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The map label for this gene is ubiE [H]

Identifier: 118581053

GI number: 118581053

Start: 2869798

End: 2870508

Strand: Direct

Name: ubiE [H]

Synonym: Ppro_2641

Alternate gene names: 118581053

Gene position: 2869798-2870508 (Clockwise)

Preceding gene: 118581049

Following gene: 118581057

Centisome position: 71.6

GC content: 60.48

Gene sequence:

>711_bases
ATGTTCAGGCTTTCCGAAAAAGGCGAGAGAATCCAACAGATGTTCGGCGCCATCGCACCACGCTATGACTTCCTCAACCG
ACTGCTCAGCTTCGGCATCGATCGGCGCTGGCGCACAAAGGCGGTGCAACTGCTCCACTATGACGAGGGGTCGAGGATCC
TGGATGTGGCCACCGGCACCGGTGACGTGGCGCTGGAGATCGCACGCAGAACGCCGCCATCAGTGCGCATAACGGGAGCC
GACTTCTGCCGGGAGATGGTCGAGCTGGGACAAGAGAAGGTGGCCAGCTCCCCCTACGCCGGACGGATCGACTTCCAGGT
GGCCCCCTGCGAAGCGCTCCCTTTTGCGGACGGCACCTTTGATTCGGTTACCATTGCATTCGGAATCAGGAATGTGGTGG
ACAGGCGAATGGGGCTGGCGGAGATGCGACGGGTGCTGAAACCGGGCGGCAGACTGATCATCCTGGAGTTCTCCACGCCG
CGCTCGGCCCTGTTCAGGCAAATCTACTACTTCTACTTCCGCAGGTTGTTGCCGATGATCGGCGGACTGTTCTCACGCTA
CAACGCCTACAAATACCTGCCCGACTCGGTACTGGAGTTCCCCTCCCCGACGGAGTTCTCCCGCATGATCGCCGAGACCG
GTTTTTGCGATGTCCGGGTCCGGGAACTCACCTTCGGCATCGCTAGCATTTACAGCGGCGACAGGGTCTGA

Upstream 100 bases:

>100_bases
CGGGCAGAAGCCGTTTTTGCTGGTGTTCTCTGCTCCGAGTATGCTACAAGGCAAAAATCAGCTATATATCATCATACTTC
CGTACAAGGTTGTGCAAATC

Downstream 100 bases:

>100_bases
GCGGACGACACCAAACCTCGCTCAGGCCTTGAAGCGATTCTCCGTTCCCGCCACAAGGCGCCTGATATTCTCGTGGTGCT
TGACGATCACCACCAGGGAT

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MFRLSEKGERIQQMFGAIAPRYDFLNRLLSFGIDRRWRTKAVQLLHYDEGSRILDVATGTGDVALEIARRTPPSVRITGA
DFCREMVELGQEKVASSPYAGRIDFQVAPCEALPFADGTFDSVTIAFGIRNVVDRRMGLAEMRRVLKPGGRLIILEFSTP
RSALFRQIYYFYFRRLLPMIGGLFSRYNAYKYLPDSVLEFPSPTEFSRMIAETGFCDVRVRELTFGIASIYSGDRV

Sequences:

>Translated_236_residues
MFRLSEKGERIQQMFGAIAPRYDFLNRLLSFGIDRRWRTKAVQLLHYDEGSRILDVATGTGDVALEIARRTPPSVRITGA
DFCREMVELGQEKVASSPYAGRIDFQVAPCEALPFADGTFDSVTIAFGIRNVVDRRMGLAEMRRVLKPGGRLIILEFSTP
RSALFRQIYYFYFRRLLPMIGGLFSRYNAYKYLPDSVLEFPSPTEFSRMIAETGFCDVRVRELTFGIASIYSGDRV
>Mature_236_residues
MFRLSEKGERIQQMFGAIAPRYDFLNRLLSFGIDRRWRTKAVQLLHYDEGSRILDVATGTGDVALEIARRTPPSVRITGA
DFCREMVELGQEKVASSPYAGRIDFQVAPCEALPFADGTFDSVTIAFGIRNVVDRRMGLAEMRRVLKPGGRLIILEFSTP
RSALFRQIYYFYFRRLLPMIGGLFSRYNAYKYLPDSVLEFPSPTEFSRMIAETGFCDVRVRELTFGIASIYSGDRV

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=262, Percent_Identity=34.7328244274809, Blast_Score=161, Evalue=4e-40,
Organism=Escherichia coli, GI48994983, Length=229, Percent_Identity=36.2445414847162, Blast_Score=165, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17557039, Length=232, Percent_Identity=37.0689655172414, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25143945, Length=123, Percent_Identity=28.4552845528455, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323526, Length=250, Percent_Identity=32, Blast_Score=116, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24641702, Length=245, Percent_Identity=35.9183673469388, Blast_Score=155, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 26900; Mature: 26900

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRLSEKGERIQQMFGAIAPRYDFLNRLLSFGIDRRWRTKAVQLLHYDEGSRILDVATGT
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHEEECCCCEEEEEECCC
GDVALEIARRTPPSVRITGADFCREMVELGQEKVASSPYAGRIDFQVAPCEALPFADGTF
CHHEEEEHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCC
DSVTIAFGIRNVVDRRMGLAEMRRVLKPGGRLIILEFSTPRSALFRQIYYFYFRRLLPMI
CHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
GGLFSRYNAYKYLPDSVLEFPSPTEFSRMIAETGFCDVRVRELTFGIASIYSGDRV
HHHHHHHCCHHCCCHHHHCCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFRLSEKGERIQQMFGAIAPRYDFLNRLLSFGIDRRWRTKAVQLLHYDEGSRILDVATGT
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHEEECCCCEEEEEECCC
GDVALEIARRTPPSVRITGADFCREMVELGQEKVASSPYAGRIDFQVAPCEALPFADGTF
CHHEEEEHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCC
DSVTIAFGIRNVVDRRMGLAEMRRVLKPGGRLIILEFSTPRSALFRQIYYFYFRRLLPMI
CHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
GGLFSRYNAYKYLPDSVLEFPSPTEFSRMIAETGFCDVRVRELTFGIASIYSGDRV
HHHHHHHCCHHCCCHHHHCCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA