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The map label for this gene is accA1 [H]

Identifier: 119386347

GI number: 119386347

Start: 789367

End: 791295

Strand: Direct

Name: accA1 [H]

Synonym: Pden_3639

Alternate gene names: 119386347

Gene position: 789367-791295 (Clockwise)

Preceding gene: 119386346

Following gene: 119386348

Centisome position: 45.63

GC content: 70.66

Gene sequence:

>1929_bases
ATGTTCCAGAAAATCCTGATCGCCAACCGGGGCGAGATCGCCTGCCGGGTCATCGATACCGCCCGCAAGCTGGGCGTGCG
CACGGTCGCGGTCTATTCCGAGGCCGACCGCGCTGCGCGTCATGTCACCATCGCCGACGAGGCCGTTCCCATCGGCGGTC
CCGCACCCAAGGACAGCTACCTGCGCGGCGATGCCATCATCCGGGCTGCGCTCGACACCGGGGCGCAGGCCATCCATCCC
GGCTACGGCTTTCTCAGCGAGAACCCCGACTTCGTCGATGCAGTGACGGCCGCGGGCCTGACCTTCATCGGCCCTTCGGC
CGATGCCATCCGCAAGATGGGCCTCAAGGACGCAGCCAAGGCGCTGATGGCCGAGGCGGGCGTCCCGGTCGTCCCCGGCT
ATCACGGCGAGAACCAGGACGCCGGCCATCTTGCGGCGCAGGCGGACAAGATCGGCTATCCCGTGCTGATCAAGGCGGTG
GCCGGCGGCGGCGGCAAGGGCATGCGCCTGGTCGAGCGTGCAGGGGACTTCGCCGCTGCGCTGCAATCCGCGCAGGGCGA
GGCCGCCACCGCCTTCGGCAACCCGGCCGTACTGGTCGAGAAATACATCCAGCAGCCCCGCCATATCGAGGTGCAGGTCT
TCGGCGACGGCCATCGCGCCGTCCACCTGTTCGAGCGCGACTGTTCGCTGCAACGCCGCCACCAGAAGGTGATCGAGGAG
GCTCCGGCGCCCGGCATGACGCCCGAGATGCGTGCCGCCATGGGCGCCGCCGCCGTCCGCGCCGCCGAGGCGATCGGCTA
TGCCGGCGCCGGCACCATCGAATTCATCGTCGATGGCAGCCGGGGCCTGCGCTCCGACGGCTTCTGGTTCATGGAGATGA
ACACCCGCCTTCAGGTCGAGCATCCGGTGACCGAACTCGTCACCGGCGTCGATCTGGTGGAATGGCAGCTGCGCGTCGCC
AGCGGAGAGCCGCTGCCGGCCAGGCAGGAGGATCTGGCGATCACCGGTCATGCCTTCGAGGCGCGGCTTTATGCCGAGGA
CGTGCCCGCGGGCTTCCTGCCCGCCACCGGCCGGCTTGCGCATCTGCGTTTTCCCGACCATGCCCGGATCGAGACCGGGG
TGCGTCCCGGCGACGCGATCTCGCCCTGGTACGACCCGATGATCGCCAAGATCGTCACCCATGGCGCCACCCGCGCCATC
GCGCTGCGCGCGCTCGAGGCGGCGCTGGTCGATACCGAGGTGGCGGGCTCGGTCACCAATGTCGATTTCCTGATTGCGCT
GGCCCGGCACGAGGGTTTCGGCAAGGGCGAGGTCGATACCGGCCTGATCGCCCGCGACCTTCAGGCGCTGATCGCCGCTG
CCGAGCCCGATCCGCGGGCCAAGGCGCTGGCGGTGCTGGGCCTTGCCGGACTGGACGACCCCATGGTGCGCGGCGGCATC
ACGCTGTGGCAGCCGCTGAGCCGTACCATCGCCTGGGAAGGCGGCGAGGCGGTGCTGGAGGTGCTCGGCCCCGGCGCCGC
CCGCGTCACGCTGGACGGCAGCAGCCACGAGATCGCCTATGAAGGCGGGCGCTGGTGGGTGGATGGCAGCCCGCGCCGCT
CGCGCATCGTCAACCATGCGGCCGGCACCAGCGTCTTCGGCGGCCGCTCGCTGACGCTTGCGCCGCTCGACCCGCTGGCG
CGCGGCGGCGAAGAGGCGGGCGGCGGCATGACGCTTTCGCCCATGCCGGGGCTCGTCAAGGCGATCTTCGTCGAACCGGG
GCAGGAGGTCGCGGCGGGCGCGCGGCTGGCGATCCTCGAGGCGATGAAGATGGAACATACGCTGACCGCCGCCCGCGACG
GTCGCGTGGCCGAGGTCTTTGCCCGGGCCGGCGACCAGGTCGAGGCCGGCGCGGCGCTGATCCGGCTGGAGGAGGAAGGG
GACGCATGA

Upstream 100 bases:

>100_bases
GTGGAAGAGGCCCGCCGATGATTTCTCCGTTTTCCAAATACTCCACGGGGGTCCGGGGGTGTGAAACCCCCGGTGCCTCG
CCCGCCACAAGAGGTGCCGG

Downstream 100 bases:

>100_bases
TCCTGCACCATGTCCCCGGCTCGCGCTCGATGCGCGTCCTCTGGCTGATCGAGGAACTGGGGCTCGATTGCGAATTGCGG
CTCTGGTCGCTGACCGATGG

Product: carbamoyl-phosphate synthase L chain, ATP-binding

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 642; Mature: 642

Protein sequence:

>642_residues
MFQKILIANRGEIACRVIDTARKLGVRTVAVYSEADRAARHVTIADEAVPIGGPAPKDSYLRGDAIIRAALDTGAQAIHP
GYGFLSENPDFVDAVTAAGLTFIGPSADAIRKMGLKDAAKALMAEAGVPVVPGYHGENQDAGHLAAQADKIGYPVLIKAV
AGGGGKGMRLVERAGDFAAALQSAQGEAATAFGNPAVLVEKYIQQPRHIEVQVFGDGHRAVHLFERDCSLQRRHQKVIEE
APAPGMTPEMRAAMGAAAVRAAEAIGYAGAGTIEFIVDGSRGLRSDGFWFMEMNTRLQVEHPVTELVTGVDLVEWQLRVA
SGEPLPARQEDLAITGHAFEARLYAEDVPAGFLPATGRLAHLRFPDHARIETGVRPGDAISPWYDPMIAKIVTHGATRAI
ALRALEAALVDTEVAGSVTNVDFLIALARHEGFGKGEVDTGLIARDLQALIAAAEPDPRAKALAVLGLAGLDDPMVRGGI
TLWQPLSRTIAWEGGEAVLEVLGPGAARVTLDGSSHEIAYEGGRWWVDGSPRRSRIVNHAAGTSVFGGRSLTLAPLDPLA
RGGEEAGGGMTLSPMPGLVKAIFVEPGQEVAAGARLAILEAMKMEHTLTAARDGRVAEVFARAGDQVEAGAALIRLEEEG
DA

Sequences:

>Translated_642_residues
MFQKILIANRGEIACRVIDTARKLGVRTVAVYSEADRAARHVTIADEAVPIGGPAPKDSYLRGDAIIRAALDTGAQAIHP
GYGFLSENPDFVDAVTAAGLTFIGPSADAIRKMGLKDAAKALMAEAGVPVVPGYHGENQDAGHLAAQADKIGYPVLIKAV
AGGGGKGMRLVERAGDFAAALQSAQGEAATAFGNPAVLVEKYIQQPRHIEVQVFGDGHRAVHLFERDCSLQRRHQKVIEE
APAPGMTPEMRAAMGAAAVRAAEAIGYAGAGTIEFIVDGSRGLRSDGFWFMEMNTRLQVEHPVTELVTGVDLVEWQLRVA
SGEPLPARQEDLAITGHAFEARLYAEDVPAGFLPATGRLAHLRFPDHARIETGVRPGDAISPWYDPMIAKIVTHGATRAI
ALRALEAALVDTEVAGSVTNVDFLIALARHEGFGKGEVDTGLIARDLQALIAAAEPDPRAKALAVLGLAGLDDPMVRGGI
TLWQPLSRTIAWEGGEAVLEVLGPGAARVTLDGSSHEIAYEGGRWWVDGSPRRSRIVNHAAGTSVFGGRSLTLAPLDPLA
RGGEEAGGGMTLSPMPGLVKAIFVEPGQEVAAGARLAILEAMKMEHTLTAARDGRVAEVFARAGDQVEAGAALIRLEEEG
DA
>Mature_642_residues
MFQKILIANRGEIACRVIDTARKLGVRTVAVYSEADRAARHVTIADEAVPIGGPAPKDSYLRGDAIIRAALDTGAQAIHP
GYGFLSENPDFVDAVTAAGLTFIGPSADAIRKMGLKDAAKALMAEAGVPVVPGYHGENQDAGHLAAQADKIGYPVLIKAV
AGGGGKGMRLVERAGDFAAALQSAQGEAATAFGNPAVLVEKYIQQPRHIEVQVFGDGHRAVHLFERDCSLQRRHQKVIEE
APAPGMTPEMRAAMGAAAVRAAEAIGYAGAGTIEFIVDGSRGLRSDGFWFMEMNTRLQVEHPVTELVTGVDLVEWQLRVA
SGEPLPARQEDLAITGHAFEARLYAEDVPAGFLPATGRLAHLRFPDHARIETGVRPGDAISPWYDPMIAKIVTHGATRAI
ALRALEAALVDTEVAGSVTNVDFLIALARHEGFGKGEVDTGLIARDLQALIAAAEPDPRAKALAVLGLAGLDDPMVRGGI
TLWQPLSRTIAWEGGEAVLEVLGPGAARVTLDGSSHEIAYEGGRWWVDGSPRRSRIVNHAAGTSVFGGRSLTLAPLDPLA
RGGEEAGGGMTLSPMPGLVKAIFVEPGQEVAAGARLAILEAMKMEHTLTAARDGRVAEVFARAGDQVEAGAALIRLEEEG
DA

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=673, Percent_Identity=45.7652303120357, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI65506442, Length=678, Percent_Identity=40.4129793510324, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI189095269, Length=678, Percent_Identity=40.4129793510324, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI295821183, Length=658, Percent_Identity=40.7294832826748, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI106049528, Length=480, Percent_Identity=42.2916666666667, Blast_Score=346, Evalue=5e-95,
Organism=Homo sapiens, GI106049295, Length=480, Percent_Identity=42.2916666666667, Blast_Score=346, Evalue=5e-95,
Organism=Homo sapiens, GI106049292, Length=480, Percent_Identity=42.2916666666667, Blast_Score=346, Evalue=5e-95,
Organism=Homo sapiens, GI38679974, Length=726, Percent_Identity=29.2011019283747, Blast_Score=259, Evalue=7e-69,
Organism=Homo sapiens, GI38679971, Length=726, Percent_Identity=29.2011019283747, Blast_Score=259, Evalue=7e-69,
Organism=Homo sapiens, GI38679960, Length=726, Percent_Identity=29.2011019283747, Blast_Score=259, Evalue=8e-69,
Organism=Homo sapiens, GI38679977, Length=726, Percent_Identity=29.2011019283747, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI38679967, Length=726, Percent_Identity=29.2011019283747, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI134142062, Length=548, Percent_Identity=30.1094890510949, Blast_Score=221, Evalue=1e-57,
Organism=Escherichia coli, GI1789654, Length=452, Percent_Identity=48.6725663716814, Blast_Score=398, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=659, Percent_Identity=46.1305007587253, Blast_Score=532, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17567343, Length=682, Percent_Identity=41.0557184750733, Blast_Score=461, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17562816, Length=481, Percent_Identity=41.1642411642412, Blast_Score=325, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI71997168, Length=510, Percent_Identity=29.8039215686275, Blast_Score=205, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=29.3877551020408, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=499, Percent_Identity=29.8597194388778, Blast_Score=203, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6319685, Length=446, Percent_Identity=47.085201793722, Blast_Score=420, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319695, Length=490, Percent_Identity=41.2244897959184, Blast_Score=325, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6321376, Length=490, Percent_Identity=41.6326530612245, Blast_Score=318, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6324343, Length=731, Percent_Identity=28.0437756497948, Blast_Score=231, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6323863, Length=467, Percent_Identity=31.6916488222698, Blast_Score=219, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24651757, Length=677, Percent_Identity=46.5288035450517, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24651759, Length=640, Percent_Identity=44.84375, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24652212, Length=488, Percent_Identity=42.2131147540984, Blast_Score=344, Evalue=9e-95,
Organism=Drosophila melanogaster, GI24652210, Length=488, Percent_Identity=42.2131147540984, Blast_Score=344, Evalue=9e-95,
Organism=Drosophila melanogaster, GI24652214, Length=488, Percent_Identity=42.2131147540984, Blast_Score=344, Evalue=9e-95,
Organism=Drosophila melanogaster, GI19921944, Length=488, Percent_Identity=42.2131147540984, Blast_Score=344, Evalue=9e-95,
Organism=Drosophila melanogaster, GI24652216, Length=488, Percent_Identity=42.2131147540984, Blast_Score=344, Evalue=9e-95,
Organism=Drosophila melanogaster, GI281363050, Length=488, Percent_Identity=42.2131147540984, Blast_Score=344, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24652224, Length=488, Percent_Identity=42.2131147540984, Blast_Score=344, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24652222, Length=488, Percent_Identity=42.2131147540984, Blast_Score=344, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24652220, Length=488, Percent_Identity=42.2131147540984, Blast_Score=344, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24652218, Length=488, Percent_Identity=42.2131147540984, Blast_Score=344, Evalue=1e-94,
Organism=Drosophila melanogaster, GI161076407, Length=728, Percent_Identity=28.9835164835165, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24586460, Length=728, Percent_Identity=28.9835164835165, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI161076409, Length=728, Percent_Identity=28.9835164835165, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24586458, Length=728, Percent_Identity=28.9835164835165, Blast_Score=233, Evalue=4e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 67549; Mature: 67549

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKILIANRGEIACRVIDTARKLGVRTVAVYSEADRAARHVTIADEAVPIGGPAPKDSY
CCCEEEEECCCCEEEEEEHHHHHCCCEEEEEECCHHHHHEEEEEECCCEECCCCCCCCCC
LRGDAIIRAALDTGAQAIHPGYGFLSENPDFVDAVTAAGLTFIGPSADAIRKMGLKDAAK
CCCHHHEEEHHHCCCCEECCCCCCCCCCCCHHHHHHHCCEEEECCCHHHHHHCCHHHHHH
ALMAEAGVPVVPGYHGENQDAGHLAAQADKIGYPVLIKAVAGGGGKGMRLVERAGDFAAA
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
LQSAQGEAATAFGNPAVLVEKYIQQPRHIEVQVFGDGHRAVHLFERDCSLQRRHQKVIEE
HHHCCCCEEEECCCCHHHHHHHHCCCCEEEEEEEECCCEEEEEEHHCHHHHHHHHHHHHH
APAPGMTPEMRAAMGAAAVRAAEAIGYAGAGTIEFIVDGSRGLRSDGFWFMEMNTRLQVE
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEEECCEEEEC
HPVTELVTGVDLVEWQLRVASGEPLPARQEDLAITGHAFEARLYAEDVPAGFLPATGRLA
CCHHHHHHCCEEEEEEEEEECCCCCCCCCCCEEEECCEEEEEEECCCCCCCCCCCCCCEE
HLRFPDHARIETGVRPGDAISPWYDPMIAKIVTHGATRAIALRALEAALVDTEVAGSVTN
EEECCCCCCEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCC
VDFLIALARHEGFGKGEVDTGLIARDLQALIAAAEPDPRAKALAVLGLAGLDDPMVRGGI
HHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHEEEEEECCCCCHHHHCCC
TLWQPLSRTIAWEGGEAVLEVLGPGAARVTLDGSSHEIAYEGGRWWVDGSPRRSRIVNHA
HHHHHHHHHEECCCCHHHHHHHCCCCEEEEECCCCCEEEEECCEEEECCCCHHHHHHHHH
AGTSVFGGRSLTLAPLDPLARGGEEAGGGMTLSPMPGLVKAIFVEPGQEVAAGARLAILE
CCCCEECCCEEEECCCCHHHCCCCCCCCCEEECCCCCCEEEEEECCCHHHHCCHHHHHHH
AMKMEHTLTAARDGRVAEVFARAGDQVEAGAALIRLEEEGDA
HHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCC
>Mature Secondary Structure
MFQKILIANRGEIACRVIDTARKLGVRTVAVYSEADRAARHVTIADEAVPIGGPAPKDSY
CCCEEEEECCCCEEEEEEHHHHHCCCEEEEEECCHHHHHEEEEEECCCEECCCCCCCCCC
LRGDAIIRAALDTGAQAIHPGYGFLSENPDFVDAVTAAGLTFIGPSADAIRKMGLKDAAK
CCCHHHEEEHHHCCCCEECCCCCCCCCCCCHHHHHHHCCEEEECCCHHHHHHCCHHHHHH
ALMAEAGVPVVPGYHGENQDAGHLAAQADKIGYPVLIKAVAGGGGKGMRLVERAGDFAAA
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
LQSAQGEAATAFGNPAVLVEKYIQQPRHIEVQVFGDGHRAVHLFERDCSLQRRHQKVIEE
HHHCCCCEEEECCCCHHHHHHHHCCCCEEEEEEEECCCEEEEEEHHCHHHHHHHHHHHHH
APAPGMTPEMRAAMGAAAVRAAEAIGYAGAGTIEFIVDGSRGLRSDGFWFMEMNTRLQVE
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEEECCEEEEC
HPVTELVTGVDLVEWQLRVASGEPLPARQEDLAITGHAFEARLYAEDVPAGFLPATGRLA
CCHHHHHHCCEEEEEEEEEECCCCCCCCCCCEEEECCEEEEEEECCCCCCCCCCCCCCEE
HLRFPDHARIETGVRPGDAISPWYDPMIAKIVTHGATRAIALRALEAALVDTEVAGSVTN
EEECCCCCCEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCC
VDFLIALARHEGFGKGEVDTGLIARDLQALIAAAEPDPRAKALAVLGLAGLDDPMVRGGI
HHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHEEEEEECCCCCHHHHCCC
TLWQPLSRTIAWEGGEAVLEVLGPGAARVTLDGSSHEIAYEGGRWWVDGSPRRSRIVNHA
HHHHHHHHHEECCCCHHHHHHHCCCCEEEEECCCCCEEEEECCEEEECCCCHHHHHHHHH
AGTSVFGGRSLTLAPLDPLARGGEEAGGGMTLSPMPGLVKAIFVEPGQEVAAGARLAILE
CCCCEECCCEEEECCCCHHHCCCCCCCCCEEECCCCCCEEEEEECCCHHHHCCHHHHHHH
AMKMEHTLTAARDGRVAEVFARAGDQVEAGAALIRLEEEGDA
HHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]