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The map label for this gene is hemE

Identifier: 119773528

GI number: 119773528

Start: 478996

End: 480060

Strand: Direct

Name: hemE

Synonym: Sama_0387

Alternate gene names: 119773528

Gene position: 478996-480060 (Clockwise)

Preceding gene: 119773523

Following gene: 119773529

Centisome position: 11.12

GC content: 57.75

Gene sequence:

>1065_bases
ATGGCAGAATTGAAAAACGATCGTTACCTGCGCGCCCTGCTTAAACAACCCGTGGATGTCACTCCCGTTTGGATGATGCG
TCAGGCGGGCCGTTATCTTCCTGAATACCGTGCAACCCGTGCCCAGGCCGGTGACTTTATGTCACTGTGCAAAAACGCCG
AACTGGCCTGCGAAGTAACGCTGCAGCCACTGCGCCGTTACGAGCTGGATGCGGCTATCCTGTTCTCTGATATTCTGACC
ATTCCCGATGCCATGGGCCTGGGTCTGTACTTTGAAGCCGGCGAAGGCCCACGTTTCGAGCGCAAGGCCGACACCCTGGA
AGCCATCAAGGCACTGCCTATCCCGGATCCCGAAGATGAGCTGGGCTACGTGATGCGTGCCGTGAGCACCATCCGCCGTG
AGCTTAAGGGTGAAGTTCCTCTGATTGGTTTCTCCGGCTCGCCATGGACCCTGGCCACCTACATGGTGGAAGGTGGCTCC
AGCAAGGCGTTCGAAAAAATCAAGCGTATGATGTACTCAGAGCCAATGGCATTGCACCTGTTGCTGGACAAGCTGGCCGA
CTCGGTCATCCTGTACCTGAACGCGCAAATCGCCAATGGTGCTCAGTCGGTGATGATTTTTGACTCCTGGGGCGGCGCCC
TGTCTCACAGCGCCTACCGTGAGTTCTCCCTGCGTTACATGCAGAAGATTGTTGACGGCCTGACCCGCGAAGCCGATGGC
CGCAAAGTGCCTGTGACCCTGTTCACCAAGGGTGGCGGTCTGTGGCTCGAATCTATGGCCGAAACCGGCTGTGATGCCCT
GGGTCTGGACTGGACCGTGGACATCGCCGATGCCCGCCGCCGCGTAGGCCACAAGGTTGCGCTGCAGGGCAACATGGACC
CATCCATGCTGTACGCGCCAATCCCACGCATCGAAGAAGAAGTTGAGCAAATTCTGGCTGGCTTCGGCGAAGGTACTGGT
CACGTGTTTAACCTCGGCCACGGTATCCATCAGCATGTGGATCCTGAGCACGCAGGCGCCTTCATCAAGGCCGTACACGA
GAAGTCGCGCAAGTATCACAAGTAA

Upstream 100 bases:

>100_bases
AGGCGCCGTGCAGCTCACAGAAATGAATTTTGAAAGGTTACTTTATTCCCGTAAATGCTAAACTACCGCGCAGCTTTCAT
AAGAACAGGAATCACGCCAA

Downstream 100 bases:

>100_bases
GCTTGTGCAACTGCAAAGGCCCGCGATAGCGGGCCTTTTGGTTTTGGCTGTGTCCCCATACTCTGCAAAGGGTTAGACAT
CAGGCATAACACTTTTTGGC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MAELKNDRYLRALLKQPVDVTPVWMMRQAGRYLPEYRATRAQAGDFMSLCKNAELACEVTLQPLRRYELDAAILFSDILT
IPDAMGLGLYFEAGEGPRFERKADTLEAIKALPIPDPEDELGYVMRAVSTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFEKIKRMMYSEPMALHLLLDKLADSVILYLNAQIANGAQSVMIFDSWGGALSHSAYREFSLRYMQKIVDGLTREADG
RKVPVTLFTKGGGLWLESMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAPIPRIEEEVEQILAGFGEGTG
HVFNLGHGIHQHVDPEHAGAFIKAVHEKSRKYHK

Sequences:

>Translated_354_residues
MAELKNDRYLRALLKQPVDVTPVWMMRQAGRYLPEYRATRAQAGDFMSLCKNAELACEVTLQPLRRYELDAAILFSDILT
IPDAMGLGLYFEAGEGPRFERKADTLEAIKALPIPDPEDELGYVMRAVSTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFEKIKRMMYSEPMALHLLLDKLADSVILYLNAQIANGAQSVMIFDSWGGALSHSAYREFSLRYMQKIVDGLTREADG
RKVPVTLFTKGGGLWLESMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAPIPRIEEEVEQILAGFGEGTG
HVFNLGHGIHQHVDPEHAGAFIKAVHEKSRKYHK
>Mature_353_residues
AELKNDRYLRALLKQPVDVTPVWMMRQAGRYLPEYRATRAQAGDFMSLCKNAELACEVTLQPLRRYELDAAILFSDILTI
PDAMGLGLYFEAGEGPRFERKADTLEAIKALPIPDPEDELGYVMRAVSTIRRELKGEVPLIGFSGSPWTLATYMVEGGSS
KAFEKIKRMMYSEPMALHLLLDKLADSVILYLNAQIANGAQSVMIFDSWGGALSHSAYREFSLRYMQKIVDGLTREADGR
KVPVTLFTKGGGLWLESMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAPIPRIEEEVEQILAGFGEGTGH
VFNLGHGIHQHVDPEHAGAFIKAVHEKSRKYHK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=357, Percent_Identity=48.1792717086835, Blast_Score=323, Evalue=1e-88,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=81.9209039548023, Blast_Score=604, Evalue=1e-174,
Organism=Saccharomyces cerevisiae, GI6320252, Length=357, Percent_Identity=38.9355742296919, Blast_Score=264, Evalue=2e-71,
Organism=Drosophila melanogaster, GI19921920, Length=348, Percent_Identity=42.816091954023, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI221330099, Length=348, Percent_Identity=42.816091954023, Blast_Score=276, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_SHEAM (A1S2J2)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_926268.1
- ProteinModelPortal:   A1S2J2
- SMR:   A1S2J2
- STRING:   A1S2J2
- GeneID:   4602643
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0387
- NMPDR:   fig|326297.7.peg.367
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   A1S2J2
- ProtClustDB:   PRK00115
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39446; Mature: 39315

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 77-77 BINDING 154-154 BINDING 209-209 BINDING 327-327

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELKNDRYLRALLKQPVDVTPVWMMRQAGRYLPEYRATRAQAGDFMSLCKNAELACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEE
LQPLRRYELDAAILFSDILTIPDAMGLGLYFEAGEGPRFERKADTLEAIKALPIPDPEDE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHH
LGYVMRAVSTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFEKIKRMMYSEPMALHL
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHH
LLDKLADSVILYLNAQIANGAQSVMIFDSWGGALSHSAYREFSLRYMQKIVDGLTREADG
HHHHHHHHEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RKVPVTLFTKGGGLWLESMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAP
CEEEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEHHHHHHHCCCEEEEECCCCCHHEECC
IPRIEEEVEQILAGFGEGTGHVFNLGHGIHQHVDPEHAGAFIKAVHEKSRKYHK
CHHHHHHHHHHHHHCCCCCCCEEECCCCHHHCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AELKNDRYLRALLKQPVDVTPVWMMRQAGRYLPEYRATRAQAGDFMSLCKNAELACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEE
LQPLRRYELDAAILFSDILTIPDAMGLGLYFEAGEGPRFERKADTLEAIKALPIPDPEDE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHH
LGYVMRAVSTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFEKIKRMMYSEPMALHL
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHH
LLDKLADSVILYLNAQIANGAQSVMIFDSWGGALSHSAYREFSLRYMQKIVDGLTREADG
HHHHHHHHEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RKVPVTLFTKGGGLWLESMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAP
CEEEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEHHHHHHHCCCEEEEECCCCCHHEECC
IPRIEEEVEQILAGFGEGTGHVFNLGHGIHQHVDPEHAGAFIKAVHEKSRKYHK
CHHHHHHHHHHHHHCCCCCCCEEECCCCHHHCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA