BacMap

Definition	Paracoccus denitrificans PD1222 chromosome 2, complete sequence.
Accession	NC_008687
Length	1,730,097

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The map label for this gene is fabG [C]

Identifier: 119386253

GI number: 119386253

Start: 690766

End: 691551

Strand: Direct

Name: fabG [C]

Synonym: Pden_3542

Alternate gene names: 119386253

Gene position: 690766-691551 (Clockwise)

Preceding gene: 119386252

Following gene: 119386254

Centisome position: 39.93

GC content: 70.87

Gene sequence:

>786_bases
ATGCTGGAACCAAGCAATCTGGACGGACGGACGGCCATCGTGACCGGCGCGGGGCAGGGGATCGGCCTTGCGATCGCCGA
GGCGCTGCTTGCAGCGGGCGCGCATGTCCTGGCCGTCGATCGCGAAGCGGCGGGCATCGAGGCGCTGGCGGCCCGCCCCG
GGGTAACGGCCGTCCTGGGCGATGTCACCGACCCGGGCCTGCCGGAGCAGATCGGCGCGGTCCTGGACGGCGCCCGGGCG
CGGCTGGACATCCTGGTGAACAATGCGGGGATCGCGCGCGGCGCCCATGCGCTGCATACCGGCGACGAGGATTTCACCCG
CTATTTCGACATCAACGTGCTTGGCCTTTTCCGCCTGTCACGCTGGGCCGTGCAGCGGATGATGGATGCGGGCGGCGGCG
CCATCGTCAACACCGCCTCGATCTTCGGGCTGATCGGCGCGCAGAACTCCTGCGGCTATTCCGCGTCGAAGGCGGCGGTG
ATCGGGCTGACCCGGCAGATGGCCACCGATTTCGGCCCGAACGGCATCCGGGTGAATGCCGTCGCGCCCGGCCTGATCGA
GACGCCGCTGACGGCCGAACGCATCCGCAGCGAGCCGTGGCGGCGGCACCAGATGATCGACGGCTGCCCGCTGCGCCGCG
TCGGCAAGCCCGAGGATGTGGCCCGCGCCGTCCGCTTCCTCGCCTCGGACGAGGCGTCGTTCATCACCGGCCATGTCCTG
ACGGTGGACGGGGGCTGGGCCATCGGCCGCTTCCCGCGCCAGGAGGCCATCCATGCCGAAGCCTGA

Upstream 100 bases:

>100_bases
CGCCGATCCGCGTGCGGAATATGTCACCGGGCAAGTGCTGATCGTCGATGGCGGCCGCTCGGTCGGCGGCACCGCGGCAT
TCTGAAACGGGAGAGGGGAA

Downstream 100 bases:

>100_bases
TCTGCCGGACCTGCCCGATACCTGCGACCTTCTGGTCGTGGGTTCGGGTGCCGCGGGCATGGCGGCGGCGATCTCTGCCC
ATCATCACGGGTTGAAGCCG

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MLEPSNLDGRTAIVTGAGQGIGLAIAEALLAAGAHVLAVDREAAGIEALAARPGVTAVLGDVTDPGLPEQIGAVLDGARA
RLDILVNNAGIARGAHALHTGDEDFTRYFDINVLGLFRLSRWAVQRMMDAGGGAIVNTASIFGLIGAQNSCGYSASKAAV
IGLTRQMATDFGPNGIRVNAVAPGLIETPLTAERIRSEPWRRHQMIDGCPLRRVGKPEDVARAVRFLASDEASFITGHVL
TVDGGWAIGRFPRQEAIHAEA

Sequences:

>Translated_261_residues
MLEPSNLDGRTAIVTGAGQGIGLAIAEALLAAGAHVLAVDREAAGIEALAARPGVTAVLGDVTDPGLPEQIGAVLDGARA
RLDILVNNAGIARGAHALHTGDEDFTRYFDINVLGLFRLSRWAVQRMMDAGGGAIVNTASIFGLIGAQNSCGYSASKAAV
IGLTRQMATDFGPNGIRVNAVAPGLIETPLTAERIRSEPWRRHQMIDGCPLRRVGKPEDVARAVRFLASDEASFITGHVL
TVDGGWAIGRFPRQEAIHAEA
>Mature_261_residues
MLEPSNLDGRTAIVTGAGQGIGLAIAEALLAAGAHVLAVDREAAGIEALAARPGVTAVLGDVTDPGLPEQIGAVLDGARA
RLDILVNNAGIARGAHALHTGDEDFTRYFDINVLGLFRLSRWAVQRMMDAGGGAIVNTASIFGLIGAQNSCGYSASKAAV
IGLTRQMATDFGPNGIRVNAVAPGLIETPLTAERIRSEPWRRHQMIDGCPLRRVGKPEDVARAVRFLASDEASFITGHVL
TVDGGWAIGRFPRQEAIHAEA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI66933014, Length=246, Percent_Identity=34.9593495934959, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=36.3265306122449, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI15277342, Length=251, Percent_Identity=35.8565737051793, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI40254992, Length=241, Percent_Identity=34.4398340248963, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=33.469387755102, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=35.6862745098039, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI59889578, Length=227, Percent_Identity=34.8017621145374, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI10190704, Length=253, Percent_Identity=32.4110671936759, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI19923817, Length=263, Percent_Identity=31.5589353612167, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI126723750, Length=250, Percent_Identity=30, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI83715985, Length=255, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI31542939, Length=206, Percent_Identity=34.4660194174757, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI5031737, Length=252, Percent_Identity=30.952380952381, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI109715829, Length=247, Percent_Identity=31.1740890688259, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI210032110, Length=192, Percent_Identity=31.25, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI4504505, Length=264, Percent_Identity=30.6818181818182, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI7706318, Length=195, Percent_Identity=27.6923076923077, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4503301, Length=252, Percent_Identity=26.984126984127, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI224922801, Length=174, Percent_Identity=35.0574712643678, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4503817, Length=234, Percent_Identity=28.2051282051282, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI210032112, Length=186, Percent_Identity=29.0322580645161, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI126723191, Length=181, Percent_Identity=30.3867403314917, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI33667109, Length=198, Percent_Identity=30.8080808080808, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4557649, Length=192, Percent_Identity=26.5625, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI225579078, Length=206, Percent_Identity=27.1844660194175, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=246, Percent_Identity=39.4308943089431, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI87082160, Length=247, Percent_Identity=35.6275303643725, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=36.046511627907, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=33.8582677165354, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787905, Length=254, Percent_Identity=37.4015748031496, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=34.251968503937, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI2367365, Length=248, Percent_Identity=36.6935483870968, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=30.4347826086957, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI2367175, Length=246, Percent_Identity=34.5528455284553, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1789057, Length=256, Percent_Identity=30.859375, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1789378, Length=251, Percent_Identity=33.0677290836653, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788459, Length=251, Percent_Identity=33.0677290836653, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787820, Length=221, Percent_Identity=28.0542986425339, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1787545, Length=269, Percent_Identity=30.4832713754647, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786701, Length=186, Percent_Identity=30.1075268817204, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17555706, Length=246, Percent_Identity=35.7723577235772, Blast_Score=138, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25147288, Length=252, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=33.8709677419355, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI115534694, Length=253, Percent_Identity=34.7826086956522, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=32.6771653543307, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71994604, Length=253, Percent_Identity=36.3636363636364, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17559104, Length=259, Percent_Identity=33.5907335907336, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71994600, Length=250, Percent_Identity=32.8, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI72000259, Length=261, Percent_Identity=31.0344827586207, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17538182, Length=248, Percent_Identity=32.6612903225806, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=33.0827067669173, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=32.6996197718631, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17563726, Length=258, Percent_Identity=30.2325581395349, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17560150, Length=265, Percent_Identity=29.4339622641509, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=29.3893129770992, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI193204405, Length=266, Percent_Identity=31.5789473684211, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17562910, Length=263, Percent_Identity=29.277566539924, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17544670, Length=263, Percent_Identity=27.3764258555133, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17565030, Length=261, Percent_Identity=32.183908045977, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=29.277566539924, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17562908, Length=268, Percent_Identity=33.955223880597, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=268, Percent_Identity=31.3432835820896, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17536651, Length=256, Percent_Identity=29.6875, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17536025, Length=260, Percent_Identity=30.3846153846154, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=270, Percent_Identity=31.4814814814815, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17551412, Length=267, Percent_Identity=28.4644194756554, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17508895, Length=198, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17508651, Length=156, Percent_Identity=35.2564102564103, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=271, Percent_Identity=29.1512915129151, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=27.6515151515151, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=262, Percent_Identity=28.6259541984733, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17561272, Length=256, Percent_Identity=27.34375, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI32563809, Length=217, Percent_Identity=30.4147465437788, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17507613, Length=217, Percent_Identity=30.4147465437788, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=192, Percent_Identity=26.0416666666667, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=189, Percent_Identity=26.4550264550265, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17567345, Length=223, Percent_Identity=25.5605381165919, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=196, Percent_Identity=26.0204081632653, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=268, Percent_Identity=26.865671641791, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322861, Length=196, Percent_Identity=32.6530612244898, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322067, Length=228, Percent_Identity=29.3859649122807, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323882, Length=247, Percent_Identity=28.3400809716599, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320089, Length=185, Percent_Identity=26.4864864864865, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24643142, Length=253, Percent_Identity=32.8063241106719, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=35.0597609561753, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI23397609, Length=246, Percent_Identity=32.9268292682927, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=32.2709163346614, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24644337, Length=254, Percent_Identity=36.2204724409449, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=34.9206349206349, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24644339, Length=250, Percent_Identity=32.4, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17737361, Length=256, Percent_Identity=33.59375, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21356301, Length=216, Percent_Identity=27.3148148148148, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI18859837, Length=187, Percent_Identity=30.4812834224599, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI116007236, Length=255, Percent_Identity=30.1960784313725, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281364892, Length=204, Percent_Identity=28.4313725490196, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24584752, Length=193, Percent_Identity=32.6424870466321, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24656154, Length=250, Percent_Identity=30.4, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI19922628, Length=250, Percent_Identity=30.4, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21358495, Length=197, Percent_Identity=26.3959390862944, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281364494, Length=204, Percent_Identity=28.4313725490196, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27286; Mature: 27286

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEPSNLDGRTAIVTGAGQGIGLAIAEALLAAGAHVLAVDREAAGIEALAARPGVTAVLG
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCCEEEEC
DVTDPGLPEQIGAVLDGARARLDILVNNAGIARGAHALHTGDEDFTRYFDINVLGLFRLS
CCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHCCCCCHHEEEEECCHHHHHHHH
RWAVQRMMDAGGGAIVNTASIFGLIGAQNSCGYSASKAAVIGLTRQMATDFGPNGIRVNA
HHHHHHHHHCCCCEEEEHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEE
VAPGLIETPLTAERIRSEPWRRHQMIDGCPLRRVGKPEDVARAVRFLASDEASFITGHVL
ECCCHHCCCCCHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEE
TVDGGWAIGRFPRQEAIHAEA
EECCCEEECCCCCHHCCCCCC
>Mature Secondary Structure
MLEPSNLDGRTAIVTGAGQGIGLAIAEALLAAGAHVLAVDREAAGIEALAARPGVTAVLG
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCCEEEEC
DVTDPGLPEQIGAVLDGARARLDILVNNAGIARGAHALHTGDEDFTRYFDINVLGLFRLS
CCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHCCCCCHHEEEEECCHHHHHHHH
RWAVQRMMDAGGGAIVNTASIFGLIGAQNSCGYSASKAAVIGLTRQMATDFGPNGIRVNA
HHHHHHHHHCCCCEEEEHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEE
VAPGLIETPLTAERIRSEPWRRHQMIDGCPLRRVGKPEDVARAVRFLASDEASFITGHVL
ECCCHHCCCCCHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEE
TVDGGWAIGRFPRQEAIHAEA
EECCCEEECCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]