Click here to switch to the map view.

The map label for this gene is hap [H]

Identifier: 119773568

GI number: 119773568

Start: 524819

End: 527146

Strand: Reverse

Name: hap [H]

Synonym: Sama_0428

Alternate gene names: 119773568

Gene position: 527146-524819 (Counterclockwise)

Preceding gene: 119773569

Following gene: 119773566

Centisome position: 12.24

GC content: 57.17

Gene sequence:

>2328_bases
ATGCGCAAGCAACAACTCTCACTCTTGTTTATCGCCGTTTCGGCAACCCTGGGTACATCAGCCTATGCCGCCAACGTAGT
GGACGTGGCCAAGATGCGCCACGCCACTGGCGACATCGGCAGCGTACTGCAACTGGCTCCCGGCCACGAGTTCCGCACCG
CAAAACAACTGGATCTGGGCAAAGGCCTGAAAAAAGAGCGTCTGCAGCAATACTTCCACGGAGTGCCTGTTTATGGTTTC
ACTGTGGCCGCTGATCGCTCTGAGATGGGTTTCTACAGCAACCTCAAAGGCCAGATGCTGGCCAATATCGACAAGGATGC
GGCTTTTGCCAAGCCCAGCCTGAGCAAAGACAAAGCCCTGGAAATCGCCAAGGCCGCCAAGGGTGGCCATGGTCTTAAGG
CCGGCAAGACCCGTAACGACAGCGCCCAGCCATGGATCATCCTGTACGGCAAAGCGCAGGAGCCACGACTGGTGTATATC
ACCTCTTACGTGGTTGATGGCGATACCCCAAGCCGTCCATTCACCATGGTAGACGCCCACACAGGTGAAGTACTGGAGCG
CTGGGAAGGTCTGAACCATGCCGGCACAGGTACCGGCCCCGGCGGTAACGCCAAAACCGGCCAGTATGAGTACGGCACTG
ACTTCGGCAACCTGGATGTGGAAGTGAATGGTGACACCTGCACCATGAACAATGCCAACGTGAAAACCGTGAACCTGAAC
CACGGCACCAGCGGCAATACGGCATTCAGCTACACCTGCCCACGCAACACGGTAAAAGAAATCAACGGTGCCTACTCACC
GCTGAACGATGCCCACTACTTCGGTGGCGTGGTGTATGACATGTACGATCAGTGGTATGGCACAGCGCCCCTGTCCTTCC
AGCTGACCATGCGCGTGCACTACAGCAACAACTATGAAAACGCCTTCTGGGACGGCAGCGCCATGACCTTCGGTGATGGC
CAGAGCTACTTCTACCCACTGGTGTCTCTGGACGTATCAGCCCACGAAGTGAGCCACGGCTTTACCGAACAGAACTCGGG
CCTGGTGTATGCCAACCAATCCGGTGGTATGAACGAAGCCTTCTCGGACATGGCAGGTGAAGCGGCCGAATTCTTTATGA
AAGGCAGCAACGACTGGCTGGTTGGCGCCGATATCTTCAAAGGCGATGGCGCACTGCGCTACATGGCTGACCCAACTCAG
GACGGCAAGTCTATCGGTCATATCGACGACTACTACGATGGTCTGGATGTGCACTACAGCTCAGGTGTGTTCAATAAAGC
CTTCTACACCCTGGCTACCACCGAAGGCTGGGATACCCGCAAAGCCTTTGAAGTCTTCGTTATCGCCAACCAATTGTACT
GGACGCCCAACAGCCTGATGTATGAAGGTGCCTGTGGCGTGAGAAATGCCGCCACCGATAAGGGCTACAGCACTGCTGAC
GTAGATGCAGCATTCGCAGCCGTGGGGATCACCCCCTGCGAAGTTCCACCACCACCGCCACCACCAGAAGCTGAGGTACT
GCAAAATGGCGTAGCCGTGACGGACATCAGCGGCGCTTCAGGCAGCAAGCAGTATTGGACTCTCGATGTCCCGGCCGGTG
CCAGCAATCTGGTGTTCAACCTGTCCGGTGGCTCGGGCGATGCCGACCTCTATGTGAAGTTTGGCGCCAACCCAACCAGC
ACTGACTACGATTGCCGCCCCTATGCAGCAGGCAACAATGAAAACTGTGCCATCAGCAATGTCCAGCAAGGTACTTACTG
GGTGATGCTGAACGGCTACAGTTCGTACAGCGGCACGACCCTGGTAGGCAGCTTCGATGGCGGCAGCACTGAGCCAAACG
AAGCCCCGGTTGCCAGCTTCACCGCCGACTACACGGGTGCCCTGTACAATTTCACCAGCACTGCTACCGACTCTGACGGC
AACGTGGTCGCCTGGAGCTGGGACTTCGGTGACGGTGAAACGGCTACCGGTTCTGCTGCAAGCCATCAGTATCTGGTGAG
TGGCAGCTACACTGTCACCCTGACCGTTACCGACGATGATGGCGCCACCGCCAGCACCTCTGAAGTGTTCAACGTGGAAG
TGCCTGCCGCCGAGATGGATCTGAGCATCACCAAGGTGAACGTGTCACGCCGTGGCAGCGCCCGTATCGGTTTGGAATGG
ACAGGTAACAGCGCCTCTTACACTGTGCTGCGTAACGGTGAAGCCGTCGGCACCACCAGCGCCAACAGCTATGTTGACCG
CTTCACTGCCACTGCCGGCAGCAGCGTCACCTTCCAGGTGTGCAACTCCGATGGTGGTTGCTCCGACATTGAAACCGTAA
GCTTCTGA

Upstream 100 bases:

>100_bases
AAACCTGTTGAGCTATGGCCATTCGCCGGTACACCGGTTGATGGCACTAAGGAAGTGCTTCGCGGCAGCCTAGCCGCAAC
ACAACAAGGACAAGTCACCT

Downstream 100 bases:

>100_bases
TAAGCAAACCGGTTTAAACTGAAAACGCCGTCCAGTGGACGGCGTTTTCTATTATCTGGACTCGCTTGAGGGCACTGGCG
GCACCGGCATATAACGCTGG

Product: peptidase M4, thermolysin

Products: NA

Alternate protein names: HA/protease; Vibriolysin [H]

Number of amino acids: Translated: 775; Mature: 775

Protein sequence:

>775_residues
MRKQQLSLLFIAVSATLGTSAYAANVVDVAKMRHATGDIGSVLQLAPGHEFRTAKQLDLGKGLKKERLQQYFHGVPVYGF
TVAADRSEMGFYSNLKGQMLANIDKDAAFAKPSLSKDKALEIAKAAKGGHGLKAGKTRNDSAQPWIILYGKAQEPRLVYI
TSYVVDGDTPSRPFTMVDAHTGEVLERWEGLNHAGTGTGPGGNAKTGQYEYGTDFGNLDVEVNGDTCTMNNANVKTVNLN
HGTSGNTAFSYTCPRNTVKEINGAYSPLNDAHYFGGVVYDMYDQWYGTAPLSFQLTMRVHYSNNYENAFWDGSAMTFGDG
QSYFYPLVSLDVSAHEVSHGFTEQNSGLVYANQSGGMNEAFSDMAGEAAEFFMKGSNDWLVGADIFKGDGALRYMADPTQ
DGKSIGHIDDYYDGLDVHYSSGVFNKAFYTLATTEGWDTRKAFEVFVIANQLYWTPNSLMYEGACGVRNAATDKGYSTAD
VDAAFAAVGITPCEVPPPPPPPEAEVLQNGVAVTDISGASGSKQYWTLDVPAGASNLVFNLSGGSGDADLYVKFGANPTS
TDYDCRPYAAGNNENCAISNVQQGTYWVMLNGYSSYSGTTLVGSFDGGSTEPNEAPVASFTADYTGALYNFTSTATDSDG
NVVAWSWDFGDGETATGSAASHQYLVSGSYTVTLTVTDDDGATASTSEVFNVEVPAAEMDLSITKVNVSRRGSARIGLEW
TGNSASYTVLRNGEAVGTTSANSYVDRFTATAGSSVTFQVCNSDGGCSDIETVSF

Sequences:

>Translated_775_residues
MRKQQLSLLFIAVSATLGTSAYAANVVDVAKMRHATGDIGSVLQLAPGHEFRTAKQLDLGKGLKKERLQQYFHGVPVYGF
TVAADRSEMGFYSNLKGQMLANIDKDAAFAKPSLSKDKALEIAKAAKGGHGLKAGKTRNDSAQPWIILYGKAQEPRLVYI
TSYVVDGDTPSRPFTMVDAHTGEVLERWEGLNHAGTGTGPGGNAKTGQYEYGTDFGNLDVEVNGDTCTMNNANVKTVNLN
HGTSGNTAFSYTCPRNTVKEINGAYSPLNDAHYFGGVVYDMYDQWYGTAPLSFQLTMRVHYSNNYENAFWDGSAMTFGDG
QSYFYPLVSLDVSAHEVSHGFTEQNSGLVYANQSGGMNEAFSDMAGEAAEFFMKGSNDWLVGADIFKGDGALRYMADPTQ
DGKSIGHIDDYYDGLDVHYSSGVFNKAFYTLATTEGWDTRKAFEVFVIANQLYWTPNSLMYEGACGVRNAATDKGYSTAD
VDAAFAAVGITPCEVPPPPPPPEAEVLQNGVAVTDISGASGSKQYWTLDVPAGASNLVFNLSGGSGDADLYVKFGANPTS
TDYDCRPYAAGNNENCAISNVQQGTYWVMLNGYSSYSGTTLVGSFDGGSTEPNEAPVASFTADYTGALYNFTSTATDSDG
NVVAWSWDFGDGETATGSAASHQYLVSGSYTVTLTVTDDDGATASTSEVFNVEVPAAEMDLSITKVNVSRRGSARIGLEW
TGNSASYTVLRNGEAVGTTSANSYVDRFTATAGSSVTFQVCNSDGGCSDIETVSF
>Mature_775_residues
MRKQQLSLLFIAVSATLGTSAYAANVVDVAKMRHATGDIGSVLQLAPGHEFRTAKQLDLGKGLKKERLQQYFHGVPVYGF
TVAADRSEMGFYSNLKGQMLANIDKDAAFAKPSLSKDKALEIAKAAKGGHGLKAGKTRNDSAQPWIILYGKAQEPRLVYI
TSYVVDGDTPSRPFTMVDAHTGEVLERWEGLNHAGTGTGPGGNAKTGQYEYGTDFGNLDVEVNGDTCTMNNANVKTVNLN
HGTSGNTAFSYTCPRNTVKEINGAYSPLNDAHYFGGVVYDMYDQWYGTAPLSFQLTMRVHYSNNYENAFWDGSAMTFGDG
QSYFYPLVSLDVSAHEVSHGFTEQNSGLVYANQSGGMNEAFSDMAGEAAEFFMKGSNDWLVGADIFKGDGALRYMADPTQ
DGKSIGHIDDYYDGLDVHYSSGVFNKAFYTLATTEGWDTRKAFEVFVIANQLYWTPNSLMYEGACGVRNAATDKGYSTAD
VDAAFAAVGITPCEVPPPPPPPEAEVLQNGVAVTDISGASGSKQYWTLDVPAGASNLVFNLSGGSGDADLYVKFGANPTS
TDYDCRPYAAGNNENCAISNVQQGTYWVMLNGYSSYSGTTLVGSFDGGSTEPNEAPVASFTADYTGALYNFTSTATDSDG
NVVAWSWDFGDGETATGSAASHQYLVSGSYTVTLTVTDDDGATASTSEVFNVEVPAAEMDLSITKVNVSRRGSARIGLEW
TGNSASYTVLRNGEAVGTTSANSYVDRFTATAGSSVTFQVCNSDGGCSDIETVSF

Specific function: May play a role in the pathogenesis of cholera. Hap nicks and activates the A subunit of cholera enterotoxin and related enterotoxins [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR007280
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C; PF04151 PPC [H]

EC number: NA

Molecular weight: Translated: 82721; Mature: 82721

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS50093 PKD ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKQQLSLLFIAVSATLGTSAYAANVVDVAKMRHATGDIGSVLQLAPGHEFRTAKQLDLG
CCCHHEEEEEEEEEHHCCCCHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCHHHHHHC
KGLKKERLQQYFHGVPVYGFTVAADRSEMGFYSNLKGQMLANIDKDAAFAKPSLSKDKAL
CCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCEEECCCCCHHHCCCCCCCHHHH
EIAKAAKGGHGLKAGKTRNDSAQPWIILYGKAQEPRLVYITSYVVDGDTPSRPFTMVDAH
HHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEEECCCCCCCCEEEEECC
TGEVLERWEGLNHAGTGTGPGGNAKTGQYEYGTDFGNLDVEVNGDTCTMNNANVKTVNLN
CHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEEEECCCEEEECCCEEEEEEEC
HGTSGNTAFSYTCPRNTVKEINGAYSPLNDAHYFGGVVYDMYDQWYGTAPLSFQLTMRVH
CCCCCCEEEEEECCCHHHHHHCCCCCCCCCCHHHCCEEEEHHHHHCCCCCEEEEEEEEEE
YSNNYENAFWDGSAMTFGDGQSYFYPLVSLDVSAHEVSHGFTEQNSGLVYANQSGGMNEA
ECCCCCCEEECCCEEEECCCCCEEEEEEEEECCHHHHHCCCCCCCCCEEEECCCCCCHHH
FSDMAGEAAEFFMKGSNDWLVGADIFKGDGALRYMADPTQDGKSIGHIDDYYDGLDVHYS
HHHHHCHHHHHHCCCCCCEEEEEEEEECCCEEEEECCCCCCCCCCCCCHHHCCCCEEEEC
SGVFNKAFYTLATTEGWDTRKAFEVFVIANQLYWTPNSLMYEGACGVRNAATDKGYSTAD
CCCCCCEEEEEEECCCCCCCCEEEEEEEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCC
VDAAFAAVGITPCEVPPPPPPPEAEVLQNGVAVTDISGASGSKQYWTLDVPAGASNLVFN
CHHHHHEECCCCCCCCCCCCCCHHHHHHCCEEEEEECCCCCCCEEEEEECCCCCCEEEEE
LSGGSGDADLYVKFGANPTSTDYDCRPYAAGNNENCAISNVQQGTYWVMLNGYSSYSGTT
ECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCE
LVGSFDGGSTEPNEAPVASFTADYTGALYNFTSTATDSDGNVVAWSWDFGDGETATGSAA
EEEECCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCC
SHQYLVSGSYTVTLTVTDDDGATASTSEVFNVEVPAAEMDLSITKVNVSRRGSARIGLEW
CCEEEEECCEEEEEEEECCCCCCCCCCEEEEEECCCHHCCEEEEEEEECCCCCEEEEEEE
TGNSASYTVLRNGEAVGTTSANSYVDRFTATAGSSVTFQVCNSDGGCSDIETVSF
CCCCCEEEEEECCCEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEECC
>Mature Secondary Structure
MRKQQLSLLFIAVSATLGTSAYAANVVDVAKMRHATGDIGSVLQLAPGHEFRTAKQLDLG
CCCHHEEEEEEEEEHHCCCCHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCHHHHHHC
KGLKKERLQQYFHGVPVYGFTVAADRSEMGFYSNLKGQMLANIDKDAAFAKPSLSKDKAL
CCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCEEECCCCCHHHCCCCCCCHHHH
EIAKAAKGGHGLKAGKTRNDSAQPWIILYGKAQEPRLVYITSYVVDGDTPSRPFTMVDAH
HHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEEECCCCCCCCEEEEECC
TGEVLERWEGLNHAGTGTGPGGNAKTGQYEYGTDFGNLDVEVNGDTCTMNNANVKTVNLN
CHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEEEECCCEEEECCCEEEEEEEC
HGTSGNTAFSYTCPRNTVKEINGAYSPLNDAHYFGGVVYDMYDQWYGTAPLSFQLTMRVH
CCCCCCEEEEEECCCHHHHHHCCCCCCCCCCHHHCCEEEEHHHHHCCCCCEEEEEEEEEE
YSNNYENAFWDGSAMTFGDGQSYFYPLVSLDVSAHEVSHGFTEQNSGLVYANQSGGMNEA
ECCCCCCEEECCCEEEECCCCCEEEEEEEEECCHHHHHCCCCCCCCCEEEECCCCCCHHH
FSDMAGEAAEFFMKGSNDWLVGADIFKGDGALRYMADPTQDGKSIGHIDDYYDGLDVHYS
HHHHHCHHHHHHCCCCCCEEEEEEEEECCCEEEEECCCCCCCCCCCCCHHHCCCCEEEEC
SGVFNKAFYTLATTEGWDTRKAFEVFVIANQLYWTPNSLMYEGACGVRNAATDKGYSTAD
CCCCCCEEEEEEECCCCCCCCEEEEEEEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCC
VDAAFAAVGITPCEVPPPPPPPEAEVLQNGVAVTDISGASGSKQYWTLDVPAGASNLVFN
CHHHHHEECCCCCCCCCCCCCCHHHHHHCCEEEEEECCCCCCCEEEEEECCCCCCEEEEE
LSGGSGDADLYVKFGANPTSTDYDCRPYAAGNNENCAISNVQQGTYWVMLNGYSSYSGTT
ECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCE
LVGSFDGGSTEPNEAPVASFTADYTGALYNFTSTATDSDGNVVAWSWDFGDGETATGSAA
EEEECCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCC
SHQYLVSGSYTVTLTVTDDDGATASTSEVFNVEVPAAEMDLSITKVNVSRRGSARIGLEW
CCEEEEECCEEEEEEEECCCCCCCCCCEEEEEECCCHHCCEEEEEEEECCCCCEEEEEEE
TGNSASYTVLRNGEAVGTTSANSYVDRFTATAGSSVTFQVCNSDGGCSDIETVSF
CCCCCEEEEEECCCEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2045361; 10952301; 2123831 [H]