Click here to switch to the map view.

The map label for this gene is moaA [H]

Identifier: 118479860

GI number: 118479860

Start: 4518468

End: 4519487

Strand: Reverse

Name: moaA [H]

Synonym: BALH_4298

Alternate gene names: 118479860

Gene position: 4519487-4518468 (Counterclockwise)

Preceding gene: 118479861

Following gene: 118479859

Centisome position: 85.97

GC content: 38.14

Gene sequence:

>1020_bases
GTGGCGATGCAGGAGATGGTTACAGATTTTTTTGGACGCCCACTTCAAGATTTACGCATATCTGTCATTGATCGTTGCAA
TTTTAGATGTACATATTGTATGCCAGCGGAAGTGTTTGGGCCAGATTATGCTTTTTTAAAAGATGAGTTTTTACTGACGT
TTGATGAAATTGAGCGTGTAGCAAAACTATTTGTTAGCATCGGTGTACGAAAAATTAGACTTACTGGTGGCGAGCCACTA
CTTCGTAAAGATTTAGCAAAACTTATTGCACGTCTCGTGAAAATTGACGGGCTATTAGATATAGGGTTAACGACCAATGC
AATTCATTTAACAAAGCAAGCAAAAGCATTAAAAGAAGCTGGATTACATAGAGTAAATGTTAGCTTGGATGCAATAGATG
ATGATGTATTTAAGGCTATTAATGGCCGAAATATTAATACGAAACCTGTTATAAAGGGAATTATGGCTGCAAAAGAGGCA
GGACTTGATGTAAAGGTAAACATGGTTGTGAAAAAAGGGATGAACGATCATCAAGTACTTCCGATGGCTGCGTATTTTAA
AGAGCAAGGAATCACGCTAAGGTTCATTGAGTTTATGGATGTTGGTAGTACGAATGGATGGAACTTTGATCAAGTTGTTA
CGAAGCGAGAGTTAATTGAGATGATTCATCGCGTGTATCCGCTTGAGCCAGCTGAAGCGCATTATTTTGGTGAAGTTGCG
AAGCGATATCGTTACGTTGGAACAAATGTTGAAGTCGGTTTTATTACTTCTGTTTCTGAGTCATTTTGTTCTTCTTGTAC
GAGAGCGAGAATTTCGGCAGATGGAAAGTTTTATACTTGTTTGTTTGCGACAGAAGGTCTCGACATAAGGGAACTTCTTA
GAGCAAAGCTTTCAGATGATGAGCTATTAAGCGTTATACAAGATGTATGGATGAATAGAAAAGATAGGTATTCGGATGAA
CGGACAGAAGAAAGTGCGAAAAATCGTCCGAAAATTGAAATGTCTTATATAGGAGGATAA

Upstream 100 bases:

>100_bases
TGATTAGGAAAGTTTTACTTTATTCACATGAGTAAAAACATCGCAGTTCGAAAATATATTATAATAGAATGAAAAGAGAG
AAATTTGGCAGAAAGGGAGG

Downstream 100 bases:

>100_bases
GAAGGGAGGCTATCGTATGCAGGAGCGATATTCAAGGCAAATATTATTTTCTGGTGTTGGAGAAGAAGGACAGAGAAAAA
TTAGAGAGAAGCATGTGCTT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MAMQEMVTDFFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLKDEFLLTFDEIERVAKLFVSIGVRKIRLTGGEPL
LRKDLAKLIARLVKIDGLLDIGLTTNAIHLTKQAKALKEAGLHRVNVSLDAIDDDVFKAINGRNINTKPVIKGIMAAKEA
GLDVKVNMVVKKGMNDHQVLPMAAYFKEQGITLRFIEFMDVGSTNGWNFDQVVTKRELIEMIHRVYPLEPAEAHYFGEVA
KRYRYVGTNVEVGFITSVSESFCSSCTRARISADGKFYTCLFATEGLDIRELLRAKLSDDELLSVIQDVWMNRKDRYSDE
RTEESAKNRPKIEMSYIGG

Sequences:

