: thiamine pyrophosphate enzyme-like TPP binding region

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 605; Mature: 604

Protein sequence:

>605_residues
MTSISQNLGQAYSEQLPNLGQSLCDILCFFGLKRVYGVGGDFVANLINALDGPLQVLPSSNEMHAGFSACAQAELTGLGA
CLTTYTVGSLPCVSAAALARTEGLPVIFMSGAPGENEIQGHALHHMVHPGSGWHTDLNAALNAFKALGIRAERLQGQRHQ
GQPNVAAARFFELVCEAVQSRQPVYIEVPRDLVMQPTQSLRLPLNIDELNAMTRLNLAGAGLIADDICSRLVKAKHPLVY
LGERLRMNSALLERIVHFCQRLGLPYATSWFAKGMVDESHPLCLGAYNGVFSQCRGQAYIEENADYVLEFGTAIYDSDTN
NAFASGTHAIDTHPNKTLLKGTARWELDLQAVVDALERANLPVRNLALVNQNKDLHEAITPDTSSSLGYANLAQTINQFQ
RAAGKDFILVPEVGNALFAAFALDARSSDVGRSFLANPWYAAMGTSLPYARAIADELNAKGSPQPILLITGDGGFNFQCN
ELINLQKQNANLIILYMRNNLFHLGKCGDAPIYACNDLRFDVSKLIAAYGGKYHLCQSVDRLYEALAMGVQGGLHLIEVP
TSTEPEQQSPIAIKLNTYISAKNGNPEALISWNKLCGNLPPTDAQ

Sequences:

>Translated_605_residues
MTSISQNLGQAYSEQLPNLGQSLCDILCFFGLKRVYGVGGDFVANLINALDGPLQVLPSSNEMHAGFSACAQAELTGLGA
CLTTYTVGSLPCVSAAALARTEGLPVIFMSGAPGENEIQGHALHHMVHPGSGWHTDLNAALNAFKALGIRAERLQGQRHQ
GQPNVAAARFFELVCEAVQSRQPVYIEVPRDLVMQPTQSLRLPLNIDELNAMTRLNLAGAGLIADDICSRLVKAKHPLVY
LGERLRMNSALLERIVHFCQRLGLPYATSWFAKGMVDESHPLCLGAYNGVFSQCRGQAYIEENADYVLEFGTAIYDSDTN
NAFASGTHAIDTHPNKTLLKGTARWELDLQAVVDALERANLPVRNLALVNQNKDLHEAITPDTSSSLGYANLAQTINQFQ
RAAGKDFILVPEVGNALFAAFALDARSSDVGRSFLANPWYAAMGTSLPYARAIADELNAKGSPQPILLITGDGGFNFQCN
ELINLQKQNANLIILYMRNNLFHLGKCGDAPIYACNDLRFDVSKLIAAYGGKYHLCQSVDRLYEALAMGVQGGLHLIEVP
TSTEPEQQSPIAIKLNTYISAKNGNPEALISWNKLCGNLPPTDAQ
>Mature_604_residues
TSISQNLGQAYSEQLPNLGQSLCDILCFFGLKRVYGVGGDFVANLINALDGPLQVLPSSNEMHAGFSACAQAELTGLGAC
LTTYTVGSLPCVSAAALARTEGLPVIFMSGAPGENEIQGHALHHMVHPGSGWHTDLNAALNAFKALGIRAERLQGQRHQG
QPNVAAARFFELVCEAVQSRQPVYIEVPRDLVMQPTQSLRLPLNIDELNAMTRLNLAGAGLIADDICSRLVKAKHPLVYL
GERLRMNSALLERIVHFCQRLGLPYATSWFAKGMVDESHPLCLGAYNGVFSQCRGQAYIEENADYVLEFGTAIYDSDTNN
AFASGTHAIDTHPNKTLLKGTARWELDLQAVVDALERANLPVRNLALVNQNKDLHEAITPDTSSSLGYANLAQTINQFQR
AAGKDFILVPEVGNALFAAFALDARSSDVGRSFLANPWYAAMGTSLPYARAIADELNAKGSPQPILLITGDGGFNFQCNE
LINLQKQNANLIILYMRNNLFHLGKCGDAPIYACNDLRFDVSKLIAAYGGKYHLCQSVDRLYEALAMGVQGGLHLIEVPT
STEPEQQSPIAIKLNTYISAKNGNPEALISWNKLCGNLPPTDAQ

