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The map label for this gene is 119715244

Identifier: 119715244

GI number: 119715244

Start: 1051979

End: 1053361

Strand: Direct

Name: 119715244

Synonym: Noca_1001

Alternate gene names: NA

Gene position: 1051979-1053361 (Clockwise)

Preceding gene: 119715243

Following gene: 119715245

Centisome position: 21.1

GC content: 74.48

Gene sequence:

>1383_bases
ATGAGCAGCCCGGTCCTGACGTTCCTGGGTGCGGCCGAGTCGGTGACCGGCAGCAAGTTCCTCGTGGACACCCACAGCTC
GCGCACGTTGGTCGACGCGGGGCTCTACCAGGGCCTGGCCGACCTGCGCCGCCGCAACTGGACGCCGTTCCCGGTCCCGG
CGTCCGGGCTCGGGTCGGTCGTGGTGACGCACGCGCACCTCGACCACTGCGGCTTCCTCCCGCGCCTGGTGAAGGAGGGC
TTCGACGGCCCGATCCTCTGCTCACCCGACACCGCGGAGCTCGTGGAGATCGTGCTGCGCGACAGCGCCCACCTGCAGGA
GGAGGACGCGCGCCAGGCCAACGCGGGCGGCTACTCCAAGCACCGTCCCGCGCTGCCGCTCTACGACCTCGAGGACGTCG
AGCGCACGCTGCCGCTCCTGACGCCGACGGACTTCGGGACCGCCGTCGACCTGGCCCCCGACGTCCGGGCGGAGCTGCGC
CCCGCCGGCCACATCCTGGGGTCGTCCACCGTGCTCCTCGACGCCGCCGGCCGGCGCACCCTGTTCAGCGGCGACCTCGG
CCGCGACCACCACCCGATCCTGCGTGCGCCCGCCGACCCACCCGCGGCACACGTGGTCGTCGTGGAGTCGACGTACGGCG
ACCGGCGCCACCCCGCCACCGACGCCGAGGTGCTCGCATCGGCCGTGCGCCGCACCATCGGCCGCGGTGGGACCGTGCTG
GTGCCGGCGTTCGCAGTCGACCGCACCGAGCTGGTGCTGCTCGAGCTGCACCGGCTGATGGAGGCCGGCGAGGTGCCGCG
GGTCCCGGTCCACCTCGACAGCCCGATGGCGTTGCGAGCCCTGACCGTCTACCGCGAAGCCCTCGACACCGGGTCCGTGC
AGCTGCGCCCCGACCTGGACCAGGTCCGCGCCGCCCTCGGCGCGATGCACGTCGATGCCGTCCCGGACGTGGCCGGGTCG
ATGCGGCTCAACCGGCCCGGAAAGCCCTGCATCGTGGTCTCGGCGTCGGGCATGGCCACCGGCGGCCGCGTCGTGCACCA
CCTCGCGCACCAGCTCCCGGACCCGCGCAACACCGTCGTGCTCACCGGCTACCAGGCCGTCGGCACCCGCGGGCGCCAGC
TCCTGGACGGCGCCCGCCAGGTGAAGATGCACGGGCGCTACGTGCCCGTCCGGGCCGAGATCGTCGATGTGCCGTACTTC
TCGGTGCACGCCGACGCCGACGACATCGTCGGCTGGCTGGGCCGCGCCCCCGAGCCGCCCGAGATCGTGTACGTCGTGCA
CGGCGAGCCGGCCGCCTCGGCGGCGCTGGCCCGGCGGATCACCGAGGACCTCGGCTGGCCGGCGGTGGTGCCGCGGCTCG
GCGAGCGGGTCCGGCTGGACTGA

Upstream 100 bases:

>100_bases
GACGGGCCGATGAGCGTGCGGGGCCGGGCCCAACGGGGCAGCCCGGCCCCGCCGGTCGGCGCACCGAGGGCGCCGGTCGA
CAACTGAGACGAGGTGCCAG

Downstream 100 bases:

>100_bases
GCCCGCGCGGCCGATGATGACCGTCGCCCGAGTCCGAGGGACCTTGGGCCCTGACCCCGAGACGAGCAGTGGGGGTTCCC
TTGACCCACGACCCACACGA

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MSSPVLTFLGAAESVTGSKFLVDTHSSRTLVDAGLYQGLADLRRRNWTPFPVPASGLGSVVVTHAHLDHCGFLPRLVKEG
FDGPILCSPDTAELVEIVLRDSAHLQEEDARQANAGGYSKHRPALPLYDLEDVERTLPLLTPTDFGTAVDLAPDVRAELR
PAGHILGSSTVLLDAAGRRTLFSGDLGRDHHPILRAPADPPAAHVVVVESTYGDRRHPATDAEVLASAVRRTIGRGGTVL
VPAFAVDRTELVLLELHRLMEAGEVPRVPVHLDSPMALRALTVYREALDTGSVQLRPDLDQVRAALGAMHVDAVPDVAGS
MRLNRPGKPCIVVSASGMATGGRVVHHLAHQLPDPRNTVVLTGYQAVGTRGRQLLDGARQVKMHGRYVPVRAEIVDVPYF
SVHADADDIVGWLGRAPEPPEIVYVVHGEPAASAALARRITEDLGWPAVVPRLGERVRLD

Sequences:

>Translated_460_residues
MSSPVLTFLGAAESVTGSKFLVDTHSSRTLVDAGLYQGLADLRRRNWTPFPVPASGLGSVVVTHAHLDHCGFLPRLVKEG
FDGPILCSPDTAELVEIVLRDSAHLQEEDARQANAGGYSKHRPALPLYDLEDVERTLPLLTPTDFGTAVDLAPDVRAELR
PAGHILGSSTVLLDAAGRRTLFSGDLGRDHHPILRAPADPPAAHVVVVESTYGDRRHPATDAEVLASAVRRTIGRGGTVL
VPAFAVDRTELVLLELHRLMEAGEVPRVPVHLDSPMALRALTVYREALDTGSVQLRPDLDQVRAALGAMHVDAVPDVAGS
MRLNRPGKPCIVVSASGMATGGRVVHHLAHQLPDPRNTVVLTGYQAVGTRGRQLLDGARQVKMHGRYVPVRAEIVDVPYF
SVHADADDIVGWLGRAPEPPEIVYVVHGEPAASAALARRITEDLGWPAVVPRLGERVRLD
>Mature_459_residues
SSPVLTFLGAAESVTGSKFLVDTHSSRTLVDAGLYQGLADLRRRNWTPFPVPASGLGSVVVTHAHLDHCGFLPRLVKEGF
DGPILCSPDTAELVEIVLRDSAHLQEEDARQANAGGYSKHRPALPLYDLEDVERTLPLLTPTDFGTAVDLAPDVRAELRP
AGHILGSSTVLLDAAGRRTLFSGDLGRDHHPILRAPADPPAAHVVVVESTYGDRRHPATDAEVLASAVRRTIGRGGTVLV
PAFAVDRTELVLLELHRLMEAGEVPRVPVHLDSPMALRALTVYREALDTGSVQLRPDLDQVRAALGAMHVDAVPDVAGSM
RLNRPGKPCIVVSASGMATGGRVVHHLAHQLPDPRNTVVLTGYQAVGTRGRQLLDGARQVKMHGRYVPVRAEIVDVPYFS
VHADADDIVGWLGRAPEPPEIVYVVHGEPAASAALARRITEDLGWPAVVPRLGERVRLD

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=465, Percent_Identity=26.8817204301075, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI7706427, Length=434, Percent_Identity=24.6543778801843, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI32566029, Length=469, Percent_Identity=27.5053304904051, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI32564696, Length=460, Percent_Identity=25, Blast_Score=135, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6323307, Length=438, Percent_Identity=24.4292237442922, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24648013, Length=434, Percent_Identity=24.8847926267281, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21358523, Length=459, Percent_Identity=24.1830065359477, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 49448; Mature: 49317

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPVLTFLGAAESVTGSKFLVDTHSSRTLVDAGLYQGLADLRRRNWTPFPVPASGLGSV
CCCCCEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
VVTHAHLDHCGFLPRLVKEGFDGPILCSPDTAELVEIVLRDSAHLQEEDARQANAGGYSK
EEEEEHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCCC
HRPALPLYDLEDVERTLPLLTPTDFGTAVDLAPDVRAELRPAGHILGSSTVLLDAAGRRT
CCCCCCCCCHHHHHHHCCCCCCCCCCCEEECCCCHHHHCCCCHHHCCCCEEEEECCCCCE
LFSGDLGRDHHPILRAPADPPAAHVVVVESTYGDRRHPATDAEVLASAVRRTIGRGGTVL
EEECCCCCCCCCEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
VPAFAVDRTELVLLELHRLMEAGEVPRVPVHLDSPMALRALTVYREALDTGSVQLRPDLD
EEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEECCCHH
QVRAALGAMHVDAVPDVAGSMRLNRPGKPCIVVSASGMATGGRVVHHLAHQLPDPRNTVV
HHHHHHHHHHHCCCCCCCCCCEECCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCEEE
LTGYQAVGTRGRQLLDGARQVKMHGRYVPVRAEIVDVPYFSVHADADDIVGWLGRAPEPP
EECCHHHCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCEEEEECCHHHHHHHHCCCCCCC
EIVYVVHGEPAASAALARRITEDLGWPAVVPRLGERVRLD
CEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCC
>Mature Secondary Structure 
SSPVLTFLGAAESVTGSKFLVDTHSSRTLVDAGLYQGLADLRRRNWTPFPVPASGLGSV
CCCCEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
VVTHAHLDHCGFLPRLVKEGFDGPILCSPDTAELVEIVLRDSAHLQEEDARQANAGGYSK
EEEEEHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCCC
HRPALPLYDLEDVERTLPLLTPTDFGTAVDLAPDVRAELRPAGHILGSSTVLLDAAGRRT
CCCCCCCCCHHHHHHHCCCCCCCCCCCEEECCCCHHHHCCCCHHHCCCCEEEEECCCCCE
LFSGDLGRDHHPILRAPADPPAAHVVVVESTYGDRRHPATDAEVLASAVRRTIGRGGTVL
EEECCCCCCCCCEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
VPAFAVDRTELVLLELHRLMEAGEVPRVPVHLDSPMALRALTVYREALDTGSVQLRPDLD
EEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEECCCHH
QVRAALGAMHVDAVPDVAGSMRLNRPGKPCIVVSASGMATGGRVVHHLAHQLPDPRNTVV
HHHHHHHHHHHCCCCCCCCCCEECCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCEEE
LTGYQAVGTRGRQLLDGARQVKMHGRYVPVRAEIVDVPYFSVHADADDIVGWLGRAPEPP
EECCHHHCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCEEEEECCHHHHHHHHCCCCCCC
EIVYVVHGEPAASAALARRITEDLGWPAVVPRLGERVRLD
CEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA