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The map label for this gene is phoP [H]

Identifier: 119773577

GI number: 119773577

Start: 535989

End: 536702

Strand: Direct

Name: phoP [H]

Synonym: Sama_0437

Alternate gene names: 119773577

Gene position: 535989-536702 (Clockwise)

Preceding gene: 119773576

Following gene: 119773578

Centisome position: 12.45

GC content: 56.02

Gene sequence:

>714_bases
ATGGACTTAAACGAATTTATCCTGCTGGTGGATGACGATCAGGAACTGACCGAGCTGCTCAGTGACTTTCTGACCAAGAA
CGGCTTTGAGGTCAGAACCGAATCCAATGGTCTCAATGCGGCCAGACGCATCGTAGAAGAGCGCCCGCGACTGGTGGTGC
TTGACGTGATGCTGCCAGACATGGATGGGCTGTCCATTTGTCGCAAGGTGCGTTCTCAATACGCCGGGCCCATTTTGATG
CTGACCGGCCTTGGGGACGATATCGATGAGGTGGCGGGGCTTGAAACCGGTGCCGATGACTATATCGCCAAACCCGTCCG
TTCCCGGGTTCTGCTCGCCCGCATTCGCAGCTTGCTGCGCCGCTCAGAATTGCAGGAGACCCAACTTCAGGACGCACCGG
CTTCCAGTGAATCGCGACTCGTGGTCAATGGGCTTATTCTCGATAAGCTTGAGCGCACGGCGGCTCTGCACGGTGATAAT
CTGGAATTGACCCTGGCTGAATTTGAGCTGCTGTGGCTCTTAACCAAGCACGCTGGCCGCATCTTGGATCGTGACGCAAT
TTGCGACCACTTCAAAGACATTGGCTACGACAGTACCCCCCGTACTATCGATCTCAGGGTGTCGCACCTGCGCCGCAAAA
TGGGCGACGATCCCCGTGAGCCAGCACTCATCAAAACCATGCGTGGCCAGGGCTACGTACTGACCTTGAATTGA

Upstream 100 bases:

>100_bases
GTTTCCGGTAGTGTCTGCTTGGTCACTACCGGAATACAGAGTTTGAATTTTGTACGTAATTACATACAATCAAGTCCATA
GCTTCAGGGAACAGGCAATC

Downstream 100 bases:

>100_bases
AATGACGCAGTCATCGGCAGTACCCCACCCTGAAGGACGCCGCTCGCGGTTGGGTGGGATGCCATGGCTGTCGGCGCTCT
CGTCCTGCGTGCCGGCAATG

Product: response regulator receiver protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MDLNEFILLVDDDQELTELLSDFLTKNGFEVRTESNGLNAARRIVEERPRLVVLDVMLPDMDGLSICRKVRSQYAGPILM
LTGLGDDIDEVAGLETGADDYIAKPVRSRVLLARIRSLLRRSELQETQLQDAPASSESRLVVNGLILDKLERTAALHGDN
LELTLAEFELLWLLTKHAGRILDRDAICDHFKDIGYDSTPRTIDLRVSHLRRKMGDDPREPALIKTMRGQGYVLTLN

Sequences:

>Translated_237_residues
MDLNEFILLVDDDQELTELLSDFLTKNGFEVRTESNGLNAARRIVEERPRLVVLDVMLPDMDGLSICRKVRSQYAGPILM
LTGLGDDIDEVAGLETGADDYIAKPVRSRVLLARIRSLLRRSELQETQLQDAPASSESRLVVNGLILDKLERTAALHGDN
LELTLAEFELLWLLTKHAGRILDRDAICDHFKDIGYDSTPRTIDLRVSHLRRKMGDDPREPALIKTMRGQGYVLTLN
>Mature_237_residues
MDLNEFILLVDDDQELTELLSDFLTKNGFEVRTESNGLNAARRIVEERPRLVVLDVMLPDMDGLSICRKVRSQYAGPILM
LTGLGDDIDEVAGLETGADDYIAKPVRSRVLLARIRSLLRRSELQETQLQDAPASSESRLVVNGLILDKLERTAALHGDN
LELTLAEFELLWLLTKHAGRILDRDAICDHFKDIGYDSTPRTIDLRVSHLRRKMGDDPREPALIKTMRGQGYVLTLN

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=236, Percent_Identity=41.5254237288136, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=40.8510638297872, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=40.4347826086956, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=40.6113537117904, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=37.4449339207048, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI87082012, Length=226, Percent_Identity=34.070796460177, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786599, Length=233, Percent_Identity=30.9012875536481, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1790860, Length=232, Percent_Identity=33.1896551724138, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=35.3711790393013, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1790552, Length=232, Percent_Identity=34.051724137931, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=30.0429184549356, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=29.4372294372294, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1786911, Length=234, Percent_Identity=30.3418803418803, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787375, Length=232, Percent_Identity=28.8793103448276, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1788550, Length=100, Percent_Identity=32, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322000, Length=139, Percent_Identity=34.5323741007194, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26721; Mature: 26721

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLNEFILLVDDDQELTELLSDFLTKNGFEVRTESNGLNAARRIVEERPRLVVLDVMLPD
CCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCEEEEEEECCC
MDGLSICRKVRSQYAGPILMLTGLGDDIDEVAGLETGADDYIAKPVRSRVLLARIRSLLR
CCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RSELQETQLQDAPASSESRLVVNGLILDKLERTAALHGDNLELTLAEFELLWLLTKHAGR
HHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
ILDRDAICDHFKDIGYDSTPRTIDLRVSHLRRKMGDDPREPALIKTMRGQGYVLTLN
HHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHCCCCCCCHHHHEECCCEEEEEEC
>Mature Secondary Structure
MDLNEFILLVDDDQELTELLSDFLTKNGFEVRTESNGLNAARRIVEERPRLVVLDVMLPD
CCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCEEEEEEECCC
MDGLSICRKVRSQYAGPILMLTGLGDDIDEVAGLETGADDYIAKPVRSRVLLARIRSLLR
CCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RSELQETQLQDAPASSESRLVVNGLILDKLERTAALHGDNLELTLAEFELLWLLTKHAGR
HHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
ILDRDAICDHFKDIGYDSTPRTIDLRVSHLRRKMGDDPREPALIKTMRGQGYVLTLN
HHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHCCCCCCCHHHHEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]