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The map label for this gene is hutH [H]

Identifier: 119386230

GI number: 119386230

Start: 665822

End: 667486

Strand: Direct

Name: hutH [H]

Synonym: Pden_3519

Alternate gene names: 119386230

Gene position: 665822-667486 (Clockwise)

Preceding gene: 119386229

Following gene: 119386231

Centisome position: 38.48

GC content: 66.79

Gene sequence:

>1665_bases
ATGTCCGTTCGAACCGGAACCGGCCGCCACCACTGCCTGACCGCCCTTTGCCTGACGGCCGCGCTTGGCGGTTCCGCCGC
ATGGGCCGAGGATTGGACCATCGACGGGCGAACCCTGACGGTCGAGCAGGTCGCGGGCATCGCGCGGGACGACGGCGCCA
GGATCGTCCTGACTCAAGGCGCGGACACGCAGATCGCCCAGGGCTTCGCCCTGGTGATGGAGGCGGCGCTGCAAGGCAAG
GCCGTCTACGGGCTGACGGTCGGCGTCGGCTGGAACAAGGACCGCCCGGTCTTTGCGATCAAGGACGGCAAGCGGGTGCT
GGACGATGAGCTTTTGCAGCTGTCGCGCGCCTTCAACCTGACCTCGTTGCGCGCGCACGGCGCGGGCGTGGGCGAGCCGA
TGCCCGTCGAGGCGGTGCGGGCGGGGATGGCCATTCGCCTGAACCAGATCGCGACAGGGCGGACGGGCGTGCAGCCCGCC
GTGGCCGAGATGTATCGCCAGTTCCTTGAGCGCGGCATCACGCCGGTCGTGCCCTCGCGCGGCTCGGTGGGCGAGGCGGA
CATCACCCTGGCCTCGCATATCGGCCTGGCCATGATCGGCGAGGGCGAGGTGTTCGTGAACGGCGACCGCATGGCTGCCC
GGCAGGCATTGTCGGATGCGGGGATCGCCCCATTGGAGCCGGTCGGCAAGGACTTCCTGTCGATCCTCAGCACCAATGCG
CTGACGGCGGGGCATGCTGCCCTGCTGGCCCATGACGTCGACGCCTATCTGGACAAGGAAGCCATCGTCTTTGCCCTTGC
GCTGGAGGGGTTCAACGGCAACGTCGCGCCGTTCCTGTCCGAGACGAACGATATCCGCCCCTTTCCGGAAAACCTCGCCG
GCGCACGGGCGATCCGCGATGCGTTGCAGGGCAGCTATCTGTGGTCGCCCTCCGATGAGCGCGCCTTGCAGGATCCGCTG
TCGTTCCGCACCATGGCCTATGTGCTGGGCGGCGCCCGGGTCGCGACGCAGGACCTGGTGAAGGTGCTGGAAATTCAGAT
CAACCACAGCGACGACAATCCGGGGGTCGTCGTCGGCGCGGTGGATGAAAAGACCTCGGCCCAGGTCTCCGCCTATTTCA
TCGAGGGCGAGGTCGCGGGCGCGATCTATCCGACCGCGGGCTTCGAGATGCTGCCGGTGGCGACAAGCGTCGAGGCGTTG
AATGCCGCGTTGGTGCGCCTGTCCCAGGCGATCACCATGCAGACGATCCGTTTCGAAAATCCCGAGATGACCCACCTGCC
GCGCTTCCTTGCGGCCGAGACCAATCACGGCCATGCCTTCGGGGCGATCCAGAAGCCGCTCGTGGCGCTTCTGGCCGAGA
ACCGCCAGATCGGTGCGCAGGCCCCGGCCGGCTCGGTCGCGATGGCGGGGAATATCGAGGATCTGGACAGCCACGCGCCG
CTTTCCGTCGCCAATCTGGGGCGGATCCTCGACAATCTCTACTGGATGTCCTCGATCCAGTTGCTGCATGCCGCCCAGGC
CGTCGACCTGCGCAAGCGGCCGGCATTGGGGAGGGCCACGAAGAACCTTCTCGACGATTATCGCCGGCACGTTCCCTTCG
TCGACAAGGATCGCATCTACTCCGAGGATTTCGCGGCCGGGCGCCGTATCCTCATGGAACGATGA

Upstream 100 bases:

>100_bases
CGGTGCTGGTGCTGCCAAAGCCCTATTCGACGAATTGCGGGCGCGGGGCCGTTCCGGCCCCCGCCGATCCTTGATGCGGC
AACCATGGAAAGGAAATCTC

Downstream 100 bases:

>100_bases
CCCGGCATCTTGGCCCGAGACATCGCCTCGGGCCGAGTTCGAGCGCATTGTCCGCGCCATGATGTCGCCATGAGGATGGG
TAGGCAGTGCGACCGGCAGG

Product: phenylalanine/histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MSVRTGTGRHHCLTALCLTAALGGSAAWAEDWTIDGRTLTVEQVAGIARDDGARIVLTQGADTQIAQGFALVMEAALQGK
AVYGLTVGVGWNKDRPVFAIKDGKRVLDDELLQLSRAFNLTSLRAHGAGVGEPMPVEAVRAGMAIRLNQIATGRTGVQPA
VAEMYRQFLERGITPVVPSRGSVGEADITLASHIGLAMIGEGEVFVNGDRMAARQALSDAGIAPLEPVGKDFLSILSTNA
LTAGHAALLAHDVDAYLDKEAIVFALALEGFNGNVAPFLSETNDIRPFPENLAGARAIRDALQGSYLWSPSDERALQDPL
SFRTMAYVLGGARVATQDLVKVLEIQINHSDDNPGVVVGAVDEKTSAQVSAYFIEGEVAGAIYPTAGFEMLPVATSVEAL
NAALVRLSQAITMQTIRFENPEMTHLPRFLAAETNHGHAFGAIQKPLVALLAENRQIGAQAPAGSVAMAGNIEDLDSHAP
LSVANLGRILDNLYWMSSIQLLHAAQAVDLRKRPALGRATKNLLDDYRRHVPFVDKDRIYSEDFAAGRRILMER

Sequences:

>Translated_554_residues
MSVRTGTGRHHCLTALCLTAALGGSAAWAEDWTIDGRTLTVEQVAGIARDDGARIVLTQGADTQIAQGFALVMEAALQGK
AVYGLTVGVGWNKDRPVFAIKDGKRVLDDELLQLSRAFNLTSLRAHGAGVGEPMPVEAVRAGMAIRLNQIATGRTGVQPA
VAEMYRQFLERGITPVVPSRGSVGEADITLASHIGLAMIGEGEVFVNGDRMAARQALSDAGIAPLEPVGKDFLSILSTNA
LTAGHAALLAHDVDAYLDKEAIVFALALEGFNGNVAPFLSETNDIRPFPENLAGARAIRDALQGSYLWSPSDERALQDPL
SFRTMAYVLGGARVATQDLVKVLEIQINHSDDNPGVVVGAVDEKTSAQVSAYFIEGEVAGAIYPTAGFEMLPVATSVEAL
NAALVRLSQAITMQTIRFENPEMTHLPRFLAAETNHGHAFGAIQKPLVALLAENRQIGAQAPAGSVAMAGNIEDLDSHAP
LSVANLGRILDNLYWMSSIQLLHAAQAVDLRKRPALGRATKNLLDDYRRHVPFVDKDRIYSEDFAAGRRILMER
>Mature_553_residues
SVRTGTGRHHCLTALCLTAALGGSAAWAEDWTIDGRTLTVEQVAGIARDDGARIVLTQGADTQIAQGFALVMEAALQGKA
VYGLTVGVGWNKDRPVFAIKDGKRVLDDELLQLSRAFNLTSLRAHGAGVGEPMPVEAVRAGMAIRLNQIATGRTGVQPAV
AEMYRQFLERGITPVVPSRGSVGEADITLASHIGLAMIGEGEVFVNGDRMAARQALSDAGIAPLEPVGKDFLSILSTNAL
TAGHAALLAHDVDAYLDKEAIVFALALEGFNGNVAPFLSETNDIRPFPENLAGARAIRDALQGSYLWSPSDERALQDPLS
FRTMAYVLGGARVATQDLVKVLEIQINHSDDNPGVVVGAVDEKTSAQVSAYFIEGEVAGAIYPTAGFEMLPVATSVEALN
AALVRLSQAITMQTIRFENPEMTHLPRFLAAETNHGHAFGAIQKPLVALLAENRQIGAQAPAGSVAMAGNIEDLDSHAPL
SVANLGRILDNLYWMSSIQLLHAAQAVDLRKRPALGRATKNLLDDYRRHVPFVDKDRIYSEDFAAGRRILMER

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=530, Percent_Identity=23.7735849056604, Blast_Score=125, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17567831, Length=532, Percent_Identity=24.0601503759398, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 59205; Mature: 59074

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRTGTGRHHCLTALCLTAALGGSAAWAEDWTIDGRTLTVEQVAGIARDDGARIVLTQG
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCCEEEHHHHHCCCCCCCCEEEEECC
ADTQIAQGFALVMEAALQGKAVYGLTVGVGWNKDRPVFAIKDGKRVLDDELLQLSRAFNL
CCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHCCC
TSLRAHGAGVGEPMPVEAVRAGMAIRLNQIATGRTGVQPAVAEMYRQFLERGITPVVPSR
CEEHCCCCCCCCCCCHHHHHCCCEEEEEHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GSVGEADITLASHIGLAMIGEGEVFVNGDRMAARQALSDAGIAPLEPVGKDFLSILSTNA
CCCCCCCEEHHHCCCEEEEECCCEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
LTAGHAALLAHDVDAYLDKEAIVFALALEGFNGNVAPFLSETNDIRPFPENLAGARAIRD
CCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
ALQGSYLWSPSDERALQDPLSFRTMAYVLGGARVATQDLVKVLEIQINHSDDNPGVVVGA
HHCCCEEECCCCCHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCCCCEEEEE
VDEKTSAQVSAYFIEGEVAGAIYPTAGFEMLPVATSVEALNAALVRLSQAITMQTIRFEN
CCCCCCCEEEEEEEECEECCEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHEEEECCC
PEMTHLPRFLAAETNHGHAFGAIQKPLVALLAENRQIGAQAPAGSVAMAGNIEDLDSHAP
CCHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHCCCCCC
LSVANLGRILDNLYWMSSIQLLHAAQAVDLRKRPALGRATKNLLDDYRRHVPFVDKDRIY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
SEDFAAGRRILMER
HHHHHHHHHHHCCC
>Mature Secondary Structure 
SVRTGTGRHHCLTALCLTAALGGSAAWAEDWTIDGRTLTVEQVAGIARDDGARIVLTQG
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCCEEEHHHHHCCCCCCCCEEEEECC
ADTQIAQGFALVMEAALQGKAVYGLTVGVGWNKDRPVFAIKDGKRVLDDELLQLSRAFNL
CCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHCCC
TSLRAHGAGVGEPMPVEAVRAGMAIRLNQIATGRTGVQPAVAEMYRQFLERGITPVVPSR
CEEHCCCCCCCCCCCHHHHHCCCEEEEEHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GSVGEADITLASHIGLAMIGEGEVFVNGDRMAARQALSDAGIAPLEPVGKDFLSILSTNA
CCCCCCCEEHHHCCCEEEEECCCEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
LTAGHAALLAHDVDAYLDKEAIVFALALEGFNGNVAPFLSETNDIRPFPENLAGARAIRD
CCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
ALQGSYLWSPSDERALQDPLSFRTMAYVLGGARVATQDLVKVLEIQINHSDDNPGVVVGA
HHCCCEEECCCCCHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCCCCEEEEE
VDEKTSAQVSAYFIEGEVAGAIYPTAGFEMLPVATSVEALNAALVRLSQAITMQTIRFEN
CCCCCCCEEEEEEEECEECCEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHEEEECCC
PEMTHLPRFLAAETNHGHAFGAIQKPLVALLAENRQIGAQAPAGSVAMAGNIEDLDSHAP
CCHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHCCCCCC
LSVANLGRILDNLYWMSSIQLLHAAQAVDLRKRPALGRATKNLLDDYRRHVPFVDKDRIY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
SEDFAAGRRILMER
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA