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The map label for this gene is yuxL [H]

Identifier: 119773538

GI number: 119773538

Start: 495289

End: 497262

Strand: Direct

Name: yuxL [H]

Synonym: Sama_0398

Alternate gene names: 119773538

Gene position: 495289-497262 (Clockwise)

Preceding gene: 119773537

Following gene: 119773539

Centisome position: 11.5

GC content: 54.36

Gene sequence:

>1974_bases
ATGAAAAAGACCCTGCTGACACTCAGCCTGACTGCGGTGGCGCTGGCTGGTTGCCAATCGCCCCAATCCAATCAGGCAAC
GGATACGGCGGCGACTGCCAACGTCACCAATCATCAGAATGCCGCCACGGCCAAGCAGCCCTACGCCAAGCCCTTGCTGC
TGGCACACCCCAATTACGATGCCAAAACCTTTTTTGATACCACGTCTTACACGGGCTCCAGCATTTCTGCCGACGGCAGC
GCTGTGCTGGTGGGTTCGGATGAATCGGGTATTTATAACCTGTATCGTCTTAGCTTGCTCGATGGCAGCAAAACCCAGCT
GACCAACTTTGAAGACAGTACTTTCCCGGTGCGTTGGTTCCCCGGGGATGACAGGGTGCTGTTGAGTAAGGACAAGGGCG
GTAATGAGCTGAACCACCTGTATGTGCGGGAACTGGATGGCAGCGTGAAAGACATGACTCCGGGAGAGAATACCCGGGCG
AGCTTTGCTGGATTCAGTGGTGATGGCAAGGCGTTTTTTGTGCAGACCAACGAGCGCAATCCCAAGTTTATGGATTTGTA
TCGCTACGATGCCAGTACCTATGAGCGCACTCTGGTCTTCCAAAACGATGAAGGCTATTCACTGGGTGATATAGACCGCA
GTGGCCGCTTCGTTGCGCTGAATAAGTCGGTCAGCAACAAGGATATCGATATTTATCTGCTGGACCTCAGAAGCCGTGCT
CTCAAACCCGTGATGGTGAGTGAGCCAGGGCTGGAGGCCGCAGAGGAGGTATTCAGCTTTGCCCATAATGGCCAAACCCT
GTATTACGGCAGCGATGCCAAATCCGAATTTAACGAGGTGTGGGCATACGATATCGCCTCCGGCAAGCGTCAACCGATCG
CCAGCCATGATTGGGATGTCAGCTACTACGGTTTTTCGGAAAGTGGTCGCTATCAGGCCATGGCGGTGAATGCCGATGCC
AGCACCAAGGTCACCATCACAGATACCCAAACCGGCAAGGCTTTGGCCCTGCCGCCTTTGCCACCGGGGGATTTCCGTGG
TGTAAGTTTTTCTAAAGACGATAAAACCATGGTGTTTTATCTGAATTCAGATATTTCACCGTCTGAGCTGTATGTCTGGC
AGATAGGCGAGCCTTCGGTAAAGCGGCTTACCAAGGCCCTCAGTCCTGCCATGGACAGCGCCAATCTTGTACCTTCTGAG
GTGGTGAGGTTCAAGAGTTTTGATGGGCTGGAGATCCCAGGGCTTTTGTATCGACCCAAGCTGGCCCACGCCGCCAGTCC
GTCCCCTGCAGTGATTTATGTGCACGGCGGCCCGGGTGGACAGAGCCGCAGTGGTTACAATCCTGCCATTCAACATCTGG
TCAATCACGGCTACGTCGTCTTTGCCATTAACAACCGCGGTAGCTCGGGCTATGGCAAAACCTTCTTCCATCTGGATGAC
AAAAATCACGGCGATGGCGACCTGAAAGATATGGTATGGGGCAAGAAATACCTCCAGAGCCTGGATTGGGTGGATAAGGA
GCGTATCGGCATTATGGGGGGCAGCTACGGTGGCTACATGGTGGCGGCCGCGCTGGCCTTTACCCCCGAAGAGTTCAAGG
TGGGGATAGATATCTTCGGTGTTACCAACTGGGTGCGTACCCTGAACTCCATCCCGCCCTGGTGGGAAAGTTTCCGTAAG
TCGTTGTACGACGAGATGGGTGACCCTGCGACAGATGCCGAGCGACACAAGGCCATTTCGCCGCTATTCCATGCCGAAAA
CATTGTTCGCCCCCTGATGGTCATTCAGGGCGCCAACGATCCGCGGGTACTTCAGGTGGAAAGCGATGAGCTGGTCGAAA
AAGTCCGCGCCAATGGGGTGCCGGTGGAGTATGTGCTGTTCGATGACGAAGGCCACGGCTTTACCAAGAAAGCCAATAGG
ATCACCGCATCCGAAGCGTACCTCAAGTTTCTGGATACTTACCTGAAACCCTGA

Upstream 100 bases:

>100_bases
GTATTTGTTTACAAAATAGACTTGTTTTCGTGGCATTGGCATTGAATGATGTGGAGGTTCCTGCGGTAACGGACTGACCT
TATTACAAAGAGGGATATAC

Downstream 100 bases:

>100_bases
GATGAAGGCAATCAAAAAAGGCACTCATTGAGTGCCTTTTTTATTGGATAAGGTTATGACCTTATTTGCTTTTTTTGCCG
AGGTTTTCAACCTTTCCGCT

Product: peptidase

Products: Hydrolyzed protein [C]

Alternate protein names: NA

Number of amino acids: Translated: 657; Mature: 657

Protein sequence:

>657_residues
MKKTLLTLSLTAVALAGCQSPQSNQATDTAATANVTNHQNAATAKQPYAKPLLLAHPNYDAKTFFDTTSYTGSSISADGS
AVLVGSDESGIYNLYRLSLLDGSKTQLTNFEDSTFPVRWFPGDDRVLLSKDKGGNELNHLYVRELDGSVKDMTPGENTRA
SFAGFSGDGKAFFVQTNERNPKFMDLYRYDASTYERTLVFQNDEGYSLGDIDRSGRFVALNKSVSNKDIDIYLLDLRSRA
LKPVMVSEPGLEAAEEVFSFAHNGQTLYYGSDAKSEFNEVWAYDIASGKRQPIASHDWDVSYYGFSESGRYQAMAVNADA
STKVTITDTQTGKALALPPLPPGDFRGVSFSKDDKTMVFYLNSDISPSELYVWQIGEPSVKRLTKALSPAMDSANLVPSE
VVRFKSFDGLEIPGLLYRPKLAHAASPSPAVIYVHGGPGGQSRSGYNPAIQHLVNHGYVVFAINNRGSSGYGKTFFHLDD
KNHGDGDLKDMVWGKKYLQSLDWVDKERIGIMGGSYGGYMVAAALAFTPEEFKVGIDIFGVTNWVRTLNSIPPWWESFRK
SLYDEMGDPATDAERHKAISPLFHAENIVRPLMVIQGANDPRVLQVESDELVEKVRANGVPVEYVLFDDEGHGFTKKANR
ITASEAYLKFLDTYLKP

Sequences:

>Translated_657_residues
MKKTLLTLSLTAVALAGCQSPQSNQATDTAATANVTNHQNAATAKQPYAKPLLLAHPNYDAKTFFDTTSYTGSSISADGS
AVLVGSDESGIYNLYRLSLLDGSKTQLTNFEDSTFPVRWFPGDDRVLLSKDKGGNELNHLYVRELDGSVKDMTPGENTRA
SFAGFSGDGKAFFVQTNERNPKFMDLYRYDASTYERTLVFQNDEGYSLGDIDRSGRFVALNKSVSNKDIDIYLLDLRSRA
LKPVMVSEPGLEAAEEVFSFAHNGQTLYYGSDAKSEFNEVWAYDIASGKRQPIASHDWDVSYYGFSESGRYQAMAVNADA
STKVTITDTQTGKALALPPLPPGDFRGVSFSKDDKTMVFYLNSDISPSELYVWQIGEPSVKRLTKALSPAMDSANLVPSE
VVRFKSFDGLEIPGLLYRPKLAHAASPSPAVIYVHGGPGGQSRSGYNPAIQHLVNHGYVVFAINNRGSSGYGKTFFHLDD
KNHGDGDLKDMVWGKKYLQSLDWVDKERIGIMGGSYGGYMVAAALAFTPEEFKVGIDIFGVTNWVRTLNSIPPWWESFRK
SLYDEMGDPATDAERHKAISPLFHAENIVRPLMVIQGANDPRVLQVESDELVEKVRANGVPVEYVLFDDEGHGFTKKANR
ITASEAYLKFLDTYLKP
>Mature_657_residues
MKKTLLTLSLTAVALAGCQSPQSNQATDTAATANVTNHQNAATAKQPYAKPLLLAHPNYDAKTFFDTTSYTGSSISADGS
AVLVGSDESGIYNLYRLSLLDGSKTQLTNFEDSTFPVRWFPGDDRVLLSKDKGGNELNHLYVRELDGSVKDMTPGENTRA
SFAGFSGDGKAFFVQTNERNPKFMDLYRYDASTYERTLVFQNDEGYSLGDIDRSGRFVALNKSVSNKDIDIYLLDLRSRA
LKPVMVSEPGLEAAEEVFSFAHNGQTLYYGSDAKSEFNEVWAYDIASGKRQPIASHDWDVSYYGFSESGRYQAMAVNADA
STKVTITDTQTGKALALPPLPPGDFRGVSFSKDDKTMVFYLNSDISPSELYVWQIGEPSVKRLTKALSPAMDSANLVPSE
VVRFKSFDGLEIPGLLYRPKLAHAASPSPAVIYVHGGPGGQSRSGYNPAIQHLVNHGYVVFAINNRGSSGYGKTFFHLDD
KNHGDGDLKDMVWGKKYLQSLDWVDKERIGIMGGSYGGYMVAAALAFTPEEFKVGIDIFGVTNWVRTLNSIPPWWESFRK
SLYDEMGDPATDAERHKAISPLFHAENIVRPLMVIQGANDPRVLQVESDELVEKVRANGVPVEYVLFDDEGHGFTKKANR
ITASEAYLKFLDTYLKP

Specific function: Cleaves Peptide Bonds On The C-Terminal Side Of Lysyl And Argininyl Residues. [C]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI194394146, Length=330, Percent_Identity=23.9393939393939, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI18450280, Length=257, Percent_Identity=28.7937743190661, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI37577089, Length=257, Percent_Identity=28.7937743190661, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI23510451, Length=263, Percent_Identity=23.9543726235741, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI16933540, Length=267, Percent_Identity=25.0936329588015, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI18765694, Length=449, Percent_Identity=21.1581291759465, Blast_Score=66, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI25144537, Length=348, Percent_Identity=32.7586206896552, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI25144540, Length=348, Percent_Identity=32.7586206896552, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17552908, Length=541, Percent_Identity=25.1386321626617, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI25144543, Length=257, Percent_Identity=29.9610894941634, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI25149159, Length=233, Percent_Identity=28.3261802575107, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221510989, Length=467, Percent_Identity=23.1263383297645, Blast_Score=80, Evalue=6e-15,
Organism=Drosophila melanogaster, GI45551969, Length=291, Percent_Identity=25.7731958762887, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45550825, Length=291, Percent_Identity=25.7731958762887, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45553511, Length=291, Percent_Identity=25.7731958762887, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24582257, Length=212, Percent_Identity=27.8301886792453, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR011659
- InterPro:   IPR001375 [H]

Pfam domain/function: PF07676 PD40; PF00326 Peptidase_S9 [H]

EC number: 3.4.21.83 [C]

Molecular weight: Translated: 72441; Mature: 72441

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTLLTLSLTAVALAGCQSPQSNQATDTAATANVTNHQNAATAKQPYAKPLLLAHPNYD
CCCEEEEEEHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCEEEECCCCC
AKTFFDTTSYTGSSISADGSAVLVGSDESGIYNLYRLSLLDGSKTQLTNFEDSTFPVRWF
CCEEEECCCCCCCCCCCCCCEEEEECCCCCCEEEEEEEEECCCCCEECCCCCCCEEEEEE
PGDDRVLLSKDKGGNELNHLYVRELDGSVKDMTPGENTRASFAGFSGDGKAFFVQTNERN
CCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCEEEEEECCCC
PKFMDLYRYDASTYERTLVFQNDEGYSLGDIDRSGRFVALNKSVSNKDIDIYLLDLRSRA
CCEEEEEECCCCCCEEEEEEECCCCCEECCCCCCCCEEEEECCCCCCCEEEEEEECCCCC
LKPVMVSEPGLEAAEEVFSFAHNGQTLYYGSDAKSEFNEVWAYDIASGKRQPIASHDWDV
CCCEEECCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHEEEEECCCCCCCCCCCCCCCE
SYYGFSESGRYQAMAVNADASTKVTITDTQTGKALALPPLPPGDFRGVSFSKDDKTMVFY
EEEECCCCCCEEEEEECCCCCEEEEEEECCCCCEEECCCCCCCCCCCCEECCCCCEEEEE
LNSDISPSELYVWQIGEPSVKRLTKALSPAMDSANLVPSEVVRFKSFDGLEIPGLLYRPK
ECCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCEEECCC
LAHAASPSPAVIYVHGGPGGQSRSGYNPAIQHLVNHGYVVFAINNRGSSGYGKTFFHLDD
HHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCEEEEEEECCCCCCCCCEEEEECC
KNHGDGDLKDMVWGKKYLQSLDWVDKERIGIMGGSYGGYMVAAALAFTPEEFKVGIDIFG
CCCCCCCHHHHHHHHHHHHHCCCCCCHHEEEECCCCCHHHHHHHHHCCHHHHEEEEEEEE
VTNWVRTLNSIPPWWESFRKSLYDEMGDPATDAERHKAISPLFHAENIVRPLMVIQGAND
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCHHHHHHHHHCEEEEEECCCC
PRVLQVESDELVEKVRANGVPVEYVLFDDEGHGFTKKANRITASEAYLKFLDTYLKP
CEEEEECHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKTLLTLSLTAVALAGCQSPQSNQATDTAATANVTNHQNAATAKQPYAKPLLLAHPNYD
CCCEEEEEEHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCEEEECCCCC
AKTFFDTTSYTGSSISADGSAVLVGSDESGIYNLYRLSLLDGSKTQLTNFEDSTFPVRWF
CCEEEECCCCCCCCCCCCCCEEEEECCCCCCEEEEEEEEECCCCCEECCCCCCCEEEEEE
PGDDRVLLSKDKGGNELNHLYVRELDGSVKDMTPGENTRASFAGFSGDGKAFFVQTNERN
CCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCEEEEEECCCC
PKFMDLYRYDASTYERTLVFQNDEGYSLGDIDRSGRFVALNKSVSNKDIDIYLLDLRSRA
CCEEEEEECCCCCCEEEEEEECCCCCEECCCCCCCCEEEEECCCCCCCEEEEEEECCCCC
LKPVMVSEPGLEAAEEVFSFAHNGQTLYYGSDAKSEFNEVWAYDIASGKRQPIASHDWDV
CCCEEECCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHEEEEECCCCCCCCCCCCCCCE
SYYGFSESGRYQAMAVNADASTKVTITDTQTGKALALPPLPPGDFRGVSFSKDDKTMVFY
EEEECCCCCCEEEEEECCCCCEEEEEEECCCCCEEECCCCCCCCCCCCEECCCCCEEEEE
LNSDISPSELYVWQIGEPSVKRLTKALSPAMDSANLVPSEVVRFKSFDGLEIPGLLYRPK
ECCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCEEECCC
LAHAASPSPAVIYVHGGPGGQSRSGYNPAIQHLVNHGYVVFAINNRGSSGYGKTFFHLDD
HHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCEEEEEEECCCCCCCCCEEEEECC
KNHGDGDLKDMVWGKKYLQSLDWVDKERIGIMGGSYGGYMVAAALAFTPEEFKVGIDIFG
CCCCCCCHHHHHHHHHHHHHCCCCCCHHEEEECCCCCHHHHHHHHHCCHHHHEEEEEEEE
VTNWVRTLNSIPPWWESFRKSLYDEMGDPATDAERHKAISPLFHAENIVRPLMVIQGAND
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCHHHHHHHHHCEEEEEECCCC
PRVLQVESDELVEKVRANGVPVEYVLFDDEGHGFTKKANRITASEAYLKFLDTYLKP
CEEEEECHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): 11820 [C]

Specific activity: NA

Km value (mM): 0.23 {tosyl-Arg} 0.33 {N-benzyloxycarbonyl-Lys} 0.31 {N-benzyloxycarbonyl-Lys} 0.92 {benzoyl-Lys} 0.6 {N-benzoyl-Arg} 0.5 {benzoyl-Arg} 0.48 {benzoyl-Arg} 0.25 {benzoyl-Arg} 80 {acetyl-tyrosine} 0.47 {tosyl-Lys-methyl} [C]

Substrates: Protein; H2O [C]

Specific reaction: Protein + H2O = hydrolyzed protein [C]

General reaction: Peptide bond hydrolysis [C]

Inhibitor: Antipain; Aromaticamidines; Benzamidine; Co2+; DFP; Fe2+; Hg2+; L-Arginine; Leupeptin sulfhydryl agents, trypsin inhibitors, 1, 10-phenanthroline; p-Aminobenzamidine; Tosyl -Leuchloromethyl ketone; Zn2+ [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 3098560 [H]