>Translated_339_residues
MAMQEMVTDFFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLKDEFLLTFDEIERVAKLFVSIGVRKIRLTGGEPL
LRKDLAKLIARLVKIDGLLDIGLTTNAIHLTKQAKALKEAGLHRVNVSLDAIDDDVFKAINGRNINTKPVIKGIMAAKEA
GLDVKVNMVVKKGMNDHQVLPMAAYFKEQGITLRFIEFMDVGSTNGWNFDQVVTKRELIEMIHRVYPLEPAEAHYFGEVA
KRYRYVGTNVEVGFITSVSESFCSSCTRARISADGKFYTCLFATEGLDIRELLRAKLSDDELLSVIQDVWMNRKDRYSDE
RTEESAKNRPKIEMSYIGG
>Mature_338_residues
AMQEMVTDFFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLKDEFLLTFDEIERVAKLFVSIGVRKIRLTGGEPLL
RKDLAKLIARLVKIDGLLDIGLTTNAIHLTKQAKALKEAGLHRVNVSLDAIDDDVFKAINGRNINTKPVIKGIMAAKEAG
LDVKVNMVVKKGMNDHQVLPMAAYFKEQGITLRFIEFMDVGSTNGWNFDQVVTKRELIEMIHRVYPLEPAEAHYFGEVAK
RYRYVGTNVEVGFITSVSESFCSSCTRARISADGKFYTCLFATEGLDIRELLRAKLSDDELLSVIQDVWMNRKDRYSDER
TEESAKNRPKIEMSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=334, Percent_Identity=39.2215568862275, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI22027536, Length=334, Percent_Identity=39.2215568862275, Blast_Score=226, Evalue=2e-59,
Organism=Escherichia coli, GI1786999, Length=346, Percent_Identity=34.971098265896, Blast_Score=188, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI32566329, Length=334, Percent_Identity=35.3293413173653, Blast_Score=197, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI32566331, Length=326, Percent_Identity=35.5828220858896, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17561210, Length=332, Percent_Identity=35.5421686746988, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI28574488, Length=334, Percent_Identity=35.9281437125749, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI28574490, Length=314, Percent_Identity=36.3057324840764, Blast_Score=204, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38448; Mature: 38317

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMQEMVTDFFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLKDEFLLTFDEIERV
CCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHCCCCHHHHHHHHEEEHHHHHHH
AKLFVSIGVRKIRLTGGEPLLRKDLAKLIARLVKIDGLLDIGLTTNAIHLTKQAKALKEA
HHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHC
GLHRVNVSLDAIDDDVFKAINGRNINTKPVIKGIMAAKEAGLDVKVNMVVKKGMNDHQVL
CCEEEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCC
PMAAYFKEQGITLRFIEFMDVGSTNGWNFDQVVTKRELIEMIHRVYPLEPAEAHYFGEVA
HHHHHHHHCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KRYRYVGTNVEVGFITSVSESFCSSCTRARISADGKFYTCLFATEGLDIRELLRAKLSDD
HHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHCCHH
ELLSVIQDVWMNRKDRYSDERTEESAKNRPKIEMSYIGG
HHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECCC
>Mature Secondary Structure 
AMQEMVTDFFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLKDEFLLTFDEIERV
CHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHCCCCHHHHHHHHEEEHHHHHHH
AKLFVSIGVRKIRLTGGEPLLRKDLAKLIARLVKIDGLLDIGLTTNAIHLTKQAKALKEA
HHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHC
GLHRVNVSLDAIDDDVFKAINGRNINTKPVIKGIMAAKEAGLDVKVNMVVKKGMNDHQVL
CCEEEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCC
PMAAYFKEQGITLRFIEFMDVGSTNGWNFDQVVTKRELIEMIHRVYPLEPAEAHYFGEVA
HHHHHHHHCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KRYRYVGTNVEVGFITSVSESFCSSCTRARISADGKFYTCLFATEGLDIRELLRAKLSDD
HHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHCCHH
ELLSVIQDVWMNRKDRYSDERTEESAKNRPKIEMSYIGG
HHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA