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The map label for this gene is prs [H]

Identifier: 119357475

GI number: 119357475

Start: 1902273

End: 1903256

Strand: Direct

Name: prs [H]

Synonym: Cpha266_1674

Alternate gene names: 119357475

Gene position: 1902273-1903256 (Clockwise)

Preceding gene: 119357473

Following gene: 119357476

Centisome position: 60.7

GC content: 48.27

Gene sequence:

>984_bases
ATGCAGGATGCATTGGTAAAACCAATCAAAATTTTTGCAGGCCGCAGCAATCCGGCCATTGCAGAAAAAATCGCCGAATA
TCTCGACATGCCGCTCTGCGATGCAAAGGTCGAGAATTTTTCTGACGGGGAAATATCTGTTAATTACTTCGAATCGATCC
GAGGCTCGGATCTGTTCATTATTCAATCGACAAATCCCCCTGCCGACAACCTGATGGAGCTCCTGATCATGATCGATGCC
GCCAGACGATCATCAGCAGCGAGAATAACGGCAGTTATCCCCTACTACGGCTACGCACGGCAGGACAGAAAAGACAAGCC
GCGTGTCGCCATTACAGCAAAGCTGGTTGCGAACCTGCTGACCACTGCCGGAGCAAACAGAATTCTGACTATGGATCTTC
ATGCGCCGCAAATCCAGGGATTTTTTGATATTCCTTTTGACCATCTCTACTCCAGCGTCATGCTGATCAACGACATCCGC
CAGAGGGATTTTCGTGAAAATCTTGTCGTAGCATCTCCCGATGTGGGCGGCGTAAAACTTGCCCGAAAATTTGCAGAAGA
GCTCGGCACAGACCTGGTCATTGTCGACAAAAGAAGACCGAAAGCAAACGTTGCTGAAGTCATGAACATCATTGGCGACG
TCAGTGGCAAAAACGTTCTGCTCGTCGACGATATGATCGATACGGCAGGAACCCTTGTCAATGCAGCAAAGGCAATACGC
GATGCAGGCGGACTGAGAGTCTATGCCGCCGCGACACATCCTATTCTTTCAGGCCCGGCAATAGAAAGAATAAATGCATC
CGTCATTGAAAAGCTGATCGTTTCCGATTCTGTAGTGACCAATCATGCCTACTCACCGAAAATCGAAACCGTCACAGTCA
GCTCGCTGTTCGGTGAAGCGATCAAAAGAATATACGAGGACGATTCGGTCAGTTGCCTCTTCGACAGTAAAGACATAAGC
ACCAAGATCAAAAACTATCATTAA

Upstream 100 bases:

>100_bases
ATTCGAAGTCCAGAGCGGTTATCAGTGGGTATGGTAACAATGCCGGGACGAGCTGCTTAAAACGAATTACTGACGTTAAT
ATAACCGGTTTCATCTGAAA

Downstream 100 bases:

>100_bases
CATCACAAGAGAAAAAAAGAGATAGAGGAAAAGCATGGAAATCATCGCATTGGGGGTTGAACCTCGCATTATCAGAAAAA
AAGAAGCGGCAAAACTGCGT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MQDALVKPIKIFAGRSNPAIAEKIAEYLDMPLCDAKVENFSDGEISVNYFESIRGSDLFIIQSTNPPADNLMELLIMIDA
ARRSSAARITAVIPYYGYARQDRKDKPRVAITAKLVANLLTTAGANRILTMDLHAPQIQGFFDIPFDHLYSSVMLINDIR
QRDFRENLVVASPDVGGVKLARKFAEELGTDLVIVDKRRPKANVAEVMNIIGDVSGKNVLLVDDMIDTAGTLVNAAKAIR
DAGGLRVYAAATHPILSGPAIERINASVIEKLIVSDSVVTNHAYSPKIETVTVSSLFGEAIKRIYEDDSVSCLFDSKDIS
TKIKNYH

Sequences:

>Translated_327_residues
MQDALVKPIKIFAGRSNPAIAEKIAEYLDMPLCDAKVENFSDGEISVNYFESIRGSDLFIIQSTNPPADNLMELLIMIDA
ARRSSAARITAVIPYYGYARQDRKDKPRVAITAKLVANLLTTAGANRILTMDLHAPQIQGFFDIPFDHLYSSVMLINDIR
QRDFRENLVVASPDVGGVKLARKFAEELGTDLVIVDKRRPKANVAEVMNIIGDVSGKNVLLVDDMIDTAGTLVNAAKAIR
DAGGLRVYAAATHPILSGPAIERINASVIEKLIVSDSVVTNHAYSPKIETVTVSSLFGEAIKRIYEDDSVSCLFDSKDIS
TKIKNYH
>Mature_327_residues
MQDALVKPIKIFAGRSNPAIAEKIAEYLDMPLCDAKVENFSDGEISVNYFESIRGSDLFIIQSTNPPADNLMELLIMIDA
ARRSSAARITAVIPYYGYARQDRKDKPRVAITAKLVANLLTTAGANRILTMDLHAPQIQGFFDIPFDHLYSSVMLINDIR
QRDFRENLVVASPDVGGVKLARKFAEELGTDLVIVDKRRPKANVAEVMNIIGDVSGKNVLLVDDMIDTAGTLVNAAKAIR
DAGGLRVYAAATHPILSGPAIERINASVIEKLIVSDSVVTNHAYSPKIETVTVSSLFGEAIKRIYEDDSVSCLFDSKDIS
TKIKNYH

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=311, Percent_Identity=46.6237942122186, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI28557709, Length=310, Percent_Identity=45.4838709677419, Blast_Score=268, Evalue=5e-72,
Organism=Homo sapiens, GI4506129, Length=310, Percent_Identity=44.8387096774194, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI84875539, Length=313, Percent_Identity=44.408945686901, Blast_Score=262, Evalue=3e-70,
Organism=Homo sapiens, GI4506133, Length=344, Percent_Identity=34.0116279069767, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI194018537, Length=346, Percent_Identity=34.6820809248555, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI310128524, Length=140, Percent_Identity=33.5714285714286, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI310115209, Length=140, Percent_Identity=33.5714285714286, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI310118259, Length=140, Percent_Identity=33.5714285714286, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI310119946, Length=140, Percent_Identity=33.5714285714286, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1787458, Length=312, Percent_Identity=52.5641025641026, Blast_Score=323, Evalue=8e-90,
Organism=Caenorhabditis elegans, GI25149168, Length=311, Percent_Identity=45.016077170418, Blast_Score=271, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI17554702, Length=318, Percent_Identity=44.3396226415094, Blast_Score=271, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI71989924, Length=317, Percent_Identity=44.4794952681388, Blast_Score=269, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=44.6601941747573, Blast_Score=267, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=32.6409495548961, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319403, Length=318, Percent_Identity=44.9685534591195, Blast_Score=259, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6320946, Length=309, Percent_Identity=44.9838187702265, Blast_Score=255, Evalue=7e-69,
Organism=Saccharomyces cerevisiae, GI6321776, Length=310, Percent_Identity=41.2903225806452, Blast_Score=239, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6322667, Length=201, Percent_Identity=39.8009950248756, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324511, Length=110, Percent_Identity=40.9090909090909, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21355239, Length=310, Percent_Identity=46.4516129032258, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI45551540, Length=333, Percent_Identity=43.2432432432432, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24651458, Length=362, Percent_Identity=32.5966850828729, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24651456, Length=362, Percent_Identity=32.5966850828729, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI281362873, Length=362, Percent_Identity=32.5966850828729, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24651454, Length=362, Percent_Identity=32.5966850828729, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24651462, Length=210, Percent_Identity=37.6190476190476, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24651464, Length=210, Percent_Identity=37.6190476190476, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI45552010, Length=210, Percent_Identity=37.6190476190476, Blast_Score=127, Evalue=8e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35855; Mature: 35855

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDALVKPIKIFAGRSNPAIAEKIAEYLDMPLCDAKVENFSDGEISVNYFESIRGSDLFI
CCCCHHCCHHEEECCCCCHHHHHHHHHHCCCCCCHHCCCCCCCCEEEHHHHHCCCCEEEE
IQSTNPPADNLMELLIMIDAARRSSAARITAVIPYYGYARQDRKDKPRVAITAKLVANLL
EECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHH
TTAGANRILTMDLHAPQIQGFFDIPFDHLYSSVMLINDIRQRDFRENLVVASPDVGGVKL
HHCCCCEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHH
ARKFAEELGTDLVIVDKRRPKANVAEVMNIIGDVSGKNVLLVDDMIDTAGTLVNAAKAIR
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHH
DAGGLRVYAAATHPILSGPAIERINASVIEKLIVSDSVVTNHAYSPKIETVTVSSLFGEA
CCCCEEEEEEECCCCCCCCHHHHHCHHHHHHHHHCCHHHCCCCCCCCEEEEEHHHHHHHH
IKRIYEDDSVSCLFDSKDISTKIKNYH
HHHHHCCCCEEEEECCCCHHHHCCCCC
>Mature Secondary Structure
MQDALVKPIKIFAGRSNPAIAEKIAEYLDMPLCDAKVENFSDGEISVNYFESIRGSDLFI
CCCCHHCCHHEEECCCCCHHHHHHHHHHCCCCCCHHCCCCCCCCEEEHHHHHCCCCEEEE
IQSTNPPADNLMELLIMIDAARRSSAARITAVIPYYGYARQDRKDKPRVAITAKLVANLL
EECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHH
TTAGANRILTMDLHAPQIQGFFDIPFDHLYSSVMLINDIRQRDFRENLVVASPDVGGVKL
HHCCCCEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHH
ARKFAEELGTDLVIVDKRRPKANVAEVMNIIGDVSGKNVLLVDDMIDTAGTLVNAAKAIR
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHH
DAGGLRVYAAATHPILSGPAIERINASVIEKLIVSDSVVTNHAYSPKIETVTVSSLFGEA
CCCCEEEEEEECCCCCCCCHHHHHCHHHHHHHHHCCHHHCCCCCCCCEEEEEHHHHHHHH
IKRIYEDDSVSCLFDSKDISTKIKNYH
HHHHHCCCCEEEEECCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]