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The map label for this gene is emrA [H]

Identifier: 119773542

GI number: 119773542

Start: 499845

End: 500891

Strand: Direct

Name: emrA [H]

Synonym: Sama_0402

Alternate gene names: 119773542

Gene position: 499845-500891 (Clockwise)

Preceding gene: 119773539

Following gene: 119773543

Centisome position: 11.61

GC content: 58.74

Gene sequence:

>1047_bases
ATGAGCAAGTCAAAAGCCCTGGTGCTGTTACCCGTACTGCTGGTGCTGGCCGGTGGTGGCTTCTATCTGTGGCACAGCCT
CAGATTTATTGAACACACAGACAACGCCTATGTTGAAGCCGATATTTCCCAATTAAGCGTTAAAGTGCCGGGGCTGGTCG
TGCAATCTGAGGTGCAGGACAACCAATATGTCACCGCCGGAACCCTTTTGGCGAAGCTGGATGACAGCGAGTTTCGCGCC
AGAGTATTGCAAAGTGAGGCCAGGCTGGCCAGCGTGGGCGCAGAGCTCGCGACCCTGGAAGCCAAGCTGCTGCTGCAGGC
ATCCCTGATTGCCCAGGCCAAAGCGGGAGTGCAGGCGACAGAGGCCGATGTCCGCCGGGTACAGCAGCAACTGACACGCG
CCAGCGAGCTGCGTCGTCGTGATTACAGCTCTCAGGATGATGTTGATCGTCTGACCGCGGAGTTTGACGGGGCTGAGGCT
CGTCTTGCCGAGTCCAGGGCATCACTGGCTGCCAGAGAGCAGGAGCTTGGGGTGCTCAAGGCCCAGCGTGAGCAGCTTTT
TGCTGCCCGTGCCGAAGCCAACGCGGGGCTGGAGCTGGCCCAACTTCAATTGAAAGATACCGAAATTCGCGCGCCCTTCA
ATGGCATTGTGGGTAAGCGCGGCGCCTTTGTCGGCCAATATGTGCAGCCGGGGCAGGCGCTTTTCAGTTTGGTACCGGAC
GGAACTGTATGGATTACGGCGAACTTTAAAGAGACCCAAATCCAGGCCATGGTTCCGGGCCAGCCGGTGGCAGTGTCACT
CGACGCGTTTCCCGACCATGATTTCCATGGAGTCATCGACAGCCTGTCACCGGCTTCCGGCGCCAAATTCAGCTTATTGC
CCGCCGAAAATGCCACTGGCAATTTCACCAAAATTGTACAGCGCATTCCTGTTCGTATCCGTCTTGAGCTGCCACCCGGA
GAGCAAAAGGTGGTACCGGGGCTCAGCGCCGTAGTGTCCGTGGATACGGCCGCAACGCCCGCGCTGACAGTGACCGCCGG
TCGCTGA

Upstream 100 bases:

>100_bases
TTATTGTTACACCTGTGAAACAGTGGGTTGAATTTTCACTGACTAATAATATTTAAGAGACAGTTTTACAATAGCAGCCA
CTGATTAAGGAGTCTATTGT

Downstream 100 bases:

>100_bases
GGGGACGGGCATGAGTGCGAGTATCGCGTTGCCGCAAACCGATGTGGATTACGGTGTAGGCAGTCGCCGCGCCTGGATTG
CCGTGATGGGCGGCCTTATC

Product: HlyD family secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MSKSKALVLLPVLLVLAGGGFYLWHSLRFIEHTDNAYVEADISQLSVKVPGLVVQSEVQDNQYVTAGTLLAKLDDSEFRA
RVLQSEARLASVGAELATLEAKLLLQASLIAQAKAGVQATEADVRRVQQQLTRASELRRRDYSSQDDVDRLTAEFDGAEA
RLAESRASLAAREQELGVLKAQREQLFAARAEANAGLELAQLQLKDTEIRAPFNGIVGKRGAFVGQYVQPGQALFSLVPD
GTVWITANFKETQIQAMVPGQPVAVSLDAFPDHDFHGVIDSLSPASGAKFSLLPAENATGNFTKIVQRIPVRIRLELPPG
EQKVVPGLSAVVSVDTAATPALTVTAGR

Sequences:

>Translated_348_residues
MSKSKALVLLPVLLVLAGGGFYLWHSLRFIEHTDNAYVEADISQLSVKVPGLVVQSEVQDNQYVTAGTLLAKLDDSEFRA
RVLQSEARLASVGAELATLEAKLLLQASLIAQAKAGVQATEADVRRVQQQLTRASELRRRDYSSQDDVDRLTAEFDGAEA
RLAESRASLAAREQELGVLKAQREQLFAARAEANAGLELAQLQLKDTEIRAPFNGIVGKRGAFVGQYVQPGQALFSLVPD
GTVWITANFKETQIQAMVPGQPVAVSLDAFPDHDFHGVIDSLSPASGAKFSLLPAENATGNFTKIVQRIPVRIRLELPPG
EQKVVPGLSAVVSVDTAATPALTVTAGR
>Mature_347_residues
SKSKALVLLPVLLVLAGGGFYLWHSLRFIEHTDNAYVEADISQLSVKVPGLVVQSEVQDNQYVTAGTLLAKLDDSEFRAR
VLQSEARLASVGAELATLEAKLLLQASLIAQAKAGVQATEADVRRVQQQLTRASELRRRDYSSQDDVDRLTAEFDGAEAR
LAESRASLAAREQELGVLKAQREQLFAARAEANAGLELAQLQLKDTEIRAPFNGIVGKRGAFVGQYVQPGQALFSLVPDG
TVWITANFKETQIQAMVPGQPVAVSLDAFPDHDFHGVIDSLSPASGAKFSLLPAENATGNFTKIVQRIPVRIRLELPPGE
QKVVPGLSAVVSVDTAATPALTVTAGR

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=345, Percent_Identity=33.0434782608696, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1789041, Length=328, Percent_Identity=32.9268292682927, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1790519, Length=332, Percent_Identity=29.2168674698795, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI87081951, Length=338, Percent_Identity=26.0355029585799, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1790024, Length=279, Percent_Identity=26.1648745519713, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790012, Length=277, Percent_Identity=24.5487364620939, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789637, Length=189, Percent_Identity=26.4550264550265, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37402; Mature: 37271

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSKALVLLPVLLVLAGGGFYLWHSLRFIEHTDNAYVEADISQLSVKVPGLVVQSEVQD
CCCCCHHHHHHHHHHHHCCCEEEHHHEEEEEECCCCEEEECHHHEEEECCCEEEEECCCC
NQYVTAGTLLAKLDDSEFRARVLQSEARLASVGAELATLEAKLLLQASLIAQAKAGVQAT
CCEEEHHHEEEECCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHH
EADVRRVQQQLTRASELRRRDYSSQDDVDRLTAEFDGAEARLAESRASLAAREQELGVLK
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AQREQLFAARAEANAGLELAQLQLKDTEIRAPFNGIVGKRGAFVGQYVQPGQALFSLVPD
HHHHHHHHHHHCCCCCCEEEEEEEECCEECCCHHHCCCCCCCHHCCCCCCHHHHHHCCCC
GTVWITANFKETQIQAMVPGQPVAVSLDAFPDHDFHGVIDSLSPASGAKFSLLPAENATG
CEEEEEECCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHCCCCCCCCEEEEEECCCCCC
NFTKIVQRIPVRIRLELPPGEQKVVPGLSAVVSVDTAATPALTVTAGR
HHHHHHHHCCEEEEEECCCCCCCCCCCCHHEEEECCCCCCEEEEECCC
>Mature Secondary Structure 
SKSKALVLLPVLLVLAGGGFYLWHSLRFIEHTDNAYVEADISQLSVKVPGLVVQSEVQD
CCCCHHHHHHHHHHHHCCCEEEHHHEEEEEECCCCEEEECHHHEEEECCCEEEEECCCC
NQYVTAGTLLAKLDDSEFRARVLQSEARLASVGAELATLEAKLLLQASLIAQAKAGVQAT
CCEEEHHHEEEECCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHH
EADVRRVQQQLTRASELRRRDYSSQDDVDRLTAEFDGAEARLAESRASLAAREQELGVLK
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AQREQLFAARAEANAGLELAQLQLKDTEIRAPFNGIVGKRGAFVGQYVQPGQALFSLVPD
HHHHHHHHHHHCCCCCCEEEEEEEECCEECCCHHHCCCCCCCHHCCCCCCHHHHHHCCCC
GTVWITANFKETQIQAMVPGQPVAVSLDAFPDHDFHGVIDSLSPASGAKFSLLPAENATG
CEEEEEECCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHCCCCCCCCEEEEEECCCCCC
NFTKIVQRIPVRIRLELPPGEQKVVPGLSAVVSVDTAATPALTVTAGR
HHHHHHHHCCEEEEEECCCCCCCCCCCCHHEEEECCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]