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The map label for this gene is dut [H]

Identifier: 119717132

GI number: 119717132

Start: 3090702

End: 3091148

Strand: Reverse

Name: dut [H]

Synonym: Noca_2908

Alternate gene names: 119717132

Gene position: 3091148-3090702 (Counterclockwise)

Preceding gene: 119717135

Following gene: 119717131

Centisome position: 62.0

GC content: 73.6

Gene sequence:

>447_bases
GTGACCAGCGACCTCGAGATCCCGGTGCAGCGGCTCGACCCGGGCCTCCCGCTGCCGGCGTACGCCCATCCCGGCGACGC
GGGCGCCGACCTGCTCACGACCGTGGACGTGACCCTGGCGCCGGGGGAGCGGGCGATGGTGCCGACCGGCATCGCGCTCG
CCCTGCCCGAGGGGTACGCCGCCTTCGTGCACCCGCGCTCCGGCCTCGCGGCCCGGCACGGGCTGTCGATCGTCAACACG
CCGGGCACCATCGACGCCGGCTACCGGGGCGAGATCAAGGTGATGCTGGTCAACCACGATCCGCGCGAGCCGATCGAGCT
GCGCCGCGGCGACCGGATCGCCCAGCTCGTCGTGCAGCGCGTCGAGCGCGCCCGGTTCACCGAGGTGGGGGAACTCCCCG
CTTCGGTCCGTGGTGCCGGGGGTTACGGTTCTACCGGTGGTTTCTGA

Upstream 100 bases:

>100_bases
CGCAGCGGCACGCCCAGGCGCTCGCTGTAGACGGGGGTGAGGGTCACGGGCGGAATCCTTCCATTCCTCGGCCGGGGGCC
GGGCGGTAGGGTCCCGCGAC

Downstream 100 bases:

>100_bases
TCCCGTCTGAGGAGTGCTCGTGAAGTTCCGTCGCAAGTCTGCCGACGCCGAGGCGGCGTCCGAGATCTCGGCCGGGTCCG
AGGCCGCGGACCTCGTCGTC

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 148; Mature: 147

Protein sequence:

>148_residues
MTSDLEIPVQRLDPGLPLPAYAHPGDAGADLLTTVDVTLAPGERAMVPTGIALALPEGYAAFVHPRSGLAARHGLSIVNT
PGTIDAGYRGEIKVMLVNHDPREPIELRRGDRIAQLVVQRVERARFTEVGELPASVRGAGGYGSTGGF

Sequences:

>Translated_148_residues
MTSDLEIPVQRLDPGLPLPAYAHPGDAGADLLTTVDVTLAPGERAMVPTGIALALPEGYAAFVHPRSGLAARHGLSIVNT
PGTIDAGYRGEIKVMLVNHDPREPIELRRGDRIAQLVVQRVERARFTEVGELPASVRGAGGYGSTGGF
>Mature_147_residues
TSDLEIPVQRLDPGLPLPAYAHPGDAGADLLTTVDVTLAPGERAMVPTGIALALPEGYAAFVHPRSGLAARHGLSIVNTP
GTIDAGYRGEIKVMLVNHDPREPIELRRGDRIAQLVVQRVERARFTEVGELPASVRGAGGYGSTGGF

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=142, Percent_Identity=40.8450704225352, Blast_Score=101, Evalue=2e-22,
Organism=Homo sapiens, GI4503423, Length=142, Percent_Identity=40.8450704225352, Blast_Score=100, Evalue=4e-22,
Organism=Homo sapiens, GI70906441, Length=142, Percent_Identity=40.8450704225352, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI1790071, Length=148, Percent_Identity=38.5135135135135, Blast_Score=96, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71988561, Length=146, Percent_Identity=41.0958904109589, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319729, Length=146, Percent_Identity=36.986301369863, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19921126, Length=120, Percent_Identity=37.5, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24583610, Length=120, Percent_Identity=37.5, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15587; Mature: 15456

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSDLEIPVQRLDPGLPLPAYAHPGDAGADLLTTVDVTLAPGERAMVPTGIALALPEGYA
CCCCCCCCHHHCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEECCCCCE
AFVHPRSGLAARHGLSIVNTPGTIDAGYRGEIKVMLVNHDPREPIELRRGDRIAQLVVQR
EEEECCCCCHHHCCCEEEECCCCCCCCCCCEEEEEEECCCCCCCHHHCCCCHHHHHHHHH
VERARFTEVGELPASVRGAGGYGSTGGF
HHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSDLEIPVQRLDPGLPLPAYAHPGDAGADLLTTVDVTLAPGERAMVPTGIALALPEGYA
CCCCCCCHHHCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEECCCCCE
AFVHPRSGLAARHGLSIVNTPGTIDAGYRGEIKVMLVNHDPREPIELRRGDRIAQLVVQR
EEEECCCCCHHHCCCEEEECCCCCCCCCCCEEEEEEECCCCCCCHHHCCCCHHHHHHHHH
VERARFTEVGELPASVRGAGGYGSTGGF
HHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]