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The map label for this gene is ribA [H]

Identifier: 119715111

GI number: 119715111

Start: 904854

End: 905501

Strand: Direct

Name: ribA [H]

Synonym: Noca_0866

Alternate gene names: 119715111

Gene position: 904854-905501 (Clockwise)

Preceding gene: 119715110

Following gene: 119715112

Centisome position: 18.15

GC content: 72.84

Gene sequence:

>648_bases
ATGAGGCCGGCCACCGGGGAGGTGCCCGTCCGGGTGCGTGCCGAGATCGACCTGACGATGGCGGCCGGCGGCCGGACCCT
CCCGGGCCGGGTACACACGTTCACCGGGCTGCCCGGCGCCGAGGAGCACCTGGTCGTCGCGGTCGGGCCCTACCGGCGGC
CGCGAGGCGGCGTGCCGCTGGTTCGGCTCCACTCCGAGTGCCTGACCGGGGACGTCTTCGGCTCCCGGCGCTGCGACTGC
GGACCGCAGCTCGACGAGGCGCTCGTCCGGATCGCCGAGCACGGCGGCTACCTGGTCTATCTGCGCCAGGAGGGCCGAGG
CATCGGTCTCTACGCCAAGCTCGACGCCTACCGGCTCCAGGATCAGGGGCTCGACACGTTCGAGGCGAACCGGGCGCTCG
GCTACCCCGAGGACGCTCGGGGGTACGAGGTGGCCGGCCGGATGCTGCGGGCTCTCGACGTGTTGCAGGTGGACCTGATG
ACCGGCAACCCGCAGAAGGCCGCAGGGCTCGCCGCCGGTGGGGTCGCCGTACGACGAACCTTGCCTACCGCGCTGCACGA
GACGACCGAGAACCTCCGCTACCTGCACGCCAAGCGGCGGCGCGGCTTCCGGTTCGCCGGGGACCACGGGTCGTTGAGCG
TCTCGTGA

Upstream 100 bases:

>100_bases
TGGACGACCTCGACTCGCTCGCCGCCGTCCTGGATGGACGCTGCGGTCGGCACACGCGGGCGGCCGCGGCGCGCCTGGGC
CCGGCGCTGGAGGCTGTGGG

Downstream 100 bases:

>100_bases
GGACGGCCGGGATCGGGTGCTGTGGGGCCATGCGAACGCCGAGCTCACGACCGGGGTGACCGGTGCGGCACGGGGCTCAG
GTCAGCCGCGCGTCGGCAGC

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MRPATGEVPVRVRAEIDLTMAAGGRTLPGRVHTFTGLPGAEEHLVVAVGPYRRPRGGVPLVRLHSECLTGDVFGSRRCDC
GPQLDEALVRIAEHGGYLVYLRQEGRGIGLYAKLDAYRLQDQGLDTFEANRALGYPEDARGYEVAGRMLRALDVLQVDLM
TGNPQKAAGLAAGGVAVRRTLPTALHETTENLRYLHAKRRRGFRFAGDHGSLSVS

Sequences:

>Translated_215_residues
MRPATGEVPVRVRAEIDLTMAAGGRTLPGRVHTFTGLPGAEEHLVVAVGPYRRPRGGVPLVRLHSECLTGDVFGSRRCDC
GPQLDEALVRIAEHGGYLVYLRQEGRGIGLYAKLDAYRLQDQGLDTFEANRALGYPEDARGYEVAGRMLRALDVLQVDLM
TGNPQKAAGLAAGGVAVRRTLPTALHETTENLRYLHAKRRRGFRFAGDHGSLSVS
>Mature_215_residues
MRPATGEVPVRVRAEIDLTMAAGGRTLPGRVHTFTGLPGAEEHLVVAVGPYRRPRGGVPLVRLHSECLTGDVFGSRRCDC
GPQLDEALVRIAEHGGYLVYLRQEGRGIGLYAKLDAYRLQDQGLDTFEANRALGYPEDARGYEVAGRMLRALDVLQVDLM
TGNPQKAAGLAAGGVAVRRTLPTALHETTENLRYLHAKRRRGFRFAGDHGSLSVS

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=170, Percent_Identity=43.5294117647059, Blast_Score=131, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6319438, Length=119, Percent_Identity=49.5798319327731, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 23370; Mature: 23370

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPATGEVPVRVRAEIDLTMAAGGRTLPGRVHTFTGLPGAEEHLVVAVGPYRRPRGGVPL
CCCCCCCCCEEEEEEEEEEEECCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCE
VRLHSECLTGDVFGSRRCDCGPQLDEALVRIAEHGGYLVYLRQEGRGIGLYAKLDAYRLQ
EEEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCEEEEEEECCEEEHH
DQGLDTFEANRALGYPEDARGYEVAGRMLRALDVLQVDLMTGNPQKAAGLAAGGVAVRRT
CCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCHHCCEECCCCHHHHH
LPTALHETTENLRYLHAKRRRGFRFAGDHGSLSVS
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEC
>Mature Secondary Structure
MRPATGEVPVRVRAEIDLTMAAGGRTLPGRVHTFTGLPGAEEHLVVAVGPYRRPRGGVPL
CCCCCCCCCEEEEEEEEEEEECCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCE
VRLHSECLTGDVFGSRRCDCGPQLDEALVRIAEHGGYLVYLRQEGRGIGLYAKLDAYRLQ
EEEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCEEEEEEECCEEEHH
DQGLDTFEANRALGYPEDARGYEVAGRMLRALDVLQVDLMTGNPQKAAGLAAGGVAVRRT
CCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCHHCCEECCCCHHHHH
LPTALHETTENLRYLHAKRRRGFRFAGDHGSLSVS
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA