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The map label for this gene is pgl [H]

Identifier: 119716762

GI number: 119716762

Start: 2703965

End: 2704690

Strand: Reverse

Name: pgl [H]

Synonym: Noca_2536

Alternate gene names: 119716762

Gene position: 2704690-2703965 (Counterclockwise)

Preceding gene: 119716763

Following gene: 119716761

Centisome position: 54.25

GC content: 75.21

Gene sequence:

>726_bases
ATGAGCGCCACGCCCCGGGTCGAGGTGCACCCCGACCGCGCTGCGTTGGCCACCGCCGTCGCGGGTGAGCTGCTCACCCG
GCTCGCCGACGCGCAGGCGGCCGGCGGGGTGCCCCAGATCGTCCTGACCGGCGGCACCATCGCCGAGGACATCCACCGCG
AGTTGGCCCGCCTGTCGCCCGCCTCGGAGGTCGACTGGTCCCAGGTGGTCGTGTGGTGGGGTGACGAGCGGTTCGTCCCG
CCCGACTCCCCCGACCGCAACGCCGGCCAGGCCCGTGCGGCCTTCCTCGACGCCGTCGGGGTCGACCCGGCGCGCGTGCA
CGAGATGCCCTCGACCGCAGACGCGGCCGACGTCGAGGCCGGTGCAGCGTCGTACGCCGCCGTGCTGAGCGAGCACGCCG
CCGACTTCGACGTGCTGATGCTCGGCATCGGGCCGGACGGCCACATCGCCTCACTGTTCCCGGGCTTCGCCCAGCTCGCC
GTGACCGATCGGGCCGCGGTCGGCGTGACCGGGTCGCCGAAGCCGCCACCGGAGCGGATCAGCCTGACCTTCCCGGTGCT
CAACCGGGCCCGCTCGGTCTGGTTCCTGGTCAGCGGTGACGGCAAGGCCGACGCCGTGGCCCGCGCCCTCGGTGGCGCCG
ACGTCCGCGACGTCCCGGCCGCGGGCGTCACCGGCCACGACGAGACGATCTGGTTCCTCGACCGCCCCGCCGCCTCCCGC
CTCTGA

Upstream 100 bases:

>100_bases
GCGATCTCCCCGAGCTGCTCGCCGAGGAGCTGCGCCGCCTGGACGAGGACGACATCTACGCCGAGACCGCGCGGGCCCTC
GTCACGATGGGTGATCGCGG

Downstream 100 bases:

>100_bases
CGTCGAGTCGGCGCATCCTGCCCGCGCCCAGCGCCCGAGTCGGCGCATCTTGCCCGCGTTATCCACAGGTGGCGAACTCG
CACGCCTACAGATCCTCGAT

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MSATPRVEVHPDRAALATAVAGELLTRLADAQAAGGVPQIVLTGGTIAEDIHRELARLSPASEVDWSQVVVWWGDERFVP
PDSPDRNAGQARAAFLDAVGVDPARVHEMPSTADAADVEAGAASYAAVLSEHAADFDVLMLGIGPDGHIASLFPGFAQLA
VTDRAAVGVTGSPKPPPERISLTFPVLNRARSVWFLVSGDGKADAVARALGGADVRDVPAAGVTGHDETIWFLDRPAASR
L

Sequences:

>Translated_241_residues
MSATPRVEVHPDRAALATAVAGELLTRLADAQAAGGVPQIVLTGGTIAEDIHRELARLSPASEVDWSQVVVWWGDERFVP
PDSPDRNAGQARAAFLDAVGVDPARVHEMPSTADAADVEAGAASYAAVLSEHAADFDVLMLGIGPDGHIASLFPGFAQLA
VTDRAAVGVTGSPKPPPERISLTFPVLNRARSVWFLVSGDGKADAVARALGGADVRDVPAAGVTGHDETIWFLDRPAASR
L
>Mature_240_residues
SATPRVEVHPDRAALATAVAGELLTRLADAQAAGGVPQIVLTGGTIAEDIHRELARLSPASEVDWSQVVVWWGDERFVPP
DSPDRNAGQARAAFLDAVGVDPARVHEMPSTADAADVEAGAASYAAVLSEHAADFDVLMLGIGPDGHIASLFPGFAQLAV
TDRAAVGVTGSPKPPPERISLTFPVLNRARSVWFLVSGDGKADAVARALGGADVRDVPAAGVTGHDETIWFLDRPAASRL

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912586, Length=242, Percent_Identity=35.5371900826446, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI52145310, Length=239, Percent_Identity=31.7991631799163, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115533058, Length=246, Percent_Identity=32.520325203252, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI115533060, Length=243, Percent_Identity=32.9218106995885, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321957, Length=247, Percent_Identity=28.7449392712551, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321687, Length=220, Percent_Identity=30.4545454545455, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324362, Length=178, Percent_Identity=32.5842696629214, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319918, Length=179, Percent_Identity=35.195530726257, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24641119, Length=206, Percent_Identity=35.4368932038835, Blast_Score=110, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900 [H]

Pfam domain/function: NA

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 25048; Mature: 24917

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATPRVEVHPDRAALATAVAGELLTRLADAQAAGGVPQIVLTGGTIAEDIHRELARLSP
CCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCC
ASEVDWSQVVVWWGDERFVPPDSPDRNAGQARAAFLDAVGVDPARVHEMPSTADAADVEA
CCCCCCEEEEEEECCCEECCCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCHHHC
GAASYAAVLSEHAADFDVLMLGIGPDGHIASLFPGFAQLAVTDRAAVGVTGSPKPPPERI
CHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHCCCHHHHEECCCEEECCCCCCCCCCCCE
SLTFPVLNRARSVWFLVSGDGKADAVARALGGADVRDVPAAGVTGHDETIWFLDRPAASR
EEEHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCHHCC
L
C
>Mature Secondary Structure 
SATPRVEVHPDRAALATAVAGELLTRLADAQAAGGVPQIVLTGGTIAEDIHRELARLSP
CCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCC
ASEVDWSQVVVWWGDERFVPPDSPDRNAGQARAAFLDAVGVDPARVHEMPSTADAADVEA
CCCCCCEEEEEEECCCEECCCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCHHHC
GAASYAAVLSEHAADFDVLMLGIGPDGHIASLFPGFAQLAVTDRAAVGVTGSPKPPPERI
CHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHCCCHHHHEECCCEEECCCCCCCCCCCCE
SLTFPVLNRARSVWFLVSGDGKADAVARALGGADVRDVPAAGVTGHDETIWFLDRPAASR
EEEHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCHHCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]