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The map label for this gene is mtlA [H]

Identifier: 119717388

GI number: 119717388

Start: 3361581

End: 3363587

Strand: Reverse

Name: mtlA [H]

Synonym: Noca_3164

Alternate gene names: 119717388

Gene position: 3363587-3361581 (Counterclockwise)

Preceding gene: 119717390

Following gene: 119717383

Centisome position: 67.46

GC content: 68.16

Gene sequence:

>2007_bases
ATGGCCACAGCCACGCAGACACCTGCCGAGCGAACCTCGACTCGCGTCCACGTCCAACGCTTCGGGACGTTCCTGTCCAA
CATGGTGATGCCCAACATCGGCGCGTTCATCGCGTGGGGCCTCATCACCGCGATGTTCATCGAGGTCGGGTGGTTGAACC
TCGGCGGCGGCGACCACGGATGGCTCGGCCCGGGAAGCTGGGTCGCTCATATCGGCGGCTGGGGAGACTACGCCGGTGGC
GGGATCGTCGGCCCGATGATCACCTACCTGCTGCCGGTGCTGATCGGCTACACCGGCGGCAAGATGGTCTACAACGACCT
GGTCCGCGGCGGCGTGGTCGGCGCGATCGCCACCTTCGGCGTCATCGCCGGCACCAGCGTCCCGATGTTCATGGGCGCGA
TGATCATGGGCCCGCTGGCCGGCTGGTCGATGAAGAAGATCGACAGCACGTGGGACGGCAAGATCAAGCCGGGCTTCGAG
ATGCTGGTCGACAACTTCTCGGCCGGCATCTGGGGTGGCATCCTCGCCACCTTCGGCTTCTTCGCGCTCAGCGACGTCCT
GACCTGGATCTCGGACCGGCTCGGCGACGGCGTCGAGTTCCTGGTCGAGCACGACCTGCTGCCGTTCGCCTCGTTCGTGA
TCGAGCCCGCCAAGGTGCTGTTCCTCAACAACGCGCTCAACCACGGCGTGCTGACCCCGCTCGGTCTCGCGGAGTCCGCC
GACAGCGGCAAGTCGATCCTGTTCCTGCTCGAGGCCAACCCGGCCGCCGGTATCGGCCTGCTGCTCGCGTACAGCATCTT
CGGCAAGGGGCTGGCCAAGGCCTCCGCGCCCGGCGCCGCGATCATCCACTTCTTCGGCGGTATCCACGAGGTCTACTTCC
CGTTCGTGCTGATGAAGCCCAAGCTGATCCTCGCGATGATCGCCGGTGGCTTCACCCAGATCCTGATCAACGTCATCTTC
TCCAGCGGTCTGCGTTCTCCCGCAGCGCCGGGCTCGGTGTTCGCGGTCTACATCTCCGCGCCGACCGACCTGCGGAACCT
CACCGGTGTCACGCTGTCGATCCTCGGCGGCGCGGCGGCGTCGTTCTTCGTCGCGGCCATCCTGCTCAAGACCGACAAGA
CGATCGAGGCCGAGGACGAGCTGGTCAGTGCCACCGCGAACATGGAGGCGATGAAGGGCAAGAAGTCCATCGCGTCCTCG
CTCGTCGGCTCCTCGACCGCGCACTCCGGCGCGATCACCAGCATCGTGTTCGCCTGCGACGCCGGCATGGGCTCCTCGGC
GATGGGCGCCTCGGTGCTCCGCAAGAAGATCCACGGCGCCGGCTTCACCGACGTGACCGTGGTCAACAAGGCCATCGCGA
ACCTCACCGACAGCTACGACCTGGTCGTCACCCACCAGGACCTGACCGACCGCGCCCGGCTGAAGACCGGCTCGGCGATC
CAGGTGTCGGTCGAGAACTTCATGGGCAGCCCGCGGTACGACGAGATCGTCGAGCTGGTCCGGGAGCGCAACGGCGGCGC
GGCGCCGGCGTCGGTCGGCTCCGCCGACGCAGAGGAGCCTGCTCTAGCCGGTGGGCTCCTGGCCGACGACGCGATCGTCC
TGGACGCGCCCGCGGGGGAGTCGCGCGACGCGGCCATCACCCGCGCCGGTGAGCTGCTGCTCGCGAGCGGTGCCGCCACC
CGGGCCTACGTCGAGGCGATGCACACCCGCGAGGGCTCGGTCTCCACGGCGATGGGCAACCTGCTGGCGATCCCGCACGG
CACCAACGAGGCGAAGACCGAGGTCAGCCGCACGGCGCTCTCCTTCGTCCGCTACCCCGAGCCGATCGACTGGAACGGCA
AGCCGGTGCGCTACGTGGTGGGCATCGCGGCGATGGGCAACGAGCACCTCAAGCTGCTCGGCCGGATCGCCGAGGTGTTC
GTCGACCCCGAGCAGGTGCGCCGGCTCGAGGAAGCGGGCTCGGCCGCCGACGTCCGTGCGGTTCTCGGTGAGGTCCAGCC
GGTCTAG

Upstream 100 bases:

>100_bases
ATCACAGATTCGTCATGGCGCTCGTCACATTTCGGTGCGGGCCCTCGACGACCAGGCCCGACCAGCCTGCGCAGGCTGGA
GCCTCAGGAGGAAGAGCAGC

Downstream 100 bases:

>100_bases
CCGGAGAACCAGCCGCAGAACCGGCTAGAACACCAGGCGGACCAGGGCTGCTGCCAGGGCGGCGCCGAACACCACCACCA
GGAACGGCGCCCGCACCAGC

Product: phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2

Products: NA

Alternate protein names: EIICBA-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component; Mannitol-specific phosphotransferase enzyme IIA component; PTS system mannitol-specific EIIA component [H]

Number of amino acids: Translated: 668; Mature: 667

Protein sequence:

>668_residues
MATATQTPAERTSTRVHVQRFGTFLSNMVMPNIGAFIAWGLITAMFIEVGWLNLGGGDHGWLGPGSWVAHIGGWGDYAGG
GIVGPMITYLLPVLIGYTGGKMVYNDLVRGGVVGAIATFGVIAGTSVPMFMGAMIMGPLAGWSMKKIDSTWDGKIKPGFE
MLVDNFSAGIWGGILATFGFFALSDVLTWISDRLGDGVEFLVEHDLLPFASFVIEPAKVLFLNNALNHGVLTPLGLAESA
DSGKSILFLLEANPAAGIGLLLAYSIFGKGLAKASAPGAAIIHFFGGIHEVYFPFVLMKPKLILAMIAGGFTQILINVIF
SSGLRSPAAPGSVFAVYISAPTDLRNLTGVTLSILGGAAASFFVAAILLKTDKTIEAEDELVSATANMEAMKGKKSIASS
LVGSSTAHSGAITSIVFACDAGMGSSAMGASVLRKKIHGAGFTDVTVVNKAIANLTDSYDLVVTHQDLTDRARLKTGSAI
QVSVENFMGSPRYDEIVELVRERNGGAAPASVGSADAEEPALAGGLLADDAIVLDAPAGESRDAAITRAGELLLASGAAT
RAYVEAMHTREGSVSTAMGNLLAIPHGTNEAKTEVSRTALSFVRYPEPIDWNGKPVRYVVGIAAMGNEHLKLLGRIAEVF
VDPEQVRRLEEAGSAADVRAVLGEVQPV

Sequences:

>Translated_668_residues
MATATQTPAERTSTRVHVQRFGTFLSNMVMPNIGAFIAWGLITAMFIEVGWLNLGGGDHGWLGPGSWVAHIGGWGDYAGG
GIVGPMITYLLPVLIGYTGGKMVYNDLVRGGVVGAIATFGVIAGTSVPMFMGAMIMGPLAGWSMKKIDSTWDGKIKPGFE
MLVDNFSAGIWGGILATFGFFALSDVLTWISDRLGDGVEFLVEHDLLPFASFVIEPAKVLFLNNALNHGVLTPLGLAESA
DSGKSILFLLEANPAAGIGLLLAYSIFGKGLAKASAPGAAIIHFFGGIHEVYFPFVLMKPKLILAMIAGGFTQILINVIF
SSGLRSPAAPGSVFAVYISAPTDLRNLTGVTLSILGGAAASFFVAAILLKTDKTIEAEDELVSATANMEAMKGKKSIASS
LVGSSTAHSGAITSIVFACDAGMGSSAMGASVLRKKIHGAGFTDVTVVNKAIANLTDSYDLVVTHQDLTDRARLKTGSAI
QVSVENFMGSPRYDEIVELVRERNGGAAPASVGSADAEEPALAGGLLADDAIVLDAPAGESRDAAITRAGELLLASGAAT
RAYVEAMHTREGSVSTAMGNLLAIPHGTNEAKTEVSRTALSFVRYPEPIDWNGKPVRYVVGIAAMGNEHLKLLGRIAEVF
VDPEQVRRLEEAGSAADVRAVLGEVQPV
>Mature_667_residues
ATATQTPAERTSTRVHVQRFGTFLSNMVMPNIGAFIAWGLITAMFIEVGWLNLGGGDHGWLGPGSWVAHIGGWGDYAGGG
IVGPMITYLLPVLIGYTGGKMVYNDLVRGGVVGAIATFGVIAGTSVPMFMGAMIMGPLAGWSMKKIDSTWDGKIKPGFEM
LVDNFSAGIWGGILATFGFFALSDVLTWISDRLGDGVEFLVEHDLLPFASFVIEPAKVLFLNNALNHGVLTPLGLAESAD
SGKSILFLLEANPAAGIGLLLAYSIFGKGLAKASAPGAAIIHFFGGIHEVYFPFVLMKPKLILAMIAGGFTQILINVIFS
SGLRSPAAPGSVFAVYISAPTDLRNLTGVTLSILGGAAASFFVAAILLKTDKTIEAEDELVSATANMEAMKGKKSIASSL
VGSSTAHSGAITSIVFACDAGMGSSAMGASVLRKKIHGAGFTDVTVVNKAIANLTDSYDLVVTHQDLTDRARLKTGSAIQ
VSVENFMGSPRYDEIVELVRERNGGAAPASVGSADAEEPALAGGLLADDAIVLDAPAGESRDAAITRAGELLLASGAATR
AYVEAMHTREGSVSTAMGNLLAIPHGTNEAKTEVSRTALSFVRYPEPIDWNGKPVRYVVGIAAMGNEHLKLLGRIAEVFV
DPEQVRRLEEAGSAADVRAVLGEVQPV

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=661, Percent_Identity=47.0499243570348, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1789301, Length=491, Percent_Identity=44.1955193482688, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1788494, Length=128, Percent_Identity=36.71875, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 69731; Mature: 69600

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00052 RIBOSOMAL_S7 ; PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATATQTPAERTSTRVHVQRFGTFLSNMVMPNIGAFIAWGLITAMFIEVGWLNLGGGDHG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEECCCCCC
WLGPGSWVAHIGGWGDYAGGGIVGPMITYLLPVLIGYTGGKMVYNDLVRGGVVGAIATFG
CCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHH
VIAGTSVPMFMGAMIMGPLAGWSMKKIDSTWDGKIKPGFEMLVDNFSAGIWGGILATFGF
HHHCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHH
FALSDVLTWISDRLGDGVEFLVEHDLLPFASFVIEPAKVLFLNNALNHGVLTPLGLAESA
HHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHCCHHHEEECCCCCCCCCCCCCCCCCC
DSGKSILFLLEANPAAGIGLLLAYSIFGKGLAKASAPGAAIIHFFGGIHEVYFPFVLMKP
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHH
KLILAMIAGGFTQILINVIFSSGLRSPAAPGSVFAVYISAPTDLRNLTGVTLSILGGAAA
HHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHCCHHHHHHHHHHH
SFFVAAILLKTDKTIEAEDELVSATANMEAMKGKKSIASSLVGSSTAHSGAITSIVFACD
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEC
AGMGSSAMGASVLRKKIHGAGFTDVTVVNKAIANLTDSYDLVVTHQDLTDRARLKTGSAI
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCEE
QVSVENFMGSPRYDEIVELVRERNGGAAPASVGSADAEEPALAGGLLADDAIVLDAPAGE
EEEHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCEECCEEEEECCCCC
SRDAAITRAGELLLASGAATRAYVEAMHTREGSVSTAMGNLLAIPHGTNEAKTEVSRTAL
CCCHHHHHHCCEEEECCCHHHHHHHHHHCCCCCHHHHHCCEEECCCCCCHHHHHHHHHHH
SFVRYPEPIDWNGKPVRYVVGIAAMGNEHLKLLGRIAEVFVDPEQVRRLEEAGSAADVRA
HHHHCCCCCCCCCCCEEEEEEEHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHH
VLGEVQPV
HHHHCCCC
>Mature Secondary Structure 
ATATQTPAERTSTRVHVQRFGTFLSNMVMPNIGAFIAWGLITAMFIEVGWLNLGGGDHG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEECCCCCC
WLGPGSWVAHIGGWGDYAGGGIVGPMITYLLPVLIGYTGGKMVYNDLVRGGVVGAIATFG
CCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHH
VIAGTSVPMFMGAMIMGPLAGWSMKKIDSTWDGKIKPGFEMLVDNFSAGIWGGILATFGF
HHHCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHH
FALSDVLTWISDRLGDGVEFLVEHDLLPFASFVIEPAKVLFLNNALNHGVLTPLGLAESA
HHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHCCHHHEEECCCCCCCCCCCCCCCCCC
DSGKSILFLLEANPAAGIGLLLAYSIFGKGLAKASAPGAAIIHFFGGIHEVYFPFVLMKP
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHH
KLILAMIAGGFTQILINVIFSSGLRSPAAPGSVFAVYISAPTDLRNLTGVTLSILGGAAA
HHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHCCHHHHHHHHHHH
SFFVAAILLKTDKTIEAEDELVSATANMEAMKGKKSIASSLVGSSTAHSGAITSIVFACD
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEC
AGMGSSAMGASVLRKKIHGAGFTDVTVVNKAIANLTDSYDLVVTHQDLTDRARLKTGSAI
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCEE
QVSVENFMGSPRYDEIVELVRERNGGAAPASVGSADAEEPALAGGLLADDAIVLDAPAGE
EEEHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCEECCEEEEECCCCC
SRDAAITRAGELLLASGAATRAYVEAMHTREGSVSTAMGNLLAIPHGTNEAKTEVSRTAL
CCCHHHHHHCCEEEECCCHHHHHHHHHHCCCCCHHHHHCCEEECCCCCCHHHHHHHHHHH
SFVRYPEPIDWNGKPVRYVVGIAAMGNEHLKLLGRIAEVFVDPEQVRRLEEAGSAADVRA
HHHHCCCCCCCCCCCEEEEEEEHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHH
VLGEVQPV
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]