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The map label for this gene is yvaE [H]

Identifier: 118478594

GI number: 118478594

Start: 3158330

End: 3158623

Strand: Reverse

Name: yvaE [H]

Synonym: BALH_2971

Alternate gene names: 118478594

Gene position: 3158623-3158330 (Counterclockwise)

Preceding gene: 118478595

Following gene: 118478592

Centisome position: 60.08

GC content: 30.27

Gene sequence:

>294_bases
GTGCAGTGGATTTATTTAAGTTTAGCAATTTTATTTGAAGTAGCGGGTACAACTGCGATGAAACTATCTGATGGATTAAC
GAAACTAGTACCAAGCATTCTTATTTTTGTATTTTATGTAGTAAGTTTTCTATTTCTTTCATTTGCATTAAAAGGGATGG
AAATGTCCGTTGCATATGCGGTTTGGTCAGGTATGGGAATTGTAACGATTACAACAATTGGTTTTATTTATTTTGGAGAA
AGTATTAATGTAATTAAGATACTAGCAATTCTTTTTATTTTAATTGGAGTGTAA

Upstream 100 bases:

>100_bases
TTATTGAAAAGAGTGATTATACATTGGGAAGTATGCTTGAATCGATTATGGACATGTTACTATATGGCATTTCTAATTCG
AAATAAAAGGTGGGAGAGTA

Downstream 100 bases:

>100_bases
TATTAAATTTTAATAGTGCGGCACATGAAGCGAAGAAAAAAGAAATGGTGGAGGAACGTATACATTGAATCGATTAAAGT
ATTTTTTCCTTATTACTGAT

Product: SMR family multidrug efflux pump

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 97; Mature: 97

Protein sequence:

>97_residues
MQWIYLSLAILFEVAGTTAMKLSDGLTKLVPSILIFVFYVVSFLFLSFALKGMEMSVAYAVWSGMGIVTITTIGFIYFGE
SINVIKILAILFILIGV

Sequences:

>Translated_97_residues
MQWIYLSLAILFEVAGTTAMKLSDGLTKLVPSILIFVFYVVSFLFLSFALKGMEMSVAYAVWSGMGIVTITTIGFIYFGE
SINVIKILAILFILIGV
>Mature_97_residues
MQWIYLSLAILFEVAGTTAMKLSDGLTKLVPSILIFVFYVVSFLFLSFALKGMEMSVAYAVWSGMGIVTITTIGFIYFGE
SINVIKILAILFILIGV

Specific function: Multidrug Transporter. Confers Resistance To A Wide Range Of Toxic Compounds By Removing Them For The Cells. The Efflux Is Coupled To An Influx Of Protons. Probably Prevents The Incorporation Of Methyl VIologen Into Cells. Involved In Ethidium Bromide Ef

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=96, Percent_Identity=41.6666666666667, Blast_Score=75, Evalue=8e-16,
Organism=Escherichia coli, GI87082378, Length=97, Percent_Identity=34.020618556701, Blast_Score=69, Evalue=8e-14,
Organism=Escherichia coli, GI1787884, Length=98, Percent_Identity=39.7959183673469, Blast_Score=60, Evalue=3e-11,
Organism=Escherichia coli, GI1787883, Length=99, Percent_Identity=33.3333333333333, Blast_Score=59, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 10682; Mature: 10682

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQWIYLSLAILFEVAGTTAMKLSDGLTKLVPSILIFVFYVVSFLFLSFALKGMEMSVAYA
CCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VWSGMGIVTITTIGFIYFGESINVIKILAILFILIGV
HHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQWIYLSLAILFEVAGTTAMKLSDGLTKLVPSILIFVFYVVSFLFLSFALKGMEMSVAYA
CCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VWSGMGIVTITTIGFIYFGESINVIKILAILFILIGV
HHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]