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323163, Length=546, Percent_Identity=19.96336996337, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323073, Length=565, Percent_Identity=20.5309734513274, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017765
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 65524; Mature: 65393

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSISQNLGQAYSEQLPNLGQSLCDILCFFGLKRVYGVGGDFVANLINALDGPLQVLPSS
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECCCC
NEMHAGFSACAQAELTGLGACLTTYTVGSLPCVSAAALARTEGLPVIFMSGAPGENEIQG
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCC
HALHHMVHPGSGWHTDLNAALNAFKALGIRAERLQGQRHQGQPNVAAARFFELVCEAVQS
HHHHHEECCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
RQPVYIEVPRDLVMQPTQSLRLPLNIDELNAMTRLNLAGAGLIADDICSRLVKAKHPLVY
CCCEEEECCHHHHHCCHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEE
LGERLRMNSALLERIVHFCQRLGLPYATSWFAKGMVDESHPLCLGAYNGVFSQCRGQAYI
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCEEEECHHHHHHHHCCCEEE
EENADYVLEFGTAIYDSDTNNAFASGTHAIDTHPNKTLLKGTARWELDLQAVVDALERAN
ECCCCEEEEECCEEECCCCCCCCCCCCCEECCCCCCEEEECCCEEEEEHHHHHHHHHHCC
LPVRNLALVNQNKDLHEAITPDTSSSLGYANLAQTINQFQRAAGKDFILVPEVGNALFAA
CCHHHEEEECCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHH
FALDARSSDVGRSFLANPWYAAMGTSLPYARAIADELNAKGSPQPILLITGDGGFNFQCN
HHHCCCCCHHHHHHHCCCCHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEHH
ELINLQKQNANLIILYMRNNLFHLGKCGDAPIYACNDLRFDVSKLIAAYGGKYHLCQSVD
HHHHHEECCCCEEEEEEECCEEEECCCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHH
RLYEALAMGVQGGLHLIEVPTSTEPEQQSPIAIKLNTYISAKNGNPEALISWNKLCGNLP
HHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEEEEEEEECCCCCCEEEEHHHHHCCCC
PTDAQ
CCCCC
>Mature Secondary Structure 
TSISQNLGQAYSEQLPNLGQSLCDILCFFGLKRVYGVGGDFVANLINALDGPLQVLPSS
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECCCC
NEMHAGFSACAQAELTGLGACLTTYTVGSLPCVSAAALARTEGLPVIFMSGAPGENEIQG
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCC
HALHHMVHPGSGWHTDLNAALNAFKALGIRAERLQGQRHQGQPNVAAARFFELVCEAVQS
HHHHHEECCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
RQPVYIEVPRDLVMQPTQSLRLPLNIDELNAMTRLNLAGAGLIADDICSRLVKAKHPLVY
CCCEEEECCHHHHHCCHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEE
LGERLRMNSALLERIVHFCQRLGLPYATSWFAKGMVDESHPLCLGAYNGVFSQCRGQAYI
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCEEEECHHHHHHHHCCCEEE
EENADYVLEFGTAIYDSDTNNAFASGTHAIDTHPNKTLLKGTARWELDLQAVVDALERAN
ECCCCEEEEECCEEECCCCCCCCCCCCCEECCCCCCEEEECCCEEEEEHHHHHHHHHHCC
LPVRNLALVNQNKDLHEAITPDTSSSLGYANLAQTINQFQRAAGKDFILVPEVGNALFAA
CCHHHEEEECCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHH
FALDARSSDVGRSFLANPWYAAMGTSLPYARAIADELNAKGSPQPILLITGDGGFNFQCN
HHHCCCCCHHHHHHHCCCCHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEHH
ELINLQKQNANLIILYMRNNLFHLGKCGDAPIYACNDLRFDVSKLIAAYGGKYHLCQSVD
HHHHHEECCCCEEEEEEECCEEEECCCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHH
RLYEALAMGVQGGLHLIEVPTSTEPEQQSPIAIKLNTYISAKNGNPEALISWNKLCGNLP
HHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEEEEEEEECCCCCCEEEEHHHHHCCCC
PTDAQ
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8202090 [H]