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The map label for this gene is 119357003

Identifier: 119357003

GI number: 119357003

Start: 1340051

End: 1340920

Strand: Direct

Name: 119357003

Synonym: Cpha266_1187

Alternate gene names: NA

Gene position: 1340051-1340920 (Clockwise)

Preceding gene: 119357002

Following gene: 119357004

Centisome position: 42.76

GC content: 49.54

Gene sequence:

>870_bases
ATGGCTGAAGTGCAAATCGGGAACAGAAAGGTTGGAGACGGCCATCCTGTGTTTATAATAGCGGAGATAGGAATTAATCA
CAACGGATCACTGGATATAGCCAAAAAACTTGTTGAAGGTGCAGCCGCTCTTGGCTGCGATGCCGTGAAGTTTCAAAAAC
GTACTCCTGATCTCTGTGTTCCGCAGGATCAGCGCAGTATCGAGCGTGATACGCCCTGGGGCCTTATGACTTATATTGAT
TATCGTTACAAGGTGGAGCTCGGCTATGAAGAGTACTGCGCCATTGACCGGTGTTGTCGGGAAAACGGCATCATGTGGTT
CGCATCCTGCTGGGATGAGGATGCTGTTGATTTTATGGAGCAATTTGATCCGCCCTGCTATAAGGCCGCTTCTGCCTCGC
TTACTGATTCGGCTCTTCTTGAAAAAGTAAGGGCGACAGGGCGACCGCTGATTCTTTCAACGGGAATGTCAACCATGGAG
GAGATCACCGATGCCGTAAATCGATGTGGCAGCGAAAATCTTCTTCTTGCCCATACCAACTCGACCTATCCTTCTCCGGT
TGAAGAGCTGAATCTGAAGATGATTACGACGCTGAAGGCTATGTATCCCGAGATTCCTGCAGGATATTCCGGGCATGAAA
CAGGTTTGTCGACTACCTGGGCGGCCGTGGCTCTTGGCGCAGTGTTTGTCGAACGACATGTTACGCTCGACAGGGCGATG
TGGGGTTCCGATCAGGCAGCTTCGATAGAACTGATCGGGCTGGGAAGGCTTGTGTCAAACATTCGGGATATTGAAAAAGC
TCTTGGTGACGGAGTTAAAAAAGTTTACGAAGGTGAAGCCCTGGCACGAAAAAAACTCAGACGAGTATAA

Upstream 100 bases:

>100_bases
TCTCCCTTAAAATCCTTGCTCGGGCGTGACGTTGATGCGACAGGTCAAGCCGTCGTTTCGGCGATAAAGATGTTTTTTTA
TTCATTTATTTTTTGAGGTT

Downstream 100 bases:

>100_bases
ATGCTTTTTTGAAATTCCCGTTCTGACCGTAAATTTAGGGCACCGTTAATTAAATTTCAGGCAGAACGCGTGACATATGT
AATCGAGGTTTCTTTCATCA

Product: N-acetylneuraminate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MAEVQIGNRKVGDGHPVFIIAEIGINHNGSLDIAKKLVEGAAALGCDAVKFQKRTPDLCVPQDQRSIERDTPWGLMTYID
YRYKVELGYEEYCAIDRCCRENGIMWFASCWDEDAVDFMEQFDPPCYKAASASLTDSALLEKVRATGRPLILSTGMSTME
EITDAVNRCGSENLLLAHTNSTYPSPVEELNLKMITTLKAMYPEIPAGYSGHETGLSTTWAAVALGAVFVERHVTLDRAM
WGSDQAASIELIGLGRLVSNIRDIEKALGDGVKKVYEGEALARKKLRRV

Sequences:

>Translated_289_residues
MAEVQIGNRKVGDGHPVFIIAEIGINHNGSLDIAKKLVEGAAALGCDAVKFQKRTPDLCVPQDQRSIERDTPWGLMTYID
YRYKVELGYEEYCAIDRCCRENGIMWFASCWDEDAVDFMEQFDPPCYKAASASLTDSALLEKVRATGRPLILSTGMSTME
EITDAVNRCGSENLLLAHTNSTYPSPVEELNLKMITTLKAMYPEIPAGYSGHETGLSTTWAAVALGAVFVERHVTLDRAM
WGSDQAASIELIGLGRLVSNIRDIEKALGDGVKKVYEGEALARKKLRRV
>Mature_288_residues
AEVQIGNRKVGDGHPVFIIAEIGINHNGSLDIAKKLVEGAAALGCDAVKFQKRTPDLCVPQDQRSIERDTPWGLMTYIDY
RYKVELGYEEYCAIDRCCRENGIMWFASCWDEDAVDFMEQFDPPCYKAASASLTDSALLEKVRATGRPLILSTGMSTMEE
ITDAVNRCGSENLLLAHTNSTYPSPVEELNLKMITTLKAMYPEIPAGYSGHETGLSTTWAAVALGAVFVERHVTLDRAMW
GSDQAASIELIGLGRLVSNIRDIEKALGDGVKKVYEGEALARKKLRRV

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=284, Percent_Identity=38.3802816901408, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI21357081, Length=256, Percent_Identity=36.328125, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 31886; Mature: 31755

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVQIGNRKVGDGHPVFIIAEIGINHNGSLDIAKKLVEGAAALGCDAVKFQKRTPDLCV
CCCEECCCEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCC
PQDQRSIERDTPWGLMTYIDYRYKVELGYEEYCAIDRCCRENGIMWFASCWDEDAVDFME
CCHHHHCCCCCCCEEEEEEEEEEEEEECHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
QFDPPCYKAASASLTDSALLEKVRATGRPLILSTGMSTMEEITDAVNRCGSENLLLAHTN
HCCCCHHHHHCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCEEEEECC
STYPSPVEELNLKMITTLKAMYPEIPAGYSGHETGLSTTWAAVALGAVFVERHVTLDRAM
CCCCCCHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WGSDQAASIELIGLGRLVSNIRDIEKALGDGVKKVYEGEALARKKLRRV
CCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
AEVQIGNRKVGDGHPVFIIAEIGINHNGSLDIAKKLVEGAAALGCDAVKFQKRTPDLCV
CCEECCCEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCC
PQDQRSIERDTPWGLMTYIDYRYKVELGYEEYCAIDRCCRENGIMWFASCWDEDAVDFME
CCHHHHCCCCCCCEEEEEEEEEEEEEECHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
QFDPPCYKAASASLTDSALLEKVRATGRPLILSTGMSTMEEITDAVNRCGSENLLLAHTN
HCCCCHHHHHCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCEEEEECC
STYPSPVEELNLKMITTLKAMYPEIPAGYSGHETGLSTTWAAVALGAVFVERHVTLDRAM
CCCCCCHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WGSDQAASIELIGLGRLVSNIRDIEKALGDGVKKVYEGEALARKKLRRV
CCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]