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The map label for this gene is lpxC

Identifier: 119773500

GI number: 119773500

Start: 430462

End: 431382

Strand: Direct

Name: lpxC

Synonym: Sama_0359

Alternate gene names: 119773500

Gene position: 430462-431382 (Clockwise)

Preceding gene: 119773499

Following gene: 119773502

Centisome position: 10.0

GC content: 52.23

Gene sequence:

>921_bases
ATGATTTTTCAAAGAACAGTTAAAGAAATGGTTAAGACCACCGGTGTTGGATTGCACTCCGGTAACAAGGTCACACTTAC
CATTAAACCCGCGCCAATCAATACAGGGATAGTACTGATGCGTACCGACCTGAACCCCGCCGTGGCCATTCCAGCCAAGG
CGAATATGGTTCGGGAAACGACCATGTGTACCGCCCTGGTAAATGATGAAGGTGTTCGCATTTCGACTATCGAGCACCTG
TTTGCTGCCCTGGCAGGCCTCGGCATTGATAATGCCGTTATCGAAGTGGACGCGCCCGAAATCCCGATTATGGATGGCAG
CGCCAGCCCCTTCGTATTCCTGCTTCAGAGTGCCGGTATCCAGGAGCAGTCAGCGCCTAAAAAATATCTGCGTATCAAGC
GCACCGTACGTGTGGAAGACGGCGACAAGTGGGCGGAAATCCGTCCGTTCCAGGGCTTCAGAGTCAACTTTGCCATTGAC
TTCAATCACCCTGAGATCGCCCGCAGCCAACAGCATATGGTGATGGACTTTTCCTCTACTGCCTTTGTGAAAGATATCAG
CCGTGCCCGTACTTTCGGGTTTATGCGAGATATTGAGTATCTGCGTGCCAACAACCTGGCGCTGGGTGGCAGCATGGAAA
ATGCCGTGGTGCTTGATGAATACCGCGTCCTCAACCCCGATGGCCTGCGTTATGAGGACGAGTTCGTTAAGCACAAGATC
CTGGATGCATTTGGCGATCTCTATGTCGCCGGTCATGCCATCATAGGTGAGTTTTGTGCCTATAAGACCGGCCATGCCCT
GAACAATCAATTGGTCAGGGCAGTGCTTGCCGCTCAGGATGCCTGGGAATTGGTAAGCTTTGACAAAGAAGCTGATGCAC
CTGTCAGTTTCGCCATGCCCGGCAATGCAGTGTTTGCCTGA

Upstream 100 bases:

>100_bases
TGCCTGACTTGTGGTAGCATGTCTGACCAGCCGCACTATTGGCTGTCGTTTTCGACTGCCTGAGTGACAGTGATTTGTTG
AATGCATAACGGGTAACTGA

Downstream 100 bases:

>100_bases
GCATAATAAGTTAACTTCATGACTGCCTGTGACGGCTGGCCAATGCAGCCAGCCGTTTCAGTTTTTGGCCCAGACTGCCT
TCGGTATGTTCTGCCAGCGC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MIFQRTVKEMVKTTGVGLHSGNKVTLTIKPAPINTGIVLMRTDLNPAVAIPAKANMVRETTMCTALVNDEGVRISTIEHL
FAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSAGIQEQSAPKKYLRIKRTVRVEDGDKWAEIRPFQGFRVNFAID
FNHPEIARSQQHMVMDFSSTAFVKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
LDAFGDLYVAGHAIIGEFCAYKTGHALNNQLVRAVLAAQDAWELVSFDKEADAPVSFAMPGNAVFA

Sequences:

>Translated_306_residues
MIFQRTVKEMVKTTGVGLHSGNKVTLTIKPAPINTGIVLMRTDLNPAVAIPAKANMVRETTMCTALVNDEGVRISTIEHL
FAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSAGIQEQSAPKKYLRIKRTVRVEDGDKWAEIRPFQGFRVNFAID
FNHPEIARSQQHMVMDFSSTAFVKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
LDAFGDLYVAGHAIIGEFCAYKTGHALNNQLVRAVLAAQDAWELVSFDKEADAPVSFAMPGNAVFA
>Mature_306_residues
MIFQRTVKEMVKTTGVGLHSGNKVTLTIKPAPINTGIVLMRTDLNPAVAIPAKANMVRETTMCTALVNDEGVRISTIEHL
FAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSAGIQEQSAPKKYLRIKRTVRVEDGDKWAEIRPFQGFRVNFAID
FNHPEIARSQQHMVMDFSSTAFVKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
LDAFGDLYVAGHAIIGEFCAYKTGHALNNQLVRAVLAAQDAWELVSFDKEADAPVSFAMPGNAVFA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=306, Percent_Identity=65.0326797385621, Blast_Score=424, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_SHEAM (A1S2G4)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_926240.1
- ProteinModelPortal:   A1S2G4
- SMR:   A1S2G4
- STRING:   A1S2G4
- GeneID:   4602615
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0359
- NMPDR:   fig|326297.7.peg.340
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- PhylomeDB:   A1S2G4
- ProtClustDB:   PRK13186
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33720; Mature: 33720

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFQRTVKEMVKTTGVGLHSGNKVTLTIKPAPINTGIVLMRTDLNPAVAIPAKANMVRET
CCCHHHHHHHHHHCCCCEECCCEEEEEEECCCCCCCEEEEEECCCCEEECCCCHHHHHHH
TMCTALVNDEGVRISTIEHLFAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSAGI
HHEEEEECCCCCEEHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCEEEEEECCCC
QEQSAPKKYLRIKRTVRVEDGDKWAEIRPFQGFRVNFAIDFNHPEIARSQQHMVMDFSST
CCCCCCHHHHEEEEEEEECCCCCEEEECCCCCEEEEEEEECCCCHHHCCCCEEEEECCCH
AFVKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECEEEECCCCCCCHHHHHHHHH
LDAFGDLYVAGHAIIGEFCAYKTGHALNNQLVRAVLAAQDAWELVSFDKEADAPVSFAMP
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECC
GNAVFA
CCCCCC
>Mature Secondary Structure
MIFQRTVKEMVKTTGVGLHSGNKVTLTIKPAPINTGIVLMRTDLNPAVAIPAKANMVRET
CCCHHHHHHHHHHCCCCEECCCEEEEEEECCCCCCCEEEEEECCCCEEECCCCHHHHHHH
TMCTALVNDEGVRISTIEHLFAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSAGI
HHEEEEECCCCCEEHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCEEEEEECCCC
QEQSAPKKYLRIKRTVRVEDGDKWAEIRPFQGFRVNFAIDFNHPEIARSQQHMVMDFSST
CCCCCCHHHHEEEEEEEECCCCCEEEECCCCCEEEEEEEECCCCHHHCCCCEEEEECCCH
AFVKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECEEEECCCCCCCHHHHHHHHH
LDAFGDLYVAGHAIIGEFCAYKTGHALNNQLVRAVLAAQDAWELVSFDKEADAPVSFAMP
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECC
GNAVFA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA