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The map label for this gene is comEC [H]

Identifier: 119386426

GI number: 119386426

Start: 866992

End: 869145

Strand: Direct

Name: comEC [H]

Synonym: Pden_3718

Alternate gene names: 119386426

Gene position: 866992-869145 (Clockwise)

Preceding gene: 119386421

Following gene: 119386427

Centisome position: 50.11

GC content: 70.19

Gene sequence:

>2154_bases
ATGCGCCCGCCCGTGCTTGCAGCCGGTGCAAGGCGGCATGCGGCGGCCGCGCCGCGGCCTTCCGTCAGCGTCCGGGCGGG
GCTGCTGCCCTGGGTGCCGTTCTGGCTTTCGCTGGGCATCGGGGGCTGGTTCCTGCTGCCGCGGGAACCGGGGCCGGGTC
TTTATGCGGGGCTGATTCTGGCCGGCGGGTCCTGCCTGCTGCTGTCGGCCTGGACCGTGCGGCTGGCCGATGACGGCAGG
CTCGGCTGGTTCTGGGCGGATCGGCTGCGGCTTGCCGTATTCGTGCTGTTCCTGGTCGCGCTGGGGGCGGTGCTTGCAGG
GGCCAGGACGCATATGGTCGCCGCGCCGGTGCTGGATTTCCGCTATTACGGCCCGGTCGAGGGGCGGGTGATCGGCATCG
ACCGCTCGTCGCGCGACCGGATGCGCCTGCTCATCGATCAGGTGCGGTTGCACCGAGTTGCACCCGGCCGCACGCCGGCG
CGGGTGCGGATCTCGCTGCTGACACCGCAGGAACTGCCGGTGCCCGGCCAGCGCGTCATGCTGACCGCGCATCTGGGTCC
GCCCGCCGGCCCGTCCGAGCCGGGAGGGTTCGATTTCCGCCGCATGGCCTGGTTCCAGCGGCTGGGCGCCGTGGGCTATG
CGCGCGCGCCGGTGATGACGGTGGAGCTGCCTGCCGATGGCGGCACCCTGGCGCTGCATCGCATCCGCATGTCGCTGTCC
GAGGCCATGCAGGACCGGATCGGCGGCCAGTCCGGGGCGGTCGCGGCGGCGCTGATGACAGGCGACCGCTCGGGCATTGC
CGAGCGGACCAACCAGATCATGCGCGATTCGAATCTCTATCACATCGTGTCGATCTCGGGTCTGCACATGAGCATGCTGG
CCGGTTTCGTCTATGCCGCGCTGCGCTTGGCCGGCGTGGCCGTGCACGGGCTGGGCGGTATCCGGGCGATGCCGGTGCAC
AAGCTTGCCGCGGCGGGGGCGCTATGCGCCTCGGCGCTGTATCTGTGGCTTTCGGGCGGCGGCGTCGCGACCGAGCGTTC
GTTCATCATGGTGGCGGTGATGCTGCTGGCGATCATCGCCGACCGGCGTGCGGTATCGTTGCGCACCATTGCGGTCGCGG
CCCTCATCGTGCTGGTGTTGAACCCCGAGGCGCTGACCGAGCCAGGCTTCCAGATGAGCTTTGCCGCCACGGCAGCGCTT
ATCCTGATGCAGGAGCCGTGGGCGAGGCTTGCGCCGCTGTTGCCATGGTGGACCAGGCCGGTGCTGATGCTGTTCGTTTC
GTCCTTCGTCGCCGGCATGGTGACGGCGCCGATCGCCGCGGCCCATTTCGGACGGATGTCACAATACGGGCTGCTGGCCA
ACATGCTGGTCGTGCCTGTCGTCGGCACGCTGGTGATGCCCGGCGGCGTCTTTGCGGCGCTGCTGGCGCCGCTTGGCCTT
GCGCAGCCGGCGCTGTGGCTGATGGGTCTCGGAACGGACTGGATGCTGACGGTGGCGCAATGGATATCGGATCTGGACGG
CGCGGTCACGTTGCTTCCTGCCGCGCCGCGCGCCGTTCTGCCGCTGATCGGCATCGGCGCCATGATGGCCGTGCTGGGGC
CGATTCCCGGCGGGGCGCATCGCCCCGTGCTGCTCTGGCGGCGCGGCACGGGCCTGGCCTTGCTGGCGGCGGCCGCCCTG
CTCTGGGTGGGTGACAGGCGCCCGGACGTCCTGATCTCGGCCCAGGGCGATGCGGCGGCGGTGCTGACCCCGGCGGGCAG
GATACCCTCGAAGCCAAGGGGCGGCAGCTTTGCGGTCGAGAACTGGCTTGCGGCCGATGGCGATGCCGCCGATCAGGCCG
GCGCCGCCGCGCGTCCGCTATGGCAGGGCACGCCCTCTGATCGTTGGGCGGTTCTCGACCGGGCCGGCATGCGGCTTCGC
ATCCGGCACCTGACCGGCAAGGGCGCGGCGCAGGATGCAGCCGCCCATTGCCGCGAGGGCGGCATTCTGGTCGCGAACAT
CCCTCTTTCCATGAGCGCGGAGGCCCGCAAGGAATGTCTGGTGCTGGATTCCGAATATCTGGGCAAGCGTGGTGCGACCG
CGATCTTCCTGACGGAAGGGGGGGCGAGCCTGGTTTCCGTCGACCAGCCGGGCTCTGGCCGAATTTGGCACTGA

Upstream 100 bases:

>100_bases
ATCCTTTCGAAAGGGTCGGCATGCCAATCTTGGCGCCACAGATAAGCAAGTGCCACGGCAAGGACAAGTTTCGGTGACGG
AATCGGTAAACGCTTTGCGA

Downstream 100 bases:

>100_bases
TCGCCAGCGACGGCTCATCCGAACAGGGTTTCAGGAAATGCATGGTCTCGTCAATCGTTGTATCGAGGTGTTCCTGCGCA
GCACCTATGGCAATGCGCTG

Product: ComEC/Rec2-related protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 717; Mature: 717

Protein sequence:

>717_residues
MRPPVLAAGARRHAAAAPRPSVSVRAGLLPWVPFWLSLGIGGWFLLPREPGPGLYAGLILAGGSCLLLSAWTVRLADDGR
LGWFWADRLRLAVFVLFLVALGAVLAGARTHMVAAPVLDFRYYGPVEGRVIGIDRSSRDRMRLLIDQVRLHRVAPGRTPA
RVRISLLTPQELPVPGQRVMLTAHLGPPAGPSEPGGFDFRRMAWFQRLGAVGYARAPVMTVELPADGGTLALHRIRMSLS
EAMQDRIGGQSGAVAAALMTGDRSGIAERTNQIMRDSNLYHIVSISGLHMSMLAGFVYAALRLAGVAVHGLGGIRAMPVH
KLAAAGALCASALYLWLSGGGVATERSFIMVAVMLLAIIADRRAVSLRTIAVAALIVLVLNPEALTEPGFQMSFAATAAL
ILMQEPWARLAPLLPWWTRPVLMLFVSSFVAGMVTAPIAAAHFGRMSQYGLLANMLVVPVVGTLVMPGGVFAALLAPLGL
AQPALWLMGLGTDWMLTVAQWISDLDGAVTLLPAAPRAVLPLIGIGAMMAVLGPIPGGAHRPVLLWRRGTGLALLAAAAL
LWVGDRRPDVLISAQGDAAAVLTPAGRIPSKPRGGSFAVENWLAADGDAADQAGAAARPLWQGTPSDRWAVLDRAGMRLR
IRHLTGKGAAQDAAAHCREGGILVANIPLSMSAEARKECLVLDSEYLGKRGATAIFLTEGGASLVSVDQPGSGRIWH

Sequences:

>Translated_717_residues
MRPPVLAAGARRHAAAAPRPSVSVRAGLLPWVPFWLSLGIGGWFLLPREPGPGLYAGLILAGGSCLLLSAWTVRLADDGR
LGWFWADRLRLAVFVLFLVALGAVLAGARTHMVAAPVLDFRYYGPVEGRVIGIDRSSRDRMRLLIDQVRLHRVAPGRTPA
RVRISLLTPQELPVPGQRVMLTAHLGPPAGPSEPGGFDFRRMAWFQRLGAVGYARAPVMTVELPADGGTLALHRIRMSLS
EAMQDRIGGQSGAVAAALMTGDRSGIAERTNQIMRDSNLYHIVSISGLHMSMLAGFVYAALRLAGVAVHGLGGIRAMPVH
KLAAAGALCASALYLWLSGGGVATERSFIMVAVMLLAIIADRRAVSLRTIAVAALIVLVLNPEALTEPGFQMSFAATAAL
ILMQEPWARLAPLLPWWTRPVLMLFVSSFVAGMVTAPIAAAHFGRMSQYGLLANMLVVPVVGTLVMPGGVFAALLAPLGL
AQPALWLMGLGTDWMLTVAQWISDLDGAVTLLPAAPRAVLPLIGIGAMMAVLGPIPGGAHRPVLLWRRGTGLALLAAAAL
LWVGDRRPDVLISAQGDAAAVLTPAGRIPSKPRGGSFAVENWLAADGDAADQAGAAARPLWQGTPSDRWAVLDRAGMRLR
IRHLTGKGAAQDAAAHCREGGILVANIPLSMSAEARKECLVLDSEYLGKRGATAIFLTEGGASLVSVDQPGSGRIWH
>Mature_717_residues
MRPPVLAAGARRHAAAAPRPSVSVRAGLLPWVPFWLSLGIGGWFLLPREPGPGLYAGLILAGGSCLLLSAWTVRLADDGR
LGWFWADRLRLAVFVLFLVALGAVLAGARTHMVAAPVLDFRYYGPVEGRVIGIDRSSRDRMRLLIDQVRLHRVAPGRTPA
RVRISLLTPQELPVPGQRVMLTAHLGPPAGPSEPGGFDFRRMAWFQRLGAVGYARAPVMTVELPADGGTLALHRIRMSLS
EAMQDRIGGQSGAVAAALMTGDRSGIAERTNQIMRDSNLYHIVSISGLHMSMLAGFVYAALRLAGVAVHGLGGIRAMPVH
KLAAAGALCASALYLWLSGGGVATERSFIMVAVMLLAIIADRRAVSLRTIAVAALIVLVLNPEALTEPGFQMSFAATAAL
ILMQEPWARLAPLLPWWTRPVLMLFVSSFVAGMVTAPIAAAHFGRMSQYGLLANMLVVPVVGTLVMPGGVFAALLAPLGL
AQPALWLMGLGTDWMLTVAQWISDLDGAVTLLPAAPRAVLPLIGIGAMMAVLGPIPGGAHRPVLLWRRGTGLALLAAAAL
LWVGDRRPDVLISAQGDAAAVLTPAGRIPSKPRGGSFAVENWLAADGDAADQAGAAARPLWQGTPSDRWAVLDRAGMRLR
IRHLTGKGAAQDAAAHCREGGILVANIPLSMSAEARKECLVLDSEYLGKRGATAIFLTEGGASLVSVDQPGSGRIWH

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=321, Percent_Identity=25.2336448598131, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 75699; Mature: 75699

Theoretical pI: Translated: 11.32; Mature: 11.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPPVLAAGARRHAAAAPRPSVSVRAGLLPWVPFWLSLGIGGWFLLPREPGPGLYAGLIL
CCCCCCCCCCCHHCCCCCCCCCEEECCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
AGGSCLLLSAWTVRLADDGRLGWFWADRLRLAVFVLFLVALGAVLAGARTHMVAAPVLDF
CCCCEEEEEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEHHHHHC
RYYGPVEGRVIGIDRSSRDRMRLLIDQVRLHRVAPGRTPARVRISLLTPQELPVPGQRVM
EEECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEE
LTAHLGPPAGPSEPGGFDFRRMAWFQRLGAVGYARAPVMTVELPADGGTLALHRIRMSLS
EEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHH
EAMQDRIGGQSGAVAAALMTGDRSGIAERTNQIMRDSNLYHIVSISGLHMSMLAGFVYAA
HHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHH
LRLAGVAVHGLGGIRAMPVHKLAAAGALCASALYLWLSGGGVATERSFIMVAVMLLAIIA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
DRRAVSLRTIAVAALIVLVLNPEALTEPGFQMSFAATAALILMQEPWARLAPLLPWWTRP
CCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCHHHHH
VLMLFVSSFVAGMVTAPIAAAHFGRMSQYGLLANMLVVPVVGTLVMPGGVFAALLAPLGL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
AQPALWLMGLGTDWMLTVAQWISDLDGAVTLLPAAPRAVLPLIGIGAMMAVLGPIPGGAH
CCHHHHEEECCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCC
RPVLLWRRGTGLALLAAAALLWVGDRRPDVLISAQGDAAAVLTPAGRIPSKPRGGSFAVE
CCEEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCHHH
NWLAADGDAADQAGAAARPLWQGTPSDRWAVLDRAGMRLRIRHLTGKGAAQDAAAHCREG
HCCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHCCCCEEEEEEECCCCCHHHHHHHHCCC
GILVANIPLSMSAEARKECLVLDSEYLGKRGATAIFLTEGGASLVSVDQPGSGRIWH
CEEEEECCCCCCCHHHHHEEEECHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MRPPVLAAGARRHAAAAPRPSVSVRAGLLPWVPFWLSLGIGGWFLLPREPGPGLYAGLIL
CCCCCCCCCCCHHCCCCCCCCCEEECCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
AGGSCLLLSAWTVRLADDGRLGWFWADRLRLAVFVLFLVALGAVLAGARTHMVAAPVLDF
CCCCEEEEEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEHHHHHC
RYYGPVEGRVIGIDRSSRDRMRLLIDQVRLHRVAPGRTPARVRISLLTPQELPVPGQRVM
EEECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEE
LTAHLGPPAGPSEPGGFDFRRMAWFQRLGAVGYARAPVMTVELPADGGTLALHRIRMSLS
EEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHH
EAMQDRIGGQSGAVAAALMTGDRSGIAERTNQIMRDSNLYHIVSISGLHMSMLAGFVYAA
HHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHH
LRLAGVAVHGLGGIRAMPVHKLAAAGALCASALYLWLSGGGVATERSFIMVAVMLLAIIA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
DRRAVSLRTIAVAALIVLVLNPEALTEPGFQMSFAATAALILMQEPWARLAPLLPWWTRP
CCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCHHHHH
VLMLFVSSFVAGMVTAPIAAAHFGRMSQYGLLANMLVVPVVGTLVMPGGVFAALLAPLGL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
AQPALWLMGLGTDWMLTVAQWISDLDGAVTLLPAAPRAVLPLIGIGAMMAVLGPIPGGAH
CCHHHHEEECCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCC
RPVLLWRRGTGLALLAAAALLWVGDRRPDVLISAQGDAAAVLTPAGRIPSKPRGGSFAVE
CCEEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCHHH
NWLAADGDAADQAGAAARPLWQGTPSDRWAVLDRAGMRLRIRHLTGKGAAQDAAAHCREG
HCCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHCCCCEEEEEEECCCCCHHHHHHHHCCC
GILVANIPLSMSAEARKECLVLDSEYLGKRGATAIFLTEGGASLVSVDQPGSGRIWH
CEEEEECCCCCCCHHHHHEEEECHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]