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The map label for this gene is cobT

Identifier: 119356826

GI number: 119356826

Start: 1137557

End: 1138621

Strand: Direct

Name: cobT

Synonym: Cpha266_0999

Alternate gene names: 119356826

Gene position: 1137557-1138621 (Clockwise)

Preceding gene: 119356825

Following gene: 119356827

Centisome position: 36.3

GC content: 50.61

Gene sequence:

>1065_bases
ATGCGTCAAAAACTTGAAGAGCTGCTTACCGCAATTCAATCTCCCGATCGATCGCTTGCAATCGTCGCACAGGCTCATCT
TGATGATCTTACAAAGCCGAAGGGGAGTCTCGGCTGTCTTGAAGAAATCGCACTCAGTTATGTGGTTGCAACAGGTCGCA
TAAAGCCCGTGCTCGAGCGGAAAAAAATCTGCTGTTTTGCCGGCGACCATGGTGTTGCTGCTGAGGGCGTTTCAGCTTTT
CCTCCAGAAGTGACGCCGCAGATGGTCTATAATATGCTTAACGGCGGAGCGGCCATCAATGTTCTTGCCCGTCATGCCGG
AGCCGAGCTTTCAGTGGTTGATGTCGGAGTTAATCATGATTTTCCCGATCTTCCCGGTCTTTTGAGGCGAAAAGTACGTT
ACGGAAGCAGGAACATGTCGTTAGAGCCGGCAATGAGCGAGAACGAAACGATTCATGCGCTTATGGTCGGTGCCGAACTT
GCCAGGGATGCTGCTCTTGCCGGTTTTCATCTGCTCGGTACCGGTGAAATGGGTATAGCCAATACAACGCCAGCGGCAGC
ACTTTTTGCCGTACTGCTCGATATTCCTGTTGAAACCATTACCGGCAGGGGAACGGGAATTGACGATGCACGCTTGAACC
ATAAAATAGCCGTTATCCGCAAAGCAATCAAGGTGAACGAAGCATCACTTTCGACTCCGCTTGGAACACTTGCTGCTCTT
GGAGGATATGAAATTGCCGCTATTGCAGGTTTTGTTCTCGGGGCTTCAGTCTGCAGGGTTCCGGTTGTTATTGACGGCTT
TATTTCAACCGCAGGAGCCGTTGCAGCCATGTTTCTCTCTCCAGCCGTAGCTGATTATCTTTTTTTCAGCCATCTTTCAG
GCGAACAGGGTCACCGGATCGTGATGGAGAAACTTGCCCGAAAGCCAATTCTTGATCTCGATCTGCGTCTTGGAGAGGGA
ACCGGAGGCGCTCTTGCCATGCGGATTATCGAGGCTTCTGTGAACGTGTATAATGAGATGCAGACCTTCAGCTCTGCCGG
TGTAAGCGGAAAAACAGAAGAGTAA

Upstream 100 bases:

>100_bases
CAACAGATGCATACCTGCTTTGCAGCGGCATTCCGCTTAAGCTCAGATAAAACAAAAATAAAAAGTATTTAATAAAAAGC
TGAACAGGAATACGATACAT

Downstream 100 bases:

>100_bases
CATCATGATGCCTCGCGGTTTGGTTACAGCATTGAGAACGCTCTCGATTCTGCCTGTGCCCGGGCGGGATGCGGAACGTT
TCAGTGATTCGCTTTACTGG

Product: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MRQKLEELLTAIQSPDRSLAIVAQAHLDDLTKPKGSLGCLEEIALSYVVATGRIKPVLERKKICCFAGDHGVAAEGVSAF
PPEVTPQMVYNMLNGGAAINVLARHAGAELSVVDVGVNHDFPDLPGLLRRKVRYGSRNMSLEPAMSENETIHALMVGAEL
ARDAALAGFHLLGTGEMGIANTTPAAALFAVLLDIPVETITGRGTGIDDARLNHKIAVIRKAIKVNEASLSTPLGTLAAL
GGYEIAAIAGFVLGASVCRVPVVIDGFISTAGAVAAMFLSPAVADYLFFSHLSGEQGHRIVMEKLARKPILDLDLRLGEG
TGGALAMRIIEASVNVYNEMQTFSSAGVSGKTEE

Sequences:

>Translated_354_residues
MRQKLEELLTAIQSPDRSLAIVAQAHLDDLTKPKGSLGCLEEIALSYVVATGRIKPVLERKKICCFAGDHGVAAEGVSAF
PPEVTPQMVYNMLNGGAAINVLARHAGAELSVVDVGVNHDFPDLPGLLRRKVRYGSRNMSLEPAMSENETIHALMVGAEL
ARDAALAGFHLLGTGEMGIANTTPAAALFAVLLDIPVETITGRGTGIDDARLNHKIAVIRKAIKVNEASLSTPLGTLAAL
GGYEIAAIAGFVLGASVCRVPVVIDGFISTAGAVAAMFLSPAVADYLFFSHLSGEQGHRIVMEKLARKPILDLDLRLGEG
TGGALAMRIIEASVNVYNEMQTFSSAGVSGKTEE
>Mature_354_residues
MRQKLEELLTAIQSPDRSLAIVAQAHLDDLTKPKGSLGCLEEIALSYVVATGRIKPVLERKKICCFAGDHGVAAEGVSAF
PPEVTPQMVYNMLNGGAAINVLARHAGAELSVVDVGVNHDFPDLPGLLRRKVRYGSRNMSLEPAMSENETIHALMVGAEL
ARDAALAGFHLLGTGEMGIANTTPAAALFAVLLDIPVETITGRGTGIDDARLNHKIAVIRKAIKVNEASLSTPLGTLAAL
GGYEIAAIAGFVLGASVCRVPVVIDGFISTAGAVAAMFLSPAVADYLFFSHLSGEQGHRIVMEKLARKPILDLDLRLGEG
TGGALAMRIIEASVNVYNEMQTFSSAGVSGKTEE

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family

Homologues:

Organism=Escherichia coli, GI1788300, Length=347, Percent_Identity=40.3458213256484, Blast_Score=241, Evalue=7e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBT_CHLPD (A1BF69)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911470.1
- ProteinModelPortal:   A1BF69
- SMR:   A1BF69
- STRING:   A1BF69
- GeneID:   4570921
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0999
- NMPDR:   fig|290317.7.peg.1062
- eggNOG:   COG2038
- HOGENOM:   HBG634399
- OMA:   NEMATFS
- ProtClustDB:   PRK00105
- HAMAP:   MF_00230
- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846
- Gene3D:   G3DSA:1.10.1610.10
- TIGRFAMs:   TIGR03160

Pfam domain/function: PF02277 DBI_PRT; SSF52733 NN:DBI_PRT

EC number: =2.4.2.21

Molecular weight: Translated: 37220; Mature: 37220

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: ACT_SITE 319-319

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQKLEELLTAIQSPDRSLAIVAQAHLDDLTKPKGSLGCLEEIALSYVVATGRIKPVLER
CHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHC
KKICCFAGDHGVAAEGVSAFPPEVTPQMVYNMLNGGAAINVLARHAGAELSVVDVGVNHD
CCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCEEEEEEECCCCC
FPDLPGLLRRKVRYGSRNMSLEPAMSENETIHALMVGAELARDAALAGFHLLGTGEMGIA
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCEEEEECCCCCCC
NTTPAAALFAVLLDIPVETITGRGTGIDDARLNHKIAVIRKAIKVNEASLSTPLGTLAAL
CCCHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHH
GGYEIAAIAGFVLGASVCRVPVVIDGFISTAGAVAAMFLSPAVADYLFFSHLSGEQGHRI
CCHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VMEKLARKPILDLDLRLGEGTGGALAMRIIEASVNVYNEMQTFSSAGVSGKTEE
HHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRQKLEELLTAIQSPDRSLAIVAQAHLDDLTKPKGSLGCLEEIALSYVVATGRIKPVLER
CHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHC
KKICCFAGDHGVAAEGVSAFPPEVTPQMVYNMLNGGAAINVLARHAGAELSVVDVGVNHD
CCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCEEEEEEECCCCC
FPDLPGLLRRKVRYGSRNMSLEPAMSENETIHALMVGAELARDAALAGFHLLGTGEMGIA
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCEEEEECCCCCCC
NTTPAAALFAVLLDIPVETITGRGTGIDDARLNHKIAVIRKAIKVNEASLSTPLGTLAAL
CCCHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHH
GGYEIAAIAGFVLGASVCRVPVVIDGFISTAGAVAAMFLSPAVADYLFFSHLSGEQGHRI
CCHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VMEKLARKPILDLDLRLGEGTGGALAMRIIEASVNVYNEMQTFSSAGVSGKTEE
HHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA