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The map label for this gene is hisA

Identifier: 119717264

GI number: 119717264

Start: 3238570

End: 3239304

Strand: Reverse

Name: hisA

Synonym: Noca_3040

Alternate gene names: 119717264

Gene position: 3239304-3238570 (Counterclockwise)

Preceding gene: 119717265

Following gene: 119717263

Centisome position: 64.97

GC content: 74.01

Gene sequence:

>735_bases
ATGTCTGACTATCTCGAGCTCCTCCCCGCGGTCGACATCACCGAGGGCCGCGCCGTCCAGCTGGCCCAGGGGGTGGCCGG
CTCCGAGCGCACCTACGGCGACCCGGTGGCGGCCGCGATGCGCTGGCAGGAGGCCGGCGCGGAGTGGATCCACCTGGTCG
ACCTCGATGCGGCCTTCGGCCGCGGCTCCAACCGCGAGCTGCAGGCGGAGATCGTCGGCGCCCTCGATGTCCAGGTCGAG
ATGAGCGGCGGCATCCGCGACGACGAGTCGCTCGCGGCGGCGCTGGCCACCGGCTGCCGCCGGGTCAACATCGGCACCGC
GGCGCTCGAGCAGCCGGAGTGGTGTCGGCGGGTGATCGCCGAGCACGGGGACCGGGTCGCGATCGGCCTCGACGTACGCG
GTCGCACGCTCGCCGCCCGGGGCTGGACCAAGGACGGCGGGGACCTCTACGAGACGCTCGCGCGCCTGGACGCCGAGGGC
TGCGCGCGCTACGTCGTCACCGACGTCAACAAGGACGGCATGCTGCAGGGCCCGAACCTGCAGCTGCTGCGCGACGTCTG
CGCCGCCACGTCCGCCCCCGTGGTGGCCTCCGGGGGTGTGACGACGCTCGCCGACATCGAGGCGCTGATGGAGCTGGTCC
CGGTCGGGGTCGAGGGCGCGATCGCCGGCACCGCGCTCTACGAGGGCCGGTTCACGCTCGAGGACGCGCTGGCGCTGACG
CGCGGTGGCCGATGA

Upstream 100 bases:

>100_bases
CTTCGGCGAGTGGGAGATCCGGCTCGCCGCGTTCGTGGTCAGCGTGCTGACCGCCCCCGTGTTCCACACGATGCTGTTCC
GACGTACCTGAAGGGCACCC

Downstream 100 bases:

>100_bases
CGCTCGCCGTACGCGTCATCCCGTGCCTGGACGTGGACGCCGGGCGGGTGGTCAAGGGCATCAACTTCAAGGAGCTCCGC
GACGCCGGCGACCCCGTGGA

Product: phosphoribosyl isomerase A

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MSDYLELLPAVDITEGRAVQLAQGVAGSERTYGDPVAAAMRWQEAGAEWIHLVDLDAAFGRGSNRELQAEIVGALDVQVE
MSGGIRDDESLAAALATGCRRVNIGTAALEQPEWCRRVIAEHGDRVAIGLDVRGRTLAARGWTKDGGDLYETLARLDAEG
CARYVVTDVNKDGMLQGPNLQLLRDVCAATSAPVVASGGVTTLADIEALMELVPVGVEGAIAGTALYEGRFTLEDALALT
RGGR

Sequences:

>Translated_244_residues
MSDYLELLPAVDITEGRAVQLAQGVAGSERTYGDPVAAAMRWQEAGAEWIHLVDLDAAFGRGSNRELQAEIVGALDVQVE
MSGGIRDDESLAAALATGCRRVNIGTAALEQPEWCRRVIAEHGDRVAIGLDVRGRTLAARGWTKDGGDLYETLARLDAEG
CARYVVTDVNKDGMLQGPNLQLLRDVCAATSAPVVASGGVTTLADIEALMELVPVGVEGAIAGTALYEGRFTLEDALALT
RGGR
>Mature_243_residues
SDYLELLPAVDITEGRAVQLAQGVAGSERTYGDPVAAAMRWQEAGAEWIHLVDLDAAFGRGSNRELQAEIVGALDVQVEM
SGGIRDDESLAAALATGCRRVNIGTAALEQPEWCRRVIAEHGDRVAIGLDVRGRTLAARGWTKDGGDLYETLARLDAEGC
ARYVVTDVNKDGMLQGPNLQLLRDVCAATSAPVVASGGVTTLADIEALMELVPVGVEGAIAGTALYEGRFTLEDALALTR
GGR

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=241, Percent_Identity=34.0248962655602, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1788336, Length=236, Percent_Identity=25, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_NOCSJ (A1SL57)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_924229.1
- ProteinModelPortal:   A1SL57
- SMR:   A1SL57
- STRING:   A1SL57
- GeneID:   4596488
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_3040
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   CARYVVT
- PhylomeDB:   A1SL57
- ProtClustDB:   PRK14024
- BioCyc:   NSP35761:NOCA_3040-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR010188
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01919

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 25749; Mature: 25618

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: NA

Important sites: ACT_SITE 12-12 ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDYLELLPAVDITEGRAVQLAQGVAGSERTYGDPVAAAMRWQEAGAEWIHLVDLDAAFG
CCCHHHHHCCCCCCCCCEEEHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECHHHHC
RGSNRELQAEIVGALDVQVEMSGGIRDDESLAAALATGCRRVNIGTAALEQPEWCRRVIA
CCCCCEEHEEEEEEEEEEEEECCCCCCHHHHHHHHHHCCEEEECCHHHCCCHHHHHHHHH
EHGDRVAIGLDVRGRTLAARGWTKDGGDLYETLARLDAEGCARYVVTDVNKDGMLQGPNL
HCCCEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHCHHHHHEEEEEECCCCCCEECCCH
QLLRDVCAATSAPVVASGGVTTLADIEALMELVPVGVEGAIAGTALYEGRFTLEDALALT
HHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCEEHHEEECCCCCHHHHHHHH
RGGR
CCCC
>Mature Secondary Structure 
SDYLELLPAVDITEGRAVQLAQGVAGSERTYGDPVAAAMRWQEAGAEWIHLVDLDAAFG
CCHHHHHCCCCCCCCCEEEHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECHHHHC
RGSNRELQAEIVGALDVQVEMSGGIRDDESLAAALATGCRRVNIGTAALEQPEWCRRVIA
CCCCCEEHEEEEEEEEEEEEECCCCCCHHHHHHHHHHCCEEEECCHHHCCCHHHHHHHHH
EHGDRVAIGLDVRGRTLAARGWTKDGGDLYETLARLDAEGCARYVVTDVNKDGMLQGPNL
HCCCEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHCHHHHHEEEEEECCCCCCEECCCH
QLLRDVCAATSAPVVASGGVTTLADIEALMELVPVGVEGAIAGTALYEGRFTLEDALALT
HHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCEEHHEEECCCCCHHHHHHHH
RGGR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA