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The map label for this gene is cobB [H]

Identifier: 119717111

GI number: 119717111

Start: 3068607

End: 3071018

Strand: Reverse

Name: cobB [H]

Synonym: Noca_2887

Alternate gene names: 119717111

Gene position: 3071018-3068607 (Counterclockwise)

Preceding gene: 119717112

Following gene: 119717110

Centisome position: 61.59

GC content: 72.14

Gene sequence:

>2412_bases
GTGGCGGCGCCATCGACCGGTCAAGGCAAGACGACCGTCGCGACGGGGCTGATGGCGGCCCTGCGCATCTCCGGCCACGA
GGTCAGCGGCCACAAGGTCGGGCCGGACTACATCGACCCCGGCTACCACGCCCTCGCCACCGGAAGACCCGGCCGCAACC
TCGACCCCCACCTGGTGGGGGAGGAGCGGATCGTCCCGTTGCTGCTCCACGGCGCGTGCGGCGCCGACATCGCGGTCATC
GAAGGCGTCATGGGCCTCTACGACGGCCGCCTCGGCACCGACGGCTTCGCCTCGACCGCTCACGTCGCGACGCTCACCCG
CTCACCCGTCGTGCTCGTCGTCGACGTGGCCCGGCTGTCTCGCACCGCGGCGGCGATCGCCGCAGGCATGGCGGCGTTCG
ACGACGGCCTCGAGATCGCCGGTGTCGTCCTCAACCGCACCGGCTCGGCAGCGAACGACGCCGAGATCGTGCGCGCCATG
GAGCGCACCGGGCTGCCCGTCCTCGGCCGCCTCCCTCGCAACGAGGATCTCGCCACACCGTCGCGCCACCTCGGCCTGGT
GCCCGCCGCCGAACGCGACGAGTCCGCCGCCATGCTGCACCGCCTCGGTGAGCAGGTCGCCGAGCACCTCGACCTCGACG
CAGTGCTGACGATCGCACGCGCCGCGCCAGAGCTTGACGCGGAACCGTGGGAACCGCACGCCGAGATCACGGCGGGTGGT
GACGGGCGACCGGTCATCGCGGTGGCCGGAGGCCGCGCCTTCACGTTCCGCTACGCCGAGACAGAGGAGCTGCTGCGGGC
CGCGGGCTGCGAGGTCGTCACCTTCGATCCGATCAGCGACCCGGCCCTTCCGCCGCGCACGCAGGGGATCTACCTCGGCG
GCGGGTTCCCCGAGGTCTACGCCGCAGAGCTCGCCGCCAACCGCCGCCTACTCGACGACCTGCGCGCCGCCGTCGACACG
GGTGTGCCGACGGTCGCCGAGTGCGCCGGCCTGCTCTACCTCGCCGAGACCCTCGATGGTGCACCGATGGCCGCCGCCCT
TCCGTTCACGGCTGCCATGAACGAGCGACTGACGCTGCGCTATCCCACGGCCACCGCAGCAACGGACTCGCTGCTCACCC
GGGTCGGTGAGAGGGTCACCGGTCACGAGTTCCACCGCACCCAGATCTCGCCCGCGAGCAGCATCCGGCCAGCGTGGACC
ATCGACGGCCTGCCGACCGGACACGCGACCGATATCGTGCACGCGTCGTACCTCCACGTCCATTGGGCCGGCCACCCGCG
ACTCGCCCAGCGCTTCGCTGACGCCGCACACCGCGCGGTGCCGCACGCCACCGAGCCGCGCGAGGCCGTTGCCGCCCGTG
ACCAACCGGCGACCGCGACGCCACGCCCGACCGAGCCCCTGCGCCACCACGGCGACGCCGAGACCGGGCCCGACCTGCTC
GACTTCGCCGTGAACGTGTACGACGCCCGACGGCCGCCGTGGCTCGACCACGCTCTCGCCATGTCGGTCGCAGAGGTCCA
GGCCTATCCCGACGCGACCCCGGCCGCTGCCGCGATCGCTCAACGGCACGGCCGCAAGCTCGACGAGATCCTCCCGACAG
CAGGGGCGGCTGAAGCCTTCAGCCTCATCGCACGACTCCGATCCTGGCAGAAGCCGGTCGTCATCCATCCGCAGTTCACC
GAGCCGCACGCCGCGCTCGAGCAGGCCGGCCACGAGGTCACCTCCGTGCTGTGCCGACCGGAGGACGGCTATTCACTCGA
CCCGGCAGCGGTTCCCGAGGATGCCGACCTCGTCATCGTCGGCAATCCCACGAACCCGACCGGCGTCCTGCACCAGGCGA
GCACGATCAGCCGACTGCGCCGCAAGGGCCGACTGGTCGTGGTCGACGAGGCGTTCATGGACGCCGTGCCCGGCGAGGCC
GAGTCCCTGATCCGCGAGCGGCTCCGCGACCTCGTCGTCATCCGAAGCCTCACCAAGCACTGGTCGATCCCAGGCATCCG
CGCCGGCTACGTGGTGGGTCACCGCCTCGTCATCAAGCACCTCGCCCGACGCCAGACCCCATGGTCGGTCTCGACCCCGG
CGATCGCGGCCATCCGTGCCTGCACGACGCGCGAGGCGGCGGCGGAGTCGCGAGAACGCGCCGTCGCCCTCGCGCGCTGG
CGCGACGTCCTGGAGGACGGTCTCCACGGGCGCGGCATCGAGACGGTTCCTTCGGATGCCTCCTTCGTCCTGGCCCGTGT
CGGCCGTGACGCCCACGCGCAGCTGCGTGCCCGAGGCATCGCCGTACGCCGCTGCGACACGTTCCCCGGACTCGACGCGA
GCTGGGTGCGCATCGCCGTGCGCCCACCCGCCACCACCCGCCACCTGCTCGAAGCCCTCGACCACATCCGTGCCCCGCAC
CTCACTCACTGA

