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The map label for this gene is yegE [H]

Identifier: 118578870

GI number: 118578870

Start: 449899

End: 451194

Strand: Direct

Name: yegE [H]

Synonym: Ppro_0429

Alternate gene names: 118578870

Gene position: 449899-451194 (Clockwise)

Preceding gene: 118578869

Following gene: 118578872

Centisome position: 11.23

GC content: 60.49

Gene sequence:

>1296_bases
ATGAGCGATTCGACCTGCCGCATACTGGAACAGTTGGCCAAGGGACGTGTGCCGGAGGCCATTCCCGACGATGCCGTCTG
CGCCGATGAACTGCGGCGGTTGGCCGAGTATCTTGCGGCTGTACAATGCTTCACCGTTGCGCTGGGCAACGGTGATCTGA
GCACGTCGCTCACGGGCTTCGGCGGCCCGGTCGCCGGAGGGCTGAAGTCGCTCCAGGCCAGCCTGCGTCATCTCACCTGG
CAGACGCGGCAGGTTGCGGCGGGAGACTTCAGCCAGCGGGTTGATTTCATGGGCGAGTTCGCGGCAAGTTTCAACGCCAT
GGTTGTCAGTCTGGCCGAGGCGCGCCGGGACATGGAGCGCATGAATGCCAGGTTACAGGAAGAACTGGCCCAGCAGCTGG
CCATGGCGGAGGCGTTGCGGGAAAACCAGGAGTGCTTCAGGCTGATCACCGAAAATGTCAACGTGGTTATCTGGATCATG
GATGCTACCACGCTGCGCTTCACCTATGTGGGGCCCTATATCACCAGGCTCCGCGGACTGAGTGTTGAGGAGGCGCTGGC
CGAGACGTTTGAGGAATCCCTGGCCCCTGATTCACGGGTGCGGGTCATGGAGAAGATGGCGCAGAACATGGAACGCTTTC
GCCAGACCGCTGATGTTTCCGTCTTCTTCGACAGCATCGAGGTGGAACAGCTTTGCAGGGATGGTCGTTGTGTTCACGTT
GAGATGGTGATCTCAGCCATTACGGATAAAGCGGGAAAACTGAAAGATTTCGTAGGAGTCTCCCGTGACATTTCGACACG
CAAGGCTGTCGAGCAAGAGCTTACCTATCTGAGCAACCACGACTCGTTAACCGGACTCTATAACCGGGCATTCTTCGATG
CCGAGCTGGAACGGGCGACCCATTCCCGGGACTTTCCCCTGAGCATTATCGCAGCTGACCTGGACGGCCTGAAAACGGTC
AACGACACCCTGGGCCACGCCATGGGCGACCGGCTGATCAAGGGGGCTGCCGCTGTCCTGCTGATGGCATTCCGGGATGA
TGACATTATCTCCCGTACGGGGGGCGACGAATTCGTGGTTCTGCTCCCCTGCATGGGGACCGAGGCCGCGACCGTCCTGC
TGGGCCGCATCAGGGCCTGCGAGGAGAGCTACAACGCCACCGAGGAAGGTCCGGCGGTGAGGATGTCGCTGGGAGTGGCA
ACGGCGCTGAACAGTGGTGAGGTTGCCCAGGCGCTGGCGGATGCCGATGCCCGCATGTATGCCGACAAGGCGTTGCGAAA
GCAGAAGAGGGGATAA

Upstream 100 bases:

>100_bases
TGCTGGAGGGCTTCTGTGGTAAAAAATTCGTGGTCAAGGAGGTGGATTGCTGGTGCACCGGTGATCGCACCTGCCGCTTC
AGGGCCGAGGCGGATGTCCC

Downstream 100 bases:

>100_bases
TGCTTGCGTAAGGGGTCTGGCCCGCACCATTCACGGTGCGGGCCAGACGATGGGGTATGACGGGGAACTGCAGCTGGTGT
TACAGGGTGCGACCGGACTG

Product: PAS/PAC sensor-containing diguanylate cyclase

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSDSTCRILEQLAKGRVPEAIPDDAVCADELRRLAEYLAAVQCFTVALGNGDLSTSLTGFGGPVAGGLKSLQASLRHLTW
QTRQVAAGDFSQRVDFMGEFAASFNAMVVSLAEARRDMERMNARLQEELAQQLAMAEALRENQECFRLITENVNVVIWIM
DATTLRFTYVGPYITRLRGLSVEEALAETFEESLAPDSRVRVMEKMAQNMERFRQTADVSVFFDSIEVEQLCRDGRCVHV
EMVISAITDKAGKLKDFVGVSRDISTRKAVEQELTYLSNHDSLTGLYNRAFFDAELERATHSRDFPLSIIAADLDGLKTV
NDTLGHAMGDRLIKGAAAVLLMAFRDDDIISRTGGDEFVVLLPCMGTEAATVLLGRIRACEESYNATEEGPAVRMSLGVA
TALNSGEVAQALADADARMYADKALRKQKRG

Sequences:

>Translated_431_residues
MSDSTCRILEQLAKGRVPEAIPDDAVCADELRRLAEYLAAVQCFTVALGNGDLSTSLTGFGGPVAGGLKSLQASLRHLTW
QTRQVAAGDFSQRVDFMGEFAASFNAMVVSLAEARRDMERMNARLQEELAQQLAMAEALRENQECFRLITENVNVVIWIM
DATTLRFTYVGPYITRLRGLSVEEALAETFEESLAPDSRVRVMEKMAQNMERFRQTADVSVFFDSIEVEQLCRDGRCVHV
EMVISAITDKAGKLKDFVGVSRDISTRKAVEQELTYLSNHDSLTGLYNRAFFDAELERATHSRDFPLSIIAADLDGLKTV
NDTLGHAMGDRLIKGAAAVLLMAFRDDDIISRTGGDEFVVLLPCMGTEAATVLLGRIRACEESYNATEEGPAVRMSLGVA
TALNSGEVAQALADADARMYADKALRKQKRG
>Mature_430_residues
SDSTCRILEQLAKGRVPEAIPDDAVCADELRRLAEYLAAVQCFTVALGNGDLSTSLTGFGGPVAGGLKSLQASLRHLTWQ
TRQVAAGDFSQRVDFMGEFAASFNAMVVSLAEARRDMERMNARLQEELAQQLAMAEALRENQECFRLITENVNVVIWIMD
ATTLRFTYVGPYITRLRGLSVEEALAETFEESLAPDSRVRVMEKMAQNMERFRQTADVSVFFDSIEVEQLCRDGRCVHVE
MVISAITDKAGKLKDFVGVSRDISTRKAVEQELTYLSNHDSLTGLYNRAFFDAELERATHSRDFPLSIIAADLDGLKTVN
DTLGHAMGDRLIKGAAAVLLMAFRDDDIISRTGGDEFVVLLPCMGTEAATVLLGRIRACEESYNATEEGPAVRMSLGVAT
ALNSGEVAQALADADARMYADKALRKQKRG

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: COG2199

COG function: function code T; FOG: GGDEF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=300, Percent_Identity=28.3333333333333, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI87082007, Length=178, Percent_Identity=32.5842696629214, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1787262, Length=164, Percent_Identity=33.5365853658537, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081881, Length=195, Percent_Identity=29.2307692307692, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1787541, Length=185, Percent_Identity=30.8108108108108, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786584, Length=185, Percent_Identity=35.1351351351351, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87081974, Length=146, Percent_Identity=32.1917808219178, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI145693134, Length=150, Percent_Identity=30, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787816, Length=155, Percent_Identity=29.0322580645161, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 47377; Mature: 47246

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50113 PAC ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSTCRILEQLAKGRVPEAIPDDAVCADELRRLAEYLAAVQCFTVALGNGDLSTSLTGF
CCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCC
GGPVAGGLKSLQASLRHLTWQTRQVAAGDFSQRVDFMGEFAASFNAMVVSLAEARRDMER
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNARLQEELAQQLAMAEALRENQECFRLITENVNVVIWIMDATTLRFTYVGPYITRLRGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEEEEECCHHHHHHCCC
SVEEALAETFEESLAPDSRVRVMEKMAQNMERFRQTADVSVFFDSIEVEQLCRDGRCVHV
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEHH
EMVISAITDKAGKLKDFVGVSRDISTRKAVEQELTYLSNHDSLTGLYNRAFFDAELERAT
HHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
HSRDFPLSIIAADLDGLKTVNDTLGHAMGDRLIKGAAAVLLMAFRDDDIISRTGGDEFVV
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEE
LLPCMGTEAATVLLGRIRACEESYNATEEGPAVRMSLGVATALNSGEVAQALADADARMY
EEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHH
ADKALRKQKRG
HHHHHHHHCCC
>Mature Secondary Structure 
SDSTCRILEQLAKGRVPEAIPDDAVCADELRRLAEYLAAVQCFTVALGNGDLSTSLTGF
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCC
GGPVAGGLKSLQASLRHLTWQTRQVAAGDFSQRVDFMGEFAASFNAMVVSLAEARRDMER
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNARLQEELAQQLAMAEALRENQECFRLITENVNVVIWIMDATTLRFTYVGPYITRLRGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEEEEECCHHHHHHCCC
SVEEALAETFEESLAPDSRVRVMEKMAQNMERFRQTADVSVFFDSIEVEQLCRDGRCVHV
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEHH
EMVISAITDKAGKLKDFVGVSRDISTRKAVEQELTYLSNHDSLTGLYNRAFFDAELERAT
HHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
HSRDFPLSIIAADLDGLKTVNDTLGHAMGDRLIKGAAAVLLMAFRDDDIISRTGGDEFVV
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEE
LLPCMGTEAATVLLGRIRACEESYNATEEGPAVRMSLGVATALNSGEVAQALADADARMY
EEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHH
ADKALRKQKRG
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]