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The map label for this gene is folP1 [H]

Identifier: 119714886

GI number: 119714886

Start: 675751

End: 676617

Strand: Reverse

Name: folP1 [H]

Synonym: Noca_0638

Alternate gene names: 119714886

Gene position: 676617-675751 (Counterclockwise)

Preceding gene: 119714887

Following gene: 119714885

Centisome position: 13.57

GC content: 65.28

Gene sequence:

>867_bases
ATGGTCCGTCTGCTAGGCGTCGTCAACGTGACGCCCGACTCCTTCTCCGATGGCGGTCTCTACCCCAGCGTTGACGCAGC
TGTAGGCGCGGGATTGCAGATGGTGGATGACGGAGCGTGGGCGGTCGATGTCGGCGGATGTTCGACTCGCCCGGGCGCGA
CTCCTACCGATGCTCAAACCGAGCTAGAGCGAGTCGCTCCCGTGGTGCGCGCGCTGACGCGCGCCGGTGCACGGGTGAGC
ATCGACAGCATGGACGCCGGAGTGGTCGACGCGTGCTTGAGCCTCGGCGCCACAATGATCAACGACGTCAGCGGCGGGCT
GTATGACAATCGCATGCTGGACCTTGCAGCGCGGTCGGGCGCGACGCTCGTCGTGTCGCACTGGCGGGCGCCGAGCGACC
AAATGGCTGCGCGAGCAGTGTACTCGGACGTGGCTCACGAGGTGCGAGATGAGCTCGCTGATCGCGTCGACGCCGCCCTC
GAAGCGGGCGTGAAAGCCAGCAACCTGATCGTCGATCCGGGCATTGGTTTCGCCAAGACCGCGTCGCAGAACTGGGAGCT
CCTGACCAATCTCTCTGTTCTCCGGGCCCTGGGCTACGAGCTGATGATTGGGACCTCTCGAAAGAGCCTCTTCCGTGAAA
TTCTCGGCACGGCCGACCTGCCCGAGGACGAGCCCGGGACTCGTGACGACCTGACAGCCGCGTCGACGGCGCTCGCCGCC
CTCCTCGGCATTGACTACGTGAGAGTCCACAACGTCCCTGCTAACCGTCGCGCGGCCGCCGTCGGCATGCGGTGGCGGGG
TGAGATGCCGTCGGGCGGAACAGAGACTCGTTCGTCTGTTACATCGGAACTTGAGGTCGGTGATTAG

Upstream 100 bases:

>100_bases
CCGATCTTCGAGCTCGTCGACTTCGGCGTGGTGGGCGACCTGCACACGGTCCTCCCCGCGCTGACCGACGAAGTCACCAA
GCGCAAGGGCTGAGTGCGAC

Downstream 100 bases:

>100_bases
CCGTACGATGTAACAACCCAGCAACAACGGTATTCTCTCGTGTACGCGCGTGTGATTATGAAGGCGTGAGCCTGACGGTC
GAATCGCTCGTCACGGACCC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS 1; Dihydropteroate pyrophosphorylase 1 [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MVRLLGVVNVTPDSFSDGGLYPSVDAAVGAGLQMVDDGAWAVDVGGCSTRPGATPTDAQTELERVAPVVRALTRAGARVS
IDSMDAGVVDACLSLGATMINDVSGGLYDNRMLDLAARSGATLVVSHWRAPSDQMAARAVYSDVAHEVRDELADRVDAAL
EAGVKASNLIVDPGIGFAKTASQNWELLTNLSVLRALGYELMIGTSRKSLFREILGTADLPEDEPGTRDDLTAASTALAA
LLGIDYVRVHNVPANRRAAAVGMRWRGEMPSGGTETRSSVTSELEVGD

Sequences:

>Translated_288_residues
MVRLLGVVNVTPDSFSDGGLYPSVDAAVGAGLQMVDDGAWAVDVGGCSTRPGATPTDAQTELERVAPVVRALTRAGARVS
IDSMDAGVVDACLSLGATMINDVSGGLYDNRMLDLAARSGATLVVSHWRAPSDQMAARAVYSDVAHEVRDELADRVDAAL
EAGVKASNLIVDPGIGFAKTASQNWELLTNLSVLRALGYELMIGTSRKSLFREILGTADLPEDEPGTRDDLTAASTALAA
LLGIDYVRVHNVPANRRAAAVGMRWRGEMPSGGTETRSSVTSELEVGD
>Mature_288_residues
MVRLLGVVNVTPDSFSDGGLYPSVDAAVGAGLQMVDDGAWAVDVGGCSTRPGATPTDAQTELERVAPVVRALTRAGARVS
IDSMDAGVVDACLSLGATMINDVSGGLYDNRMLDLAARSGATLVVSHWRAPSDQMAARAVYSDVAHEVRDELADRVDAAL
EAGVKASNLIVDPGIGFAKTASQNWELLTNLSVLRALGYELMIGTSRKSLFREILGTADLPEDEPGTRDDLTAASTALAA
LLGIDYVRVHNVPANRRAAAVGMRWRGEMPSGGTETRSSVTSELEVGD

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=251, Percent_Identity=35.0597609561753, Blast_Score=150, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6324073, Length=306, Percent_Identity=27.1241830065359, Blast_Score=122, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30141; Mature: 30141

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRLLGVVNVTPDSFSDGGLYPSVDAAVGAGLQMVDDGAWAVDVGGCSTRPGATPTDAQT
CEEEEEEEEECCCCCCCCCCCCCHHHHHCCCCEEECCCCEEEEECCCCCCCCCCCCCHHH
ELERVAPVVRALTRAGARVSIDSMDAGVVDACLSLGATMINDVSGGLYDNRMLDLAARSG
HHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCC
ATLVVSHWRAPSDQMAARAVYSDVAHEVRDELADRVDAALEAGVKASNLIVDPGIGFAKT
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHC
ASQNWELLTNLSVLRALGYELMIGTSRKSLFREILGTADLPEDEPGTRDDLTAASTALAA
CCCCHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
LLGIDYVRVHNVPANRRAAAVGMRWRGEMPSGGTETRSSVTSELEVGD
HHCCCCEEEECCCCCCHHHHCCCEECCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MVRLLGVVNVTPDSFSDGGLYPSVDAAVGAGLQMVDDGAWAVDVGGCSTRPGATPTDAQT
CEEEEEEEEECCCCCCCCCCCCCHHHHHCCCCEEECCCCEEEEECCCCCCCCCCCCCHHH
ELERVAPVVRALTRAGARVSIDSMDAGVVDACLSLGATMINDVSGGLYDNRMLDLAARSG
HHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCC
ATLVVSHWRAPSDQMAARAVYSDVAHEVRDELADRVDAALEAGVKASNLIVDPGIGFAKT
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHC
ASQNWELLTNLSVLRALGYELMIGTSRKSLFREILGTADLPEDEPGTRDDLTAASTALAA
CCCCHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
LLGIDYVRVHNVPANRRAAAVGMRWRGEMPSGGTETRSSVTSELEVGD
HHCCCCEEEECCCCCCHHHHCCCEECCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10474189; 10542185; 11234002 [H]