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The map label for this gene is moeA [H]

Identifier: 118478811

GI number: 118478811

Start: 3394842

End: 3396158

Strand: Reverse

Name: moeA [H]

Synonym: BALH_3205

Alternate gene names: 118478811

Gene position: 3396158-3394842 (Counterclockwise)

Preceding gene: 118478812

Following gene: 118478810

Centisome position: 64.6

GC content: 39.33

Gene sequence:

>1317_bases
TTGTCAATAATGGAAAGAAGAGTGCCAATTACGGTTGAAGAAGCTGTTCGTAAAGTAATGGAATTTACTAATGAGGGTTT
AAAGGAGCTACTACCTATTGAATTAGCTTACGGACGTGTATTAGCGGAGGATTTAGTAGCTGACCATGACGTACCTTCAT
TCAATCGTTCCCCGTATGACGGATTTGCTATTAGAGCAGAAGATACGAATGTAGCAAGTTATGAAACGCCAATTGTATTT
GAAGTAGTGGGTGAAATTGGTGCAGGATCGCTATTCGATGAGAAAGTAGGTCCGTTTCAAGCAGTTCGAATTATGACGGG
AGCACAGATTCCGAGTGGATGTGATGCAGTTGTTATGCTAGAGCTGACTCGTCAATATGAGGAGGCTGGCAGTAAGTATA
TGGAATTGAAACGGCCATTCAAAACGGGCGATAATATTTCTTTTCAAGGTGAAGATGCTCGTAAAGGAACGGTTCTTGCA
AAGAAAGGAACATACATTAATCCAGGTATTTCAGCTCTTCTTGCTACGTTTGGGTATAGCGAGGTGCCAGTTGCGAGAAA
GCCTGTAGTTGGACTATTAGCGACTGGCAGTGAATTACTGGATGTAAACGATTCATTACAGCCAGGGAAAATCCGAAATA
GTAATACGTATATGATATTGTCTCAAATCCGAAGAGCAGGCGGAAGAGTAAAATATTTTGGGAAGTTTAGCGATGATTTT
CATACGTGTTTTACGGCTGTAAAAGAAGCATTAAGCCAAGTAGATATGCTCATTACAACAGGTGGTGTATCCGTAGGGGA
TTACGATTATTTGCCAGCTATATACGAAAAATTAGGTGCATCAGTTCTTTTTAATAAAGTTGCAATGCGGCCAGGAAGTG
TAACGACTGTAGCGCAATTAAATGGCAAGTTATTATTTGGTTTATCAGGAAATCCCTCTGCTTGTTACGTAGGGTTTGAA
TTGTTTGTAAGACCTTGTATTCGGACGTATATGTTTAGTGAAAAAGCACATGTAAAAAGAGAAAAAGCGTTATTAGGAGA
AGACTTTTTAAAGCCAAATCCATTTACAAGATTTGTACGAGCAAAATTGACATATAACGAAGGTCAGTTAATTGCTTATC
CGTCAGGGTTTGATAAATCTAGCTCAGTTTCCTCTCTAGCGGAGACAAATATATTTATTGTACTTCCAGGTGGTACGAGA
GGTTATAAAAAAGGTATGTTCGTAGATGTGCTCTTGTTGGAAGATAACGAAGGTAGTGAATGGCCTTGGACATTTTATAA
AGTGAGAGGTGATTCTAATGGGGCAAGTGCTATTTGA

Upstream 100 bases:

>100_bases
CGTCGTTATTTTTCGAGATGGTCGTGTTTTCATTCATGGTACAAATGATATTTCAAAAGCGAAACAGTTATATTATCGCG
TATTCGGTTAATAGAAAGGG

Downstream 100 bases:

>100_bases
AATTGTAGATATACCGATTGTAGTTGAAGAAGTAACGAATAAGGTTGCAAGAAGAGACGCAGGTGCGATTACAACTTTTA
TTGGTACAGTGAGAGAATTA

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSIMERRVPITVEEAVRKVMEFTNEGLKELLPIELAYGRVLAEDLVADHDVPSFNRSPYDGFAIRAEDTNVASYETPIVF
EVVGEIGAGSLFDEKVGPFQAVRIMTGAQIPSGCDAVVMLELTRQYEEAGSKYMELKRPFKTGDNISFQGEDARKGTVLA
KKGTYINPGISALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDF
HTCFTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFE
LFVRPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRAKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTR
GYKKGMFVDVLLLEDNEGSEWPWTFYKVRGDSNGASAI

Sequences:

>Translated_438_residues
MSIMERRVPITVEEAVRKVMEFTNEGLKELLPIELAYGRVLAEDLVADHDVPSFNRSPYDGFAIRAEDTNVASYETPIVF
EVVGEIGAGSLFDEKVGPFQAVRIMTGAQIPSGCDAVVMLELTRQYEEAGSKYMELKRPFKTGDNISFQGEDARKGTVLA
KKGTYINPGISALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDF
HTCFTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFE
LFVRPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRAKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTR
GYKKGMFVDVLLLEDNEGSEWPWTFYKVRGDSNGASAI
>Mature_437_residues
SIMERRVPITVEEAVRKVMEFTNEGLKELLPIELAYGRVLAEDLVADHDVPSFNRSPYDGFAIRAEDTNVASYETPIVFE
VVGEIGAGSLFDEKVGPFQAVRIMTGAQIPSGCDAVVMLELTRQYEEAGSKYMELKRPFKTGDNISFQGEDARKGTVLAK
KGTYINPGISALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFH
TCFTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFEL
FVRPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRAKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRG
YKKGMFVDVLLLEDNEGSEWPWTFYKVRGDSNGASAI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=423, Percent_Identity=34.9881796690307, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI66932975, Length=423, Percent_Identity=34.9881796690307, Blast_Score=207, Evalue=2e-53,
Organism=Escherichia coli, GI1787049, Length=386, Percent_Identity=33.419689119171, Blast_Score=182, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI25147659, Length=398, Percent_Identity=29.3969849246231, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17562606, Length=393, Percent_Identity=27.9898218829517, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17136978, Length=367, Percent_Identity=29.4277929155313, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24638841, Length=367, Percent_Identity=29.4277929155313, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 48104; Mature: 47972

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIMERRVPITVEEAVRKVMEFTNEGLKELLPIELAYGRVLAEDLVADHDVPSFNRSPYD
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GFAIRAEDTNVASYETPIVFEVVGEIGAGSLFDEKVGPFQAVRIMTGAQIPSGCDAVVML
CEEEEECCCCCCCCCCCCCEEEHHCCCCCCCCHHCCCCHHEEEEEECCCCCCCCCEEEHH
ELTRQYEEAGSKYMELKRPFKTGDNISFQGEDARKGTVLAKKGTYINPGISALLATFGYS
HHHHHHHHHCHHHHHHHCCCCCCCCEEECCCCCCCCEEEEECCCEECCCHHHHHHHCCCC
EVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDF
CCCCCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCEEHHHHHHHCCCCEEEEECCCCHH
HTCFTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQL
HHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCEEEEEEC
NGKLLFGLSGNPSACYVGFELFVRPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVR
CCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHEEEE
AKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYKKGMFVDVLLLEDNEGSE
EEEEECCCEEEEECCCCCCCCHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEEECCCCCC
WPWTFYKVRGDSNGASAI
CCEEEEEEECCCCCCCCC
>Mature Secondary Structure 
SIMERRVPITVEEAVRKVMEFTNEGLKELLPIELAYGRVLAEDLVADHDVPSFNRSPYD
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GFAIRAEDTNVASYETPIVFEVVGEIGAGSLFDEKVGPFQAVRIMTGAQIPSGCDAVVML
CEEEEECCCCCCCCCCCCCEEEHHCCCCCCCCHHCCCCHHEEEEEECCCCCCCCCEEEHH
ELTRQYEEAGSKYMELKRPFKTGDNISFQGEDARKGTVLAKKGTYINPGISALLATFGYS
HHHHHHHHHCHHHHHHHCCCCCCCCEEECCCCCCCCEEEEECCCEECCCHHHHHHHCCCC
EVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDF
CCCCCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCEEHHHHHHHCCCCEEEEECCCCHH
HTCFTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQL
HHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCEEEEEEC
NGKLLFGLSGNPSACYVGFELFVRPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVR
CCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHEEEE
AKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYKKGMFVDVLLLEDNEGSE
EEEEECCCEEEEECCCCCCCCHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEEECCCCCC
WPWTFYKVRGDSNGASAI
CCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]