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The map label for this gene is ispD [H]

Identifier: 119357443

GI number: 119357443

Start: 1871579

End: 1872334

Strand: Direct

Name: ispD [H]

Synonym: Cpha266_1642

Alternate gene names: 119357443

Gene position: 1871579-1872334 (Clockwise)

Preceding gene: 119357442

Following gene: 119357444

Centisome position: 59.72

GC content: 44.84

Gene sequence:

>756_bases
ATGACAATACAGGCTGTTGCCATAATTGCTGCAAGCGGAATAGGCAAACGAATGCAGCTTAAAGGAGGAGTGAGCAAACA
GATGCTTCAAATTGCCGGGTATCCGGTTATTTATCACACTCTCAAAGCCTTTGAAAACGCATCGACAATAAAAGAGATAT
ACATTGCCACCAAAAAAGAAGCTATCGCATCGCTTGAAGAGCTGGTAAAAGCAAGCGGATTCAAAAAAGTGAAGCGCGTC
ATCGAGGGTGGACTGGAACGACAGGATTCGGTTAACAACTGCATTAAAGCCATCGAGCAGGAGATTCGGTCTTCTGCTCA
GGTTCCCGATGTCATTATGGTACATGATGGCGCCAGACCATTCATACAGTCTCATGAAATCGATGAAATCGCATGTCTGA
CCATCGAGCATGGGGCCTGCGTTCCTGCTAACAGACCGAAAGACACGATTAAACATATCGGCAGCCATCCAGGTTTTTTC
GGAGAAACTCTTGACAGAAGCAAACTGCTTCAGGTACAGACTCCGCAAAGTTTTTTGAGCCGTCTTCTGATACAGGCACA
TGAACAGGCTGAACTGGAACAGTGGTATGCCACTGACGATGCCGCCCTTGTTGAAAGATTCTTTCCGGAACAGAACATCA
GAATCCTCGAAACAGGATACCACAACATCAAAATAACAACGCCTGAAGATATCAGACTTGCTGAAGCGATTTACAACGGC
ATGACAGAGAAAATAGAAGAGGAAGAAAAAAATTAA

Upstream 100 bases:

>100_bases
TGCTTATGGATGCTTACAAGGTAGCTCTGAAATCAGAATATCAGTTTCTTGCATACGGTGACGCAATGTTTATCTATTAA
ATACTCACCTCGGTTACATC

Downstream 100 bases:

>100_bases
AACCTTCCGGATTATTAATTGTTTTTTGATAAGGGGTAACGTATATTAACACCCCATAAACCGGTGAGGTAGCTCAGTTG
GTTAGAGCACAGGATTCATA

Product: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MTIQAVAIIAASGIGKRMQLKGGVSKQMLQIAGYPVIYHTLKAFENASTIKEIYIATKKEAIASLEELVKASGFKKVKRV
IEGGLERQDSVNNCIKAIEQEIRSSAQVPDVIMVHDGARPFIQSHEIDEIACLTIEHGACVPANRPKDTIKHIGSHPGFF
GETLDRSKLLQVQTPQSFLSRLLIQAHEQAELEQWYATDDAALVERFFPEQNIRILETGYHNIKITTPEDIRLAEAIYNG
MTEKIEEEEKN

Sequences:

>Translated_251_residues
MTIQAVAIIAASGIGKRMQLKGGVSKQMLQIAGYPVIYHTLKAFENASTIKEIYIATKKEAIASLEELVKASGFKKVKRV
IEGGLERQDSVNNCIKAIEQEIRSSAQVPDVIMVHDGARPFIQSHEIDEIACLTIEHGACVPANRPKDTIKHIGSHPGFF
GETLDRSKLLQVQTPQSFLSRLLIQAHEQAELEQWYATDDAALVERFFPEQNIRILETGYHNIKITTPEDIRLAEAIYNG
MTEKIEEEEKN
>Mature_250_residues
TIQAVAIIAASGIGKRMQLKGGVSKQMLQIAGYPVIYHTLKAFENASTIKEIYIATKKEAIASLEELVKASGFKKVKRVI
EGGLERQDSVNNCIKAIEQEIRSSAQVPDVIMVHDGARPFIQSHEIDEIACLTIEHGACVPANRPKDTIKHIGSHPGFFG
ETLDRSKLLQVQTPQSFLSRLLIQAHEQAELEQWYATDDAALVERFFPEQNIRILETGYHNIKITTPEDIRLAEAIYNGM
TEKIEEEEKN

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=248, Percent_Identity=28.2258064516129, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI157671913, Length=138, Percent_Identity=31.8840579710145, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1789104, Length=249, Percent_Identity=29.718875502008, Blast_Score=78, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 28053; Mature: 27921

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQAVAIIAASGIGKRMQLKGGVSKQMLQIAGYPVIYHTLKAFENASTIKEIYIATKKE
CCHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHH
AIASLEELVKASGFKKVKRVIEGGLERQDSVNNCIKAIEQEIRSSAQVPDVIMVHDGARP
HHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
FIQSHEIDEIACLTIEHGACVPANRPKDTIKHIGSHPGFFGETLDRSKLLQVQTPQSFLS
HHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCCHHHHCHHHEEEEECHHHHHH
RLLIQAHEQAELEQWYATDDAALVERFFPEQNIRILETGYHNIKITTPEDIRLAEAIYNG
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHH
MTEKIEEEEKN
HHHHHHHHCCC
>Mature Secondary Structure 
TIQAVAIIAASGIGKRMQLKGGVSKQMLQIAGYPVIYHTLKAFENASTIKEIYIATKKE
CHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHH
AIASLEELVKASGFKKVKRVIEGGLERQDSVNNCIKAIEQEIRSSAQVPDVIMVHDGARP
HHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
FIQSHEIDEIACLTIEHGACVPANRPKDTIKHIGSHPGFFGETLDRSKLLQVQTPQSFLS
HHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCCHHHHCHHHEEEEECHHHHHH
RLLIQAHEQAELEQWYATDDAALVERFFPEQNIRILETGYHNIKITTPEDIRLAEAIYNG
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHH
MTEKIEEEEKN
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA