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The map label for this gene is cbs [H]

Identifier: 119715184

GI number: 119715184

Start: 985091

End: 986479

Strand: Direct

Name: cbs [H]

Synonym: Noca_0939

Alternate gene names: 119715184

Gene position: 985091-986479 (Clockwise)

Preceding gene: 119715182

Following gene: 119715185

Centisome position: 19.76

GC content: 71.35

Gene sequence:

>1389_bases
GTGAACTCACTCCTCGACCTGATCGGCAACACCCCGCTGCTGAGGCTCTCGACGTCCATGGGCTCCCTGAACGGCGCGAA
GGGACCGATCGTCCTCGCCAAGGTGGAGTACCTCAACCCCGGCGGCTCCGTGAAGGACCGCATCGCCACCCGGATGATCG
AGGCGGCCGAGGCGTCCGGGGAGCTTCAGCCCGGCGGCACCATCGTCGAGCCGACGTCCGGCAACACCGGCGTCGGGCTG
GCGATGGTCGCCCAGGCGAAGGGCTACAGGTGCGTCTTCGTCTGCCCGGACAAGGTCAGCGAGGACAAGCGCAACGTGCT
GAAGGCGTACGGCGCGGAGGTGGTCGTCTGCCCGACCGCGGTCGAGCCGGAGCACCCCGACTCCTACTACAACGTCTCCG
ACCGGCTCGCCTCGCAGCCGGGTGCCTGGAAGCCGGACCAGTACTCCAACCCGCACAACCCGCGGTCGCACTACGAGACG
ACCGGCCCGGAGATCTGGGCGCAGACCGAGGGGCGGGTCACCCACTTCGTCGCCGGCGTCGGCACCGGCGGCACCATCAG
CGGCACCGGGCGCTACCTCAAGGAGCAGAACTCCTCGGTCCAGGTCATCGGGGCCGACCCGGCGGGCTCGGTCTACTCCG
GCGGCACCGGCCGGCCCTACCTCGTCGAGGGAGTGGGCGAGGACTTCTGGCCGGAGGCCTACGATCGCGACGTCGCCGAC
CGGATCATCGAGGTCTCCGACGCCGACTCGTTCGCGATGACGCGGCGGCTGGCCCGCGAGGAGGCCCTGCTGGTCGGCGG
TTCCTCCGGCATGGCCGTGCACGCGGCGGTCCAGCTCGCCCACGAGCTCGCCGGCACCCCCGAGGGCGAGGACGCGGTGA
TCGTCGTACTCCTCCCGGACTCCGGCCGCGGCTACCTCACGAAGGTCTTCAACGACGACTGGCTCGCGCAGTACGGATTC
CCGGTCGACGGCGCCGAGCGCTCCGTGCAGTCCGTCGGGGAGGTGCTCCGCGGCAAGAGCGGGCGGCTGCCCGACCTCGT
GCACACCCACCCGAACGAGACCATCGCCGAAGCCGTCGCGATCCTCCAGGAGTACAACGTCTCCCAGATGCCGGTCGTGC
GCGCGGAGCCTCCGGTGGTGGCCGCCGAGGTCGTCGGATCGGTCTCCGAGCGGACCCTGCTCGACCTGCTGTTCACCGGC
TCGGCCAAGCTCACCGACAGCGTCGGCGAGCACATGGCGCCCCCGCTGCCGACGATCGGCTCCACCGAGCCCGCCTCCGA
GGCCGTCGCCGCACTCGAGGGCGCCGACGCCCTGTTGGTGCACGAGGACGGCAAGCCCGTCGGCGTCGTCACCCGCCACG
ACCTGCTGGCCTACCTCGCGCGCGGCTGA

Upstream 100 bases:

>100_bases
CGGCTTTACCCACGCCGTCACTCTACGGACGCCGGCCAGCGCGGACGCCCGGGGTTTACGAGAAGGTGCGGACCGCCCCT
AGATTGGCCGGGTGCAGTAC

Downstream 100 bases:

>100_bases
GTCAGTTGGCTGCGGGGTTCGGCTGCTGGCAGCCGAACCCCGAAGCTGCGTCACCGCCTATAGTGAGAACACGTTCTAGT
TCTCAGGAGGGCTGATGACG

Product: cystathionine beta-synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MNSLLDLIGNTPLLRLSTSMGSLNGAKGPIVLAKVEYLNPGGSVKDRIATRMIEAAEASGELQPGGTIVEPTSGNTGVGL
AMVAQAKGYRCVFVCPDKVSEDKRNVLKAYGAEVVVCPTAVEPEHPDSYYNVSDRLASQPGAWKPDQYSNPHNPRSHYET
TGPEIWAQTEGRVTHFVAGVGTGGTISGTGRYLKEQNSSVQVIGADPAGSVYSGGTGRPYLVEGVGEDFWPEAYDRDVAD
RIIEVSDADSFAMTRRLAREEALLVGGSSGMAVHAAVQLAHELAGTPEGEDAVIVVLLPDSGRGYLTKVFNDDWLAQYGF
PVDGAERSVQSVGEVLRGKSGRLPDLVHTHPNETIAEAVAILQEYNVSQMPVVRAEPPVVAAEVVGSVSERTLLDLLFTG
SAKLTDSVGEHMAPPLPTIGSTEPASEAVAALEGADALLVHEDGKPVGVVTRHDLLAYLARG

Sequences:

>Translated_462_residues
MNSLLDLIGNTPLLRLSTSMGSLNGAKGPIVLAKVEYLNPGGSVKDRIATRMIEAAEASGELQPGGTIVEPTSGNTGVGL
AMVAQAKGYRCVFVCPDKVSEDKRNVLKAYGAEVVVCPTAVEPEHPDSYYNVSDRLASQPGAWKPDQYSNPHNPRSHYET
TGPEIWAQTEGRVTHFVAGVGTGGTISGTGRYLKEQNSSVQVIGADPAGSVYSGGTGRPYLVEGVGEDFWPEAYDRDVAD
RIIEVSDADSFAMTRRLAREEALLVGGSSGMAVHAAVQLAHELAGTPEGEDAVIVVLLPDSGRGYLTKVFNDDWLAQYGF
PVDGAERSVQSVGEVLRGKSGRLPDLVHTHPNETIAEAVAILQEYNVSQMPVVRAEPPVVAAEVVGSVSERTLLDLLFTG
SAKLTDSVGEHMAPPLPTIGSTEPASEAVAALEGADALLVHEDGKPVGVVTRHDLLAYLARG
>Mature_462_residues
MNSLLDLIGNTPLLRLSTSMGSLNGAKGPIVLAKVEYLNPGGSVKDRIATRMIEAAEASGELQPGGTIVEPTSGNTGVGL
AMVAQAKGYRCVFVCPDKVSEDKRNVLKAYGAEVVVCPTAVEPEHPDSYYNVSDRLASQPGAWKPDQYSNPHNPRSHYET
TGPEIWAQTEGRVTHFVAGVGTGGTISGTGRYLKEQNSSVQVIGADPAGSVYSGGTGRPYLVEGVGEDFWPEAYDRDVAD
RIIEVSDADSFAMTRRLAREEALLVGGSSGMAVHAAVQLAHELAGTPEGEDAVIVVLLPDSGRGYLTKVFNDDWLAQYGF
PVDGAERSVQSVGEVLRGKSGRLPDLVHTHPNETIAEAVAILQEYNVSQMPVVRAEPPVVAAEVVGSVSERTLLDLLFTG
SAKLTDSVGEHMAPPLPTIGSTEPASEAVAALEGADALLVHEDGKPVGVVTRHDLLAYLARG

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=477, Percent_Identity=39.832285115304, Blast_Score=296, Evalue=4e-80,
Organism=Homo sapiens, GI295821200, Length=477, Percent_Identity=39.832285115304, Blast_Score=296, Evalue=4e-80,
Organism=Homo sapiens, GI4557415, Length=477, Percent_Identity=39.832285115304, Blast_Score=296, Evalue=4e-80,
Organism=Escherichia coli, GI2367138, Length=319, Percent_Identity=39.1849529780564, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI1788754, Length=322, Percent_Identity=40.9937888198758, Blast_Score=181, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17534315, Length=330, Percent_Identity=43.9393939393939, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17562970, Length=323, Percent_Identity=42.1052631578947, Blast_Score=228, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI17535051, Length=306, Percent_Identity=42.483660130719, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI32566674, Length=303, Percent_Identity=43.2343234323432, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI115535073, Length=330, Percent_Identity=42.1212121212121, Blast_Score=217, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI25147552, Length=328, Percent_Identity=40.5487804878049, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17561720, Length=334, Percent_Identity=38.622754491018, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI32566672, Length=232, Percent_Identity=40.5172413793103, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71996324, Length=311, Percent_Identity=23.1511254019293, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321594, Length=501, Percent_Identity=37.3253493013972, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6321449, Length=338, Percent_Identity=36.094674556213, Blast_Score=153, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24643623, Length=483, Percent_Identity=37.0600414078675, Blast_Score=258, Evalue=7e-69,
Organism=Drosophila melanogaster, GI20129101, Length=483, Percent_Identity=37.0600414078675, Blast_Score=258, Evalue=7e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 48730; Mature: 48730

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSLLDLIGNTPLLRLSTSMGSLNGAKGPIVLAKVEYLNPGGSVKDRIATRMIEAAEASG
CCHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCC
ELQPGGTIVEPTSGNTGVGLAMVAQAKGYRCVFVCPDKVSEDKRNVLKAYGAEVVVCPTA
CCCCCCEEEECCCCCCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCC
VEPEHPDSYYNVSDRLASQPGAWKPDQYSNPHNPRSHYETTGPEIWAQTEGRVTHFVAGV
CCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEC
GTGGTISGTGRYLKEQNSSVQVIGADPAGSVYSGGTGRPYLVEGVGEDFWPEAYDRDVAD
CCCCCCCCCCHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCHHCCCHHH
RIIEVSDADSFAMTRRLAREEALLVGGSSGMAVHAAVQLAHELAGTPEGEDAVIVVLLPD
HHEECCCCHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECC
SGRGYLTKVFNDDWLAQYGFPVDGAERSVQSVGEVLRGKSGRLPDLVHTHPNETIAEAVA
CCCCEEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHH
ILQEYNVSQMPVVRAEPPVVAAEVVGSVSERTLLDLLFTGSAKLTDSVGEHMAPPLPTIG
HHHHCCCCCCCEEECCCCEEHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCC
STEPASEAVAALEGADALLVHEDGKPVGVVTRHDLLAYLARG
CCCCHHHHHHHHCCCCEEEEECCCCCEEEEEHHHHHHHHHCC
>Mature Secondary Structure
MNSLLDLIGNTPLLRLSTSMGSLNGAKGPIVLAKVEYLNPGGSVKDRIATRMIEAAEASG
CCHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCC
ELQPGGTIVEPTSGNTGVGLAMVAQAKGYRCVFVCPDKVSEDKRNVLKAYGAEVVVCPTA
CCCCCCEEEECCCCCCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCC
VEPEHPDSYYNVSDRLASQPGAWKPDQYSNPHNPRSHYETTGPEIWAQTEGRVTHFVAGV
CCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEC
GTGGTISGTGRYLKEQNSSVQVIGADPAGSVYSGGTGRPYLVEGVGEDFWPEAYDRDVAD
CCCCCCCCCCHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCHHCCCHHH
RIIEVSDADSFAMTRRLAREEALLVGGSSGMAVHAAVQLAHELAGTPEGEDAVIVVLLPD
HHEECCCCHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECC
SGRGYLTKVFNDDWLAQYGFPVDGAERSVQSVGEVLRGKSGRLPDLVHTHPNETIAEAVA
CCCCEEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHH
ILQEYNVSQMPVVRAEPPVVAAEVVGSVSERTLLDLLFTGSAKLTDSVGEHMAPPLPTIG
HHHHCCCCCCCEEECCCCEEHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCC
STEPASEAVAALEGADALLVHEDGKPVGVVTRHDLLAYLARG
CCCCHHHHHHHHCCCCEEEEECCCCCEEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]