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The map label for this gene is murC

Identifier: 119717286

GI number: 119717286

Start: 3259082

End: 3260422

Strand: Reverse

Name: murC

Synonym: Noca_3062

Alternate gene names: 119717286

Gene position: 3260422-3259082 (Counterclockwise)

Preceding gene: 119717287

Following gene: 119717285

Centisome position: 65.39

GC content: 76.21

Gene sequence:

>1341_bases
ATGAGGCTGCCCGTCCCCGACCAGGTGCTGCCCGCCGACCGGCTCGGACGGGTGCACTTCGTCGGCATCGGTGGCGCCGG
CCTGTCCGGCATCGCCCGGATCATGCTGGCCCGCGGCATCACCGTCAGCGGCAGCGATGGCACCGACTCCCCGACGCTGA
CGGCCCTGCGCGAGCTGGGCGCCCGGGTGCACCTGGGCCACGACGCCGCCCACGTCCACGACGTCGACACCCTGGTCGTC
TCGACCGCGGTGCGCGAGGACAACCCGGAGTACGTCGAGGCCGTGCGCCAGGGCCTGCGCGTGCTGCCGCGATCGGCCGC
GCTGGCCGCCGTGATGGCCGGGCGGCGCGTGGTCGCCGTCGCCGGCACGCACGGCAAGACCACCACGACCTCCCTGCTCA
CGGTCGCGCTGCAGGCCGCCGGCGCGGACCCGACGTACGCCATCGGCGGTGACCTGGCTGCGACCGGTGTCAACGCCGCC
GAGGGCACCGGCGACCTGTTCGTCGCCGAGGCCGACGAGAGCGACGGAGCCTTCCTGCACTACTCGCCGTACGCCGCCGT
GGTCACCAACATCGAGGCCGACCACCTCGACCAGTGGGGCACGCCGGAGGCCTACGCCGCGGCGTTCGACGAGTTCGCCG
ACACCCTCGCGCCGGACGGCTTCCTGGTCTGCGTGGCCGACGATCCCGGTGCCGCGGCGCTCGCCGAGCGGCACCGCGCG
GCCGGGCGGCGGGTGGTGACCGTCTCCGCCCGCGACGCCGGCGCCCTGGACGGCGTGACCCTCTGGTCGCCGGGGGAGCA
CTACCTCGCCGACGCGCTGGCCGCGCTCGCCGCCGGCGTCGAGCTCGGGTACGCCGCCGCCGACCTGGCCCGCGGGCTCG
CGTCGTACACCGGGACCAAGCGGCGGATGGAGCGCAAGGGCGAGGCCGGGGGGGTGCGTGTCTACGACAGCTACGCCCAC
CACCCGACCGAGATCGCGGGGGACCTGCAGGCGGCCCGCGCCGTCGCCGGGTCCGGCCGGGTCGTCGTCGCCTTCCAGCC
GCACCTGGTCTCCCGGACCCGGATCTTCGGCACCGCGATGGGCCGGGCGCTCGGGGCGGCCGACGAGGTCGTGGTGCTCG
ACGTCTACCTCGCCCGCGAGGATCCCGACCCCGAGGTCACCGGCGCGCTGGTCGCCGGTGCGGTGCCGCTACCCGCGGAG
CGGGTCGCCTACGTCGCCGACTTCGACGCGGTGGCGGCGGAGCTGGTCGCCCGGGCCCGGCCCGGCGACCTGGTCCTGAC
CTTGGGCGCCGGAACCGTCACGGCGATCGGGCCCCGGGTGCTGGGGCTGCTGGATGGCTAG

Upstream 100 bases:

>100_bases
TGGCCGCGATGGGTGCCGCCGCGGCCGCGCTGATCCCGCGCGACGCCGACGAGCGGCTGGCCCGGATCGTGCTCGAGCTC
GGCCTCGGATCGTCCGCCCG

Downstream 100 bases:

>100_bases
CCGGATGCCTGGGCGCGACCCGGCCGACCGCAGCCGCCGGCGGTTCGCGCGCCGGCAGTGGGCGCGGCGCTGGCTGGCGT
GGCGGTACGTCGTCGCCGTG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MRLPVPDQVLPADRLGRVHFVGIGGAGLSGIARIMLARGITVSGSDGTDSPTLTALRELGARVHLGHDAAHVHDVDTLVV
STAVREDNPEYVEAVRQGLRVLPRSAALAAVMAGRRVVAVAGTHGKTTTTSLLTVALQAAGADPTYAIGGDLAATGVNAA
EGTGDLFVAEADESDGAFLHYSPYAAVVTNIEADHLDQWGTPEAYAAAFDEFADTLAPDGFLVCVADDPGAAALAERHRA
AGRRVVTVSARDAGALDGVTLWSPGEHYLADALAALAAGVELGYAAADLARGLASYTGTKRRMERKGEAGGVRVYDSYAH
HPTEIAGDLQAARAVAGSGRVVVAFQPHLVSRTRIFGTAMGRALGAADEVVVLDVYLAREDPDPEVTGALVAGAVPLPAE
RVAYVADFDAVAAELVARARPGDLVLTLGAGTVTAIGPRVLGLLDG

Sequences:

>Translated_446_residues
MRLPVPDQVLPADRLGRVHFVGIGGAGLSGIARIMLARGITVSGSDGTDSPTLTALRELGARVHLGHDAAHVHDVDTLVV
STAVREDNPEYVEAVRQGLRVLPRSAALAAVMAGRRVVAVAGTHGKTTTTSLLTVALQAAGADPTYAIGGDLAATGVNAA
EGTGDLFVAEADESDGAFLHYSPYAAVVTNIEADHLDQWGTPEAYAAAFDEFADTLAPDGFLVCVADDPGAAALAERHRA
AGRRVVTVSARDAGALDGVTLWSPGEHYLADALAALAAGVELGYAAADLARGLASYTGTKRRMERKGEAGGVRVYDSYAH
HPTEIAGDLQAARAVAGSGRVVVAFQPHLVSRTRIFGTAMGRALGAADEVVVLDVYLAREDPDPEVTGALVAGAVPLPAE
RVAYVADFDAVAAELVARARPGDLVLTLGAGTVTAIGPRVLGLLDG
>Mature_446_residues
MRLPVPDQVLPADRLGRVHFVGIGGAGLSGIARIMLARGITVSGSDGTDSPTLTALRELGARVHLGHDAAHVHDVDTLVV
STAVREDNPEYVEAVRQGLRVLPRSAALAAVMAGRRVVAVAGTHGKTTTTSLLTVALQAAGADPTYAIGGDLAATGVNAA
EGTGDLFVAEADESDGAFLHYSPYAAVVTNIEADHLDQWGTPEAYAAAFDEFADTLAPDGFLVCVADDPGAAALAERHRA
AGRRVVTVSARDAGALDGVTLWSPGEHYLADALAALAAGVELGYAAADLARGLASYTGTKRRMERKGEAGGVRVYDSYAH
HPTEIAGDLQAARAVAGSGRVVVAFQPHLVSRTRIFGTAMGRALGAADEVVVLDVYLAREDPDPEVTGALVAGAVPLPAE
RVAYVADFDAVAAELVARARPGDLVLTLGAGTVTAIGPRVLGLLDG

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=457, Percent_Identity=36.3238512035011, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1790680, Length=464, Percent_Identity=32.3275862068966, Blast_Score=182, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_NOCSJ (A1SL79)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_924251.1
- ProteinModelPortal:   A1SL79
- SMR:   A1SL79
- STRING:   A1SL79
- GeneID:   4600179
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_3062
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   A1SL79
- BioCyc:   NSP35761:NOCA_3062-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 45731; Mature: 45731

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLPVPDQVLPADRLGRVHFVGIGGAGLSGIARIMLARGITVSGSDGTDSPTLTALRELG
CCCCCCCCCCCHHHCCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHCC
ARVHLGHDAAHVHDVDTLVVSTAVREDNPEYVEAVRQGLRVLPRSAALAAVMAGRRVVAV
CEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEE
AGTHGKTTTTSLLTVALQAAGADPTYAIGGDLAATGVNAAEGTGDLFVAEADESDGAFLH
ECCCCCCHHHHHHHHHHHHCCCCCCEEECCCHHCCCCCCCCCCCCEEEEECCCCCCEEEE
YSPYAAVVTNIEADHLDQWGTPEAYAAAFDEFADTLAPDGFLVCVADDPGAAALAERHRA
ECCCEEEEECCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHH
AGRRVVTVSARDAGALDGVTLWSPGEHYLADALAALAAGVELGYAAADLARGLASYTGTK
CCCEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
RRMERKGEAGGVRVYDSYAHHPTEIAGDLQAARAVAGSGRVVVAFQPHLVSRTRIFGTAM
HHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHH
GRALGAADEVVVLDVYLAREDPDPEVTGALVAGAVPLPAERVAYVADFDAVAAELVARAR
HHHHCCCCCEEEEEEEEECCCCCCCHHHHHHCCCCCCCHHHEEEEHHHHHHHHHHHHHCC
PGDLVLTLGAGTVTAIGPRVLGLLDG
CCCEEEEECCCCEECCCCHHEEECCC
>Mature Secondary Structure
MRLPVPDQVLPADRLGRVHFVGIGGAGLSGIARIMLARGITVSGSDGTDSPTLTALRELG
CCCCCCCCCCCHHHCCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHCC
ARVHLGHDAAHVHDVDTLVVSTAVREDNPEYVEAVRQGLRVLPRSAALAAVMAGRRVVAV
CEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEE
AGTHGKTTTTSLLTVALQAAGADPTYAIGGDLAATGVNAAEGTGDLFVAEADESDGAFLH
ECCCCCCHHHHHHHHHHHHCCCCCCEEECCCHHCCCCCCCCCCCCEEEEECCCCCCEEEE
YSPYAAVVTNIEADHLDQWGTPEAYAAAFDEFADTLAPDGFLVCVADDPGAAALAERHRA
ECCCEEEEECCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHH
AGRRVVTVSARDAGALDGVTLWSPGEHYLADALAALAAGVELGYAAADLARGLASYTGTK
CCCEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
RRMERKGEAGGVRVYDSYAHHPTEIAGDLQAARAVAGSGRVVVAFQPHLVSRTRIFGTAM
HHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHH
GRALGAADEVVVLDVYLAREDPDPEVTGALVAGAVPLPAERVAYVADFDAVAAELVARAR
HHHHCCCCCEEEEEEEEECCCCCCCHHHHHHCCCCCCCHHHEEEEHHHHHHHHHHHHHCC
PGDLVLTLGAGTVTAIGPRVLGLLDG
CCCEEEEECCCCEECCCCHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA