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The map label for this gene is fumC [H]

Identifier: 119715299

GI number: 119715299

Start: 1117666

End: 1119063

Strand: Reverse

Name: fumC [H]

Synonym: Noca_1059

Alternate gene names: 119715299

Gene position: 1119063-1117666 (Counterclockwise)

Preceding gene: 119715300

Following gene: 119715295

Centisome position: 22.44

GC content: 72.03

Gene sequence:

>1398_bases
ATGACCCTTGACGACACCGCGGACTTCCGCGTCGAGCACGACAGCATGGGCGAGGTCCGCGTCCCCGCGGACGCGCTCTG
GCGGGCCCAGACCCAGCGAGCGGTCGAGAACTTCCCGATCAGCGGCACGCCGATCGAGCCGGCGCTGATCCACGCCATCG
GCCGGGTGAAGGCGGCGGCGGCCACGGTGAACGCCGAGCTCGGGGTGCTCGACGGGGAGCAGGCGGAGGCGATCGTCGCG
GCCGCGAACGCGGTCGCGGAGGGGCGACACGACGGCGGGTTCCCCATCGACGTCTTCCAGACCGGCTCGGGCACCAGCTC
GAACATGAACGCCAACGAGGTGATCGCGACCCTCGCCCAGCGAGCCGGCACCGACGTGCACCCCAACGACCACGTCAACG
CCAGCCAGTCGAGCAACGACACGTTCCCGACCGCGATCCACGTGGCGTCGACGCTGGCGGTGACCGGCGACCTGCTGCCC
GGCCTGGCCGTCCTCCAGGCCAGCCTGCAGCGCAAGGCCGACGAGTTCGCCGGCCTGGTGAAGTCGGGGCGCACCCACCT
GATGGACGCCACGCCGGTGATGCTCGGGCAGGAGCTCGGCGGCTACGCCGCGACGGTGCGGTACGCCGCGGAGCGTCTCC
AGTCGGTGCTGCCGCGGGTGCGCGAGCTGCCCCTGGGCGGTACGGCGGTCGGCACCGGGATCAACACCCCGCCCGGGTTC
GCCGAGCGGGTGATCGCCGTACTCGGCGAGACGACCGGCGAGCCGTTCACCGAGGCCCGCGACCACTTCGAGGCGCAGGG
GACCCGCGACTCGCTGGTCGAGCTGAGCGGCGTGCTGCGCACGATCGCGGTCGGGCTGATCAAGATCTGCAACGACCTGC
GGTGGATGTCCTCCGGGCCGACGACCGGCCTCGCCGAGATCCACCTGCCCGACCTCCAGCCGGGGTCGAGCATCATGCCC
GGCAAGGTGAACCCGGTGCTGCCGGAGGCGACCCTGATGGTGTGCTTCCAGGTGATCGGCAACGACGCGGCCGTCACCGC
CGCCGGCGCGAGCGGCAGCTTCGAGCTCAACGTCGCGATGCCGGTCATCGCCCGCAACGTGCTGGAGTCCGCGCGCCTGC
TGGCCGCGTCGTCCCGGGTGCTGGCCGAGCGCTGCATCGACGGCATCACCGCGAACGCCGAGCGGATGCGGCAGTACGCC
GAGACCTCACCGTCCGTGGTGACGCCGCTGAACAAGCACATCGGCTACGAGGCCGCGGCCAAGGTGGCCAAGCGGGCGCT
CGCCGAGGGCGCGACGATCCGCGAGACCGTGATCGCGATGGGCTACGTCGAGCGCGGCGAGCTCACCGAGGCGCAGCTCG
ACGAGGCCCTCGACGTGGAGTCGATGACCCACCCCTGA

Upstream 100 bases:

>100_bases
ACTCGGTGTTCGGCAACGTCGAGGCGACGCCGTACGAGGTGCTGCTGCAGGACCGCGACGAGCAGTACTGGCTCTACGCG
GCGCGGGTAACGTCCGACGC

Downstream 100 bases:

>100_bases
CGGGGTCAGTACCAGCCGACGGCCTGGGAGTGGCCCCAGGCACCGCACGGGCTGCCGTAGCGGTCCTGGATGTAGCCGAG
GCCCCAGGTGATCTGGGTGA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MTLDDTADFRVEHDSMGEVRVPADALWRAQTQRAVENFPISGTPIEPALIHAIGRVKAAAATVNAELGVLDGEQAEAIVA
AANAVAEGRHDGGFPIDVFQTGSGTSSNMNANEVIATLAQRAGTDVHPNDHVNASQSSNDTFPTAIHVASTLAVTGDLLP
GLAVLQASLQRKADEFAGLVKSGRTHLMDATPVMLGQELGGYAATVRYAAERLQSVLPRVRELPLGGTAVGTGINTPPGF
AERVIAVLGETTGEPFTEARDHFEAQGTRDSLVELSGVLRTIAVGLIKICNDLRWMSSGPTTGLAEIHLPDLQPGSSIMP
GKVNPVLPEATLMVCFQVIGNDAAVTAAGASGSFELNVAMPVIARNVLESARLLAASSRVLAERCIDGITANAERMRQYA
ETSPSVVTPLNKHIGYEAAAKVAKRALAEGATIRETVIAMGYVERGELTEAQLDEALDVESMTHP

Sequences:

>Translated_465_residues
MTLDDTADFRVEHDSMGEVRVPADALWRAQTQRAVENFPISGTPIEPALIHAIGRVKAAAATVNAELGVLDGEQAEAIVA
AANAVAEGRHDGGFPIDVFQTGSGTSSNMNANEVIATLAQRAGTDVHPNDHVNASQSSNDTFPTAIHVASTLAVTGDLLP
GLAVLQASLQRKADEFAGLVKSGRTHLMDATPVMLGQELGGYAATVRYAAERLQSVLPRVRELPLGGTAVGTGINTPPGF
AERVIAVLGETTGEPFTEARDHFEAQGTRDSLVELSGVLRTIAVGLIKICNDLRWMSSGPTTGLAEIHLPDLQPGSSIMP
GKVNPVLPEATLMVCFQVIGNDAAVTAAGASGSFELNVAMPVIARNVLESARLLAASSRVLAERCIDGITANAERMRQYA
ETSPSVVTPLNKHIGYEAAAKVAKRALAEGATIRETVIAMGYVERGELTEAQLDEALDVESMTHP
>Mature_464_residues
TLDDTADFRVEHDSMGEVRVPADALWRAQTQRAVENFPISGTPIEPALIHAIGRVKAAAATVNAELGVLDGEQAEAIVAA
ANAVAEGRHDGGFPIDVFQTGSGTSSNMNANEVIATLAQRAGTDVHPNDHVNASQSSNDTFPTAIHVASTLAVTGDLLPG
LAVLQASLQRKADEFAGLVKSGRTHLMDATPVMLGQELGGYAATVRYAAERLQSVLPRVRELPLGGTAVGTGINTPPGFA
ERVIAVLGETTGEPFTEARDHFEAQGTRDSLVELSGVLRTIAVGLIKICNDLRWMSSGPTTGLAEIHLPDLQPGSSIMPG
KVNPVLPEATLMVCFQVIGNDAAVTAAGASGSFELNVAMPVIARNVLESARLLAASSRVLAERCIDGITANAERMRQYAE
TSPSVVTPLNKHIGYEAAAKVAKRALAEGATIRETVIAMGYVERGELTEAQLDEALDVESMTHP

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=470, Percent_Identity=50.4255319148936, Blast_Score=429, Evalue=1e-120,
Organism=Escherichia coli, GI1787896, Length=460, Percent_Identity=49.7826086956522, Blast_Score=430, Evalue=1e-122,
Organism=Escherichia coli, GI87082375, Length=468, Percent_Identity=42.3076923076923, Blast_Score=342, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI17553882, Length=470, Percent_Identity=48.936170212766, Blast_Score=420, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI32565146, Length=331, Percent_Identity=48.9425981873112, Blast_Score=314, Evalue=6e-86,
Organism=Saccharomyces cerevisiae, GI6324993, Length=470, Percent_Identity=47.2340425531915, Blast_Score=419, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24640179, Length=470, Percent_Identity=50.2127659574468, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24640177, Length=470, Percent_Identity=50.2127659574468, Blast_Score=447, Evalue=1e-125,
Organism=Drosophila melanogaster, GI78710009, Length=468, Percent_Identity=47.6495726495726, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24662684, Length=476, Percent_Identity=45.7983193277311, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24583245, Length=454, Percent_Identity=41.6299559471366, Blast_Score=345, Evalue=4e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 48786; Mature: 48654

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDDTADFRVEHDSMGEVRVPADALWRAQTQRAVENFPISGTPIEPALIHAIGRVKAAA
CCCCCCCCCEECCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
ATVNAELGVLDGEQAEAIVAAANAVAEGRHDGGFPIDVFQTGSGTSSNMNANEVIATLAQ
HHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHH
RAGTDVHPNDHVNASQSSNDTFPTAIHVASTLAVTGDLLPGLAVLQASLQRKADEFAGLV
HCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSGRTHLMDATPVMLGQELGGYAATVRYAAERLQSVLPRVRELPLGGTAVGTGINTPPGF
HCCCHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCH
AERVIAVLGETTGEPFTEARDHFEAQGTRDSLVELSGVLRTIAVGLIKICNDLRWMSSGP
HHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TTGLAEIHLPDLQPGSSIMPGKVNPVLPEATLMVCFQVIGNDAAVTAAGASGSFELNVAM
CCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEHH
PVIARNVLESARLLAASSRVLAERCIDGITANAERMRQYAETSPSVVTPLNKHIGYEAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEECCHHHHCCHHHHH
KVAKRALAEGATIRETVIAMGYVERGELTEAQLDEALDVESMTHP
HHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHCCCC
>Mature Secondary Structure 
TLDDTADFRVEHDSMGEVRVPADALWRAQTQRAVENFPISGTPIEPALIHAIGRVKAAA
CCCCCCCCEECCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
ATVNAELGVLDGEQAEAIVAAANAVAEGRHDGGFPIDVFQTGSGTSSNMNANEVIATLAQ
HHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHH
RAGTDVHPNDHVNASQSSNDTFPTAIHVASTLAVTGDLLPGLAVLQASLQRKADEFAGLV
HCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSGRTHLMDATPVMLGQELGGYAATVRYAAERLQSVLPRVRELPLGGTAVGTGINTPPGF
HCCCHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCH
AERVIAVLGETTGEPFTEARDHFEAQGTRDSLVELSGVLRTIAVGLIKICNDLRWMSSGP
HHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TTGLAEIHLPDLQPGSSIMPGKVNPVLPEATLMVCFQVIGNDAAVTAAGASGSFELNVAM
CCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEHH
PVIARNVLESARLLAASSRVLAERCIDGITANAERMRQYAETSPSVVTPLNKHIGYEAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEECCHHHHCCHHHHH
KVAKRALAEGATIRETVIAMGYVERGELTEAQLDEALDVESMTHP
HHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]