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The map label for this gene is fkpA [H]

Identifier: 119773827

GI number: 119773827

Start: 853533

End: 854003

Strand: Reverse

Name: fkpA [H]

Synonym: Sama_0689

Alternate gene names: 119773827

Gene position: 854003-853533 (Counterclockwise)

Preceding gene: 119773828

Following gene: 119773825

Centisome position: 19.83

GC content: 53.5

Gene sequence:

>471_bases
ATGAGAGTTGCCCTCGCTGTTATTGTGATTGCCTGCGTCATTTTTTACTTTTTCACCACCATGAATAATCAAAAGGCCGC
CAAGCTCAATGAAGAGAAAGGCGCCGTCTTCCTCGCTGAAAACGCCAAGCGTGACGGTGTAACCACCACGGCATCGGGCC
TGCAGTATGAGCTTTTGATTGCCGGCAGTGGCGAACGTCATCCCAGTGCCAGCGACACTGTGCGCGTGCACTATCACGGC
ACCCTGACCGATGGCACTGTGTTCGACTCGTCAGTTGAGCGTGGTGAGAGCATTGCCTTCCCGCTGAATCGGGTTATCAA
GGGCTGGACCGAAGGCGTGCAACTGATGAAAGAAGGTGACAAGATGCGCTTTTTCATCCCGGCAAGCCTGGGTTACGGCA
ACCGTAGCGTAGGCAAAATCCCCGGTGGTTCTGTGCTGATTTTCGATGTGGAACTGATAGCCATCGAATGA

Upstream 100 bases:

>100_bases
GCCTTGGCACCGACATCCAGGCTTTACCCGGCAGCAGCTTAACCATAAGATATTGAGTTCCATACGATAGTCAAAAGTCA
GCCATTACGGAATCCATCCC

Downstream 100 bases:

>100_bases
ATGCTGACTGAAGCGAAATAAAAAACGGAGGCCTGTGCCTCCGTTTTTTTATTGTCCCTTACAAGCCAAACGGATTGTCA
ATGGAATGGGAAGGGAGAGT

Product: peptidyl-prolyl cis-trans isomerase, FKBP-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MRVALAVIVIACVIFYFFTTMNNQKAAKLNEEKGAVFLAENAKRDGVTTTASGLQYELLIAGSGERHPSASDTVRVHYHG
TLTDGTVFDSSVERGESIAFPLNRVIKGWTEGVQLMKEGDKMRFFIPASLGYGNRSVGKIPGGSVLIFDVELIAIE

Sequences:

>Translated_156_residues
MRVALAVIVIACVIFYFFTTMNNQKAAKLNEEKGAVFLAENAKRDGVTTTASGLQYELLIAGSGERHPSASDTVRVHYHG
TLTDGTVFDSSVERGESIAFPLNRVIKGWTEGVQLMKEGDKMRFFIPASLGYGNRSVGKIPGGSVLIFDVELIAIE
>Mature_156_residues
MRVALAVIVIACVIFYFFTTMNNQKAAKLNEEKGAVFLAENAKRDGVTTTASGLQYELLIAGSGERHPSASDTVRVHYHG
TLTDGTVFDSSVERGESIAFPLNRVIKGWTEGVQLMKEGDKMRFFIPASLGYGNRSVGKIPGGSVLIFDVELIAIE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=88, Percent_Identity=48.8636363636364, Blast_Score=86, Evalue=9e-18,
Organism=Homo sapiens, GI17149844, Length=88, Percent_Identity=48.8636363636364, Blast_Score=86, Evalue=9e-18,
Organism=Homo sapiens, GI17149842, Length=88, Percent_Identity=48.8636363636364, Blast_Score=86, Evalue=9e-18,
Organism=Homo sapiens, GI224809329, Length=136, Percent_Identity=36.0294117647059, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI224809327, Length=136, Percent_Identity=36.0294117647059, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI4758384, Length=136, Percent_Identity=36.0294117647059, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI224809331, Length=136, Percent_Identity=36.0294117647059, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=40.1869158878505, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=40.1869158878505, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI33469985, Length=91, Percent_Identity=42.8571428571429, Blast_Score=73, Evalue=8e-14,
Organism=Homo sapiens, GI4503727, Length=143, Percent_Identity=32.8671328671329, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI8923659, Length=95, Percent_Identity=40, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI192448443, Length=91, Percent_Identity=41.7582417582418, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=36.4485981308411, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI4503729, Length=95, Percent_Identity=40, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI87082390, Length=124, Percent_Identity=51.6129032258064, Blast_Score=122, Evalue=8e-30,
Organism=Escherichia coli, GI1789745, Length=133, Percent_Identity=47.3684210526316, Blast_Score=110, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17561782, Length=94, Percent_Identity=51.063829787234, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17540882, Length=88, Percent_Identity=51.1363636363636, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=39.622641509434, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320727, Length=89, Percent_Identity=53.9325842696629, Blast_Score=86, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324194, Length=105, Percent_Identity=40, Blast_Score=78, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6323566, Length=93, Percent_Identity=41.9354838709677, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323482, Length=108, Percent_Identity=37.962962962963, Blast_Score=61, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=40.1869158878505, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281363946, Length=95, Percent_Identity=44.2105263157895, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17352457, Length=95, Percent_Identity=44.2105263157895, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21356629, Length=95, Percent_Identity=46.3157894736842, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=38.4615384615385, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16944; Mature: 16944

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVALAVIVIACVIFYFFTTMNNQKAAKLNEEKGAVFLAENAKRDGVTTTASGLQYELLI
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCEEECCCEEEEEEE
AGSGERHPSASDTVRVHYHGTLTDGTVFDSSVERGESIAFPLNRVIKGWTEGVQLMKEGD
ECCCCCCCCCCCEEEEEEEEEECCCEEECCHHHCCCEEECCHHHHHHHHHHHHHHHHCCC
KMRFFIPASLGYGNRSVGKIPGGSVLIFDVELIAIE
EEEEEEECCCCCCCCCCCCCCCCEEEEEEEEEEEEC
>Mature Secondary Structure
MRVALAVIVIACVIFYFFTTMNNQKAAKLNEEKGAVFLAENAKRDGVTTTASGLQYELLI
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCEEECCCEEEEEEE
AGSGERHPSASDTVRVHYHGTLTDGTVFDSSVERGESIAFPLNRVIKGWTEGVQLMKEGD
ECCCCCCCCCCCEEEEEEEEEECCCEEECCHHHCCCEEECCHHHHHHHHHHHHHHHHCCC
KMRFFIPASLGYGNRSVGKIPGGSVLIFDVELIAIE
EEEEEEECCCCCCCCCCCCCCCCEEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]