Upstream 100 bases:

>100_bases
TCGCCGACCTCGTCACCGAGATGACGAAGATCAAGCACCCGATGGACGCCGGCCAGAAGGGCCAGAAGGGCATCGAGTGG
TGAGGCTGCCCCGCCTCGTG

Downstream 100 bases:

>100_bases
CAGGCCCCCGCGCATGCCCTACGTCTCCCCACCTTCCGACATCGCCCGCGACCACGCGACCAAGCGCCTCGCGGCTCTGG
CCACCCCACCCGGCGCGCTC

Product: cobyrinic acid a,c-diamide synthase

Products: 2-Oxoglutarate; L-Histidinol phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 803; Mature: 802

Protein sequence:

>803_residues
MAAPSTGQGKTTVATGLMAALRISGHEVSGHKVGPDYIDPGYHALATGRPGRNLDPHLVGEERIVPLLLHGACGADIAVI
EGVMGLYDGRLGTDGFASTAHVATLTRSPVVLVVDVARLSRTAAAIAAGMAAFDDGLEIAGVVLNRTGSAANDAEIVRAM
ERTGLPVLGRLPRNEDLATPSRHLGLVPAAERDESAAMLHRLGEQVAEHLDLDAVLTIARAAPELDAEPWEPHAEITAGG
DGRPVIAVAGGRAFTFRYAETEELLRAAGCEVVTFDPISDPALPPRTQGIYLGGGFPEVYAAELAANRRLLDDLRAAVDT
GVPTVAECAGLLYLAETLDGAPMAAALPFTAAMNERLTLRYPTATAATDSLLTRVGERVTGHEFHRTQISPASSIRPAWT
IDGLPTGHATDIVHASYLHVHWAGHPRLAQRFADAAHRAVPHATEPREAVAARDQPATATPRPTEPLRHHGDAETGPDLL
DFAVNVYDARRPPWLDHALAMSVAEVQAYPDATPAAAAIAQRHGRKLDEILPTAGAAEAFSLIARLRSWQKPVVIHPQFT
EPHAALEQAGHEVTSVLCRPEDGYSLDPAAVPEDADLVIVGNPTNPTGVLHQASTISRLRRKGRLVVVDEAFMDAVPGEA
ESLIRERLRDLVVIRSLTKHWSIPGIRAGYVVGHRLVIKHLARRQTPWSVSTPAIAAIRACTTREAAAESRERAVALARW
RDVLEDGLHGRGIETVPSDASFVLARVGRDAHAQLRARGIAVRRCDTFPGLDASWVRIAVRPPATTRHLLEALDHIRAPH
LTH

Sequences:

>Translated_803_residues
MAAPSTGQGKTTVATGLMAALRISGHEVSGHKVGPDYIDPGYHALATGRPGRNLDPHLVGEERIVPLLLHGACGADIAVI
EGVMGLYDGRLGTDGFASTAHVATLTRSPVVLVVDVARLSRTAAAIAAGMAAFDDGLEIAGVVLNRTGSAANDAEIVRAM
ERTGLPVLGRLPRNEDLATPSRHLGLVPAAERDESAAMLHRLGEQVAEHLDLDAVLTIARAAPELDAEPWEPHAEITAGG
DGRPVIAVAGGRAFTFRYAETEELLRAAGCEVVTFDPISDPALPPRTQGIYLGGGFPEVYAAELAANRRLLDDLRAAVDT
GVPTVAECAGLLYLAETLDGAPMAAALPFTAAMNERLTLRYPTATAATDSLLTRVGERVTGHEFHRTQISPASSIRPAWT
IDGLPTGHATDIVHASYLHVHWAGHPRLAQRFADAAHRAVPHATEPREAVAARDQPATATPRPTEPLRHHGDAETGPDLL
DFAVNVYDARRPPWLDHALAMSVAEVQAYPDATPAAAAIAQRHGRKLDEILPTAGAAEAFSLIARLRSWQKPVVIHPQFT
EPHAALEQAGHEVTSVLCRPEDGYSLDPAAVPEDADLVIVGNPTNPTGVLHQASTISRLRRKGRLVVVDEAFMDAVPGEA
ESLIRERLRDLVVIRSLTKHWSIPGIRAGYVVGHRLVIKHLARRQTPWSVSTPAIAAIRACTTREAAAESRERAVALARW
RDVLEDGLHGRGIETVPSDASFVLARVGRDAHAQLRARGIAVRRCDTFPGLDASWVRIAVRPPATTRHLLEALDHIRAPH
LTH
>Mature_802_residues
AAPSTGQGKTTVATGLMAALRISGHEVSGHKVGPDYIDPGYHALATGRPGRNLDPHLVGEERIVPLLLHGACGADIAVIE
GVMGLYDGRLGTDGFASTAHVATLTRSPVVLVVDVARLSRTAAAIAAGMAAFDDGLEIAGVVLNRTGSAANDAEIVRAME
RTGLPVLGRLPRNEDLATPSRHLGLVPAAERDESAAMLHRLGEQVAEHLDLDAVLTIARAAPELDAEPWEPHAEITAGGD
GRPVIAVAGGRAFTFRYAETEELLRAAGCEVVTFDPISDPALPPRTQGIYLGGGFPEVYAAELAANRRLLDDLRAAVDTG
VPTVAECAGLLYLAETLDGAPMAAALPFTAAMNERLTLRYPTATAATDSLLTRVGERVTGHEFHRTQISPASSIRPAWTI
DGLPTGHATDIVHASYLHVHWAGHPRLAQRFADAAHRAVPHATEPREAVAARDQPATATPRPTEPLRHHGDAETGPDLLD
FAVNVYDARRPPWLDHALAMSVAEVQAYPDATPAAAAIAQRHGRKLDEILPTAGAAEAFSLIARLRSWQKPVVIHPQFTE
PHAALEQAGHEVTSVLCRPEDGYSLDPAAVPEDADLVIVGNPTNPTGVLHQASTISRLRRKGRLVVVDEAFMDAVPGEAE
SLIRERLRDLVVIRSLTKHWSIPGIRAGYVVGHRLVIKHLARRQTPWSVSTPAIAAIRACTTREAAAESRERAVALARWR
DVLEDGLHGRGIETVPSDASFVLARVGRDAHAQLRARGIAVRRCDTFPGLDASWVRIAVRPPATTRHLLEALDHIRAPHL
TH

Specific function: Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1797

COG function: function code H; Cobyrinic acid a,c-diamide synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=300, Percent_Identity=26, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR004484
- InterPro:   IPR017929
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 2.6.1.9 [C]

Molecular weight: Translated: 85794; Mature: 85663

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAPSTGQGKTTVATGLMAALRISGHEVSGHKVGPDYIDPGYHALATGRPGRNLDPHLVG
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
EERIVPLLLHGACGADIAVIEGVMGLYDGRLGTDGFASTAHVATLTRSPVVLVVDVARLS
CCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHEECCCCEEEEEEHHHHH
RTAAAIAAGMAAFDDGLEIAGVVLNRTGSAANDAEIVRAMERTGLPVLGRLPRNEDLATP
HHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCC
SRHLGLVPAAERDESAAMLHRLGEQVAEHLDLDAVLTIARAAPELDAEPWEPHAEITAGG
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEECC
DGRPVIAVAGGRAFTFRYAETEELLRAAGCEVVTFDPISDPALPPRTQGIYLGGGFPEVY
CCCEEEEEECCCEEEEEECCHHHHHHHCCCCEEEECCCCCCCCCCCCCEEEECCCCHHHH
AAELAANRRLLDDLRAAVDTGVPTVAECAGLLYLAETLDGAPMAAALPFTAAMNERLTLR
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHCCHHHHCCCCEEEE
YPTATAATDSLLTRVGERVTGHEFHRTQISPASSIRPAWTIDGLPTGHATDIVHASYLHV
CCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCEEECCCCCCCHHHHEEEEEEEE
HWAGHPRLAQRFADAAHRAVPHATEPREAVAARDQPATATPRPTEPLRHHGDAETGPDLL
EECCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCHHH
DFAVNVYDARRPPWLDHALAMSVAEVQAYPDATPAAAAIAQRHGRKLDEILPTAGAAEAF
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHCCCCCHHHHH
SLIARLRSWQKPVVIHPQFTEPHAALEQAGHEVTSVLCRPEDGYSLDPAAVPEDADLVIV
HHHHHHHHCCCCEEEECCCCCHHHHHHHCCHHHHHHEECCCCCCCCCCCCCCCCCCEEEE
GNPTNPTGVLHQASTISRLRRKGRLVVVDEAFMDAVPGEAESLIRERLRDLVVIRSLTKH
CCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
WSIPGIRAGYVVGHRLVIKHLARRQTPWSVSTPAIAAIRACTTREAAAESRERAVALARW
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDVLEDGLHGRGIETVPSDASFVLARVGRDAHAQLRARGIAVRRCDTFPGLDASWVRIAV
HHHHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCEEEEECCCCCCCCCCEEEEEE
RPPATTRHLLEALDHIRAPHLTH
CCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AAPSTGQGKTTVATGLMAALRISGHEVSGHKVGPDYIDPGYHALATGRPGRNLDPHLVG
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
EERIVPLLLHGACGADIAVIEGVMGLYDGRLGTDGFASTAHVATLTRSPVVLVVDVARLS
CCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHEECCCCEEEEEEHHHHH
RTAAAIAAGMAAFDDGLEIAGVVLNRTGSAANDAEIVRAMERTGLPVLGRLPRNEDLATP
HHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCC
SRHLGLVPAAERDESAAMLHRLGEQVAEHLDLDAVLTIARAAPELDAEPWEPHAEITAGG
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEECC
DGRPVIAVAGGRAFTFRYAETEELLRAAGCEVVTFDPISDPALPPRTQGIYLGGGFPEVY
CCCEEEEEECCCEEEEEECCHHHHHHHCCCCEEEECCCCCCCCCCCCCEEEECCCCHHHH
AAELAANRRLLDDLRAAVDTGVPTVAECAGLLYLAETLDGAPMAAALPFTAAMNERLTLR
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHCCHHHHCCCCEEEE
YPTATAATDSLLTRVGERVTGHEFHRTQISPASSIRPAWTIDGLPTGHATDIVHASYLHV
CCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCEEECCCCCCCHHHHEEEEEEEE
HWAGHPRLAQRFADAAHRAVPHATEPREAVAARDQPATATPRPTEPLRHHGDAETGPDLL
EECCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCHHH
DFAVNVYDARRPPWLDHALAMSVAEVQAYPDATPAAAAIAQRHGRKLDEILPTAGAAEAF
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHCCCCCHHHHH
SLIARLRSWQKPVVIHPQFTEPHAALEQAGHEVTSVLCRPEDGYSLDPAAVPEDADLVIV
HHHHHHHHCCCCEEEECCCCCHHHHHHHCCHHHHHHEECCCCCCCCCCCCCCCCCCEEEE
GNPTNPTGVLHQASTISRLRRKGRLVVVDEAFMDAVPGEAESLIRERLRDLVVIRSLTKH
CCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
WSIPGIRAGYVVGHRLVIKHLARRQTPWSVSTPAIAAIRACTTREAAAESRERAVALARW
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDVLEDGLHGRGIETVPSDASFVLARVGRDAHAQLRARGIAVRRCDTFPGLDASWVRIAV
HHHHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCEEEEECCCCCCCCCCEEEEEE
RPPATTRHLLEALDHIRAPHLTH
CCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-Glutamate; 3-(Imidazol-4-yl)-2-oxopropyl phosphate [C]

Specific reaction: L-Glutamate + 3-(Imidazol-4-yl)-2-oxopropyl phosphate --> 2-Oxoglutarate + L-Histidinol phosphate [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA